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Results for “ANTIVENINS”

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At least 127 records · Page 7Linked to original sources
PubMed1998

Vipera palaestinae antivenin.

A review is presented of the methods developed to raise the neutralizing capacity of anti-Vipera palaestinae (Vp) venom. These include formaldehyde detoxification of the venom, immunization with carboxymethyl-cellulose-bound neurotoxin, and enzymatic fragmentation of the neutralizing antibody.

Animals↗
PubMed1978

Preparation of highly potent Naja naja atra (Formosan cobra) antivenin.

As the preparation of high titer antiserum against Naja naja atra venom is a time-consuming process, attempts were made to develop a immunization procedure for producing highly potent antiserums within a short period. Rabbits were immunized for 12 weeks with (1) whole venom as used routinely in our Institute, (II) whole venom adsorbed on carboxymethyl-cellulose (CMC) and mixed with Freund's complete adjuvant and (III) neurotoxin adsorbed on CMC and adjuvant mixture followed by CMC-whole venom-adjuvant mixture. The results showed that one ml of the antiserum prepared by method (III) could neutralize 445 LD50 of whole venom, in other words, its potency was 4 and 40 times higher than those prepared by methods (II) and (I), respectively.

Animals↗
PubMedDate not supplied

Snake antivenin.

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Antivenins↗
PubMed1992

[Hematologic values and serum enzymes in horses inoculated with snake venoms for the production of antivenins in Costa Rica].

Blood components were studied in six horses immunized with snake venoms for the production of polyvalent antivenom in Costa Rica. No significant changes in hemoglobin or hematocrit throughout the immunization period were observed, whereas a significant increment in total serum proteins occurred in the second half of the immunization process, probably due to an increased synthesis of immunoglobulins. There were no significant changes in creatine kinase, but a slight increment was detected in both transaminases, although they did not exceed normal limits. These findings suggest the absence of relevant tissue damage in skeletal muscle, cardiac muscle and liver. In agreement with these results, horses did not develop signs of systemic poisoning, presenting only minor alterations at the site of venom injection, such as oedema, abscesses and fistulas. The development of anti-phospholipase A2 antibody response showed a prominent individual variability, as previously described.

Animals↗