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Results for “Conjunctival Neoplasms”

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PubMed1994

The cytological, immunocytochemical and molecular genetic analysis in diagnosis of the neoplasms of the eye, eye adnexa and orbit.

The fine needle aspiration biopsy was performed in 91 patients including 57 cases of retrobulbar tumors done under CT control. All aspirates were cytologically examined. In 21 cases immunocytochemical examination was performed in order to distinguish poorly differentiated neoplasms. In 19 cases malignant lymphoma was distinguished from pseudolymphoma. Cytological diagnosis was confirmed by histopathological examination in 77 cases /84%/. One result was false positive, 3-false negative. The value of immunocytochemical methods in differential diagnosis of poorly differentiated neoplasms was stressed.

Adolescent↗
PubMed1996

[Automatic image analysis of argentophil protein granule quantitative measurement on nucleolus area of limbus epithelial neoplasms].

OBJECTIVE: To study the pathological diagnostic significance of argentophil protein (AgNOR) quantitative analysis at nucleolus area of limbus epithelial neoplasms. METHODS: Automatic image analysis system was used for argentophil protein granule measurement in the pathologic diagnosis of 45 cases with limbus epithelial neoplasms, including benign hyperplasia, atypical hyperplasia, carcinoma in situ and squamous cell carcinoma. RESULTS: In various lesions, there were the differences in the distributive pattern, size and area of AgNOR granules, which were closely related to the nature of the neoplasms (benign or malignant) and its cell differentiation. CONCLUSION: Automatic image analysis of AgNOR quantitative measurement on limbus epithelial neoplasms may indicate the proliferative activity and cell differentiation in various lesions, help to differentiate benign or malignant neoplasms and effectively enhance the level of pathologic diagnosis.

Carcinoma in Situ↗
PubMed1995

Epitheloid cell malignant melanoma of the conjunctiva.

Primary malignant melanoma of the conjunctiva is an uncommon neoplasm comprising only 2% of the malignant tumors of the eye. The tumors are usually composed of epitheloid, spindle or mixed cells and classified according to the predominant cells. Recently we encountered a conjunctival malignant melanoma occurring in a man. After full clinical and laboratory investigations, a clinical diagnosis of malignant melanoma of the conjunctiva in the left eye was entertained. The tumor was resected under local anesthesia and upon histological examination, the case was confirmed as a conjunctival malignant melanoma. Approximately one month after resection, orbital exenteration was carried out. The patient was followed-up for more than a year with no signs of metastasis or recurrence.

Biomarkers, Tumor↗
PubMed1996

Molecular analysis of ocular adnexal lymphoid proliferations. Characteristics of immunoglobulin VH, D and J segment usage.

We investigated the molecular characteristics of six cases of ocular adnexal lymphoid proliferation. Although their clinical diagnoses varied, all of them were diagnosed as having malignant lymphomas by immunohistochemical examinations and molecular approaches. Proliferating cells showed the B cell phenotype, positive for L26/CD20 and negative for UCHL1/CD45RO, and genotypic study by Southern blotting revealed that all cases had gene rearrangements of the immunoglobulin heavy chain with or without those of the kappa (kappa) light chain. Epstein-Barr virus infection was not identified. Usage of variable domains of the immunoglobulin heavy chain was analyzed. Subgroup 3 of the VH gene was present relatively often, in 3 of 6 cases, perhaps due to its having the largest number of VH gene segments. On the other hand, an unexpectedly high frequency of the DLR family of the D gene segment was observed by sequencing the third complementarity determining region. These molecular characteristics in ocular adnexal lymphoid neoplasms might be related to the clinical course.

Adult↗
PubMed2005

Mucoepidermoid carcinoma of the eyelid: a case report and review of the literature.

PURPOSE: To report the clinical features, therapeutic method, and histopathological findings of a case of mucoepidermoid carcinoma in the lower eyelid and review the literature about the mucoepidermoid carcinoma arising from the eye. METHODS: Case report and review of the literature. RESULTS: An 88-year-old man developed a painless, indurated nodule in the left lower eyelid for two years and ulceration of the skin existed for a year. He underwent tumor resection and reconstruction of the eyelid. By histopathology, tumor cells showed an admixture of epidermoid and mucus-secreting cells, which was consistent with mucoepidermoid carcinoma. Mucoepidermoid carcinoma is a common malignant tumor of the salivary glands, but rare in the eye tissues among which conjunctiva and lacrimal gland are most commonly involved. It has a higher degree of malignancy than basal cell carcinoma and squamous cell carcinoma. It displays an unusual capacity of aggressive local invasion and recurs easily after simple excision and tumors may require enucleation or exenteration because of the involvement of the intraocular structures and/or orbit. Frequent follow-up is necessary for the patient after operation. CONCLUSIONS: Mucoepidermoid carcinoma arising from the eye is rare and has a high degree of malignancy. It should be differentiated from other neoplasms such as basal cell carcinoma and squamous cell carcinoma.

Aged, 80 and over↗
PubMed2004

Spontaneous regression of a large-cell lymphoma in the conjunctiva and orbit.

Spontaneous and complete regression of malignant neoplasms is extremely unusual. To our knowledge, this case report is the first description of spontaneous regression of an extranodal malignant lymphoma occurring in the conjunctiva and orbit. A 40-year-old woman noticed a pink conjunctival mass at the medial aspect of her left eye that had been present for 3 weeks. She presented on May 5, 2003. Ophthalmologic examination showed a salmon-colored mass along the lateral side of the caruncle. CT revealed a mass in the medial orbit. Surgical biopsy exhibited a malignant lymphoma, diffuse large B-cell type. After biopsy, the tumor spontaneously decreased in size and completely disappeared in 5 weeks. At 6 months' follow-up, the tumor had not recurred.

Adult↗
PubMed1980

Spindle cell carcinoma of the conjunctiva.

Spindle cell carcinoma, a variant of squamous cell carcinoma, has long been recognized in numerous tissues (including the skin, the upper respiratory tract, the oral cavity, and the esophagus). Two cases of spindle cell carcinoma of the conjunctiva are reported here. Histopathologic examination of these cases shows the characteristic spindle-shaped cells in continuity with the overlying epithelium. Electron microscopy of one case showed desmosomes and cytoplasmic tonofibril-like material. Our direct experience with one of these two cases has shown the malignant neoplasm to be aggressive.

Adult↗
PubMed1987

Localized conjunctival amyloidosis associated with extranodal lymphoma.

A 62-year-old man was found to have a large asymptomatic amyloid nodule of the conjunctiva. Within the next year, a diffuse mixed small and large cell lymphoma of his scapula developed with amyloid in its stroma. No abnormal serum or urine protein was found. Subsequently, rib and paraspinal masses appeared. After irradiation and chemotherapy, the patient died of bronchopneumonia, 3 years after onset. By immunostaining, the amyloid of both conjunctiva and scapular tumor was of polyclonal immunoglobulin (AL) type, most prominently IgG and lambda chains, with lesser staining for IgA and kappa chains. The tumor cells showed a similar pattern. To our knowledge, this is the first report of systemic lymphoma and localized conjunctival amyloidosis without a serum paraprotein, and the first such association with a lymphoma of this cell type. Immunotyping of conjunctival amyloidosis should be performed to guide the workup for possible systemic disease.

Amyloidosis↗
PubMed1984

Ophthalmic involvement in acquired immunodeficiency syndrome.

Forty patients with acquired immunodeficiency syndrome (AIDS) were examined for ocular abnormalities. Twenty of these patients died and the eyes were obtained for culture and histopathologic examination. These patients have multiple opportunistic infections and neoplasms as the result of a severe depression of cellular immunity. Fifty percent of all patients with AIDS and 75% of the autopsy group have ocular signs attributable to AIDS. Ocular findings were confined to four major categories: cytomegalovirus retinitis (10 patients), retinal cotton wool spots (11 patients), conjunctival Kaposi's sarcoma (2 patients) and neuro-ophthalmic motility abnormalities (3 patients). Cytomegalovirus retinitis was a significant cause of visual loss. Seven of 40 autopsy eyes had hand motion or worse visual acuity prior to the patients' death because of CMV retinitis. This necrotic retinitis showed minimal inflammation and progressed to involve the entire retina in three to six months, resulting in a gliotic retinal membrane. Therapy with antiviral agents was not effective. Recognizing the ocular signs of AIDS may facilitate the diagnosis. The ophthalmologist also has a major role in the observation of progression or regression of these ocular manifestations, and can assist in the evaluation of therapy in patients with AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1992

Chondrosarcoma in a wild great white heron from southern Florida.

A typical chondrosarcoma is reported from the nictitating membrane of a great white heron (Ardea herodius occidentalis). This is the first report of a neoplasm in a free flying ciconiiform, and was the only one found in a survey of 957 carcasses from Florida.

Animals↗
PubMedDate not supplied

Neurofibromatosis and neural crest neoplasms: primary acquired melanosis and malignant melanoma of the conjunctiva.

With an occurrence of approximately 1 in 3000 births, von Recklinghausen neurofibromatosis (NF) is one of the most common inherited human disorders. NF is considered a neurocristopathy, a disorder of neural crest derived cells. One of the complications of NF is the development of neural crest derived malignancies such as malignant schwannoma, pheochromocytoma, and malignant melanoma of the skin and choroid. The case history of a patient with NF and conjunctival malignant melanoma which developed in an eye with primary acquired melanosis is yet another example of a neural crest malignancy developing in a NF patient.

Biopsy↗
PubMed1993

Ocular tumors of childhood.

It is important for the pediatrician to be aware of the benign and malignant ophthalmic tumors that can occur in children. This article covers some general concepts related to ocular tumors in children and briefly describes the clinical features and management of some of the more important tumors of the eyelids, conjunctiva, intraocular structures, and orbit. Although most ocular tumors in children are benign, certain malignant neoplasms can threaten the child's life as well as the child's sight. Hence, prompt recognition and patient referral to an ocular oncologist are crucial for proper clinical management.

Child↗
PubMed1986

Malignant melanoma of the conjunctiva.

The clinicopathological features of 37 patients with invasive melanoma of the conjunctiva have been studied. Prognosis was closely related to the subsite and size of the primary tumour. Twenty of 21 patients with small localized bulbar neoplasms (95%) and four of six patients with diffuse bulbar melanomas (67%) have survived with no evidence of secondary spread. By contrast, only one of six patients with neoplasms involving the fornix (17%) and two of four (50%) with caruncular melanomas have survived. Metastatic spread was very uncommon in patients with melanomas less than 1.5 mm in maximum thickness, but the outcome of the disease in patients with tumours greater than 1.5 mm was not always bad. Treatment by local excision biopsy was followed by a high rate of conjunctival recurrence (59%). Exenteration of the affected eye guarded against the development of further orbital disease, but was not infrequently followed by the appearance of metastases. Many (62%) of the tumours appeared to have arisen in a pre-existing melanotic lesion or pigmented naevus of long-standing. Histologically, the tumours could be divided into those with an adjacent intra-epithelial component, manifest as atypical melanocytic hyperplasia in the conjunctival epithelium adjacent to the invasive melanoma, and those without (nodular melanoma). However, clear separation of the former group into the subtypes described for cutaneous melanomas proved impossible. Prognosis was not related to the type of melanoma, mitotic rate, cell type or degree of pigmentation.

Adult↗
PubMed1995

[Mucoepidermoid carcinoma of the epibulbar connective tissue with diffuse intraocular epithelial invasion].

PATIENT: A 55-year-old man was treated twice with local excision and crycoagulation for a recurrent limbal mass of the left eye. The original histologic diagnosis was squamous cell carcinoma. Three months after the last recurrence the globe was enucleated because of a spontaneous perforation at the corneoscleral limbus with iris prolapse. Histologic examination, including PAS and mucicarmine stains, revealed a mucoepidermoid carcinoma of the epibulbar conjunctiva with infiltration of the cornea, sclera, iris and ciliary body. CONCLUSIONS: Examination of specially stained sections (e.g. with mucicarmine) should be routinely performed for those conjuctival neoplasms that contain a squamous component. Aggressive surgical management, such as early enucleation including normal appearing tissue next to the globe, should be considered for treatment of primary mucoepidermoid carcinoma to avoid later exenteration or metastasis.

Carcinoma, Mucoepidermoid↗
PubMedDate not supplied

[Oncocytoma of the conjunctiva].

A 72-year-old woman presented with a lesion in her right eye, which had developed over 2 years. The cherry red lesion was located in the bulbar conjunctiva in the area of the plica semilunaris. Ophthalmologic examination was otherwise normal. Differential diagnosis included a pyogenic granuloma and a hemangioma. Excision of the tumor was performed. Histological examination revealed solid nests and cords of polyhedral cells exhibiting abundant, finely granular acidophilic cytoplasm and round to oval paracentral nuclei usually containing a single prominent nucleolus. The diagnosis of oncocytoma was established. Ocular oncocytomas are rare neoplasms and are mostly found in the caruncle. A location in the bulbar conjunctiva is extremely rare and only two reports are found in the literature with both of these located in the plica semilunaris.

Adenoma, Oxyphilic↗
PubMed1998

[Non-Hodgkin lymphoma of the conjunctiva (MALT lymphoma)--clinical and pathological markers].

BACKGROUND: Lymphoid tumors of the conjunctiva are extremely rare. Primarily such tumors can appear as isolated neoplasm or secondarily within a systemic disease. PATIENTS: The difficulties relating to dignity of the clinical diagnosis and the histological examination of the biopsies are presented. Both patients received orbital radiation therapy. RESULTS: The therapeutically success and clinical course are reported.

Adult↗
PubMed2004

Primary basal cell carcinoma of the caruncle with seeding to the conjunctiva.

BACKGROUND: To report the clinical and histopathological characteristics of a patient with a primary basal cell carcinoma (BCC) of the caruncle with seeding of the tumour to the conjunctiva. METHODS: Surgical excision and histological examination. RESULTS: A 60-year-old female presented with a lesion of the caruncle. Clinical examination revealed a pale lobulated tumour without skin involvement. Computer tomography scans showed orbital invasion. The tumour was excised. Three years later a small polypoid tumour developed in the inferior fornix of the same eye. Two and a half years later, the patient developed an orbital recurrence. Microscopically, both neoplasms were composed of infiltrative islands of basaloid tumour cells, scattered mitoses and peripheral palisading consistent with the diagnosis of BCC. CONCLUSION: This case describes a primary BCC of the caruncle with seeding to the conjunctiva.

Basal Cell Carcinoma↗
PubMed1990

Deeply invasive squamous cell carcinoma of the conjunctiva: case report.

A 82-year-old man had a bulbar exophytic mass protruding through the lids and extending from the nasal side of the limbus to the caruncola in one eye. The lesion appeared 9 months before as a limbal nodule and showed a painless, slow evolution, ultimately leading to enucleation. The histopathologic examination of the neoplasm and eyeball showed an invasive squamous cell carcinoma of the conjunctiva which invaded the deep subepithelial tissue and reached the scleral surface. The evolution and pathologic features of this uncommon neoplasm were similar to that described in other cases previously reported. Such a clinical course is suggestive also of mucoepidermoid carcinoma of the conjunctiva, which closely resembles squamous cell carcinoma, but is more aggressive and locally invasive. However, after staining for mucin, this diagnosis was ruled out.

Aged↗