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Fibromyxoid areas and immature osteoid are associated with recurrence of primary aneurysmal bone cysts.

AIMS: Primary aneurysmal bone cysts have a high recurrence rate following curettage. The aim of this study was to determine clinicopathological features associated with recurrence of aneurysmal bone cysts. METHODS AND RESULTS: The clinicopathological features of 86 patients (37 males, 49 females, age range 5-62 years) with aneurysmal bone cysts were reviewed. Recurrence rates following curettage and excision were 32.7% and 5.6%, respectively (P = 0.028). The association of clinicopathological features with recurrence was studied in a subset of 45 patients treated by curettage. The presence of nodular fasciitis-like fibromyxoid areas [P = 0.033, odds ratio (OR) = 9.17, 95% confidence interval (CI) 1.06, 79.39] and immature osteoid with active osteoblasts (P = 0.041, OR = 3.7, 95% CI 1.03, 13.35) was significantly associated with an increased risk of recurrence. Clinical and radiological features were not associated with recurrence. In a multivariate analysis, the presence of immature osteoid was a better predictor of recurrence than radiological activity (hazard ratio = 3.18, 95% CI 1.04, 9.73, P = 0.043). There was no statistically significant association between radiological activity and histological features. CONCLUSIONS: Aneurysmal bone cysts with nodular fasciitis-like fibromyxoid areas and immature osteoid with active osteoblasts are more likely to recur. Mention of these features in histopathology reports will help to identify patients who require closer follow-up. Lesions that are apparently radiologically inactive may show fibroblastic and osteoblastic proliferation and therefore may recur.

Adolescent↗

Treatment of unicameral calcaneal bone cysts in children: review of literature and results using a cannulated screw for continuous decompression of the cyst.

Nine unicameral bone cysts of the calcaneus in children were managed surgically using the technique of continuous decompression with titanium cannulated cancellous screws. The average age of the patients at surgery was 12.8 years. At follow-up a minimum of 2 years after surgery, eight cysts showed complete healing; one patient showed healing with residuals. Irritation at the screw insertion site necessitated early removal of the screw in one patient; implant-related problems were not observed in the other patients. Patients were allowed to bear weight after surgery. Implant extraction was performed after full consolidation of the cyst and was uneventful in all patients. A review of the literature and the different treatment modalities used for managing calcaneal cysts is also presented.

Adolescent↗

[Aneurysmal bone cyst of the fourth metacarpal bone--a case report].

Aneurysmal bone cysts of the hand skeleton are rare (only 3 to 4 % of all ABC; Tillmann and v. Torklus 1966 ) and require a differentiated treatment. In the presented case, the fourth metacarpal bone of the right hand was affected (Enneking stage 3). On account of its rapid growth, radical excision was performed and the resected metacarpal bone was replaced by a bicortical iliac crest graft. The bone graft healed in without complications, the functional result is satisfactory. On twelve-month follow-up there were no signs of relapse.

Adult↗

Aneurysmal bone cysts treated by curettage, cryotherapy and bone grafting.

We treated 26 patients with 27 aneurysmal bone cysts by curettage and cryotherapy and evaluated local tumour control, complications and functional outcome. The mean follow-up time was 47 months (19 to 154). There was local recurrence in one patient. Two patients developed deep wound infections and one had a postoperative fracture. We compared our results with previous reports in which several different methods of treatment had been used and concluded that curettage with adjuvant cryotherapy had similar results to those of marginal resection, and that no major bony reconstruction was required. We recommend the use of cryotherapy as an adjuvant to the surgical treatment of aneurysmal bone cysts. It provides local tumour control. Combination with bone grafting achieved consolidation of the lesion in all our patients.

Adolescent↗

Titanium elastic nail--a useful instrument for the treatment of simple bone cyst.

A simple bone cyst is a common benign lytic lesion in the pediatric population. Successful methods of treatment include injections with bone marrow and curettage of the cyst and filling with bone graft or bone graft substitute. Opening the cyst walls and creating a connection with the medullary canal promote healing. We describe a simple method of opening the cyst walls without creating a large cortical defect, using the AO Titanium Elastic Nail. This flexible nail allows creation of connections to the medullary canal in several directions through one cortical hole.

Bone Cysts↗

[Aneurysmatic bone cyst of the 2nd metacarpal bone. A case report].

The aneurysmatic bone cyst of the hand is a rare clinical entity. On the basis of a 13-year-old girl with affection of the second metacarpal, the problem is explained and the various possible therapies are discussed. After ample resection, we decided in our case to transplant a vascularized bone graft from the iliac crest. Until today, this procedure has not been described in the literature.

Adolescent↗

Megavoltage radiotherapy for aneurysmal bone cysts.

PURPOSE: An aneurysmal bone cyst (ABC) is a rapidly expansile and destructive benign tumor of bone that is usually treated by curettage and bone graft, with or without adjuvant treatment. For recurrent tumors, or tumors for which surgery would result in significant functional morbidity, does radiotherapy (RT) provide a safe and effective alternative for local control? PATIENTS AND METHODS: Nine patients with histologically diagnosed aneurysmal bone cysts without other associated benign or malignant tumors were treated at the University of Florida with megavoltage RT between February 1964 and June 1992. The patients received local radiotherapy doses between 20 and 60 Gy, with 6 patients receiving 26--30 Gy. In 6 patients the diagnosis was made by biopsy alone; 3 underwent intralesional curettage before RT. Minimum follow-up was 20 months; 7 of 9 patients (77%) had follow-up greater than 11 years. RESULTS: No patient experienced a local recurrence (median follow-up, 17 years). One patient required stabilization of the cervical spine 10 months after RT because of dorsal kyphosis from vertebral body collapse. No other significant side effects were experienced, and no patients developed secondary malignancies. Four patients were lost to follow-up: at 20 months, 11.5 years, 17 years, and 20 years after the initiation of treatment, none with any evidence of local recurrence. All of the patients who had significant pain before RT had relief of their symptoms within 2 weeks of completion of therapy. CONCLUSIONS: Using modern-day RT, patients with recurrent or inoperable aneurysmal bone cysts can be treated effectively (with minimal toxicity) using a prescribed tumor dose of 26--30 Gy.

Adolescent↗

Aneurysmal bone cyst of the cuboid.

Aneurysmal bone cysts are a rare entity encountered in podiatric medicine. The frequency of aneurysmal bone cysts distal to the ankle joint is low. The authors present a literature review of the etiologies and possible treatments of an aneurysmal bone cyst. An unusual case of an aneurysmal bone cyst in the cuboid is also presented. Only one other documented case of an aneurysmal bone cyst in the cuboid has been reported since 1967.

Adult↗

Cryosurgical treatment of aneurysmal bone cysts.

An aneurysmal bone cyst is a benign, locally aggressive bone process which frequently recurs after excochleation. Exocochleation can be extended without loss of bone tissue by making use of cryosurgery. This combined technique was used in the treatment of 5 patients, without complications. None of the patients described had a demonstrable recurrence 12-60 (average 35) months after this combined therapy.

Adolescent↗

[Aneurysmal bone cyst of the mandible].

BACKGROUND: Aneurysmal bone cysts are benign lesions of bone consisting of a septated, cystic cavity filled with non-endothelium-lined, blood-filled spaces. Aneurysmal bone cysts mainly occur in children and adolescents. Only a few occur in the jaws. PATIENT: This is the report of a 9-year-old girl with an aneurysmal bone cyst in the condyle of the mandible who was admitted to the hospital with swelling in front of her right ear. Because of the location and to eliminate recurrence, complete surgical excision of the condyle was performed. DISCUSSION: Fifty-seven cases of aneurysmal bone cyst of the mandible have been reported to date. Aneurysmal bone cyst is treated by surgical excision, which ranges from enucleation and curettage to conservative resection. CONCLUSION: Simple curettage for aneurysmal bone cyst is reported to be associated with a high recurrence rate, a result of the difficulty of completely excising such a vascular lesion. We recommend complete surgical excision as the best treatment.

Bone Cysts, Aneurysmal↗

Fibro-osseous lesions of the face and skull with aneurysmal bone cyst formation.

Aneurysmal bone cyst engraftment on benign fibro-osseous lesions, well known to occur in the extracranial skeleton, has been reported infrequently in the craniofacial bones. When this combined lesion occurs in the skull the clinical and radiographic features often suggest an aggressive neoplasm. The clinical, radiographic, and pathologic features of five cases are presented, and this uncommon lesion of the craniofacial bones is discussed in view of these cases and those reported in the literature.

Adolescent↗

Treatment of aneurysmal bone cysts with saucerization and bone marrow injection in children.

In four consecutive children, healing of large, active aneurysmal cysts of the long bones was achieved with saucerization, closure of the periosteum, and instillation of autologous bone marrow into the cavity. The saucerization procedure consisted of excision of the subperiosteal new bone with its attached cyst contents and curettage of the remaining cortical bone. A centripetal pattern of bone healing was observed in which an ossification front advanced from the periphery to the center of the cavity. We conclude that autologous bone marrow injections are a simple means of augmenting the healing of aneurysmal cysts of long bones treated with saucerization. The procedure avoids the morbidity and costs associated with alternative methods of bone grafting.

Bone Cysts, Aneurysmal↗

Elastic stable intramedullary nailing for the treatment of complicated juvenile bone cysts of the humerus.

Juvenile bone cysts usually are asymptomatic and may manifest as pathological fractures. Since the new method of flexible intramedullary nailing (" Elastic Stable Intramedullary Nailing" - ESIN or " Embrochage Centro- Médullaire Elastique Stable" - ECMES) has demonstrated superb results in the treatment of non-pathologic fractures of the long bones in childhood, this method is rapidly gaining popularity for the treatment of spontaneous or pathological fractures. Given the self-limiting natural history of juvenile bone cysts with eventual spontaneous healing, our goal is to stabilise the pathological fracture and the biomechanically weakened humerus. We treated 15 patients with 16 pathological fractures (one re-fracture) due to juvenile bone cysts of the proximal humerus. All fractures healed completely without pseudarthrosis. Complications were a secondary fracture in otherwise correctly positioned nails. Five of the 15 implants remain in situ, in 6 cases a repeat osteosynthesis was necessary, in one case the nails had to be changed because of the re-fracture. Ten of the 15 juvenile bone cysts healed over a period of 3 years, the nails were removed and so far there have been no further fractures in this group. In the other 5 cases, the juvenile bone cysts have progressively filled with sclerotic bone, and the nails remain in situ.

Adolescent↗

[The evaluation of selected risk factors of solitary bone cyst recurrence after its curretage and bone graft filling].

Selected risk factors of solitary bone cyst recurrence after curretage and bone graft filling have been analyzed in this study. Seventy-four patients (42 males, 32 females) have been reviewed. The age of patients at the diagnosis ranged between 4 and 55 years (mean 12 years). During follow-up ranging from 1 year to 48 years (mean 18 years) 15 recurrences appeared. It has been found, that sex of the patient, localization and volume of the cyst, septa presence or absence within it have no statistically significant influence on the recurrence. Age below 10 years and the use of allogenic lyophilized bone grafts predispose for recurrence of solitary cyst of bone.

Adolescent↗

Vascular and cartilaginous hamartoma of the ribs in infancy with secondary aneurysmal bone cyst formation.

Three aneurysmal bone cysts of the rib in infants are presented. These tumors were engrafted on vascular and cartilaginous hamartomas and thus showed the unusual feature of hyalin cartilage associated with aneurysmal bone cyst. The entity of vascular and cartilaginous rib hamartoma is discussed with emphasis on the importance of distinguishing this malformation from a benign or malignant neoplasm.

Bone Cysts↗