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Results for “JOINT DISEASES”

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At least 1,243 records · Page 69Linked to original sources
PubMed1994

[Amyloid deposition in chronic joint disease].

As a screening procedure for the detection of amyloidosis secondary to rheumatoid arthritis, abdominal subcutaneous fat tissues were aspirated, and were examined after Congo red staining by polarized microscopy. Positive amyloid deposits were found in 7.1 percent of the rheumatoid patients, and the amyloid in the subcutaneous fat was determined to be AA type by permanganate oxidation. The occurrence of amyloid deposition was significantly correlated with the duration of the articular symptoms, the progression of the class, and also with proteinuria. Additionally the joint capsules, including the synovium and synovial fluid sediment, from patients with rheumatoid arthritis and osteoarthritis were examined for amyloid deposition. Deposits of amyloid in the hip and knee joints were found more frequently in those with rheumatoid arthritis than in those with osteoarthritis. In osteoarthritis, the frequency of amyloid deposition tended to increase with advancing age. However these amyloid deposits in the joint structure were discovered to be resistant to permanganate oxidation. Therefore it was suspected that these amyloid deposits were of a type different from AA amyloid.

Adipose Tissue↗
PubMed1999

Risk of degenerative ankle joint disease in volleyball players: study of former elite athletes.

To estimate the influence of long-term, high-intensity volleyball playing on premature osteoarthritis (OA) of the ankle joint, we examined a group of 22 former elite volleyball-players age (34 +/- 6 yrs.) who had played for at least 3 years in the highest volleyball league in Switzerland, and 19 normal healthy untrained controls (35 +/- 6 yrs.). Volleyball-athletes had played during an average of 5.5 (+/- 2) h/wk for 8.5 (+/- 3) yrs. Twenty of the 22 players had suffered from at least one ankle sprain (average: 3.5), 10 had had ruptures of the lateral ligaments (8 of them operated). Four players had severe mechanical instability, 5 a talar varus tilt in the stress X-ray of more than 8 degrees. Subchondral sclerosis and osteophytes were more prevalent in volleyballers than in controls (p < 0.001), while the difference in joint space was not significant. No severe grades of OA could be observed in these former elite volleyball players. Yet, a radiologic score of degenerative ankle disease was elevated in 19/22 of them, but only in 2/19 controls (p<0.001). In multiple regression analysis among athletes, the anterior drawer sign and a feeling of instability were the only significant and independent predictors of an increased radiological index (p = 0.003 and p = 0.02, respectively) from an initial set of 9 variables covering career length and intensity as volleyball player, clinical signs of ankle instability and age. Even if in the present study, athletes had clearly more radiologic findings than controls--such as spur formation and subchondral sclerosis--long-term, high-intensity volleyball playing alone could not be confirmed as an independent risk factor for OA of the ankle joint however, a combination of chronic lateral ankle instability with intensive volleyball playing could marginally increase the risk of ankle OA.

Adult↗
PubMedDate not supplied

[Plasminogen activator activity of the synovial fluid as an indicator of activation phenomena in degenerative joint diseases].

Activity of plasminogen activator in synovial fluids of patients with osteoarthritis was determined by a radial diffusion assay. Synovial fluid from human knee joints was obtained by joint lavage with 35 ml physiological saline containing 0.5% hydroxyethyl starch. Synovial fluids from contralateral, healthy knee joints served as controls. The activity of plasminogen activator in synovial fluid from activated (painful) osteoarthritis is significantly higher than in cases of latent osteoarthritis, whereas the activity of controls is significantly lower as in latent osteoarthritis. The findings are helpful for the discovery of patients with enhanced plasminogen activator levels in synovia which should be treated therapeutically.

Electrophoresis, Polyacrylamide Gel↗
PubMed2003

The costs of early inflammatory joint disease: a population-based study in southern Sweden.

OBJECTIVE: To study the costs and use of healthcare for patients during the first months with early joint inflammation, in a population-based prospective referral study in Southern Sweden. METHODS: Adult patients with arthritis for < 3 months and with onset of symptoms between 1 May 1999 and 1 May 2000 were referred from primary health centres to rheumatologists. Four clinical assessments were performed during a 6-month follow-up period. The direct medical costs for inpatient stays, outpatient visits, visits to general practitioners, and visits to health professionals, as well as costs for medication, radiographs, and laboratory tests were recorded from the onset of the disease up to 6 months of follow-up. Indirect costs for sick leave were also recorded. RESULTS: Fifty-six of 71 referred patients agreed to participate. Thirteen (23%) had RA, 21 (38%) had reactive arthritis (ReA), 14 (25%) had undifferentiated arthritis, and eight (14%) had other arthritides. The median cost per patient in the entire group was USD 3362. The median cost per patient in the RA group was USD 4385, and USD 4085 in the ReA group. There was no statistically significant difference in the median costs per patient in the different diagnostic groups. Sick leave accounted for 44% of the total costs in the entire group, and 46% and 47%, respectively, in the RA and ReA groups. CONCLUSION: The costs of early arthritis are already considerable during the first months of the disease following the onset of the symptoms. The indirect costs due to sick leave accounted for nearly half of the costs.

Arthritis, Reactive↗