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[Organ removal from cadavers. Brain death is disputed as a safe sigh of death].
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[Guideline for the diagnosis of brain death].
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[A diagnostic guideline on brain death].
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Radionuclide brain perfusion studies in suspected brain death.
The radionuclide brain perfusion study (RPS) has been suggested as a method of confirming suspected brain death. The hospital records and RPSs of 34 patients referred were reviewed because brain death was suspected. In every case but one the RPS showed absent or drastically reduced cerebral blood flow. No patient survived more than five days, and 25 survived less than 24 hours. These findings are consistent with the results of previous reports of a total of 248 patients; only one of 248 survived and was discharged from the hospital after having had a positive RPS. The RPS is highly accurate in confirming brain death.
[An intermediary report from the research committee on brain death of the Medico-Legal Society of Japan--could brain death be regarded as somatic death?].
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[The usefulness of ophthalmological investigations, fluoroangioscopy, in particular, for the diagnosis of brain death: III: Fluorescein tests arm-retina and retinal circulation in brain death (author's transl)].
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[Contribution of transcranial Doppler sonography to the diagnosis of brain death in children].
Brain death can be characterized by cessation of cerebral blood flow. We have measured blood flow velocity in cerebral arteries of 17 comatous children with a transcranial pulsed Doppler equipment. In 11 children who progressed to brain death, we have recorded a progressive decrease of Doppler signal with the following steps: decrease of diastolic velocity, no diastolic velocity, reverse diastolic flow, decrease of systolic signal, no signal at all. In the 6 surviving children (all except one with severe deficits), after an initial reduction but never to a retrograde flow, arterial cerebral blood flow velocity increased to high diastolic values before normalization. Transcranial Doppler technique is non invasive, reliable, can be used at the bedside and repeated; it allows evaluating the cerebral blood flow in comatous children and represents a useful adjunct to brain death diagnosis.
Cardiotocographic and sonographic findings in two cases of antenatally diagnosed intrauterine fetal brain death.
Intrauterine fetal brain death is a rare cause of a fixed fetal heart rate pattern. Seven cases have been previously reported in the literature, but only two of them were diagnosed prenatally and all the newborns died soon after delivery. Two additional cases of antepartum diagnosis of intrauterine fetal brain death, managed expectantly, are reported. We had the unique opportunity to document progressive sonographic cerebral changes during the follow-up period, following the neurological event, while the fetus continued life and growth in utero. The cardiographic and sonographic findings suggesting intrauterine fetal brain death were a prolonged fixed fetal heart rate, even following a vibroacoustic and contraction stress test; an atonic fetus without breathing and body movement; and the appearance of hydramnios and the development of ventriculomegaly.
The death of whole-brain death: the plague of the disaggregators, somaticists, and mentalists.
In its October 2001 issue, this journal published a series of articles questioning the Whole-Brain-based definition of death. Much of the concern focused on whether somatic integration-a commonly understood basis for the whole-brain death view-can survive the brain's death. The present article accepts that there are insurmountable problems with whole-brain death views, but challenges the assumption that loss of somatic integration is the proper basis for pronouncing death. It examines three major themes. First, it accepts the claim of the "disaggregators" that some behaviors traditionally associated with death can be unbundled, but argues that other behaviors (including organ procurement) must continue to be associated. Second, it rejects the claims of the "somaticists," that the integration of the body is critical, arguing instead for equating death with the irreversible loss of "embodied consciousness," that is, the loss of integration of bodily and mental function. Third, it defends higher-brain views against the charge that they are necessarily "mentalist," that is, that they equate death with losing some mental function such as consciousness or personhood. It argues, instead, for the integration of bodily and mental function as the critical feature of human life and that its irreversible loss constitutes death.
[Prognosis of comatose patients on ventilator: a prospective study of brain death].
The concept of brain death is widely accepted in most countries. However, there are differences in the criteria for the diagnosis of brain death. In Taiwan, the diagnostic criteria of brain death has just been established. These criteria require strict preconditions to be fulfilled, necessary exclusions to be made, and adequate time of observation to ensure the irremediability of the disease. Tests of brainstem reflexes and apnea are then performed and should be repeated at an interval of at least 4 hours to establish the diagnosis. This prospective study was undertaken in order to examine the reliability of the present criteria. A total of 79 comatose patients (57 males and 22 females) on the ventilator were collected. Their ages ranged from 2.3 to 89 years, with a mean of 46.3 +/- 20.3 years. The preconditions or exclusions were not fulfilled in 5 patients (3 with drug intoxication, 1 with septicemia, and 1 due to an unknown cause). Among them, 1 with alcohol intoxication recovered well. Of 16 patients with hypoxic/ischemic brain damage, brain death was diagnosed in only 2; in the remaining 14 patients, 6 became vegetative and 8 died from cardiac arrest. Fifty-eight patients sustained structural brain damage, and brain death was diagnosed in 50 of these patients. The most frequent cause of brain death was head injury (31 cases), followed by intracerebral hemorrhage (11 cases). Of the 52 patients fulfilling the criteria of brain death, all sustained cardiac asystole in a limited interval of time (96% in 7 days).(ABSTRACT TRUNCATED AT 250 WORDS)
The brain death criterion of human death. An analysis and reflections on the 1977 New York Conference on Brain Death.
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Rectal-scalp temperature difference predicts brain death in children.
When brain death in children occurs, commonly the scalp feels cold despite a normal core temperature. This phenomenon might reflect absent cerebral blood flow and metabolic activity. The authors, therefore, measured rectal-scalp temperature differences in critically ill comatose children to test the hypothesis that a particular temperature difference may correlate with clinical brain death. In a prospective cohort study set in a pediatric intensive care unit, rectal-scalp, rectal-abdomen, and rectal-mastoid temperatures in critically ill comatose children older than 18 months of age were measured before and during brain death evaluations. Twelve children were enrolled. Clinical criteria for brain death were met by seven patients, and five patients survived. All of the seven children who died had rectal-scalp temperature differences greater than 4 degrees C (mean = 6.7, range = 6.0-7.4) at the time of clinical brain death. No survivor had a rectal-scalp temperature difference of 4 degrees C at any time (mean = 3.4, range = 2.9-3.9). Rectal-scalp temperature differences of those who died and those who survived were significantly different at the P < 0.005 level. Rectal-abdomen and rectal-mastoid temperature differences did not correlate with clinical brain death or rectal-scalp temperature difference. In this preliminary study a rectal-scalp temperature difference of greater than 4 degrees C correlates with clinical criteria for brain death in children.
Brain death and organ donation.
Brain death is the irreversible cessation of all brain functions. Brainstem death is the 'physiological core' of brain death. The Indian Parliament has given legal recognition to brain death though it applies only in the context of performance of organ transplantation. Brain death is diagnosed if there is irreversible loss of consciousness, absence of brainstem reflexes and apnoea. Care and diligence in the application of the criteria for brain death provide important safeguards for Individual patients and the community in general. These criteria also allow death to be diagnosed with certainty prior to the occurrence of circulatory arrest. Solid organ transplantation has become possible through the diagnosis of brain death but is not the primary consideration; the management of a potential organ donor, who is brain dead, is also vital. If optimal preservation of organs for transplantation is to be achieved the clinician needs to understand the pathophysiology and consequences of changes occurring in various organs after brain death and active management is required to reverse or control these changes. Discussions about organ donation with relatives of brain deed patients are never easy. These should always be frank and sympathetic. It has been suggested that those whose interests lie in transplantation must bear the responsibility of educating the general public. This will help intensivists who expose themselves knowingly to the unpleasant aspects of organ donation.
Maternal brain death and somatic support.
Brain death is a concept used in situations in which life-support equipment obscures the conventional cardiopulmonary criteria of death, and it is legally recognized in most countries worldwide. Brain death during pregnancy is an occasional and tragic occurrence. The mother and fetus are two distinct organisms, and the death of the mother mandates consideration of the well-being of the fetus. Where maternal brain death occurs after the onset of fetal viability, the benefits of prolonging the pregnancy to allow further fetal maturation must be weighed against the risks of continued time in utero, and preparations must be made to facilitate urgent cesarean section and fetal resuscitation at short notice. Where the fetus is nonviable, one must consider whether continuation of maternal organ supportive measures in an attempt to attain fetal viability is appropriate, or whether it constitutes futile care. Although the gestational age of the fetus is central to resolving this issue, there is no clear upper physiological limit to the prolongation of somatic function after brain death. Furthermore, medical experience regarding prolonged somatic support is limited and can be considered experimental therapy. This article explores these issues by considering the concept of brain death and how it relates to somatic death. The current limits of fetal viability are then discussed. The complex ethical issues and the important variations in the legal context worldwide are considered. Finally, the likelihood of successfully sustaining maternal somatic function for prolonged periods and the medical and obstetric issues that are likely to arise are examined.
[Diagnostic criteria for brain death].
The diagnosis of brain death is made based on the clinical and EEG criteria. Clinical criteria include deep coma, loss of spontaneous respiration, and loss of all the brain stem reflexes. EEG should show electrocortical silence. The EEG examination should fulfill the technical criteria proposed by the Japanese as well as the American EEG societies. In Japan, the Ministry of Health and Welfare criteria for brain death was presented in 1986 after the collaborative study headed by Professor Takeuchi. Those patients with metabolic and endocrine coma, and those under the influence of central nervous depressant drugs or low body temperature should be excluded. Japanese criteria is the most strict one compared to those of other western countries. The most important and frequent source of error in the diagnosis of brain death in which actually alive patients are misdiagnosed as brain death is inappropriate EEG examination. Unless the gain of EEG machine is increased to either 4 (2.5 microV/mm) or 5 (2 microV/mm) with long distance bipolar and monopolar leads, absence or presence of electrocortical silence cannot be evaluated. With this condition, it is imperative to prove that no brain-derived activities above 2 microV are present to make a diagnosis of electrocortical silence (flat EEG). The author believes that as long as the strict clinical and EEG criteria are carefully followed by a specialist, there would be no mistake in the diagnosis of brain death.