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PubMed2005

Commentary on the prevention of paralysis after traumatic spinal cord injury in humans: the neglected factor--urgent restoration of spinal cord circulation.

Although advances in the management of spinal injuries during the past 60 years have led to greatly increased life expectancy for paralysed patients, most remain disabled. Around the world, spinal injury centres have become specialized rehabilitation units, where staff accepts the inevitability of persisting paralysis. In part, this pessimism has been based on incorrect information about the anatomy and function of the circulation of the spinal cord. Since the publication of accurate descriptions of the segmental nature of spinal vasculature, research and clinical data suggest that reversal or prevention of paralysis after spinal injury may be possible in many patients. These improved outcomes will depend on the recognition that urgent correction of cord blood supply in patients with traumatic spinal injury is critical to the long-term results of treatment. The creation of specialist spinal units within trauma centres for the urgent treatment of patients following spinal injury will require considerable logistical change, but has the potential to lead to a revolution in spinal care, driven by the knowledge that spinal cord function can often be saved.

Adult↗
PubMed1994

Epidemiology of traumatic spinal cord injury and acute hospitalization and rehabilitation charges for spinal cord injuries in Oklahoma, 1988-1990.

Few injuries result in more profound and long-term disability than traumatic spinal cord injury. This study describes the demographic and epidemiologic characteristics of traumatic spinal cord injury among Oklahoma residents reported to the statewide, population-based surveillance system in 1988-1990; initial acute hospital and rehabilitation charges for 1989 are also included. There was a reported incidence rate of 40 per million population. Based on a reporting sensitivity of 77%, the "true" incidence of spinal cord injury was estimated to be 51 per million population. Motor vehicle crashes accounted for 48% of injuries. Males aged 15-29 years and blacks were at highest risk of injury. Among blacks, the injury rate due to violence was seven times that for whites or Native Americans. Alcohol/drug use was a contributing factor in 39% of injuries and was highest among males aged 20-29 years (58%), Native Americans (57%), and victims of motor vehicle crashes (48%) or violence (51%). The combined initial charges for persons receiving both acute and rehabilitative care ranged from $9,790 to $666,510, with a median of $53,410 per patient; for complete quadriplegia, the combined median charge was $88,585. Despite its low incidence, hospitalization and rehabilitation charges for spinal cord injury in 1989 caused an economic burden of an estimated $8.4 million. While the charges presented were only a small portion of the total costs of spinal cord injury, they further substantiate the need for prevention efforts targeting these debilitating, often permanent injuries. These efforts should target young males and blacks, and should focus on preventing injuries associated with motor vehicle crashes, violence, and alcohol/drug use.

Accidents, Traffic↗
PubMed1993

[Experimental study of acute spinal cord injury: a study of spinal blood flow].

It is well known that the worsening of neurological findings after spinal cord injury is due to the secondary progression of pathological changes which may be caused by spinal cord blood flow disturbance. We measured spinal blood flow of 5mm rostrally and caudally distant portions from the injured point, using the laser Doppler flowmeter experimentally. Forty rats were used. Ten of these were used as a control group. And thirty animals were injured at the level of the tenth thoracic cord with a 50g epidural one minute compression method and measured continuously from 30 minutes before the injury to 6 hours after the injury. Twenty two surviving animals were evaluated. In the control group, spinal blood flow was stable. But in the injured group, spinal blood flow dropped by 30.6 + 9.8% on the rostral side and 37.3 + 17.6% on the caudal side in comparison with the resting value soon after the injury. Although the flow improved to 89.3 + 11.1 and 71.3 + 17.8% respectively 15 minutes later, it dropped again gradually and reached 42.8 + 14.1 and 66.2 + 16.4% respectively 6 hours after the injury had been inflicted. Lastly, in the animals, carbon perfusion was performed through the left ventricle. The normal figured vasculature in the preparation of the injured and measured portion was calculated with a microcomputer imaging analyzer and compared with control groups. The number of the normal vessels was significantly more abundant on the caudal side than on the rostral side (p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed2004

International Campaign for Cures of Spinal Cord Injury Paralysis (ICCP): another step forward for spinal cord injury research.

For over 20 years, charitable organizations have worked to promote research that will cure the paralysis associated with spinal cord injury (SCI). When they began this quest, the consequences of SCI were thought to be permanent; that once damaged, the spinal cord could not be repaired. Today, the same organizations are credited with funding research that has realized many significant advances, brought new optimism and changed the outlook of researchers, clinicians and injured individuals alike. Progress in understanding the basic biology of spinal cord repair means that it is now a case of how soon useful treatments will be available, rather than if there will ever be anything to offer. With this in mind, many of the organizations that promote spinal cord research have formed an alliance to determine the ways in which their collaboration can hasten progress. The mission and objectives of this alliance, termed the International Campaign for Cures of Spinal Cord Injury Paralysis (ICCP), are described here.

Biomedical Research↗
PubMedDate not supplied

Cervical spine fractures and soft tissue injuries.

Spinal cord injury is the major cause of quadriplegia and disability. Plain radiographs have a low sensitivity for identifying traumatic cervical spine lesions. Therefore trauma victims with plain films negative for cervical injury but with a high clinical suspicion of injury, or positive for cervical injury should undergo CT or MR for a more definitive evaluation of the cervical spine. Besides the higher sensitivity than plain radiography in detecting fractures, CT is also able to show soft-tissue abnormalities. MR is the definitive modality in assessing cervical soft-tissue injuries, especially in the evaluation of the spinal cord, intervertebral discs, and ligaments. It also allows differentiate spinal cord hemorrhage and edema, which may have a prognostic value. The role of medical imaging in the evaluation of whiplash injuries remains to be determined.

Cervical Vertebrae↗
PubMed2004

Neuropathic pain after traumatic spinal cord injury--relations to gender, spinal level, completeness, and age at the time of injury.

STUDY DESIGN: Retrospective register study. OBJECTIVE: To investigate the predictive value of age at the time of injury, gender, level of injury, and completeness of injury for the development of at level and below level neuropathic pain. SETTING: "Spinalis", a postacute spinal cord injury (SCI) outpatient clinic, serving the greater Stockholm area (Sweden). METHOD: All patients who visited the clinic in 1995-2000 (402 patients) for the first time were examined. The following items were selected: at-level and below-level neuropathic pain according to the International Association for the Study of Pain (IASP) criteria, age at the time of injury, gender, level of injury according to ASIA, and completeness of injury. Mean time of 6 years after the injury. Results were analysed with chi(2) analysis and logistic regression. RESULTS: Of all patients examined, 13% had at level pain and 27% had below level pain. Neuropathic pain was less than half as frequent (26%) in the group aged less than 20 years at the time of injury as in the oldest group (58%). The increasing trend was mainly due to below-level pain up to 39 years of age, and due to at-level pain at ages 40 and above at the time of injury. No correlation was observed to gender, level of injury or completeness of injury, except for below level pain, which was associated with complete injury. CONCLUSION: The results show that neuropathic pain after SCI is common and occurs much more often in patients injured at higher ages. This indicates the importance of neuroanalgetic intervention, in particular for patients injured in higher ages.

Adolescent↗
PubMed2000

Anorectal physiology following spinal cord injury.

PURPOSE: Spinal cord injured (SCI) patients have delayed colonic motility and anorectal dysfunction resulting in functional obstruction and constipation. This may be caused by changes in descending modulation from the central or sympathetic nervous systems. Anorectal dyssynergy may demonstrate similarities to that seen in the bladder following SCI. METHODOLOGY: Anorectal manometry was performed on 37 SCI volunteers. Patterns of rectal and sphincter function were identified. These patterns were then compared with questionnaire answers on bowel function and cystometrograms to identify a relationship between detrusor dyssynergy and anal sphincter tone. RESULTS: Rectal compliance and basal resting sphincter pressures were lower than normal values. Ramp rectal inflation demonstrated patterns of sphincter activity similar to that recorded in the patients' cystometrograms. There is no definite relationship of bowel function to the findings on manometry in SCI patients. CONCLUSIONS: SCI patients have abnormal anorectal function. Anorectal manometry results were able to be classified into four patterns on the basis of rectal pressure and sphincter tone in response to rectal distention. The patterns of anorectal manometry seen were similar to those in cystometrograms, however there is no definite relationship to bowel dysfunction. Spinal Cord (2000) 38, 573 - 580.

Adolescent↗
PubMed1976

Combined steroid and hypothermia treatment of experimental spinal cord injury.

Canine spinal cords were compressed at T-13 by an epidural balloon maintained at 160 mm Hg for one hour. After seven weeks, mean motor ratings of dogs treated with either parenteral dexamenthasone or non-irrigative local hypothermia (on the dorsal dura mater at 6 degrees C for four hours) indicated ability to walk well, whereas untreated dogs could not walk. A third treatment group received both dexamethasone and delayed local hypothermia; this group performed poorly in early weeks, but eventually surpassed the other groups and became the only group to attain a final mean motor rating which was superior to that of controls at a significance level of p less than .01. Hypothermia was induced by means of a miniature epidural heat exchanger which eliminated tissue irrigation as a possible experimental variable. The possible mechanisms of action of hypothermia are reviewed.

Animals↗
PubMed2002

[Sexual function in patients with spinal cord injuries].

A spinal cord lesion (SCL) changes most functions below the level of lesion, including sexual function. Most women had sexual intercourse after the lesion, but describe practical problems. Many of them are capable of achieving organism, and are normally fertile. During pregnancy there is an increased risk of urinary tract infection. Delivery can take place vaginally. In the case of lack of progression or severe autonomic dysreflexia, cesarean section may be necessary. For erectile dysfunction in men with SCL, oral sildenafil may be used, alternatively intracavernous injection with prostaglandin E1. To obtain ejaculation penile vibratory stimulation (PVS) is used, and if this fails then electroejaculation. Impaired sperm quality with low motility is observed. Vaginal insemination at home with sperm obtained by PVS is possible. The fertility potential may be enhanced with assisted reproduction techniques, like intrauterine insemination and in vitro fertilisation.

Coitus↗
PubMed2003

Epidemiology of spinal cord injuries: a study in the Spinal Unit, Siriraj Hospital, Thailand, 1997-2000.

A prospective study of 83 patients with spinal cord injuries admitted to the Spinal Unit, Siriraj Hospital, Bangkok, Thailand from January 1997 to December 2000 was conducted. The average age was 33.2 +/- 11.7 years (range from 10 to 68 years) with a male: female ratio of 4 : 1. Most subjects (83.2%) were aged between 16-45 years. About half of them had no associated injuries and no financial problems. Three-fourths of the spinal injuries were caused by traffic accidents (49.4 and 25.3% car and motorcycle respectively). The other two causes were falls (16.9%) and gunshot wounds (8.4%). The neurological classification was as follows: 34 (41.0%) patients had ASIA D grade of injury, 28 (33.7%) were paraplegic with ASIA A, B or C grade and 21 (25.3%) were tetraplegic with ASIA A, B, or C grade. Traffic accidents most frequently resulted in an incomplete ASIA D grade (40.3%). Males were more predominant for all causes of injury especially motorcycle accidents. The average Barthel Index score was 24.3 +/- 24.7 and 51.9 +/- 31.8 at admission and discharge respectively. The prevalence of depression was 24.1 per cent. The average length of stay for the depressed and non-depressed groups was 117.4 +/- 59.1 and 73.4 +/- 54.4 days respectively.

Adolescent↗
PubMed1979

Effect of impounder contact area on experimental spinal cord injury.

The spinal cords of two groups of dogs were subjected to 500 gm-cm impacts using two different configurations of impounders. The impounders varied only in area of contact with the dural surface. All other parameters were kept constant. With one impounder all of the dogs injured were totally paraplegic. The impounder consistently producing total paraplegia straddled the entire width of the dorsal surface of the spinal cord in a manner corresponding to the posterior arch of a vertebra. The injury produced with this impounder is not only consistently reproducible but bears a closer resemblance to clinical injury such as anterior vertebral dislocation than that produced with a smaller impounder.

Animals↗
PubMed2006

Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials.

The International Campaign for Cures of Spinal Cord Injury Paralysis (ICCP) supported an international panel tasked with reviewing the methodology for clinical trials in spinal cord injury (SCI), and making recommendations on the conduct of future trials. This is the first of four papers. Here, we examine the spontaneous rate of recovery after SCI and resulting consequences for achieving statistically significant results in clinical trials. We have reanalysed data from the Sygen trial to provide some of this information. Almost all people living with SCI show some recovery of motor function below the initial spinal injury level. While the spontaneous recovery of motor function in patients with motor-complete SCI is fairly limited and predictable, recovery in incomplete SCI patients (American spinal injury Association impairment scale (AIS) C and AIS D) is both more substantial and highly variable. With motor complete lesions (AIS A/AIS B) the majority of functional return is within the zone of partial preservation, and may be sufficient to reclassify the injury level to a lower spinal level. The vast majority of recovery occurs in the first 3 months, but a small amount can persist for up to 18 months or longer. Some sensory recovery occurs after SCI, on roughly the same time course as motor recovery. Based on previous data of the magnitude of spontaneous recovery after SCI, as measured by changes in ASIA motor scores, power calculations suggest that the number of subjects required to achieve a significant result from a trial declines considerably as the start of the study is delayed after SCI. Trials of treatments that are most efficacious when given soon after injury will therefore, require larger patient numbers than trials of treatments that are effective at later time points. As AIS B patients show greater spontaneous recovery than AIS A patients, the number of AIS A patients requiring to be enrolled into a trial is lower. This factor will have to be balanced against the possibility that some treatments will be more effective in incomplete patients. Trials involving motor incomplete SCI patients, or trials where an accurate assessment of AIS grade cannot be made before the start of the trial, will require large subject numbers and/or better objective assessment methods.

Clinical Trials as Topic↗
PubMed2004

Effects of body weight-supported treadmill training on heart rate variability and blood pressure variability in individuals with spinal cord injury.

Individuals with spinal cord injury are prone to cardiovascular dysfunction and an increased risk of cardiovascular disease. Body weight-supported treadmill training (BWSTT) may enhance ambulation in individuals with incomplete spinal cord injury; however, its effects on cardiovascular regulation have not been investigated. The purpose of this study was to examine the effects of 6-mo of BWSTT on the autonomic regulation of heart rate (HR) and blood pressure (BP) in individuals with incomplete tetraplegia. Eight individuals [age 27.6 yr (SD 5.2)] with spinal cord injury [C4-C5; American Spinal Injury Association B-C; 9.6 yr (SD 7.5) postinjury] participated. Ten-minute HR and finger arterial pressure (Finapres) recordings were collected during 1) supine rest and 2) an orthostatic stress (60 degrees head-up tilt) before and after 6 mo of BWSTT. Frequency domain measures of HR variability [low-frequency (LF) power, high-frequency (HF) power, and LF-to-HF ratio] and BP variability (systolic and diastolic LF power) were used as clinically valuable indexes of neurocardiac and neurovascular control, respectively. There was a significant reduction in HR [61.9 (SD 6.9) vs. 55.7 beats/min (SD 7.7); P=0.05] and LF-to-HF ratio [1.23 (SD 0.47) vs. 0.99 (SD 0.40); P < 0.05] after BWSTT. There was a significant reduction in LF systolic BP [183.1 (SD 46.8) vs. 158.4 mmHg2 (SD 45.2); P < 0.01] but no change in BP. There were no significant effects of training on HR variability or BP variability during 60 degrees head-up tilt. In conclusion, individuals with incomplete tetraplegia retain the ability to make positive changes in cardiovascular autonomic regulation with BWSTT without worsening orthostatic intolerance.

Adult↗
PubMed1998

Quality of life after active urological management of chronic spinal cord injury in eastern Taiwan.

OBJECTIVE: Motor cycle accidents are the major cause of head injury and spinal cord injury (SCI) in Taiwan. The incidence of SCI in Hualien county is the highest in the world. In a community hospital in Hualien, active urological management was carried out for SCI patients with voiding dysfunctions and urological complications. This study was conducted to assess the success of active urological management. METHODS: From 1988 to 1996, in the urological department, 251 SCI patients with varying voiding dysfunctions or urological complications were managed with various surgical or nonsurgical procedures according to their underlying pathologies. The satisfaction rate and quality of life index were assessed before and after active urological treatment. RESULTS: There were 118 patients with cervical SCIs, 93 patients with thoracic or lumbar SCIs, and 40 patients with sacral SCIs or infrasacral neuropathy. After initial managements, 174 patients were able to pass urine by themselves, by clean intermittent self-catheterization (CISC) or with an indwelling Foley catheter. The remaining 77 patients suffering from severe dysuria, urinary incontinence, hydronephrosis and frequent urinary tract infections were managed with various surgical procedures. The procedures included external sphincterotomy (n = 30), enterocystoplasty (n = 28), autoaugmentation (n = 6), continent urinary diversion (n = 7), periurethral Teflon injection (n = 3), and transurethral resection of the prostate (n = 3). After treatment, hydronephrosis resolved in 100% of the kidney units; frequent symptomatic urinary tract infection improved in 83.3% after external sphincterotomy and 75% after enterocystoplasty and continent diversion; while urinary incontinence disappeared or improved in 93% after enterocystoplasty and autoaugmentation. The total satisfaction rate was 84.4% after the surgical procedures. The mean quality of life index improved from -1.27 +/- 0.39 to +1.54 +/- 0.38 after management. However, some complications such as mucus secretion (76.5%), abdominal pain (20.6%), loose stool (23.5%) and frequent stone formation (11.8%) still bothered the patients undergoing enterocystoplasty and continent diversion. Repeat sphincterotomy was necessary in 16.7% of patients, and 50% were not satisfied with total incontinence after external sphincterotomy. During the follow-up period, 87% of all patients had > or = 1 yearly episode of urinary tract infection after spinal injury and 11 patients died of urosepsis. CONCLUSIONS: Active urological management to improve quality of life and to treat urological complications in SCI patients is mandatory. After long-term follow-up, SCI patients can be free of indwelling catheters, hydronephrosis usually resolves and urinary tract infections are infrequent.

Adolescent↗
PubMed2005

Chronic alterations in the cellular composition of spinal cord white matter following contusion injury.

Spinal cord injury (SCI) involves the loss of neurons and glia due to initial mechanical and secondary biochemical mechanisms. Treatment with the sodium channel blocker tetrodotoxin (TTX) reduces acute white matter pathology and increases both axon density and hindlimb function chronically at 6 weeks after injury. We investigated the cellular composition of residual white matter chronically to determine whether TTX also has a significant effect on the numbers and types of cells present. Rats received an incomplete thoracic contusion injury, in the presence or absence of TTX (0.15 nmole) injected focally, beginning at 15 min prior to injury. Six weeks later, cell density was significantly increased in the residual white matter of the dorsal, lateral, and ventral funiculi, both rostral and caudal to the injury site in both TTX-treated and injury control groups. Oligodendrocyte and astrocyte density was similar to normal but large numbers of cells expressing microglia/macrophage markers were present. Labeling with the progenitor markers nestin and NG2 showed that precursor cell density had also doubled or tripled as compared with uninjured controls. Some of these cells were also labeled for antigens that indicate their possible progression along an oligodendrocyte or astrocyte lineage. Our results support the hypothesis that the beneficial effect of TTX in SCI is related to its preservation of axons per se; no effect on chronic white matter cell composition was detected. They highlight the profound changes in cellular composition in preserved white matter chronically at 6 weeks after injury, including the accumulation of endogenous progenitor cells and the persistence of activated macrophages/microglia. The manipulation of these endogenous cells may be used in the future to enhance recovery after SCI.

Animals↗
PubMed1994

The cost-effectiveness of air medical helicopter crash survival enhancements. An evaluation of the costs, benefits and effectiveness of injury prevention interventions.

OBJECTIVE: This study evaluates EMS helicopter-injury reduction interventions and associated costs for survivable crashes. Specific injury categories evaluated include head injuries, spinal injuries and thermal injuries. The benefits and costs of the preventive interventions are evaluated through cost-effectiveness analyses that provide a basis for informed safety-enhancement decisions for EMS helicopter operators, based on the most cost-efficient interventions. METHODS: The incidence and type of injuries experienced by EMS helicopter occupants were determined, and future risk of injury was estimated. Then the costs of those injuries, as well as the costs of the preventive interventions, were determined so estimates could be made of the cost benefits of the injuries prevented. Estimates were made regarding current levels of injury prevention interventions already in the field and their effectiveness in preventing injury. RESULTS: Improvements can be made to reduce the risk of injury to medical crew and pilots in survivable crashes. Nomex uniforms, helmets, and energy-absorbing seats (EAS) for medical crew members all prove cost-effective in reducing preventable injuries in survivable crashes. CONCLUSION: Emergency medical service helicopter occupants should wear fire-resistant uniforms and helmets, and medical crew members should have EAS systems when available. These EAS systems also are recommended for pilots, although they were not shown to be cost-effective based on the projections developed in this study.

Accidents, Aviation↗