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At least 127 records · Page 7Linked to original sources
PubMed1997

Psychopharmacogenetic basis of medication-induced movement disorders.

In light of the emerging evidence for genetic vulnerability to adverse drug reactions, this article attempts to elucidate the natural history of medication-induced movement disorders from a psychopharmacogenetic perspective. Studies of the risk factors, neurobiology, and pharmacogenetics are reviewed concurrently. The relevant variables associated with 10 genetically mediated movement disorders are tabulated and compared with those of medication-induced movement disorders without a clear-cut genetic basis. As a result of this integrated analysis, it is evident that there is an intimate genetic and pathophysiological link between neuropsychiatric movement disorders of diverse origins. The emergence of drug-induced movement disorders seems to reflect a spectrum of basal ganglia derangement attributable to genetic predisposition; psychotropic medications only augment the genetic vulnerability to clinical phenotypes. It is proposed that a multidimensional analysis of the interacting variables is essential for understanding the natural history of these conditions, and that the scope of psychopharmacology should be broadened to include psychopharmacogenetics for improving therapeutic objectivity and prevention research.

Animals↗
PubMed1994

Effectiveness of strict credentialing and proctoring guidelines on outcomes of laparoscopic cholecystectomy in a community hospital.

UNLABELLED: Strict credentialing and proctoring guidelines were set up prior to initiating a program of laparoscopic cholecystectomy at the Good Samaritan Hospital in Downers Grove, Illinois. This is a private 386-bed community hospital. At the inception of the program, there were 15 general surgeons who were going to participate in this program. In 1992, there were 20 general surgeons performing the laparoscopic cholecystectomy (LC). The following guidelines were approved by the Credentials Committee and authorized by the Executive Committee: A. Training: A SAGES-approved or equivalent course in LC, meeting or exceeding SAGES guidelines. B. Proctoring: Proctoring of 10 LC cases, prior to operating independently. C. Prevention of injuries: Two surgeons credentialed in LC to operate as a surgeon-cosurgeon team. D. EVALUATION: 100% concurrent review of all LC cases.

Cholecystectomy, Laparoscopic↗
PubMed2004

Cervical pregnancy treated with transvaginal ultrasound-guided intra-amniotic instillation of methotrexate.

AIM: Aim of the study was to investigate the efficacy of single transvaginal ultrasound-guided intraamniotic installation of methotrexate in the management of cervical pregnancy with concurrent review of the literature. MATERIALS AND METHODS: Six patients with cervical pregnancy are included in the study. All patients were treated with single transvaginal ultrasound-guided intraamniotic installation of 70 mg of methotrexate plus folic acid p.o. The main presenting symptoms were mild to moderate vaginal bleeding and lower abdominal cramp-like pain, resembling the clinical presentation of a threatened abortion. The typical ultrasound findings were the absence of intrauterine gestational sac and the detection of a gestational sac within the cervical canal, invading the anterior or the posterior wall of the cervix and normal appearance of the adnexa, bilaterally. The hourglass-shaped cervix was not characteristic at 5 weeks of gestation but it was at 8 weeks of gestation. DISCUSSION: Ultrasound-guided intraamniotic installation of methotrexate in the management of cervical pregnancy appears to be an effective and safe method but the choice of the method should be depended on the gestational age of cervical pregnancy, the presence of active bleeding or not and its severity, the desire for preservation of future fertility, the presence of coexisting valuable intrauterine pregnancy and the experience of the physician in charge.

Abortifacient Agents, Nonsteroidal↗
PubMed2006

Managed care organizations' use of treatment management strategies for outpatient mental health care.

A nationally representative sample of managed care organizations was surveyed (response rate=92%) regarding use of treatment management techniques for outpatient mental health care in their commercial products in 1999. Bivariate tests and logistic regression models were used to examine the relationship between product type, behavioral health contracting arrangement and treatment management techniques (prior authorization, standards for time to initial appointment, concurrent review, standards for follow-up after discharge, case management, practice guidelines). Prevalence varied from 43% to 87% depending on the technique. HMO products and products with specialty behavioral health contracts were more likely to use the techniques. Product type and contracting arrangement had independent effects.

Ambulatory Care↗
PubMed1981

Reliability of echocardiographic and electrocardiographic parameters in assessing serial changes in left ventricular mass.

A reliable noninvasive index of left ventricular mass would be useful in following patients with valvular heart disease and left ventricular hypertrophy. We reviewed concurrent electrocardiograms and echocardiograms from 54 subjects, 39 patients with aortic or mitral valve disease and 15 normal subjects. Pre- and early postoperative echocardiographic estimates of left ventricular mass in 17 patients who had valve replacements correlated well (r = 0.96, p less than 0.001) and demonstrated little change in mean values despite altered left ventricular dimensions. Echocardiographic estimates of left ventricular mass were, therefore, used as a standard for evaluating other noninvasive indices. Precordial electrocardiographic voltage showed a weak correlation with left ventricular mass in the study group as a whole (r = 0.59, p less than 0.001), but no correlation in patients with volume overload (r = 0.36, p = NS). In 18 patients who had preoperative and three separate postoperative studies at least eight weeks apart, changes in left ventricular cross-sectional area (an index of left ventricular mass which corrects for changes in left ventricular volume) closely followed alterations in left ventricular mass. However, changes in posterior wall and interventricular septal thickness often resulted from altered ventricular volume and did not accurately reflect directional changes in left ventricular mass. Serial changes in electrocardiographic voltage were similarly unreliable. We conclude that left ventricular mass and cross-sectional area by echocardiography allow accurate noninvasive assessment of left ventricular mass, whereas wall thickness and electrocardiographic changes do not.

Cardiomegaly↗
PubMed1991

Impact of changing attitudes in carotid surgery on community hospital practice.

In 1985, institutional guidelines for the evaluation and performance of carotid surgery were established in our community hospital. During the 5-year period from 1985 through 1989, 159 carotid reconstructions were done. There were four major strokes (3%), one eventually resulting in death, with the second death in this series from a myocardial infarction (mortality 1%). The combined mortality/major stroke morbidity incidence was 3%. Three transient ischemic attacks (2%) postoperatively cleared promptly without residua. During the latter 1980s, an increasing number of vascular surgeons were doing less carotid surgery. Monitoring institutional quality assurance and individual surgeon performance within the community hospital is becoming a reality. Our experience with institutional guidelines for the evaluation and conduct of carotid surgery, together with an assessment of results and ongoing individual surgeon performance, is presented. Maintaining acceptable morbidity and mortality statistics can be enhanced by having a plan for assessment, management, and concurrent review.

Aged↗
PubMed2005

Feasibility of endovascular repair in penetrating axillosubclavian injuries: a retrospective review.

BACKGROUND: Penetrating injuries to the axillary and subclavian vessels are a source of significant morbidity and mortality. Although the endovascular repair of such injuries has been increasingly described, an algorithm for endovascular versus conventional surgical repair has yet to be clearly defined. On the basis of institutional endovascular experience treating vascular injuries in other anatomic locations, we defined an algorithm for the management of axillosubclavian vascular injuries. Subsequently, a near decade long experience with the management of axillosubclavian vascular injuries was retrospectively analyzed, so as to more accurately assess the true feasibility of endovascular treatment in these patients. METHODS: We defined a management algorithm that included (1) indications, (2) relative contraindications, and (3) strict contraindications for the endovascular repair of axillosubclavian vascular injuries. Anatomic indications for endovascular repair were restricted to relatively limited axillosubclavian injuries (pseudoaneurysms, arteriovenous fistulas, first-order branch vessel injuries, intimal flaps, and focal lacerations). Relative contraindications for endovascular repair included injury to the axillary artery's third portion, substantial venous injury (eg, transection), refractory hypotension, and upper extremity compartment syndrome with neurovascular compression. Strict contraindications to endovascular repair included long segmental injuries, injuries without sufficient proximal or distal vascular fixation points, and subtotal/total arterial transection. Within the context of these definitions, we retrospectively reviewed 46 noniatrogenic subclavian and axillary vascular injuries in 45 patients identified by a prospectively maintained computer registry during a 9-year period. Presentations were reviewed concurrently by two endovascular surgeons, and potential candidates for endovascular management were defined. RESULTS: Among 46 total case presentations and among the 40 patients who maintained vital signs on presentation, 17 were potentially treatable with endovascular therapy. Among the cohort of 40 presentations, the most common contraindications to endovascular therapy were hemodynamic instability (n = 10), vessel transection (n = 7), and no proximal vascular fixation site (n = 3). CONCLUSIONS: Despite growing enthusiasm for endovascular repair of injuries to the axillary and subclavian vessels, realistic clinical presentation and anatomic locations restrict the broad application of this technique at present. In our experience, less than but approaching 50% of all injuries encountered could be addressed with an endovascular approach. This percentage will increase during the upcoming decades if the endovascular technologies available in hybrid endovascular operating rooms uniformly improve.

Adolescent↗
PubMed1996

The value of clinical judgment in the diagnosis of nosocomial pneumonia.

BACKGROUND: Nosocomial pneumonia presents a diagnostic and therapeutic challenge in the care of critically ill patients. The present study was designed to determine as closely as possible the occurrence of nosocomial pneumonia in surgical intensive care unit (ICU) patients using clinical, radiographic, and bacteriological parameters in a prospective concurrent fashion. METHODS: This clinical study enrolled all surgical, trauma, and neurosurgical patients admitted to a surgical ICU over a 13-month period. Routine surveillance was used to identify those patients suspected of developing nosocomial pneumonia. Numerous clinical parameters concerning ventilatory support, acute lung injury, organ dysfunction, nutrition, and length of stays were used to identify factors disposing to development of pneumonia. Univariate and multivariate analyses were used for this purpose. Patients thought to have pneumonia were then followed concurrently to determine, as closely as possible, whether pneumonia was present by serial examination of clinical, bacteriologic, and radiographic data. Those "validated" by this process were then compared to those "nonvalidated" to see if any distinction could be made. RESULTS: Of the 352 patients enrolled, 46 (13%) were initially labeled as having developed nosocomial pneumonia when compared to the 306 patients without pneumonia. Univariate analysis demonstrated a greater need for intubation and mechanical ventilation, longer mechanical ventilation, more acute lung injury, longer ICU and hospital stays, poorer nutrition, and higher mortality (17% versus 5%, P < 0.01). Multivariate analysis demonstrated only length of ICU stay and length of intubation/mechanical ventilation as longer in the pneumonia group. On further concurrent review, 23 of 46 patients were validated as having pneumonia while the rest were felt not to have pneumonia. When the two groups were compared, only asymmetric and segmental radiographic infiltrates distinguished validated from nonvalidated pneumonia patients and all other clinical parameters, including mortality and length of stay, were similar. CONCLUSION: Nosocomial pneumonia was initially suspected in 13% of this ICU population. Numerous clinical parameters clearly distinguished these pneumonia patients from others and they suffered a substantially higher mortality. However, within this pneumonia group, only half of the patients could be validated as truly having pneumonia using available clinical parameters. Nevertheless, those validated were indistinguishable in their clinical behavior from those who were not. This calls into question the need for elaborate and sometimes expensive investigations for diagnosis of nosocomial pneumonia.

Adult↗
PubMed1996

The impact of selective laboratory evaluation on utilization of laboratory resources and patient care in a level-I trauma center.

BACKGROUND: Routine laboratory evaluation of preoperative patients has not been shown to be cost effective when a detailed history and physical examination are performed. However, since such a detailed history is not possible in trauma patients, the time-honored approach has been for laboratory evaluation to be protocol driven. The cost-benefit ratio of this practice has never been evaluated. METHODS: Trauma patients who underwent routine laboratory evaluation (n = 552; group I) were compared with patients who had laboratory evaluation based on clinical need (n = 603; group II). A concurrent review of each case in group II was conducted every day while a retrospective review of charts was conducted for patients in group I to determine patient care issues and identify abnormal trauma center test results. RESULTS: The number of patients with laboratory tests decreased from 97% in group I to 27% in group II (P < 0.0001). Positive chemistry profiles increased (55% versus 92%; P < 0.0001) as did coagulation profiles (8% versus 33%; P < 0.0001). There were no differences in the percentage of patients receiving intervention based on laboratory data (7% in group I versus 8% in group II). No adverse effect on patient care was identified as a result of absent laboratory information in group II. Mortality, length of stay, and intensive care unit days were statistically unchanged. There was an annualized savings of $1.5 million in billed trauma center laboratory charges in group II. CONCLUSION: Selective laboratory evaluation of trauma patients can greatly reduce medical cost and does not adversely affect care.

Adult↗
PubMed1998

The transfusion audit as an educational tool.

Audits of transfusion used as educational tools can improve transfusion practices. Effective audits must first identify problem(s) in transfusion practice and must then include as educational target, the attending physician. Educational methods that have been shown to the effective include: (1) meeting briefly one-on-one with physicians, (2) teaching at scheduled conferences, (3) making daily clinical rounds on patients who receive transfusion, (4) concurrent review of orders for transfusion prior to issue of the blood product and (5) installing algorithms and guidelines in the operating room. Transfusion practices improved with these educational audit methods.

Blood Transfusion↗
PubMed2002

Intra-operative autologous blood management.

The evolution of cardiac surgery has been accompanied by a wide variety of techniques and equipment available for blood conservation. It has also given us data that allows identification of preoperative risk factors for transfusion needs in other surgical specialties. There is however great diversity of opinion as to how this technology should be applied. Examples can be found in the literature of discrepancies between countries but also individual institutions . The authors encounter differences in opinion between practitioners regularly. The authors believe that the variance in opinion may be based on the experiences of single techniques and that a broader depth of practice is required to achieve best practices for intra-operative transfusion management. The most performed procedure in our experience is red cell salvage and processing with a cell-washing device (CS). There are two primary issues related to CS, cost and reduction in allogenic blood exposure. A recent meta-analysis has shown that cell salvage in orthopedic surgery decreases the proportion of patients requiring allogeneic blood transfusion peri-operatively, but post-operative cell salvage is only marginally effective in cardiac surgery. There are close analogies to be drawn from issues surrounding the whole picture of transfusion. Medical practice guidelines are frequently promoted as a way to improve the cost-effectiveness of healthcare. But non-compliance with guidelines is still a major issue. Guiding the decision to transfuse or autotransfuse can improve transfusion practices, but effective processes must first identify problem(s) in transfusion practice and then include the attending medical practitioner as an educational target. Process improvements that have been shown to be effective include, briefly meeting one-on-one with physicians, teaching at scheduled conferences, making daily clinical rounds of patients who receive transfusion, concurrently reviewing orders for transfusion before issue of the blood product, and installing algorithms and guidelines in the operating room. Transfusion practices improved with these process improvements. The success of a change of practice patterns relies on hospital administration, education and feedback, written and immediately available guidelines, employment of specially trained personnel, and establishing long-standing actions. It is the authors' observation that the success of an intra-operation blood management program is twofold, early identification of patients and a multi-team approach of Surgeon, Haematologist, Transfusion services, Anaesthetist and Perfusionist. This team approach offers far greater depth for management of intra-operative blood conservation and transfusion practice. Interventions must be patient specific and targeted toward the best possible patients outcome.

Blood Loss, Surgical↗
PubMedDate not supplied

Mini-open approach to the spine for anterior lumbar interbody fusion: description of the procedure, results and complications.

BACKGROUND CONTEXT: Since the introduction of threaded devices in the mid-1990s, anterior lumbar interbody fusion (ALIF) has become a staple in the armamentarium of the spine surgeon. The procedure, however, is heavily dependent on the ability of the approach surgeon to provide exposure quickly and safely in view of a reported incidence of vascular injury as high as 15% and 2.3% incidence of retrograde ejaculation. PURPOSE: This study describes a mini-open approach to the lumbar spine and discusses the results and the complications seen. STUDY DESIGN/SETTING: The study was designed to evaluate patients for possible complications of the approach while they were in the hospital undergoing ALIF. They were also followed for 6 months after the operation. PATIENT SAMPLE: A total of 686 approaches to the lumbar spine performed on 684 patients between August 1997 and December 2000 were reviewed concurrently and retrospectively. OUTCOME MEASURES: All complications of the approach were reported. These included vascular injury, retrograde ejaculation, deep vein thrombosis (DVT), pulmonary emboli, infection, wound disruption/hernia, ileus, hematoma, myocardial infarction, stroke, peripheral ischemia, rectus muscle paralysis, aborted cases and death. METHODS: The patients were observed in the perioperative period and for 6 months postoperatively to determine the occurrence of complications related to the approach. The data collected included age, weight, gender, levels approached, time of completion of the approach, size of incision and complications. RESULTS: There were six arterial injuries (0.8%), six venous injuries (0.8%) and one instance of retrograde ejaculation (0.1%). In addition, there were seven cases that developed DVT (two ileofemoral and five calf-popliteal, 1.0%), four cases of ileus lasting more than 3 days (0.6%), three wound infections above the fascia (0.4%), two hernias and two compartment syndromes. There was one myocardial infarction and one death. No rectus muscle paralysis occurred. CONCLUSIONS: This experience suggests that a well-planned small incision that preserves the musculature can be performed quickly and safely to allow the spine surgeon adequate access to the anterior lumbar spine. The learning curve, however, can be high even for experienced surgeons.

Adult↗
PubMed2006

[Appropriateness of hospital admissions to a pulmonology department].

OBJECTIVES: To analyze the rate of inappropriate admissions to a pulmonology department over the period of a year and to establish the reasons for such admission and predictors. PATIENTS AND METHODS: All 2004 admissions to the pulmonology department of the Hospital de Valme were analyzed using a version of the Appropriateness Evaluation Protocol (AEP) developed for concurrent review. Two physicians who were not directly involved in admitting the patients performed the review. A logistic regression analysis was performed in order to identify the independent predictors of inappropriate hospital admission. RESULTS: Of the 633 admissions analyzed, 92.1% (n = 583) were appropriate and 7.9% (n = 50) were inappropriate. The main reason for considering an admission to be inappropriate was that the patients in question could have been managed as outpatients (70%), whereas appropriate admissions were most frequently justified by the need for parenteral treatment (76.3%) or respiratory therapy (62%). In the logistic regression analysis, the variables that were independently associated with inappropriate admission were nonurgent admission (odds ratio, 2.82; 95% confidence interval, 1.28-6.21; P = .01), and a neoplasia diagnosis as the reason for admission (odds ratio, 8.57; 95% confidence interval, 2.69-27.24; P < .0005). CONCLUSIONS: The rate of inappropriate hospital admissions was lower than that reported in other studies. Most inappropriate admissions were of patients who could have been managed as outpatients. An admission diagnosis of neoplasm and nonurgent admission were independent predictors of inappropriateness.

Aged↗
PubMed1985

Abbreviated surveillance of nosocomial urinary tract infections: a new approach.

An abbreviated method for the surveillance of nosocomial urinary tract infection is described. Combining desirable features of both active and passive surveillance, this new method involves concurrent review of microbiology reports. Compared to traditional active surveillance methods which require review of individual patient charts, the abbreviated method requires only one-fifth the time commitment while maintaining a 98% sensitivity. Although some degree of overestimation is inherent in this method, the primary goals of surveillance--monitoring infection rates and identifying clusters of infection--should be preserved.

Cross Infection↗
PubMed2000

Acute disseminated encephalomyelitis and multiple sclerosis: magnetic resonance imaging differentiation.

The study was undertaken to compare the MR imaging features of acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS) in a country with a high prevalence of ADEM. Magnetic resonance scans from 33 patients diagnosed clinically with MS (14 patients) or ADEM (19 patients) were reviewed concurrently by two radiologists blinded to the clinical diagnosis. The size, site, morphology and pattern of brain and spinal cord involvement were recorded and the MR imaging diagnosis was compared with the clinical diagnosis. The MR imaging findings matched with the clinical diagnosis in 11 of 14 patients with MS (sensitivity = 78.6%), and with the clinical diagnosis in 15 of 18 patients with ADEM (sensitivity = 78.9%). Three patients had non-specific findings and in a further three patients discordant imaging features were present. One patient with imaging features typical of Balo's concentric sclerosis was diagnosed clinically as suffering from ADEM. In a country with a high prevalence of ADEM, the majority of patients with ADEM and MS can be differentiated on MR imaging.

Adolescent↗
PubMed2003

Web-based clinical decision support system for triage of vestibular patients.

OBJECTIVES: We sought to use a clinical decision support system (CDSS) to save costs and to improve scheduling of vestibular patients in an otolaryngology clinic. STUDY DESIGN AND SETTING: We conducted a concurrent review of 50 vestibular patients scheduled in the University of Missouri otolaryngology clinic with or without testing based on the outcome of a CDSS. The CDSS was implemented using Web-based technology. Charges incurred by the health care system through tests determined by the CDSS were compared with those incurred using the standard procedure of ordering hearing tests and electronystagmography for all patients. RESULTS: Thirty-nine tests were prescheduled using the CDSS. Twenty-five additional tests were ordered after the visit. The CDSS resulted in savings of $37,904.00 in charges to the health care system. The CDSS showed high specificity and variable sensitivity. CONCLUSION: A Web-based CDSS can be used to better manage and coordinate patient encounters. SIGNIFICANCE: One important reason to use a CDSS in health care management is to lower costs.

Adult↗
PubMed2000

Effectiveness of a vancomycin restriction policy in changing the prescribing patterns of house staff.

After noting a rise in vancomycin-resistant enterococci (VRE) infections, we initiated a program to decrease inappropriate vancomycin use that focused on improvement of house staff prescribing practices. The initial intervention in June, 1995, encouraging house staff to follow hospital guidelines for vancomycin use and eliciting support from service chiefs in this effort, had little impact. A more intensive educational intervention, beginning in January, 1996, involved concurrent review of all vancomycin orders and one-on-one discussion with the house staff regarding the rationale for the order by an infectious diseases clinical pharmacist. When usage was deemed inappropriate, the pharmacist asked that vancomycin be discontinued, but no automatic stop orders were issued. During the next two and one-half years, this second intervention proved effective at decreasing inappropriate use from 39% to 16.8% +/- 2.4% (p = 0.005). This change was primarily due to a decrease in appropriate vancomycin prophylaxis by cardiothoracic surgery. VRE infections decreased from 0.29/100 patients discharged prior to initiating the program to 0.13/100 patients discharged after the second intervention (p = 0.01). This educational program, although labor-intensive, preserved house staff decision-making skills related to antibiotic prescribing at the same time that it decreased inappropriate vancomycin use.

Antibiotic Prophylaxis↗
PubMed2005

Cost of a ventilator-associated pneumonia in a shock trauma intensive care unit.

BACKGROUND: Nosocomial pneumonia and especially ventilator-associated pneumonia (VAP) are costly complications for the hospitalized patient. Nosocomial pneumonia has been estimated to cost $5,000 per episode, but the specific cost for a VAP has not been well estimated. As part of a successful performance improvement program in decreasing VAP from 10 VAPs/100 ICU admissions to 2.5 VAPs/100 ICU admissions, we examined the costs associated with VAP. METHODS: From January 1, 2002, through September 30, 2003, Shock Trauma Intensive Care Unit patients and charts were reviewed concurrently by an infection control practitioner for development of VAP as defined by National Nosocomial Infection Surveillance (NNIS) guidelines. Costs were obtained from the hospital's cost accounting software Transition Systems version 3.1.01 (TSI). All patients requiring greater than one day of mechanical ventilation were evaluated. Seventy patients with VAP and 70 patients without VAP were matched according to age and Injury Severity Score. Differences were compared using Kruskal-Wallis and two sample T-tests. Significance was considered for p < 0.05. RESULTS: The ICU cost difference was significant (p < 0.05) between the case-controlled patients with VAP ($82,195) and those without VAP ($25,037). There was also a significant increase in ICU length of stay (21.6 versus 6.4 days) and the number of ventilator days (17.7 versus 5.8; both, p < 0.05). Mortality was not different in the case-controlled population. A substantial portion of the increased cost of a VAP was from the increase in ICU length of stay ($1,861/day). Pharmacy, respiratory and "other" also accounted for the increases when cost distribution was analyzed. This translates into a cost avoidance of approximately $428,685 per 100 admissions to the ICU. CONCLUSIONS: Ventilator-associated pneumonia not only leads to a significant increase in ventilator days and ICU length of stay, but adds substantially to hospital costs. In our ICU, an episode of VAP costs $57,000 per occurrence.

Adult↗