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Sizes of deciduous teeth in 47,XYY males.

Deciduous teeth of six 47,XYY males have been examined, and the tooth sizes were found to be larger than those of controls. We concluded that a factor or factors which influence excess dental growth in 47,XYY males are probably in effect before the age of a few months. The time needed for the achievement of final tooth growth excess seems to be limited to a 9--18 month period. It also became evident that excess dental growth of 47,XYY individuals is a developmentally stable process, and the Y chromosome apparently regulates quantitative variation of the teeth in normal males [2]. These observations on tooth sizes in 47,XYY males suggest a chromosomal influence on dental determination.

Adolescent↗

Influence of tooth-to-denture-base discrepancy on space closure following premature loss of deciduous teeth.

Influence of tooth-to-denture-base discrepancy on so-called physiologic migration of the first molar was studied on serial dental casts of 116 boys and girls, obtained through a dental health program for school children in an area in which there was no dentist. The alteration of spaces following premature loss of deciduous molars was examined comparing the anterior to posterior discrepancies between tooth and denture base. Modes of space alteration showed positive correlation with the size of the discrepancy, especially in the mandibular dental arches. The space deficiency in the posterior region seemed to have a positive effect on the mesial migration of the first molar. Mesial migration of the first molar seems to be pathologic rather than physiologic and is strongly affected by tooth-to-denture-base discrepancies. Space maintenance does not seem to be useful, because it is not necessary in minimum discrepancy cases and is not effective in severe discrepancy cases.

Adolescent↗

Odontoclastic resorption of the superficial nonmineralized layer of predentine in the shedding of human deciduous teeth.

Resorption by odontoclasts of a superficial nonmineralized layer of predentine that occurs in prior to the shedding of human deciduous teeth was studied by light and electron microscopy. As resorption of the tooth roots neared completion, multinucleate cells appeared on the predentine surface of the coronal dentine between the degenerated odontoblasts, excavated characteristic resorption lacunae in the nonmineralized predentine. These multinucleate cells had the same ultrastructural characteristics as odontoclasts and histochemical demonstration of tartrate-resistant acid phosphatase activity in the multinucleate cells revealed intense staining in numerous small granules identified as lysosomes. Occasionally, the multinucleate cells simultaneously resorbed both nonmineralized and calcospherite-mineralized matrix in the predentine. The study demonstrates that multinucleate odontoclasts can resorb nonmineralized predentine matrix in vivo, probably in the same way as they resorb demineralized organic matrix in the resorption zone underlying their ruffled border.

Acid Phosphatase↗

Remineralization of natural carious lesions with a glass ionomer cement.

Remineralization of carious lesions at the histological level is of great benefit since this will arrest lesion progression. The ability of glass ionomer cement (GIC) to (1) release fluoride it originally contains and (2) release "loosely bound" fluoride acquired from its surroundings have been previously demonstrated. This in vitro study examined the potential for caries remineralization if the lesion was placed near a GIC. Sixteen mesiodistal sections were cut through extracted deciduous molars exhibiting approximal white spot lesions. Sections were "linked" to a plastic tooth restored with a GIC to simulate the abutting surfaces of adjacent teeth. Lesions were photographed in water under polarized light initially and after one- and two-week exposures to artificial saliva. The photographs were digitized, lesion body outlined, and the area corresponding to the body of the lesion was determined to provide a comparison over time. Sixty-two percent of the sections showed a quantitative reduction in lesion body size by an average of 43% after the first week and an additional 14% reduction after the second week. All but two sections demonstrated a qualitative change thereby illustrating that a reduction in pore volume size of the lesion body had also occurred. Therefore, fluoride released from a GIC has the potential to enhance remineralization of the early carious lesion in vitro. The greatest remineralization occurred during the first week of artificial saliva exposure.

Cariostatic Agents↗