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At least 127 records · Page 7Linked to original sources
PubMed2003

Left upper division sleeve segmentectomy for early stage squamous cell carcinoma of the segmental bronchus: report of two cases.

Early hilar lung cancer is rare. It is usually curable if properly diagnosed and treated. We recently encountered two cases of early stage squamous cell carcinoma of the left upper division bronchus, which responded well to left upper division sleeve segmentectomy. Case 1 was a 74-year-old man, a heavy smoker, who was referred to our hospital after sputum cytology had resulted in a positive diagnosis while receiving inpatient care for heart failure at another hospital. Bronchoscopy revealed a thickened tumor at the spur between left B(1+2) and B(3). Squamous cell carcinoma was diagnosed by forceps biopsy via bronchoscopy. Left upper division sleeve segmentectomy with lymph node dissection was performed. Since the bronchi to be anastomosed to each other were greatly different in diameter, telescoped anastomosis was used. His postoperative course was uneventful, and he continues to show good respiratory condition, without any evidence of recurrence 25 months after surgery. Case 2 was a 60-year-old man, a heavy smoker, who was identified by sputum cytology as needing detailed examination during a mass screening of high-risk groups for early detection of lung carcinoma. Bronchoscopy revealed a nodular tumor at the orifice of the left upper division bronchus. Squamous cell carcinoma was diagnosed by forceps biopsy via bronchoscopy. Left upper division sleeve segmentectomy with lymph node dissection was performed. During surgery for this case, the lingular bronchus was dissected obliquely to make its cross-section wide enough to match the diameter of the left upper lobe bronchus to which the former was anastomosed. His postoperative course was uneventful, and he shows good respiratory condition, without any evidence of recurrence five months after surgery. The pathological stage was TisN0M0 (stage 0) in both patients, and their tumors were confirmed as early hilar lung cancer. Sleeve segmentectomy, aimed at radical resection of cancer while preserving lung function, can serve as a standard procedure for surgical treatment of cases of early hilar lung cancer confined to the segmental bronchi.

Aged↗
PubMed1992

[A case of congenital esophago-bronchial fistula communicated between esophageal diverticulum and left main bronchus in the adult--a review of 47 cases in the Japanese literature].

We experienced a successful repair of congenital esophago-bronchial fistula communicated between esophageal diverticulum and left main bronchus in adult case. The patient was a 60-year-old female. She had much wet cough on taking meals since 10 years ago. At the mass screening, a esophago-bronchial fistula was detected by upper GI series. Barium esophagography revealed a fistula between esophageal diverticulum and left main bronchus. The resection of diverticulum and fistula were undergone. In the operation, there exited no adhesion or inflammation around the fistula, therefore it was easy to isorate from the surrounding tissues. This case was categorized as Brainbridge type I esophago-bronchial fistula communicated to left main bronchus. Forty-six cases of congenital esophago-bronchial fistula with diverticulum were reported in Japan, but no cases which communicated with left main bronchus were reported. Then it is assumed that this is the first case in Japan.

Bronchial Fistula↗
PubMedDate not supplied

[Bronchial impairment of main bronchus by aspiration of ferrous sulphate tablet].

The late occurrence of broncial impairment in two children who had aspirated ferrous sulphate tablet ih presented. Local release of cytotoxic oxidant radicals led up to tissue necrosis and consequently to bronchial stenosis and obliteration. Bronchoscopy in the first child confirmed total obliteration of the left main bronchus eleven months after aspiration of iron tablet, and pulmectomy had to be done. In the second child five months after aspiration of iron tablet bronchoscopy confirmed severe stenosis of the right main bronchus and atelectasis of the right lung lobe. Reventilation of right lung has been achieved one month after administration of antibiotics, metilprednisolon and physical therapy. The patient underwent laser therapy (few times) and baloon dilatation in the University Clinic in Graz, but it did not hold passability of the right bronchus. Reventilation of the right middle and lower lobe (but not upper lobe) has been achieved by insertion of endobronchial stent in the main right bronchus. Formation of granulomatous tissue at stent borders necessitated further laser therapy and baloon dilatation. Treatment of this child must be continued.

Bronchi↗
PubMed1992

[Troubled endotracheal intubation: an adult case of anomalous tracheal bronchus].

We experienced troubled endotracheal intubation in an adult patient with asymptomatic tracheal bronchus. The breath sounds of the right upper lobe were found to be absent right after the placement of a tracheal tube. An anomalous tracheal bronchus (displaced right upper lobar bronchus originating about 1 cm above carina) was found by fiberoptic bronchoscopy. The length of trachea of the patient was about 6 cm shorter than that of the normal value of adult male, which significantly reduced the safe range of positioning a tracheal tube. In a patient with this anomaly, who is otherwise healthy, a placement of a tracheal tube may cause pulmonary complications. Thus, as a diminished breath sound is found to be located at the upper right lobe after endotracheal intubation, we have to think of tracheal bronchus as one of the possible causes.

Aged↗
PubMed1991

Functional interactions between capsaicin-sensitive and cholinergic nerves in the guinea pig bronchus.

Electrical stimulation of the right vagus nerve causes a biphasic contraction of the guinea pig isolated right bronchus. The "first-phase" is blocked by hexamethonium or atropine and the "second-phase" is eliminated by capsaicin pretreatment. We investigated a potential interaction between capsaicin-sensitive nerves and cholinergic nerves in the guinea pig bronchus. Hexamethonium (100 microM) abolished the first-phase contraction but had no effect on the capsaicin-sensitive second-phase contraction. In the presence of hexamethonium, atropine (0.1 microM) significantly decreased the amplitude of the second-phase contraction by 28%. Similar results were observed with the M3-selective muscarinic receptor antagonist, 4-diphenyl-acetoxy-M-methylpipe-radine, but not with the M2 muscarinic antagonist, AFDX-116. Atropine also reduced contractions induced by exogenously applied neurokinin A. We then analyzed the effect of stimulating capsaicin-sensitive fibers with electrical field stimulation on vagus nerve evoked cholinergic contractions. By reducing the stimulus intensity we were able to evoke vagus nerve-mediated contractions that were exclusively cholinergic in nature. The cholinergic contractions were significantly increased after stimulation of capsaicin-sensitive fibers by about 50%. By contrast, contractions elicited by exogenous methacholine were unaffected after field stimulation of capsaicin-sensitive responses. Our findings indicate that the contractions of the guinea pig bronchus elicited by stimulation of capsaicin-sensitive nerves are due in part to muscarinic cholinergic receptor activation. Secondly, our data demonstrate that the cholinergic contractions elicited by vagal preganglionic nerve stimulation are potentiated by neurotransmitter(s) released from capsaicin-sensitive fibers in bronchus.

Animals↗
PubMed1988

Depletion of bronchus-associated lymphoid tissue associated with lung allograft rejection.

Pulmonary infections remain one of the major complications of lung transplantation. The bronchus-associated lymphoid tissue (BALT) forms a local immune system that normally protects the lung from infection. The effects of lung transplantation and lung allograft rejection on the BALT were examined using immunoperoxidase techniques. The BALT was evaluated by quantifying the number of immunoglobulin-bearing plasma cells in the lamina propria of sections of trachea and mainstem bronchus. Sections of donor mainstem bronchus from 2 patients with allograft rejection were compared with sections of native trachea from these same patients, and with sections of mainstem bronchus from 2 transplanted lungs without rejection and 20 controls. Lung allografts from the 2 patients with rejection had a marked depletion of submucosal IgA-bearing and IgG-bearing plasma cells. Two sets of transplanted lungs without evidence of rejection showed only a mild reduction of the BALT. The depletion of BALT associated with allograft rejection may contribute to the increased incidence of pulmonary infections seen in these patients.

Bronchi↗
PubMed1979

The effect of head position and angle of tracheal bifurcation on bronchus catheterization in the intubated neonate.

The effect of head position and angle of tracheal bifurcation on bronchus catheterization was studied in newborn infants. Frequency of bronchus catheterization following appropriate head positioning was evaluated radiographically after passage of a No. 5 French feeding tube in eight intubated neonates within 30 minutes post mortem. Positioning the infants head to the right in preparation for a suctioning procedure may facilitate but not assure catheterization of the left main stem bronchus (LMSB). Positioning the infant's head straight or rotating to the left appears to be equally effective in catheterization of the right main stem bronchus (RMSB). The predominance of RMSB catheterization in infants with their head in the straight position may be explained by the different angles of mainstem bronchi divergence which we determined using radiographs. The angles of divergence of the LMSB and the RMSB from the trachea averaged 44.4 degrees and 24.1 degrees, respectively.

Asphyxia Neonatorum↗
PubMed1980

[Functional and morphological studies following bilateral combined bi-lobectomy with resection of th bronchus and pulmonary artery in an animal experiment].

The author carried out 91 combined bilobectomies with circular resection of the main bronchus and the pulmonary artery. The reconstruction was carried out by end-to-end anastomosis of the bronchus and autoplasty of the artery wall by means of different autografts. -- A two-phasic bilateral combined bilobectomy with resection of the bronchus and the pulmonary artery was carried out in two cases. These experiments were described. The functional and copensatoric possibilities of the remained lower parts of the lung regenerate in the late phase after the operation. The blood gas values and the acid-base balance are stabilized too. The structure of the operated lungs in the late phase after the operation is not different from the intact lung tissue. The bronchus anastomosis shows an epithelised mucosa with a soft collagen scar. The anastomosis of the pulmonary artery exhibits a little collagen scar with a swelling of the intima. The autograft was received by the vena azygos, it was structured as a vein with a well-preserved tunica muscularis. The Hering-Breuer-reflex was kept in all the time after the operation. A bilateral combined bilobectomy was not described hitherto in the bibliography.

Animals↗
PubMed1995

[Effectiveness of different methods in the treatment of the main bronchus after pneumonectomy].

Incompetence of the main bronchus within the first 3 postoperative weeks (early incompetence) is proposed as a criterion of efficacy of the main bronchus closure in pneumonectomy. The authors have performed 495 pneumo- and pleuropneumonectomies according to 5 original techniques. No cases of the main bronchus incompetence were registered. Indications to each of the bronchus treatment techniques are detailed.

Adolescent↗
PubMed1994

[Two cases of elderly people diagnosed with acute tuberculous pneumonia possibly succeeded by the perforation of lymph nodes in the bronchus].

The report is a study of the cases in which elderly people (83 years-old male and 81 years-old female) diagnosed has having acute tuberculous pneumonia possibly suffered from subsequent perforation of lymph nodes in the bronchus. Neither of the patients had a prior history of tuberculosis treatment. Both patients were admitted to the hospital after being diagnosed with pneumonia. After the administration of antibiotics, the symptoms of illness improved, but chest roentgenograms were taken failed to show improvement. The patients were then transferred to our hospital, because sputa smear tests for Mycobacteria (Ziehl-Neelsen stain) were performed, and the results were positive. Case I (male) was suspected of having endobronchial tuberculosis, since rhonchi was audible in the left-front upper chest during expiration when performing auscultation. A bronchoscopy was conducted at which time ulcer lesions on the left upper lobe of the bronchus and perforated lymph node of the upper bronchus were detected. Case II (female) was suspected of having lung cancer and a bronchoscopy was performed due to the findings of a chest roentgenogram taken after one month of chemotherapy. A perforated lymph node in right truncus intermedius was detected. In this report, we discussed the early diagnosis of tuberculous pneumonia and the perforation of caseous lymph nodes in the bronchus, which was the main cause of tuberculous pneumonia.

Acute Disease↗
PubMed1994

[An autopsy case of adenosquamous cell carcinoma of the extrahepatic bile duct with endobronchial mass obstructing the left main bronchus and masquerading as asthma].

A 65-year-old male was admitted with diagnosis of bronchial asthma. On admission, he was orthopneic, cyanotic and distressed. Marked hypoxemia with PaO2 of 31.1 mmHg was noted, but no obvious localized airway obstruction on plain chest X-ray film could be detected. These was minimal response to intensive treatment with steroid in addition to various bronchodilators on the presumed diagnosis of bronchial asthma. Two weeks later, chest X-ray disclosed complete atelectasis of the left lung. Stenosis of the left main bronchus with enlarged mediastinal lymph nodes on chest CT was suggested. Endoscopic examination disclosed complete obstruction of the left main bronchus just beyond the carina and polypoid tumors in the right main bronchus and basal segment bronchus. The biopsy specimens revealed squamous cell carcinoma. Chemotherapy with CDDP and VDS resulted in disappearance of atelectasis after one week and marked relief of respiratory distress. Four months later, at the completion of irradiation therapy, an abdominal tumor associated with pain appeared and bone scintigram showed multiple bone metastases. After four times chemotherapy including CDDP, hypercalcemia and renal hypofunction developed, and the patient died. Autopsy disclosed a tumor in the extrahepatic bile duct, cystic lesions of the pancreas and swelling of subcarinal lymph nodes, but no tumorous lesion in the lung and endobronchial tissue. Histological examination of the extrahepatic bile duct tumor revealed adenosquamous cell carcinoma, with predominantly squamous cell carcinoma. Other metastatic lesions consisted of squamous cell carcinoma. These findings are compatible with pulmonary metastases of adenosquamous cell carcinoma of the extrahepatic bile duct.

Aged↗
PubMed1996

[Selection of staple for closure of the lobar bronchus].

From January 1984 to October 1995, Stapling of lobar bronchus excluding middle lobe was investigated in 335 patients with lung cancer. We used routinely the 3.5 mm staple in the previous term and the 4.8 mm staple in the latter term. The stapling with 3.5 mm staple was performed in 220 patients. The stapling failed in the pressure proof test intraoperatively in 8 patients and bronchopleural fistula occurred postoperatively in 4 patients. The bronchus was cut or destroyed by the staple in most of them. The stapling with 4.8 mm staple was performed in 115 patients. The stapling failed in the pressure proof test intraoperatively in one patient because of loose closure of the bronchus. Bronchopleural fistula did not occur postoperatively. In conclusion, the 4.8 mm staple is a better choice for closure of the lobar bronchus except for a small woman or middle lobe.

Adult↗
PubMed1997

[Right tracheal bronchus].

We present 3 cases of tracheal bronchus. The right tracheal bronchus is an uncommon anomaly, more frequent however than on the left side. Two variations are knows, with or without real ectopy. The radiologist can recognize this abnormal bronchus on the CT slices. Most often it is a non-pathogenic finding (unlike the left-sided anomaly). One of the cases, however, had lung cancer in the segment ventilated by the anomalous right bronchus.

Adult↗
PubMed1998

Functional and binding characterization of endothelin receptors in human bronchus: evidence for a novel endothelin B receptor subtype?

Binding and functional studies were conducted to elucidate the receptor subtypes mediating contractions of human bronchus induced by endothelin (ET) receptor ligands. Binding experiments in human bronchial smooth muscle membrane preparations revealed the presence of ETA and ETB receptors in the ratio of approximately 40:60. In the presence of the combination of 1 microM BQ-123 (ETA receptor antagonist) and 1 microM S6c (ETB receptor agonist) or BQ-788 (ETB receptor antagonist) about 10 to 20% of [125I]-ET-1 binding remained. ET-1 (nonselective agonist), ET-3 (ETB receptor-preferring agonist), S6c, IRL 1620 or BQ-3020 (ETB receptor-selective agonists) potently contracted human bronchus. SB 209670 (10 microM) (ETA/ETB receptor antagonist) antagonized ET-1-induced contractions (pKB = 6.1), whereas, BQ-788 (3 microM), RES-701 (10 microM) or BQ-123 (3 microM) were without effect. The combination of BQ-788 (3 microM) and BQ-123 (3 microM) did not influence ET-1 concentration-response curves. Contractions elicited by IRL 1620 or BQ-3020, but not S6c or ET-3, were sensitive to inhibition by BQ-788 (0.03-3 microM). Based on the potent contractile effects of ETB receptor-selective agonists, and the lack of inhibitory effect of BQ-123, ET ligand-induced contractions in human bronchus appear to be mediated via an ETB receptor subtype(s). However, contractions induced by ET-1, ET-3 or S6c are not sensitive to classical ETB receptor antagonists such as BQ-788. Furthermore, a residual component (about 10-20%) of the binding of radiolabeled ET agonists is resistant to various ET ligands. Collectively, these data suggest the presence of a novel ETB receptor subtype which may mediate contraction induced by some ET ligands in human bronchus.

Bronchi↗
PubMed1981

[Bronchus cancer - surgery].

Of 9,000 patients with bronchus carcinoma observed during 1958-1980, 3.041 (33%) underwent resection. Although in principle the standard operations are lobectomy for the peripheral and bilobectomy or pneumonectomy for the central carcinoma, parenchyma-saving operations such as clamping or segmental resection or main bronchus resection are justified under certain conditions; however, here all regional lymph nodes have to be removed again. We consider the surgical indication of small-celled carcinoma like any other form of bronchus carcinoma. For stage I, the 5-year survival chance is 40% - 50%, for all stages only 20%. Extended resections including pericardium, large vessels, thoracic wall, trachea, upper thoracic aperture, are justified especially in symptomatic cases, although the 5-year survival rate is less than 10% in these cases.

Carcinoma, Bronchogenic↗
PubMed1977

Atypical (relaxant) response to histamine in cat bronchus.

Histamine, 2-methylhistamine (a specific H1-receptor agonist), 4-methylhistamine (a specific H2-receptor agonist), isoprenaline, bradykinin, prostaglandin E1, E2, and F 2alpha induce relaxation of carbachol-contracted isolated cat bronchial strips and tracheal chains. Bovine SRS-A contracts bronchus but not trachea. Histamine-induced relaxation of cat bronchus is not blocked by mepyramine (a specific H1-receptor antagonist); metiamide or burimamide (specific H2-receptor antagonists); propranolol ( a beta-adrenoceptor blocker) and indomethacin (a PG-synthetase inhibitor) suggesting non-participation of H1,H2-histamine receptors, beta-adrenoceptors (catecholamine release) and prostaglandin release in histamine-induced broncho-relaxations in the cat. The existence of an atypical histamine response, resistant to both H1- and H2-receptor antagonists is thus established in cat bronchus.

Airway Resistance↗
PubMed1981

Granular cell myoblastoma of the bronchus in a child: a case report.

Granular cell myoblastoma of of the right main bronchus in a 5-year-old girl is reported. The tumor extended to the lower trachea from the right main bronchus which was occluded completely by the tumor. The diagnosis was established histologically by a obtaining bronchoscopic biopsy specimen. Right pneumonectomy was carried out to control pulmonary suppuration caused by the tumor obstruction of the bronchus. External radiotherapy and interstitial brachytherapy were successful to control the growth of the residual tumor. She has been free from symptoms for about 12 years after the treatment.

Bronchial Neoplasms↗
PubMed1998

Leiomyoma of the esophagus and bronchus in a child.

Leiomyomas of the esophagus and/or the bronchus have rarely been reported in children. To our knowledge, the simultaneous presence of this tumor in both the esophagus and a bronchus in a child has not been previously reported. A 7-year old boy presented with respiratory and esophageal symptoms and was found to have a leiomyoma of the esophagus and right main bronchus. The esophageal leiomyoma was treated with limited myotomy, but bronchoscopic resection was possible for the bronchial lesion. The postoperative result was excellent, with normal swallowing and no residual respiratory problems at 1-year follow-up.

Bronchial Neoplasms↗