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[Observations in two cases of Adie's syndrome (author's transl)].

In this paper two cases of Adie's syndrome are discussed. In one of them a paralysis of accommodation was observed. In neither case was it possible to establish the etiology. In both cases the pupil was still enlarged, 11 and seven months later, respectively.

Accommodation, Ocular↗

[ADIE'S SYNDROME].

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Adie Syndrome↗

[Adie's syndrome].

The author has investigated patients suffering from disorders of the pupillary reflexes and of the tendon reflexes of the lower limbs which come under the heading of tonic pupil. Forty-five patients were followed up over a period of 15 years. The tendon reflexes of the lower limbs were recorded graphically and showed a very characteristic retardation of the second phase of the patellar reflex. The aetiopathogenesis of Adie's syndrome is discussed. The pathogenesis of Adie's syndrome has so far not been definitely established. We have merely tried to point out a few of the features which permit its early diagnosis and have drawn attention to the basic problem of the pathogenesis of certain neuro-muscular disorders on the basis of secondary considerations involved in this uncommon syndrome.

Adie Syndrome↗

[Adie's Syndrome].

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Adie Syndrome↗

Corneal sensation in Adie's syndrome.

Using the Cochet-Bonnet esthesiometer, we evaluated the corneal sensation of 11 patients with unilateral Adie's tonic pupil. We eliminated six other patients with bilateral Adie's pupil or disease that lowered corneal sensation. An observed unfamiliar with each patient's condition tested 12 clock hour positions in the midperiphery in both eyes of all patients. We studied 30 normal subjects (60 eyes) in a similar fashion. Of those 11 patients with unilateral Adie's syndrome, ten had a regional decrease in corneal sensation. The 30 normal subjects examined did not exhibit any significant decrease in corneal sensation in any areas. Our study supports the concept that the lesion of Adie's tonic pupil is in the ciliary ganglion or short location where the innervation of the iris sphincter and corneal sensation are found together.

Adie Syndrome↗

Asymptomatic autonomic and sweat dysfunction in patients with Adie's syndrome.

A study was conducted to determine by using noninvasive tests whether autonomic dysfunction occurs in patients with Adie's syndrome. Eighteen consecutive patients with Aide's syndrome prospectively underwent a standardized battery of five noninvasive tests of autonomic function, including three that predominantly reflected parasympathetic function and two that predominantly reflected sympathetic function. Eight of these patients additionally underwent thermoregulatory sweat testing. Of the 18 patients 10 (56%) had no abnormal autonomic test results, 5 (28%) had one abnormal result, 2 (11%) had two abnormal results, and 1 (6%) had three abnormal results. None of the patients had more than three abnormal results. Tests that predominantly reflected parasympathetic function produced abnormal results more frequently than those that predominantly reflected sympathetic function. Three of eight (38%) patients who underwent thermoregulatory sweat testing showed abnormal patterns of sweating. Although abnormal autonomic and sweat functions are not uncommon in patients with Aide's syndrome, the abnormalities are mild and are generally unassociated with symptoms of dysautonomia. Such abnormalities have little clinical significance but may be important from a nosologic point of view.

Adie Syndrome↗

[Adie's syndrome].

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Adie Syndrome↗