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PubMed2004

Hospital bioterrorism preparedness linkages with the community: improvements over time.

BACKGROUND: Strong linkages between hospitals and community response entities such as fire safety, law enforcement, emergency management agencies, emergency medical services, public health, and local government administration are an essential element of overall hospital preparedness. These pre-established relationships enable an integrated community response during an emergency. METHODS: This pilot study assessed changes in linkages between hospitals and key community entities related to preparedness for a bioterrorism (BT) event before and after the events of fall 2001. A 51-item questionnaire was mailed to two consecutive hospital samples scheduled for accreditation surveys (April-May 2001 and May-June 2002; n=68 and n=97 responses, respectively). On-site visits by surveyors verified the presence of a plan addressing bioterrorism issues. RESULTS: Substantial improvement in collaborative planning for surge capacity and lab/pharmacy issues occurred. Hospital plans that addressed BT increased significantly (47.1% to 90.7%), as did awareness of community BT-related plans (48.5% to 74.2%). Hospitals that conducted a BT-related drill increased from 19.1% to 48.5%. CONCLUSIONS: Adequate resources are needed, but opportunities remain to further improve collaborative planning, such as agreements with other hospitals on a single media spokesperson or development of a protocol for pharmaceutical distribution. Additional guidance is needed on expected levels of performance regarding linkages.

Bioterrorism↗
PubMed2003

Dentistry and bioterrorism.

Dentistry's role in responding to bioterrorism and other catastrophic events is evolving and may involve a wide range of activities. Organized dentistry. local dental societies. and interested individuals should make local emergency response planners aware of the services the dental profession can provide and should work to integrate dental resources to strengthen the disaster response capacity of community health care systems. With effective planning, education, and training, dentists can play a significant role in responding to acts of bioterrorism or other unforeseen events.

Biological Warfare↗
PubMed2006

Clinical and pathologic differential diagnosis of selected potential bioterrorism agents of interest to pediatric health care providers.

The early recognition of potential bioterrorism agents has been of increasing concern in recent years. The Centers for Disease Control and Prevention has categorized and listed biological terrorism agents. Although any or all of the highest risk biological agents (including inhalation anthrax, pneumonic plague, smallpox, tularemia, botulism, and viral hemorrhagic fevers) can be seen in the pediatric patient, several agents might closely resemble--at least in their initial stages-some of the more common childhood illnesses. The awareness of these similarities and, more importantly,their differences, are critical for all health care professionals. Selected examples of some typical childhood illnesses are presented and then compared with three of the most virulent biological agents (smallpox, anthrax and plague) that might be used in a bioterrorism attack.

Animals↗
PubMed2004

Facing the possibility of bioterrorism.

The possibility of bioterrorism has been met by significant financial outlays to map out public health responses. These have included comprehensive audits of potential agents, as well as exploring mechanisms for counteracting their impact. Psychological intervention and communication have been identified as key areas requiring further work, as fear of infection could pose a greater strain on social resources than the pathogens themselves. Bioterrorism provides a powerful metaphor for élite fears of social corrosion from within. Accordingly, a broader historical and cultural perspective is required to understand why individuals and societies feel so vulnerable to what remain largely speculative scenarios.

Bioterrorism↗
PubMedDate not supplied

The role of public health nurses in bioterrorism preparedness.

BACKGROUND: Public health nurses have a central function in the public health system. Nurses conduct disease surveillance, which is an important first step in recognizing diseases caused by bioterrorist agents. Unfortunately, the current public health infrastructure and expectations for public health nurses are not clearly defined and therefore pose serious difficulties for conducting disease surveillance. Increased surveillance activities for bioterrorism preparedness add more responsibilities to the work of public health nurses. METHODS: A qualitative study on disease surveillance was conducted with public health officials at regional and local levels, working in a variety of urban and rural settings in one large public health region in Texas. Data analysis was supported by qualitative research software, The Ethnograph. RESULTS: The study found that the nurses working at the local level were extremely dedicated to serving their communities, had formed informal partnerships that are essential for disease surveillance, and effectively used informal communication channels to obtain critical surveillance information. The study revealed that nurses had unmet needs and experienced multiple barriers to conducting disease surveillance. CONCLUSIONS: The study's findings could have implications for public policy and nursing leadership. Defining the structure of the public health system and the scope of public health nurses' responsibilities will serve as the cornerstone for improvement of bioterrorism preparedness.

Bioterrorism↗
PubMed2005

Bioterrorism, stress, and pain: the importance of an anticipatory community preparedness intervention.

This article reviews the accumulating scientific evidence demonstrating the negative impact caused by a cataclysmic event, such as bioterrorism, on the mental health of a community. Moreover, the potential mental health problems created by the continuing threat of possible future events are discussed. This close link among disaster events, stress, pain, and psychopathology is presented from a biopsychosocial perspective. Although there are now efforts being systematically developed to prepare for possible future biological or chemical terrorism events, there is currently also a critical need for early mental health intervention in response to future attacks to decrease psychiatric sequelae, especially workforce illness and morbidity. In this article, examples of such emergency bioterrorism preparedness, incorporating a major focus on mental health issues, are reviewed. Although these are now recognized needs, there is still not a concerted effort to prepare the population for the mental health sequelae that would be produced by such events.

Adaptation, Psychological↗
PubMed2006

Microwave-assisted tissue processing for same-day EM-diagnosis of potential bioterrorism and clinical samples.

The purpose of this study was to explore the turnaround times, section and image quality of a number of more "difficult" specimens destined for rapid diagnostic electron microscopy (EM) after microwave-assisted processing. The results were assessed and compared with those of conventionally processed samples. A variety of infectious agents, some with a potential for bioterrorism, and liver biopsies serving as an example for routine histopathology samples were studied. The samples represented virus-producing cell cultures (such as SARS-coronavirus, West Nile virus, Orthopox virus), bacteria suspensions (cultures of Escherichia coli and genetically knockout apathogenic Bacillus anthracis), suspensions of parasites (malaria Plasmodium falciparum, Leishmania major, Microsporidia cuniculi, Caenorhabditis elegans), and whole Drosophila melanogaster flies infected with microsporidia. Fresh liver samples and infected flies were fixed in Karnovsky-fixative by microwaving (20 min), all other samples were fixed in buffered glutaraldehyde or Karnovsky-fixative overnight or longer. Subsequently, all samples were divided to evaluate alternative processing protocols: one part of the sample was OsO4-postfixed, ethanol-dehydrated, Epon-infiltrated (overnight) in an automated tissue processor (LYNX, Leica), and polymerized at 60 degrees C for 48 h; in parallel the other part was microwave-assisted processed in the bench microwave device (REM, Milestone), including post-osmication and the resin block polymerization. The microwave-assisted processing protocol required at minimum 3 h 20 min: the respective epon resin blocks were uniformly polymerized allowing an easy sectioning of semi- and ultrathin sections. Sections collected on non-coated 200 mesh grids were stable in the electron beam and showed an excellent preservation of the ultrastructure and high contrast, thus allowing an easy, unequivocal and rapid assessment of specimens. Compared with conventional routine methods, microwave technology facilitates a significant reduction in sample processing time from days to hours without any loss in ultrastructural details. Microwave-assisted processing could, therefore, be a substantial benefit for the routine electron microscopic diagnostic workload. Due to its speed and robust performance it could be applied wherever a rapid electron microscopy diagnosis is required, e.g., if bioterrorism or emerging agents are suspected. Combining microwave technology with digital image acquisition, the 1-day diagnosis based on ultrathin section electron microscopy will become possible, with crucial or interesting findings being consulted or shared worldwide with experts using modern telemicroscopy tools via Internet.

Animals↗
PubMed2006

Current methods for the rapid diagnosis of bioterrorism-related infectious agents.

Bioterrorism is the calculated use of violence against civilians to attain political, religious, or ideologic goals using weapons of biological warfare. Bioterrorism is of particular concern because these weapons can be manufactured with ease and do not require highly sophisticated technology. Moreover, biologic agents can be delivered and spread easily and can effect a large population and geographic area. The terrorist attacks occurring around the world necessitate society's continued investment in adequate defense against these unpredictable and irrational events.

Bioterrorism↗
PubMed2004

Preventive vaccines against bioterrorism: evaluation of efficacy and safety.

This paper discusses the US Food and Drug Administration's approach to evaluation of vaccines in general, and vaccines against diseases of bioterrorism in particular. We summarize the scientific bases for development and approval of vaccines and then discuss specific issues regarding vaccines against disease organisms that could potentially be used as weapons of bioterrorism.

Animals↗
PubMed2002

Bioterrorism--are you ready for the silent killer?

Current biological threats to the United States have generated fear and panic among many, but nursing professionals who are educated about bioterrorism and its effects can answer questions confidently and calm fears when peers, family members, and friends ask about this issue. Perioperative nurses can become ambassadors of confidence via their ability to project calm and thus stem the tide of panic and fear. This article explains the definition of bioterrorism, its history, biological agents and their transmission, treatment options, and what nurses can do to facilitate preventive measures and help avert panic.

Aerosols↗
PubMed2003

Pathology and pathogenesis of bioterrorism-related inhalational anthrax.

During October and November 2001, public health authorities investigated 11 patients with inhalational anthrax related to a bioterrorism attack in the United States. Formalin-fixed samples from 8 patients were available for pathological and immunohistochemical (IHC) study using monoclonal antibodies against the Bacillus anthracis cell wall and capsule. Prominent serosanguinous pleural effusions and hemorrhagic mediastinitis were found in 5 patients who died. Pulmonary infiltrates seen on chest radiographs corresponded to intraalveolar edema and hyaline membranes. IHC assays demonstrated abundant intra- and extracellular bacilli, bacillary fragments, and granular antigen-staining in mediastinal lymph nodes, surrounding soft tissues, and pleura. IHC staining in lung, liver, spleen, and intestine was present primarily inside blood vessels and sinusoids. Gram's staining of tissues was not consistently positive. In 3 surviving patients, IHC of pleural samples demonstrated abundant granular antigen-staining and rare bacilli while transbronchial biopsies showed granular antigen-staining in interstitial cells. In surviving patients, bacilli were not observed with gram's stains. Pathological and IHC studies of patients who died of bioterrorism-related inhalational anthrax confirmed the route of infection. IHC was indispensable for diagnosis of surviving anthrax cases. The presence of B. anthracis antigens in the pleurae could explain the prominent and persistent hemorrhagic pleural effusions.

Adult↗
PubMed2003

Bioterrorism and infectious animal diseases.

After a brief historical introduction, the authors describe a list of pathogens likely to be used by bioterrorists to adversely affect animal health and production, and eventually human health in case of zoonotic agents. The selection criteria for these numerous pathogens as well as the means available for their procurement, manipulation and dispersal are discussed. The potential consequences of this bioterrorism are evaluated mainly in economic terms. The authors conclude that the threat of bioterrorism is serious and suggest appropriate measures to prevent it or to limit its consequences.

Animal Diseases↗
PubMed2003

Nipah virus--a potential agent of bioterrorism?

Nipah virus, a newly emerging deadly paramyxovirus isolated during a large outbreak of viral encephalitis in Malaysia, has many of the physical attributes to serve as a potential agent of bioterrorism. The outbreak caused widespread panic and fear because of its high mortality and the inability to control the disease initially. There were considerable social disruptions and tremendous economic loss to an important pig-rearing industry. This highly virulent virus, believed to be introduced into pig farms by fruit bats, spread easily among pigs and was transmitted to humans who came into close contact with infected animals. From pigs, the virus was also transmitted to other animals such as dogs, cats, and horses. The Nipah virus has the potential to be considered an agent of bioterrorism.

Agricultural Workers' Diseases↗
PubMed2002

Medical management of the suspected victim of bioterrorism: an algorithmic approach to the undifferentiated patient.

We have purposely expanded on the well-known ATLS paradigm to aid EHCPs in their approach to a potential bioterrorism event. By building on a process that is already familiar, we hope this will aid the EHCP to remember a systematic approach to such an incident. By following this ten-step process, we believe that all EHCPs, and especially those practicing at the first echelons of care in urgent care clinics and EDs, can approach the daunting problem of biological defense with a good deal more confidence. This same model advocated for bioterrorism also may apply to natural infectious disease epidemics, particularly of emerging or re-emerging diseases, that might not be optimally managed by reliance on the conventional public health strategy that requires physician-dependent definitive diagnosis and active reporting mechanisms. The authors hope the acquired knowledge and skills one might gain will rarely be needed, but if the events surrounding the dispersal of anthrax-contaminated mail in the fall of 2001 are any indication of the future, such competencies will be invaluable.

Algorithms↗
PubMed2002

Medical management of vulnerable populations and co-morbid conditions of victims of bioterrorism.

Planning for the medical response to bioterrorism has primarily focused around the needs of the population as a whole. There has been little discussion pertaining to certain vulnerable groups such as children, pregnant women, or immunocompromised patients, yet they will likely comprise a significant subset of the exposed population. In addition, they will be at increased risk for morbidity and mortality following an attack. The emergency response to bioterrorism will be more complex as it relates to these vulnerable populations. Careful consideration of their special needs, some of which are presented in this article, may refine our efforts.

Age Factors↗
PubMed2002

Bioterrorism preparedness. I: The emergency department and hospital.

Fundamental precepts in hospital-based planning for bioterrorist events include having a comprehensive well-rehearsed disaster plan that is based on a threat and vulnerability analysis. JCAHO Environment of Care Standards and an "all-hazards" approach to disaster planning and management form the basis for a solid bioterrorism response plan. During preparation, education and training are imperative. Clinicians must maintain a high index of suspicion for use of bioterrorism agents, be able to make a rapid diagnosis, and promptly initiate empiric treatment. Other personnel from administration, security, public relations, laboratory, pharmacy, and facilities management should be familiar with the plan, know when and how to activate it, and understand their roles in the response. A recognized incident command system should be used. Hospital leadership must be aware of the facility's capabilities and capacities, and should have plans for expansion of services to meet the surge in demand. The command center should coordinate emergency personnel teams, decontamination, security, acquisition of supplies, and notification of public health and other authorities and the media. If the plan is ever implemented, stress management with psychologic support will play an important role in recovery.

Bioterrorism↗
PubMed2002

Threats in bioterrorism. I: CDC category A agents.

Although once considered unlikely, bioterrorism is now a reality in the United States since the anthrax cases began appearing in the fall of 2001. Intelligence sources indicate there are many countries and terrorist organizations that either possess biological weapons or are attempting to procure them. In the future it is likely that we will experience additional acts of bioterrorism. The CDC category A agents represent our greatest challenge because they have the potential to cause grave harm to the medical and public health systems of a given population. Thus, it is imperative that plans be developed now to deal with the consequences of an intentional release of any one or more of these pathogens.

Anthrax↗
PubMed2005

[Emerging or re-emerging infections that can be used for bioterrorism].

USED FOR WARFARE: Bioterrorism is a perfectly foreseeable eventuality. It is defined by the international use, or menace of use, of living organisms whatever their nature, or of substances derived from these organisms, aimed at provoking a disease or the death of human beings, animals or plants. UPDATED COUNTERACTING STRATEGIES: More than 180 infectious agents could be used for terrorist ends. The recent events in the dawn of this twenty-first century have reactivated and notably updated the strategies to counteract such an event. Clinical and therapeutic guidelines have been circulated in many countries. INFECTIONS THAT REQUIRE RECOGNITION: The role of practitioners in the rapid recognition of bioterrorism-related infections is crucial. Hence, updated knowledge on these potentially emerging or reemerging infections is required.

Anthrax↗