Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “ARTIFICIAL ORGANS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 127 records · Page 7Linked to original sources
PubMed1991

B16 melanoma metastasis to an "artificial organ" implant.

The mouse B16 melanoma metastasizes in two stages, first to the lungs and then from lung metastases to systemic organs. Despite widespread dissemination, visible metastases generally occur only in the brain, adrenals, kidneys, ovaries, pancreas, and mesentery. As a novel approach to investigate the basis of metastatic patterning in this system, the possibility was explored that an implantable "artificial organ" could serve as a site for the occurrence and experimental modulation of secondary-stage metastasis. Each implant consisted of a cellulose disc 4 mm in diameter, with a central 1-mm polymer pellet to effect local sustained release of angiogenic or growth factors in a s.c. environment. During the secondary spread of tumors initiated with the B16 melanoma clone G3.12 and with the more metastatic variant G3.12/BM2, metastatic involvement of implants containing angiogenic factors was mainly as invisible micrometastases demonstrable by bioassay; visible metastases were rare and were located in implant blood vessels. Metastasis occurred in about 30% (G3.12) and 50% (G3.12/BM2) of implants with vasculature induced by ethylene-vinyl acetate copolymer alone. Endothelial cell growth factor and heparin promoted greater vascularization but did not significantly alter metastatic involvement of implants. Release of tumor cell mitogenic activity from pellets containing a crude extract of mouse lungs increased the incidence of G3.12/BM2 metastasis in implants to over 70% and stimulated growth of visible metastases within the cellulose matrix. In contrast, liver extract inhibited metastasis growth. Colonization of implants following intracardiac injection of G3.12/BM2 cells was generally similar to metastasis, but visible colonies formed more readily and were less dependent on the influence of lung extract. These results indicate that metastasis and colonization can occur regularly in implants and that the relative favorability of the implant environment for secondary tumor growth can be altered by incorporation of tumor cell growth modulators.

Animals↗
PubMed1977

Exponential growth and future of artificial organs.

One hundred thousand (100,000) people are living--thanks to Artificial Kidneys. We need more emphasis on Home Dialysis. The immediate future will bring us: WAK (Wearable Artificial Kidney) FAK (Filtrating Artificial Kidney) PAK (Peritoneal Artificial Kidney) HAK (Hemoperfusion Artificial Kidney). Intra-aortic balloon pumps and transapical left ventricular bypass may offer patients now dying from heart failure, a possibility to either recover or be maintained until an artificial heart is available. Our aim is to create an Artificial Heart to totally replace the irreparably sick human heart. We have obtained survival times up to more than six months after total replacement of the natural heart in calves. Dr. Steve Jacobsen's Artificial Arm is activated by electromyographic signals that are derived from the shoulder muscles. The Artificial Eye makes use of direct stimulation of the visual cortex of the brain by arrays of electrodes situated against the visual cortex. For the Artificial Ear, we stimulate the fibers of the eighth nerve by threading platinum wires up into the cochlea. Deaf volunteers can hear rhythm, loudness and some pitch.

Animals↗