Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Maxillofacial Development”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,243 records · Page 69Linked to original sources
PubMed1991

Dental management of the pediatric oncology patient.

Acute oral problems that frequently occur during oncologic therapy include mucositis, infection, and hemorrhage. Certain chemotherapeutic agents consistently produce significant mucositis. Herpes simplex virus infection is a frequent cause of oral ulceration. Gram-negative oral bacilli can cause severe local necrosis of oral tissues and lethal bacteremia and sepsis. Sepsis with oral streptococci is common in the early postengraftment period following bone marrow transplant. A case report describes the successful use of a new hemostatic agent to control hemorrhage in a patient with severe thrombocytopenia in leukemic relapse. Long-term dental complications of oncologic therapy include abnormal dental and craniofacial development. Dental abnormalities in children treated for acute lymphoblastic leukemia are more severe if oncologic therapy begins before 5 years of age and if cranial irradiation is used. The combination of high-dose cranial irradiation (2400 cGy) and chemotherapy before 5 years of age results in deficient mandibular growth. In children with reduced growth hormone production and deficient mandibular growth due to treatment with bone marrow transplantation, stimulation of mandibular condylar growth is reported following the use of growth hormone.

Antineoplastic Agents↗
PubMed1991

Cartilage, function and craniofacial morphogenesis.

While primary cartilage of the craniofacial complex is a derivative of the chondroskeleton, secondary cartilage develops in close association with membrane bone. Mobile function, motility, is not always a prerequisite for the genesis of secondary cartilage but seems necessary for its maintenance as also, evidently, is mechanical load. Both primary and secondary cartilage have active morphogenetic potentials. For the primary cartilage this potential is essentially instrinsic, as has been demonstrated with transgenic mice, for instance. Consequently, primary cartilage is less adaptive to external influences than secondary cartilage. Analysis of the factors controlling the growth of the cartilaginous structures renders their utilization in reconstructive surgery more predictable.

Animals↗
PubMed2007

One- or two-stage palate closure in patients with unilateral cleft lip and palate: comparing cephalometric and occlusal outcomes.

OBJECTIVE: To assess facial growth and dentoalveolar development in two groups of patients with complete unilateral cleft lip and palate. Primary surgical treatment differed in the timing of hard palate closure. DESIGN: Forty-three patients with unilateral cleft lip and palate were examined. Twenty-two patients underwent early one-stage closure of the hard and soft palate cleft (mean age 23.0 +/- 4.7 months); in 21 patients, the hard palate closure was delayed to 86.3 +/- 39.2 months of age. Lateral cephalograms and dental casts were consecutively analyzed at four stages between 6 and 18 years of age. RESULTS: Lateral cephalometric analysis revealed no significant intergroup differences in the sagittal and vertical craniofacial dimensions at any time. Dental cast analysis showed constriction of the upper anterior arch width at the ages of 6 and 10 years in patients with one-stage surgical palate closure, but a difference could no longer be verified at the ages of 15 and 18 years. CONCLUSIONS: The transverse distances in the upper jaw developed initially more positively in the group with delayed hard palate closure, but it became apparent later that the transverse deficiency after one-stage palate closure could be compensated for. When considering surgical treatment in general, the advantages of the delayed hard palate closure must be weighed against criteria favoring the early one-stage closure of the hard and soft palate.

Adolescent↗
PubMed2002

Cranio-cervical posture: a factor in the development and function of the dentofacial structures.

Many practitioners will recognize that subjects with a large mandibular plane inclination are characterized by an extended head posture and a forward inclined cervical column, i.e. an extended cranio-cervical posture. It is also typical that subjects with a short-face morphology often carry their heads somewhat lowered, and have a markedly backward-curved upper cervical spine, i.e. cervical lordosis. The aim of the paper is to link together the findings of a series of studies that attempt to clarify this relationship, and bring into focus cranio-cervical posture, which is a functional factor that seems to be involved in many clinical orthodontic problems. To provide a background for the article, the concept of standardized posture of the head and the cervical column is developed, and procedures for recording this posture, as well as categories of cephalometric variables that express the different postural relationships, are described. Findings that relate cranio-cervical posture to upper airway obstruction, to craniofacial morphology, and to malocclusion are surveyed, and a post-natal developmental mechanism that explains the findings and leads to further questions is discussed. Recent findings of a relationship between extended cranio-cervical posture and signs and symptoms of temporomandibular disorders further emphasize the biological importance of this functional parameter.

Airway Obstruction↗
PubMed1988

Development of the orbicularis oris muscle in normal and cleft lip and palate human fetuses using three-dimensional computer reconstruction.

As part of an ongoing study of cleft lip and palate fetal morphology, normal and dysmorphic development of the human fetal orbicularis oris muscle was studied in a cross-sectional sample of 29 human fetuses (20 "normal" and 9 cleft lip and palate) ranging in age from 8 to 21 postmenstrual weeks. The specimens were embedded in celloidin and sectioned at 20 microns, and every tenth section was stained with hematoxylin and eosin. A computer reconstruction technique was applied to produce three-dimensional representations of the orbicularis oris muscle. The orbicularis oris muscle in the normal fetal sample with discernible lip fibers (N = 15) increased symmetrically in both fiber density and complexity from 12 to 21 weeks. Metrically, muscle volume and thickness growth curves were consistent with qualitative observations. In contrast, the unilateral cleft lip and palate fetal specimens with discernible lip fibers (N = 3) exhibited a 3.5-week delay in overall muscle development, asymmetrical fiber distribution, and abnormal fiber insertions. However, quantitatively, no significant (p greater than 0.05) differences were noted in orbicularis oris muscle thickness or volume between the normal and cleft lip and palate fetal specimens through 21 weeks. Findings suggest that orbicularis muscle deficiency, noted clinically in cleft lip and palate neonates, may be a result of perinatal functional dysmorphogenesis rather than congenital mesenchymal reduction or deficiency.

Cleft Lip↗
PubMed2005

Class-III malocclusion: genetics or environment? A twins study.

Etiology of class-III malocclusion is generally believed to be genetic. A wide range of environmental factors have been suggested as contributing factors for the development of class-III malocclusion. Twin study is one of the most effective methods available for investigating genetically determined variables of malocclusion. Discordancy for class-III malocclusion is a frequent finding in dizygotic twins. However, class-III malocclusion discordancy in monozygotic twins is a rare finding. The purpose of this study of monozygotic twins is to assess the genetic and environmental components of variation within the cranio-dento-facial complex.

Cephalometry↗
PubMed2006

[Early surgical treatment of cutaneous hemangiomas].

Infantile hemangioma appears after the birth as a vascular tumor, which is known for its characteristic evolution in 3 phases: rapid augmentation then stabilization and involution on several years with in the best cases, classical "restitutio ad integrum". Usual surgical attitude is abstention and surgery is proposed only in order to treat sequel. But some particular situations require early surgery for life-threatening lesions or in case of functional impairment. Surgery consists in these cases in a simple volumetric diminution of the tumor with no aim for esthetic improvement. Other kinds of hemangiomas require an early surgical treatment before their complete involution. In some particular locations, deformation or growth delay can occur due to the lesion's development. In some cases, hemangiomas present a delayed involution with minor regression capacity; these are mainly located on the median part of the face and have principally a subcutaneous development. Early surgery can be proposed in order to avoid definitive deformation or growth impairment of adjacent structures. It should be performed before school age and before occurrence of psychological difficulties. Surgery is indicated in a perspective of esthetic improvement. Surgical procedure consists first in modeling excision followed by simple repair technique as linear suture or purse string closure; complex surgical procedures inducing their own sequels are usually inappropriate.

Age Factors↗
PubMed2005

Roentgen-cephalometric standards for a Swedish population. A longitudinal study between the ages of 5 and 31 years.

This study was performed to establish age- and gender-specific cephalometric normative data for a Swedish population. The material comprised 469 lateral cephalograms from two groups of subjects of Swedish origin between 5 and 31 years of age. All subjects (males and females) were diagnosed as 'normal' according to specified criteria and with no history of orthodontic treatment. Lateral cephalograms and body height measurements were taken at 5, 7, 10 and 13 years of age in one group (group E) (longitudinal follow-up). The same registrations were made in the other group (group U) at 7, 10 and13 years of age (mixed longitudinal type). Those 13 year olds were re-examined at 16, 19 and 31 years of age (longitudinal follow-up). No significant differences between age groups in the two samples were found. Therefore, subjects of the same age were combined. The study is hence regarded as a longitudinal follow-up from 5 to 31 years of age. The subjects were also grouped into dental development stages to widen the applicability of the cephalometric data.The craniofacial distances were constantly larger in males than in females, while no statistical differences as regards angular measurements were seen between genders. Distances as well as angular measurements varied with the different developmental periods. The results clearly verify that facial pattern changes existed during the observation period, with a growth acceleration of most distances between the 13 and 16 year recordings.

Adolescent↗
PubMed1996

Facial growth after primary periosteoplasty versus primary bone grafting in unilateral cleft lip and palate.

A cephalometric evaluation of long-term changes resulting from two different surgical techniques for the correction of unilateral cleft lip and palate (UCLP) was undertaken on a sample of 19 males with primary bone grafting, and 42 males with primary periosteoplasty from the Science Academy of the Czech Republic, Prague. Lateral cephalometric radiographs collected at approximately 10 and 15 years of age were traced, digitized, and analyzed using the finite-element method. Facial growth and development between the two groups were compared. Significant differences between the two groups were found in the upper face, the posterior part of the maxilla, the anterior bony chin, and nasal bone areas. The periosteoplasty group demonstrated significantly greater vertical development between anterior cranial base and the maxilla. The bony chin was larger and a greater inferior displacement of the posterior palate were found in the periosteoplasty group. An increased proclination in the nasal bone was observed in the bone graft group. This investigation both confirms the findings of a previous study of these sample populations, and provides additional important details regarding the differences between the groups.

Adolescent↗
PubMed1991

Craniofacial development in cleft lip and palate children related to different treatment regimes.

Outcome of treatment in 85 children with unilateral cleft, lip, alveolus, and palate who had been treated according to four regimes was studied using lateral skull radiographs, extra oral photographs, intra oral radiographs and orthopantographs. The treatment regimes differed with regard to: the inclusion of presurgical orthopaedics in one group, the type of lip closure, the type and timing of palatal closure, and timing of bone grafting to the alveolus. A method of pooling subgroups and comparing lateral skull radiographs from different centres was developed to obtain more meaningful comparisons between centres. The maxillary, mandibular, and vertical hard tissue development as well as the soft tissue profile were studied using lateral skull radiographs. The appearance of the extraoral soft tissue was assessed by a panel using photographs. The tooth status and the success of transplants in the cleft area were evaluated using intra oral radiographs and orthopantographs. Treatment regimes that did not include bone grafting seemed to be most favourable for maxillary and mandibular development. Treatment regimes without bone-grafting and those that included bone grafting at 10 years of age seemed to be most favourable for the vertical skeletal proportions. The soft tissue profile was developed best after regimes that included bone grafting at 10 years of age. Facial appearance was equally good in the group that received bone grafts at 6 months after presurgical orthopaedics and in the group that received bone grafts at 10 years of age. Tooth status and the percentage of successful transplants were best in the group that received bone grafts after the eruption of the incisors but before the eruption of the canines.

Adolescent↗
PubMed1990

[Change in body weight and mandibular development in rats from fluoride administration].

The body weights evolution and the development of mandible were analyzed in rats that received 0.25 mg F contained into a commercial product, during 30 and 60 days consecutively, beginning at birth. The study presented the following conclusions: 1. The treated animals showed body weights always inferior to the controls, with more evident difference at 60 days period; 2. Analysis showed a reduction in the horizontal linear measurements, but not in the length of the mandibular diastem. No influence was observed in relation to the verticals.

Animals↗
PubMed1989

Tooth development in children with cleft lip and palate: a longitudinal study from birth to adolescence.

Dental maturity was assessed in 131 children with cleft lip with or without cleft palate in two age groups from panoramic X-rays using the method of Demirjian. The subjects showed a mean delay of 6 months in the age group of 3-9 years (x = 6.4 years), which decreased to 2 months in the age group of 8-14 years (x = 11.0 years). Involvement of the palate made the delay longer than in children with cleft lip only. Geographical differences between parts of Finland were also found. To study tooth development longitudinally, the timing of the beginning of calcification of one maxillary central incisor was assessed from occlusal X-rays taken between the ages of 2 and 18 months in 107 of the above mentioned 131 subjects. Using rank-order correlations, the beginning of the calcification of the maxillary central incisor weakly predicted the subjects' tooth developmental status. The correlation of dental maturity between the ages of 6 and 11 years was, however, high.

Adolescent↗
PubMed1997

Transverse development of the jaws: norms for the posteroanterior cephalometric analysis.

Norms available for the posteroanterior (PA) cephalometric analysis yield different information. The material used to generate these standards is not clearly defined. The purpose of this study was to use data from the Bolton-Brush Growth Study to generate new norms for the PA analysis. The Bolton material is recognized as a controlled longitudinal record of growing children. The assumption that growth in the transverse dimension is the first to be completed is challenged by finding that increments in maxillary and mandibular width vary, like sagittal and vertical growth, according to gender and chronologic age.

Adolescent↗
PubMed1994

Integrin regulatory switching in development: oscillation of beta 5 integrin mRNA expression during epithelial-mesenchymal interactions in tooth development.

Integrin receptors for extracellular matrix molecules are thought to play important roles in morphogenesis since they mediate aspects of embryonic cell adhesion and migration. Using in situ hybridization, the mRNA expression pattern of the beta 5 integrin receptor subunit was examined during murine tooth development, a classical system for studying morphogenesis. In developing tooth, high-level expression of beta 5 integrin mRNA alternates from epithelium to mesenchyme and back to epithelium. Each switch in localization occurs within one day. These results demonstrate that an integrin mRNA can be precisely and rapidly up- and down-regulated over unexpectedly short time spans, and that expression can oscillate between adjacent, interacting epithelial and mesenchymal tissues during morphogenesis. This rapid modulation of mRNA expression suggests a potential regulatory role for the beta 5 integrin receptor in morphogenesis.

Animals↗
PubMedDate not supplied

Experimental nasal septoplasty; influence on nasomaxillary development. A roentgen cephalometric study in growing domestic cats.

The fear of destroying an anticipated growth centre has, with time, induced the postponement of nasal septal operations until adult age. Underdevelopment of the nose and middle face is otherwise believed to be the long-term result. In order to test this hypothesis, subepichondrial surgery was performed in growing domestic cats. The technique resembled modern corrective interventions for septum deviations in humans. Based on cephalometry, i.e. measurements on lateral skull radiograms, no significant influence could be found regarding ultimate nasal or mid-facial dimensions. The findings tentatively intimate that septal surgery might be carried out at a much earlier age than hitherto assumed.

Age Factors↗
PubMed1994

The fetal alcohol syndrome in adolescence.

At present, alcohol is recognized as the leading teratogenic agent in long-lasting CNS dysfunction. Little is known about the long-term development and outcome of children with fetal alcohol syndrome (FAS). Forty-four FAS patients who were diagnosed in early childhood were followed up for 10-14 years. This study documents the developmental changes of the manifestations of FAS from childhood to adolescence and describes a characteristic "juvenile" pattern of FAS, which may help to identify this syndrome even in adolescence. This is especially relevant for patients who were not diagnosed earlier.

Adolescent↗
PubMedDate not supplied

Metabolic transitions in rat jaw muscles during postnatal development.

The program of acquisition of adult metabolic phenotypes was studied in three jaw muscles in order to determine the link between muscle metabolism and functional development. During early postnatal stages, there were similar transitions in the masseter, anterior digastric, and internal pterygoid muscles with respect to fiber growth, fiber type composition, and whole muscle energy metabolism. Oxidative capacity, as judged by the activities of the enzymes succinate dehydrogenase (SDH), malate dehydrogenase (MDH), and beta-hydroxyacyl CoA dehydrogenase (beta OAC), rose sharply after birth to reach near maximal levels by 3 weeks. The capacities for glycolytic metabolism represented by lactate dehydrogenase (LDH), and for high-energy phosphate metabolism represented by adenylokinase (AK) and creatine kinase (CK) activities, rose gradually, not reaching peak values until 6 weeks or later. Thus, the maturation of oxidative metabolism preceded that of glycolytic metabolism in the developing jaw muscles. This was documented for individual fibers in the masseter muscle. Differential metabolic maturation among the jaw muscles was evident beyond 3 weeks. All three jaw muscles attained their specific adult fiber-type profile by about 6 weeks. This maturation program differed from that of hindlimb muscles [Nemeth et al., J Neurosci 9:2336-2343, 1989] and diaphragm muscle [Kelly et al., J Neurosci 11:1231-1242, 1991], reflecting their differential energy demands for contractile performance.

Animals↗
PubMed1998

Cervical headgear usage and the bioprogressive orthodontic philosophy.

During the past 125 years, a variety of headgear appliances have been used as adjuncts during orthodontic therapy. At the outset, a headgear was usually used in combination with the extraction of the upper first bicuspid teeth which created the space required to retract protruding upper anterior teeth. It did not take long for clinicians to understand that some form of extraoral support was required to augment the somewhat-limited anchor-age provided by the maxillary bicuspid and molar teeth during incisor retraction. Thus, the headgear became the treatment auxiliary of choice during the retraction of the anterior segment of teeth. Used in this manner, the appliance became known as occipital, or headgear anchorage. After the introduction of cephalometric radiography, it became evident that headgear appliances could be used not only to move teeth, but also as orthopedic appliances to modify the development of the jaws of growing children. With time and development, headgears lost some of their early complexity and they evolved into appliances that closely resembled modern cervical headgears. The cervical pull headgear soon became involved in a controversy when some clinicians claimed that the use of a high pull, or occipital pull headgear resulted in more optimal treatment results than the cervical pull headgear. The Bioprogressive philosophy of orthodontic therapy recommends the use of cervical headgears in the unequivocal belief that, when correctly used, they produce the most advantageous and predictable orthopedic changes in growing faces.

Cephalometry↗