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Pinworm granuloma of cervix uteri--incidental observation following IUD use and cone biopsy.

A pinworm granuloma of cervix uteri was found incidentally in a hysterectomy specimen following cone biopsy for severe epithelial atypia. This lesion was regarded as too recently formed to be related to prior IUD use. The granuloma was apparently asymptomatic, as were 24 of 34 such lesions cited as involving uterus, adnexa or pelvic peritoneum or some combination of these sites. The only previous instance to be found of apparently deep cervical invasion by pinworms was associated with grossly evident carcinoma; the intact cervix has not yet been reported as subject to pinworm invasion.

Adult↗

Cytoenzymologic investigations on carcinomas of the cervix uteri.

A study was carried out on 85 patients with lesions of the cervix uteri: 45 carcinomas and 40 dysplasias. A large battery of cytoenzymatic tests was used to determine their potential value in the diagnosis of carcinomas. An increase of LDH, G6PDH, 6PGDH and NADH2-TR activities and a loss of alpha-GP-ase I activity were demonstrated in malignant cells. It is suggested that the cytoenzymologic techniques may offer help in the distinction between normal, dyskaryotic and malignant cells of vaginal fluid. In individual patients these techniques are useful in understanding the evolution of dysplastic lesions and in the diagnosis of carcinoma. These techniques, however, cannot be used as a general screening test for malignancy.

Adult↗

Acute effects of prostaglandins on the biosynthesis of connective tissue constituents in the non-pregnant human cervix uteri.

Biochemical effects of prostaglandins (PGs) on the connective tissue of the human cervix uteri were studied by measuring the net incorporation of [3H] glycine and [3H] glucosamine into cervical specimens, incubated in vitro in the presence of PGE2 and PGF2 alpha. The net radiolabelling with these isotopes, precursors of collagen and proteoglycans, was influenced by PGE2 and PGF2 alpha in a similar manner. In the follicular phase of the menstrual cycle, both PGs induced a decreased radiolabelling with glycine but caused an increased labelling with glucosamine. In the luteal phase, the situation was reversed, i.e. the incorporation of glycine was augmented and that of glucosamine was reduced in tissue incubated with PGs. It is suggested that PGs can modulate the fibroblast biosynthesis activity in such a way that either the synthesis of fibrous structures (collagen) or that of ground substance constituents (proteoglycans) is favored.

Cervix Uteri↗