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At least 127 records · Page 7Linked to original sources
PubMed1979

Adenosarcoma of uterus and ovary: a clinicopathologic study of two cases.

We report the clinical and pathologic features of two cases of adenosarcoma. Our first case occurred in the ovary of a 51-year-old woman with extensive pelvic involvement. She was treated vigorously with radiation and chemotherapy and at the present time almost 9 years later the patient is free of disease. This represents a case with one of the longest survival reported in the literature. Our second case occurred in a 37-year-old woman and was limited to the endometrium.

Adult↗
PubMed1988

Stage I uterine adenosarcoma: a report of six cases.

Six cases of Stage I adenosarcoma of the uterus are reported. Although these neoplasms have generally been regarded as being of low malignant potential with little propensity for distant metastasis, our experience reveals some of them to be aggressive tumors with rapid clinical demise. Five (83%) patients demonstrated recurrence after initial surgery, three despite postoperative vaginal radium or external pelvic radiation. Four of the recurrences occurred in the pelvis and abdomen; the fifth was limited to the vagina. Three patients were dead of disease within three years of diagnosis, two of whom achieved clinical remission for at least one year to combination chemotherapy. One of the remaining three patients died from intercurrent disease without recurrence, and two are alive without disease after treatment for recurrence. Based on this limited experience, we believe these neoplasms should be regarded as potentially as malignant as their mixed Müllerian counterpart.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1988

Mullerian adenosarcoma of the uterus: report of a rare case and review of the literature.

A rare case of Mullerian adenosarcoma of the uterus is described, found during diagnostic curettage. Panhysterectomy was performed. These rare tumors have a low potential for malignancy and are characterized by benign epithelial and malignant stromal elements. They should be distinguished from the highly malignant mixed Mullerian tumors which contain, by definition, both carcinomatous and sarcomatous elements. The literature on the subject has been reviewed.

Female↗
PubMed1990

Endometrioid adenosarcoma of the bladder arising from endometriosis.

Vesical endometriosis is an uncommon entity characterized by the deposition of benign, hyperplastic endometrial tissue in the bladder. To date, only about 160 cases have been reported in the world literature. More uncommon, however, are case reports of extrauterine malignancies arising from pre-existing endometriosis. We report a case of a large endometrial adenosarcoma in a patient who had undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy 10 years previously for endometriosis. To our knowledge this malignancy has never been reported previously to involve the bladder. We review the pathological findings, possible mode of entry into the bladder and current concepts in its treatment.

Endometriosis↗
PubMed1981

Müllerian adenosarcoma of the uterine cervix.

We present a tumor of the uterine cervix that was composed of histologically benign glandular epithelium and a malignant stromal component, justifying the term müllerian adenosarcoma. Ultrastructurally the stromal cells resemble the endometrial stromal cells, the tumor cells of an endolymphatic stromal myosis of the uterine cervix, and the stromal cells of a stromomyoma of the uterus. In addition there is evidence strongly suggesting a differentiation toward smooth muscle. The patient exhibited no evidence of disease one year after surgery.

Female↗
PubMed1978

Extrauterine mesodermal (müllerian) adenosarcoma: a clinicopathologic analysis of five cases.

Five extrauterine examples (three pelvic and two ovarian) of a distinctive mesodermal (müllerian) mixed tumor previously described to occur in the uterus and designated müllerian adenosarcoma are reported. The tumors were diagnosed during the fifth to eight decades of life. They usually formed very large, partly cystic masses, which had occasionally spread to adjacent organs by the time of operation. On microscopic examination the tumors consisted of benign-appearing neoplastic glands lying in a sarcomatous stroma. The glands were lined by a variety of müllerian epithelial cell types, and the stromal element resembled endometrial stromal sarcoma. Three patients had malignant courses manifested by intrabdominal recurrence, distant metastases, or both. This tumor should be clearly distinguished from the more common forms of mesodermal (müllerian) mixed tumor in which the epithilial as well as the stromal component is malignant and the prognosis is much more grave.

Adult↗
PubMed1978

Müllerian adenosarcoma of the uterus. Ultrastructure before and after radiation therapy.

A case of müllerian adenosarcoma arising in the endometrium was studied by light and electron microscopy before and after radiation treatment. The tumor was composed of malignant stroma containing undifferentiated mesenchymal cells admixed with mature fibroblasts and other cell that contained crystalloids. The surface epithelium was lined by epithelial cells with and without cilia, similar to the normal surface epithelium cells of the uterus. High-dose therapeutic irradiation eliminated the undifferentiated mesenchymal cells from the tumor but did not alter the morphology of other epithelial and mesenchymal elements. The immaturity of mesenchymal cells and their radiosensitivity coupled with the ultrasonographic evidence of growth of the tumor point to the probable malignant nature of this neoplasm.

Adult↗
PubMed1979

Adenosarcoma of the uterus: ultrastructural observations.

Müllerian adenosarcoma has been recently described as a distinctive biphasic uterine tumor with benign epithelial and malignant stromal components. The lesion belongs generally to the group of mixed müllerian tumors, but the benignity of the epithelium separates it from the other neoplasms of this type. This entity usually affects postmenopausal patients who follow a protracted course. This paper reports a case fulfilling the original clinical and pathologic description of Clement and Scully and adds ultrastructural observations. Electron microscopic examination confirmed the optical impression of a biphasic neoplasm with benign epithelial and malignant stromal components. The epithelium resembled proliferative endometrium, and the stroma had features of endometrial stromal sarcoma or mixed müllerian tumor. The findings of stromal resemblance to endometrial stromal sarcoma or mixed müllerian tumor and the presence of a variety of müllerian epithelia support the proposed müllerian derivation of this lesion.

Aged↗
PubMed1985

Mesonephric adenosarcoma of the renal pelvis with heterologous elements.

A polypoid tumor located in the renal pelvis with both epithelial and sarcomatous elements is described. The epithelial component was histologically benign and resembled urothelium. The sarcomatous component showed undifferentiated cells and rhabdomyoblastic elements. The term mesonephric adenosarcoma is proposed to describe this biphasic tumor. Although this tumor might be histogenetically related to Wilms' tumor, it is morphologically distinct, and might behave more aggressively.

Female↗
PubMed1983

Müllerian adenosarcoma of the endometrium: review of the literature and report of two cases.

The author reports two cases of müllerian adenosarcoma (MAS) in the endometrium in patients aged 60 and 73 years. Both were treated by total abdominal hysterectomy and bilateral salpingo-oophorectomy. The 60-year-old patient is alive without signs of recurrence or metastases 3 years after the operation. The other patient, who received postoperative vaginal radium therapy, died of disseminated abdominal metastases 7 months after the operation. Only two cases of MAS leading to death within less than 1 year have been reported so far.

Aged↗
PubMed1980

Müllerian adenosarcoma of the uterus: a report of 5 cases.

The clinicopathologic features of 4 cases of Müllerian adenosarcoma of the uterine body and 1 of the cervix are reported. They showed the characteristic pattern of benign epithelial growth within sarcomatous stroma. In the cervical tumor, malignant heterologous stromal cells were also present. All the patients are alive and well, confirming the good prognosis of this neoplasm. The authors think that the presence of a malignant heterologous component probably does not imply a worse prognosis.

Aged↗
PubMed1987

Adenosarcoma uteri.

Adenosarcoma of the uterus is a rare tumor of low-grade malignancy. It belongs to the family of mixed mesodermal (Müllerian) tumors. It is a biphasic tumor with benign epithelium and malignant stromal components. A case in a 76-year-old woman is presented.

Aged↗
PubMed1979

Extrauterine mesodermal (müllerian) adenosarcoma. A case report.

Extrauterine mesodermal (müllerian) adenosarcomas have only recently been described, and this is the first reported case from Australia. These tumours fall within the category of common epithelial tumours' in the World Health Organisation (W.H.O.) classification of ovarian tumours and comprise benign looking epithelial structures (glands, papillae) in association with sarcomatous stroma. They are thus distinct from malignant mesodermal mixed tumours in which both epithelial and stromal elements are cytologically malignant.

Adult↗
PubMedDate not supplied

Müllerian adenosarcoma of the uterus: literature review, case report, and ultrastructural observations.

This is a report of a transmission and scanning electron microscopic examination of a müllerian adenosarcoma. The neoplasm had the characteristic pattern of benign neoplastic glands with focal squamous metaplasia and a sarcomatous stroma. Ultrastructurally, both mesenchymal and epithelial elements were identified. The mesenchymal components were ultrastructurally identical to those present in endometrial stromal sarcomas, including active collagen synthesis. The epithelial component resembled bening endometrial glands, and there was significant secretory activity as evidenced by prominent cytoplasmic glycogen collections.

Adenocarcinoma↗
PubMedDate not supplied

[Mullerian adenosarcoma of the uterus].

The paper describes a case of mullerian adenosarcoma of the uterus. The patient, a 58-year old postmenopausal woman, presented with atypical vaginal bleeding and enlarged uterus. A total hysterectomy was performed. The intrauterine mass measured 10 cm in largest diameter and had bossolated surface and 2 pedicles of 3 and 4 mm each. The cut section was white-pink in color and contained small cysts in about two third of its volume. Myometrium was not infiltrated by tumor. On microscopic examination, the tumor consisted of round glands surrounded by myofibroblastic stroma which was condensed around the glands. Glandular epithelium was pseudostratified and showed ciliated, tubal and mucinous differentiation. Periglandular stroma cells were atypical and pleiomorphic and mitotically active. The part of the tumor which lacked glands had prominent smooth muscle differentiation. Immunohistochemically stromal cells stained positively for vimentin and smooth muscle specific alpha-actin; desmin without predigestion was extensively negative.

Diagnosis, Differential↗
PubMed1990

[An occurrence of a neurogenic sarcoma in an irradiated field following the combined surgical-radiologic treatment of a childhood adenosarcoma of the kidney].

Malignant neoplasias in childhood generally are an increased risk for the patient to fall ill with a second tumor. Second tumors in former irradiation field are seldom, but are acknowledged radiogenically if histology is different to that of the first tumor and a sufficiently long period is between the two tumors. A patient is represented who had been operated and irradiated because of an adenosarcoma of the kidney at the age of seven and who has fallen ill with a neurogenic sarcoma in irradiation area more than 30 years later. The same patient had to suffer from radiogenic retardation during differentiation of lumbar apparatus of attitude and locomotion and on the other hand he became father of a healthy daughter at the age of 32.

Child↗
PubMed1989

Müllerian adenosarcoma of uterus--a case report.

A rare case of Müllerian adenosarcoma occurred in the uterine endometrium of a 40-year-old woman. Histologically, the tumor was composed of an admixture of benign-appearing glands and a sarcomatous stroma. This neoplasm appears to have a relatively low malignant potential in contrast to the more aggressive form of malignant mixed Müllerian tumor. Our case was treated with hysterectomy and radiation. She was well after two and a half years.

Adult↗
PubMed1986

Case report of two primary tumors: mullerian adenosarcoma and endometrial adenocarcinoma.

A rare case of two concomitant primary uterine neoplasmas in a 64-year-old patient who had received conjugated estrogens for the 3 preceding years is presented. Müllerian adenosarcoma, heterologous type, with stromal components suggestive of rhabdomyosarcoma, and adenocarcinoma of endometrium, were localized in different sites of the endometrium with no intermingling between them (combination tumor). The diagnostic and therapeutic problems are discussed.

Adenocarcinoma↗