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At least 1,243 records · Page 69Linked to original sources
PubMed1995

A new breakthrough in treatment of visceral leishmaniasis in children.

Fifty cases of visceral leishmaniasis were admitted in Children's Hospital, Islamabad. Common clinical features were fever (100%), splenomegaly (100%), hepatomegaly (100%), anaemia (96%), abdominal distension (40%), bronchopneumonia (26%) and bleeding diathesis (22%). Hb was below 7.0 G/dl in 80%, white cell count below 4 x 10(9)/cmm in 88% and platelet count below 100 x 10(9)/c4mm in 86%. All the patients showed leishmania donovani bodies in the marrow smears. Fourteen patients were treated with aminosidine (15 mg/kg), intramuscularly daily for 4 weeks. All responded dramatically and none of them went into relapse in a year's follow-up. No side-effects were observed. Aminosidine can therefore, be recommended as a treatment of choice for visceral leishmaniasis in children.

Anemia↗
PubMed1995

Aminosidine sulphate in experimental giardiasis.

Giardia lamblia infection may be asymptomatic or may produce diarrhea with or without malabsorption. Many drugs were used for treatment of giardiasis, but none proved to be ideal since all have potential troublesome side effects as they are absorbed from the intestine. In this study, a locally acting drug aminosidine-sulphate (gabbroral) has been tried in treatment of experimental giardiasis in a rat model under different conditions of gastric acidity which is one of the main local factors affecting the pathogenicity of the organism. The best results were obtained in the group with hyperacidity which was induced by indomethacin (indocid) with significant improvement in the pathological picture and parasitic count. While in experimental animals with normal acidity there was only partial eradication of the parasite. However, in the group with hypoacidity induced by cimetidine (cimetex), the drug showed no beneficial effects since most organisms invaded the deeper layers of the intestine escaping the local action of the drug.

Animals↗
PubMed1976

An electro-optic study of the effect of certain aminoglycoside antibiotics on the electrical polarizability of sensitive, dependent and resistant strains of Escherichia coli.

A study has been made of the effect of certain aminoglycoside antibiotics on the electrical properties of the surfaces of one sensitive, two resistant and one dependent form of E. coli K-12. The method employed was to observe the change in scattered light produced when the bacteria in suspension are orientated by an applied a. c. electric field. The effect of the antibiotics has been analysed in terms of drug accumulation at the bacterial surface. Differences have been noted in the responses of the sensitive form to different aminoglycosides and an attempt has been made to correlate these differences with mimimum inhibitory concentrations. Differences have also been noted in the response of certain resistant and dependent forms of E. coli to streptomycin.

Anti-Bacterial Agents↗
PubMed1994

[Amebic liver abscess and amebic colitis in a couple].

Amebiasis is a disease commonly extended all around the world, its prevalence depending on the population under study. In Spain, most cases published are of exotic acquisition. We present the case of a married couple from Venezuela presenting two different forms of invasive amebiasis: acute colitis and hepatic abscess. In our environment, once the diagnosis of amebiasis is established, a close follow-up of the patients must be made, including the evaluation of the closest contacts. Regarding the treatment, we think that the asymptomatic forms must be treated with a luminal amebicidal and the symptomatic forms, with hystic amebicidal followed by luminal amebicidal.

Abdomen, Acute↗
PubMed1975

[Therapeutic effect of lividomycin on infections of the respiratory tract (author's transl)].

Therapeutic effect of lividomycin was observed in patients with infections of the respiratory tract (infections in association with bronchiectasis, mixed infections of cavities after negative conversion of tubercle bacilli, pneumonia, and so forth). Significant improvement of clinical symptoms was observed in 15 cases and no improvement in 4 cases. Lividomycin was administered at a dose of 1 g/day for 3 to 15 days. Staphylococcus aureus (9 cases), Klebsiella pneumoniae (1 case), alpha-hemolytic Streptococcus (3 cases), Aerococcus (4 cases) and Pseudomonas aeruginosa (1 case) were suggested to be causative organisms in the above-mentioned patients. (In one case, however, causative organism was not determined.) Lividomycin seemed to be effective in cases of infections with Staphylococcus aureus, alpha-hemolytic Streptococcus and Klebsiella pneumoniae, whereas not effective in a case of infection with Pseudomonas aeruginosa. In order to differentiate causative organisms from the organisms constantly existing on the upper respiratory tract, alkali treatment was employed as an aid for the determination of the causative organisms. However, further studies are desirable for the evaluation of this procedure.

Adult↗
PubMed1975

[Studies on the therapeutic effects of lividomycin in respiratory infections (author's transl)].

Therapeutic effects of lividomycin (LVDM) were studied in 33 patients with respiratory infections including pneumonia, lung abscess, chronic bronchitis, etc. LVDM was intramuscularly administered at the dose of 1 or 2 g per day for consecutive 4 to 25 days. The results obtained are summarized below: 1. At the end of the first week of the treatment, rate of improvement in such parameters as cough, sputum, rales, fever and blood sedimentation rate were 69%, 56.7%, 60%, 79.2% and 70% respectively. Also, in 16% of the patients, abnormal shadow noted in X-ray film of the chest was disappeared and in 20% of the patients, size of the same was reduced during the first week of treatment. 2. Therapeutic effects of LVDM were evaluated synthetically and were graded as excellent, good, fair and ineffective. LVDM was effective in about 70 per cent of the patients, that is, excellent results were obtained in 4 patients, good in 12 patients, fair in 6 patients, and in 10 patients this antibiotic was ineffective. 3. In one patient with slight loss of high frequency perception was observed on the audiogram, but no other ototoxic effects such as subjective hearing loss, tinnitus, etc. In addition, no untoward effects on renal and hepatic function were observed. 4. The MIC values of LVDM for clinically isolated 20 strains of Pseudomonas aeruginosa were examined, using kanamycin for comparison. The MIC values of LVDM for many strains were superior to those of kanamycin. In view of the test results mentioned above, LVDM would appear to be useful medication for the treatment of some of respiratory infections.

Acute Disease↗
PubMed1994

Aminosidine sulphate in experimental cryptosporidiosis.

The present study aimed at investigating the efficiency of a recent antibiotic Aminosidine sulphate (Gabbroral) in experimental cryptosporidiosis. The course of infection was studied when the drug was given early before the infection, and late during the infection both parasitologically and histopathologically. When the drug was given early, the results were satisfactory, with a significant reduction of size, number and pathological changes of the parasites in the stool and in ileal sections of infected mice. However, the drug had no effect when given late during the infection.

Animals↗
PubMed1994

Amebiasis after bone marrow transplantation.

A patient undergoing BMT for acute non-lymphocytic leukemia (ANLL) developed bloody diarrhea due to amebiasis. The infection was successfully treated with intensive and prolonged antiparasitic therapy.

Adult↗
PubMed1976

Susceptibility of current clinical isolates of Pseudomonas aeruginosa and enteric gram-negative bacilli to amikacin and other aminoglycoside antibiotics.

The susceptibility of current clinical isolates of Pseudomonas aeruginosa and Enterobacteriaceae to amikacin and other aminoglycosides was tested by a standardized disk sensitivity method. Minimal inhibitory concentrations (MICs) were determined for all 200 isolates tested, and mean MICs were calculated for each of 10 bacterial species. Amikacin proved to be the most effective of six aminoglycosides against nine bacterial species; isolates of Proteus morganii were slightly more sensitive to gentamicin than to amikacin. Whereas 50% of the 200 isolates could be considered resistant to gentamicin (MIC, greater than 16 mug/ml), 94.4% of the 126 enteric gram-negative bacilli and all 74 isolates of P. aeruginosa were sensitive to amikacin. At a concentration of 8 mug/ml, gentamicin inhibited 50% and tobramycin inhibited 67% of the 200 isolates. At 16 mug/ml, amikacin inhibited 96.5% of the 200 isolates; the respective figures for kanamycin, aminosidine, and streptomycin were 28.5%, 26.5%, and 24%. The virtual absence of cross-resistance between amikacin and gentamicin and between amikacin and the other four aminoglycosides was confirmed.

Amikacin↗