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PubMed1988

Inpatient Memory Impairment Scale: a cross-validation and extension study.

The psychometric properties of the Inpatient Memory Impairment Scale (IMIS), a 10-item behavioural rating scale for assessing hospitalized amnesiacs, were investigated using matched groups of 18 amnesiacs, 20 chronic alcoholics, and 20 psychiatric patients. The scale was found to have a high degree of internal consistency and interrater reliability when two raters are used and to correlate significantly with a range of memory tasks. The IMIS was found to discriminate amnesiacs from chronic alcoholics and amnesiacs from psychiatric patients, which extends the findings of previous studies that used this scale. It is concluded that the IMIS has encouraging psychometric properties that have been replicated in this study and that the development of ecologically valid behavioral measures of cognitive deficit represents a promising direction for future research.

Adult↗
PubMed1984

Dementia--Alzheimer type.

At least half of the patients who present with progressive decline in their memory, cognitive, and intellectual abilities will eventually be diagnosed as having Alzheimer's disease. The diagnosis is reached by clinical and ancillary evaluation and exclusion of all other causes of dementia. Recently, considerable advances have been made in our understanding of the neurobiologic features of Alzheimer's disease. Cortical neurons contain paired helical filaments with a very specific electron microscopic appearance. These filaments contain proteins with unusual properties. A severe decline in cholinergic activity in the cortex is related to a marked loss of cholinergic neurons in deep cerebral structures, such as the nucleus basalis of Meynert in the substantia innominata. No specific treatment is available for Alzheimer's disease. Patients and the relatives who take care of them require substantial help and assistance in coping with the disease.

Acetylcholine↗
PubMed1999

Image control from childhood to adolescence.

Despite the recognized importance of imagery use by children as well as the developmental relevance for maturity and health of imagery properties such as vividness and control, only a few studies have investigated imagery of children. The aim of the present study was to examine the development of control of mental images in a sample of boys and girls aged 7 to 17 years. Children were assessed on two aspects of mental imagery, vividness and control, and teachers were asked to rate the children's intellectual and socioemotional performance. Analysis showed that the capacity for image control increased in adolescence and that children characterized by vivid and uncontrolled imagery received the lowest ratings from teachers, whereas those with nonvivid and controlled imagery received the highest ratings. The implications of these results were discussed in relation to normal and abnormal development as well as suggestions for research.

Adolescent↗
PubMed2000

Characteristics of mentally retarded criminal offenders in Northern Taiwan.

The characteristics and criminal behavior in mentally retarded individuals remain largely unstudied. This retrospective study sought to establish a set of reference of criminal behavior characteristics in an ethnic Chinese mentally retarded group. Data were collected from forensic psychiatric evaluation of 32 mentally retarded offenders. Of the 32 offenders, only four (12.5%) cases were female. Mean age at the time of the offenses was 31. By IQ testing, 23 (71.9%) of the group fell into the mild mental retardation range, seven (21.9%) into the moderate mental retardation range, and two (6.2%) into the severe mental retardation range. Nineteen (59.3%) of the group also suffered from additional mental disorder. Eight (25%) had definite neurological deficit. Fourteen (43.8%) were repeat offenders. A total of 24 (75%) of the offenders had committed crimes against property, with 13 having committed petty theft. Furthermore, the pattern of offending shows differences from that of the general population or other mental disorders. The property offenses, especially petty theft and arson, were frequently seen. There was no noteworthy above average frequency of sexual offenses.

Adolescent↗
PubMed1986

Current concepts of regulation of phosphate transport in renal proximal tubules.

The wealth of new information on BBM transport of Pi which has accumulated in recent years gives an indication of the importance and intellectual challenge that the mechanism of this process poses to investigators. In this brief reflection on the field, we have tried to draw attention to some general principles and features which may be helpful as working hypotheses in the development of the field. To date, a disproportionate amount of effort may have been spent on deciphering putative intracellular regulatory mechanisms, without knowing some essential fundamental properties of the Na+-Pi-COT. We suggest that a major effort should be exerted towards elucidating biogenesis of the Na+-Pi-COT, the possible existence of a membrane cycling mechanism, and a refined analysis of the Na+-Pi-COT in specific subsegments of proximal tubules. Advances in these areas together with studies of both the rapid and long-term adaptive regulation of Pi transport are needed, given the central role of the kidney in total body Pi homeostasis both in health and disease.

Adaptation, Physiological↗
PubMedDate not supplied

ESBRA-Nordmann 1998 Award Lecture: Visual P3 as a potential vulnerability marker of alcoholism: evidence from the Amsterdam study of children of alcoholics. European Society for Biomedical Research on Alcoholism.

Recent data from the Amsterdam Study of Children of Alcoholics add to the evidence for considering the P300 or P3 component of the event-related potential (ERP) as a potential vulnerability marker of alcoholism. In this study, multi-channel ERPs were recorded from 7- to 18-year-old children of alcoholics (COAs) and age- and sex-matched low-risk controls using several experimental paradigms, including a visual novelty oddball task and a visual selective attention task. The results indicated that differences between COAs and controls in the visual P3 amplitude: (1) can be elicited both actively by task-relevant target stimuli and passively by irrelevant novel stimuli; (2) are a function of both the attentional relevance and the target properties of the eliciting stimulus; (3) are mediated by multiple brain generators, rather than by a single generator; (4) originate from a difference in the strength, rather than in the spatial configuration, of the underlying brain generators; (5) cannot be accounted for by differences in visual attention-related earlier occurring ERP components; and (6) can be moderated by current behavioural and emotional problems, general intellectual ability, and socio-economic background. These findings support the notion that a relatively small visual P3 amplitude in COAs reflects heritable biases in attention and information processing that are related to their increased vulnerability to alcoholism.

Adolescent↗
PubMed2000

Results of barbiturate antiepileptic drug discontinuation on antipsychotic medication dose in individuals with intellectual disability.

Five individuals with intellectual disability prescribed both a barbiturate antiepileptic drug (AED) and an antipsychotic medication were identified in a public residential facility. It was hypothesized that antipsychotic medication was prescribed at doses higher than necessary as a result of inadvertent barbiturate AED behavioural side-effects thought to be part of the underlying psychiatric or behavioural condition. To test this hypothesis, barbiturate AEDs were gradually reduced, and replaced with either carbamazepine or valproic acid, and antipsychotic medication was gradually reduced as well. Challenging behaviours, such as physical aggression, self-injurious behaviour and property destruction, were measured with a frequency count or partial interval recording, and retrospectively analysed for time periods of approximately 60 days before phenobarbital reduction, after phenobarbital discontinuation and after the lowest antipsychotic medication dose. Challenging behaviour collectively decreased by 81.5% after barbiturate discontinuation, mean antipsychotic medication dose significantly decreased from 146 mg day(-1) (SD = 98) to 106 mg day(-1) (SD = 88) chlorpromazine equivalence, and antipsychotic medication was discontinued in the cases of two individuals. Compared to the prebarbiturate AED reduction period, challenging behaviour collectively decreased by 96.3% after the lowest antipsychotic medication dose, which confirmed that reduced antipsychotic medication was not achieved at the expense of behaviour deterioration. The data supported the hypothesis that discontinuation of barbiturate AEDs results in decreased challenging behaviour and less antipsychotic medication.

Adult↗
PubMed2001

Assessment of the convergent validity of the Questions About Behavioral Function scale with analogue functional analysis and the Motivation Assessment Scale.

The present study examined the convergent validity of the Questions About Behavioral Function (QABF) scale, a behavioural checklist for assessing variables maintaining aberrant behaviour, with analogue functional analyses and the Motivation Assessment Scale (MAS). The two checklists were more highly correlated with each other than either checklist with results from the analogue sessions, and the QABF was more highly correlated with analogue sessions than the MAS. Using analogue sessions, the experimenters failed to ascertain behavioural function for a number of subjects because the behaviour problems in question were low frequency/high intensity and failed to appear during the course of the analysis, pointing out a limitation of this technology. These findings, taken together with recent research outlining the psychometric properties of the QABF, seem to support the use of the QABF in a hierarchical model of functional analysis. The implications of the findings are discussed.

Adult↗
PubMedDate not supplied

[The effect of the preparation rodakson on the psychophysiological and physical adaptation of students to an academic load].

The effect of rhodaxon, an adaptogen preparation based on the Rhodiola rosea extract, upon the physical and intellectual working capacity and psychoemotional state of foreign students during their study in a Russian high school was evaluated. It was established that rhodaxon administration provided increase in the amount of veloergometric work accomplished and reliably increased the kinesthesiometric sensitivity. The drug also lead to marked increased in the general condition and a decrease in the level of psychic fatigue and situational anxiety. On the whole, the pharmacological properties of the rhodaxon preparation studied coincided with those reported for the gold root extract. The fact that the rhodaxon preparation contains no ethyl alcohol extends possibilities of the clinical administration of the new preparation.

Adaptation, Physiological↗
PubMed1989

Vasotocin improves intelligence and attention in mentally retarded children.

In mentally retarded (MR) prepubertal children, investigated both before and after six months of treatment, synthetic arginine vasotocin (AVT) (10(-6) mg/day/0.1 ml, intranasally), but not oxytocin or saline alone, significantly increased the intelligence quotient (IQ) and improved the attention parameters without affecting the short-term memory. Taking into account both the psychometric results and the clinical observations, the effects of AVT could be mainly explained by assuming the improvement of attention. Since there was a significant inverse correlation between the pretreatment levels of the IQ and attention scores and their increase after AVT, and since the AVT effects tend to be more intense in autistic children, we hypothesize that the more affected the attention mechanisms, the more they are sensitive to AVT. The present results are tentatively explained by the paradoxical sleep-enhancing properties of AVT, mechanisms by which AVT could improve the brain plasticity in MR subjects and by this, the attention performance.

Attention↗
PubMed1986

Structure, origin and effects of a supernumerary marker chromosome 15.

A de novo supernumerary small marker chromosome 15 was observed in a female infant with mental and statomotoric retardation as well as minor facial dysmorphia. The marker chromosome was analyzed by ten different staining techniques and 5-azacytidine treatment of lymphocyte cultures. It is shown that the supernumerary chromosome was derived by a non-sister chromatid exchange between the two homologous maternal chromosomes 15. The cytogenetical properties of the marker chromosome, the different activity of its two nucleolus organizer regions and the somatic pairing configurations revealed by 5-azacyidine are reported.

Child, Preschool↗
PubMed1991

Relation between receptive language and cognitive maturity in persons with mental retardation.

We examined the correlations between receptive language level and performance on indices of nonverbal cognitive functioning for 20 persons with mental retardation and for 20 children without mental retardation matched to them on nonverbal MA. The correlations suggested that the retarded group focused on the formal, sequential properties of language. The correlations also suggested that the nondisabled group placed less emphasis on the formal, sequential properties of language and more on semantic, conceptual properties. These differences in approach may explain why the persons with mental retardation did poorly on the task of understanding spoken language compared to the children without mental retardation.

Adolescent↗
PubMed2007

An evaluation of Beck's cognitive theory of depression in adults with intellectual disability.

BACKGROUND: The theories supporting cognitive treatment for depression among individuals with intellectual disability (ID) have not been formally tested with this population. The current study evaluated Beck's cognitive theory of depression to determine its appropriateness for adults with ID. METHODS: Forty-eight adults with primarily mild or moderate ID participated in semi-structured interviews, twice approximately 16 weeks apart, as did an additional 12 adults diagnosed with depression. Participants reported on depressed mood, the cognitive triad, as measured by views of the self, the world and the future, hopelessness and self-esteem. RESULTS: The Cognitive Triad Inventory for Children (CTI-C) displayed adequate psychometric properties in this sample. In addition, it was correlated with depressed mood, and individuals diagnosed with depression had significantly higher scores on the CTI-C than those with no psychiatric diagnoses. Contrary to hypotheses, a negative cognitive triad did not predict depressed mood 4 months later, but the inverse relationship where depressed mood predicted a later negative cognitive triad approached statistical significance. CONCLUSIONS: The findings indicate that the cognitive triad can be measured among individuals with mild or moderate ID and is related to depression and depressed mood. However, the role of the cognitive triad in the development of depression is still unknown. The findings provide some support for Beck's cognitive theory of depression among individuals with ID and provide suggestions for further testing the theory. Implications for the treatment of depression among individuals with ID are discussed.

Adult↗
PubMed2006

Rater bias and the measurement of support needs.

BACKGROUND: The development and use of support need instruments for funding disability services is a relatively recent initiative. Although the use of these measures appears at face value to provide an objective measure of support needs, little is known about their psychometric properties, particularly with respect to rater bias and purpose of assessment. A measure of support that has been developed in Australia to provide estimates of service needs and associated funding is the Service Need Assessment Profile (SNAP). METHOD: This study investigated whether SNAP scores obtained for different assessment purposes - research and funding - are affected by rater bias, by comparing SNAP to 3 other measures of support from 29 people with intellectual disabilities. RESULTS: We found that SNAP scores completed for funding purposes showed an individual's support needs to be much greater than comparison scores on both SNAP and the 3 other measures obtained for research purposes. CONCLUSIONS: Our results suggest that support measures such as SNAP may significantly overestimate support needs when raters know the assessment is being used for funding purposes.

Activities of Daily Living↗
PubMed1999

Stress and residential staff who work with people who have an intellectual disability: a factor analytic study.

The present study describes the development of a questionnaire, and the subsequent collection of data, to gather information on the demands and supports which influence stress (as measured by anxiety and depression scales) in direct care staff who work with people with intellectual disability. The results from the questionnaire were also used to explore the relationships between the factors derived from the questionnaire and to consider how these may be influential in building organizational models. The questionnaire was specifically constructed to measure the demands and supports experienced by direct care staff. The participants included 216 staff working in community residential services for people with intellectual disability. These individuals included staff working for two British health trusts and similar staff working for one local authority. The questionnaire consisted of 33 demands items and 23 supports items. Separate factor analyses were conducted on the demands and supports scales. Analyses of the reliability and validity of the resulting factors were conducted. Stepwise multiple regressions were conducted to further explore the relationship of factors with the measures of anxiety and depression. Four factors were extracted from the demands scale and three factors from the support scale. There was some concern over levels of reliability and validity for individual factors; however, the reliability of the main scales appeared to be satisfactory. All but one support factor correlated significantly with levels of anxiety and depression. The factors explained a modest amount of the variance in the regressions. While there are some concerns about the psychometric properties of the questionnaire, it is argued that the scales and factors can be used to confirm and further understanding of the relationship between groups of demands, supports and stress in staff. The usefulness of the questionnaire as a means of diagnosing specific sources of demand and support is considered. It is suggested that the questionnaire could form the basis for assessment and subsequent intervention in houses where staff are reporting relatively high levels of anxiety and depression.

Adult↗
PubMed1975

Heterokaryons in the analysis of genes and gene regulation.

Cytological and chemical analysis of heterokaryons, the immediate product of cell fusion, offer new possibilities for studying the factors responsible for genetic regulation in eukaryotic cells. In comparison with proliferating cell hybrids the heterokaryon state offers the important advantage that a heterokaryon contains two complete genomes since chromosome loss does not occur, but since segregation and recombination are absent, heterokaryons cannot be used for gene mapping in the same way as proliferating cell hybrids. However, if two cell types carrying different genetic defects are fused the analysis can be used for studies of gene complementation. The biological information obtained with heterokaryons has emphasized the role of the cytoplasm in the control of nuclear activity. When a G1 nucleus is brought into contact with the cytoplasm of an S phase cell the G1 nucleus is stimulated to synthesize DNA. If the nucleus is brought into a mitotic cell, the chromatin of the G1 nucleus is forced to condense into prematurely condensed chromosomes. Inactive nuclei such as the dormant chick erythrocyte nucleus will be stimulated to initiate RNA and DNA synthesis when brought into contact with an active cytoplasm by cell fusion. Specific nuclear proteins have been shown to be responsible for this process of reactivation. Other inactive nuclei such as the nuclei of macrophages and spermatozoa have likewise been shown to be reactivated by fusion with active cells. The degree of activation in all of these cases appears to be determined by the state of the active cell. Inactive nuclei are activated to the same level as the active nucleus but seldom beyond this level. If differentiated cells are fused with undifferentiated cells, usually the differentiated character is lost rapidly after fusion. This observation is in agreement with several studies on proliferating cell hybrids indicating some type of negative control of differentiated properties. In heterokaryons obtained by fusion of cells of a similar type of histotypic differentiation usually coexpression of the differentiated markers is observed.

Animals↗
PubMed1976

Quantitative morphological studies of developing human cerebellar cortex in various disease states.

A quantitative morphological assessment was carried out of the cellularity and staining properties of the cells of the layers of the human cerebellar cortex, both in the normal child and in 41 children suffering from a series of disorders including mental retardation. A computerized image analyser and highly standardized procedures were used. All of the cases of mental retardation and some cases with congenital cardiac anomalies showed abnormal cell concentrations and staining properties. 3 cases of 'cot death' also showed abnormal results. These findings are presented as a new measurable aspect of brain disease, and as a indication for further study.

Cerebellar Cortex↗
PubMed1996

Facial stereotypic movements and tardive dyskinesia in a mentally retarded population.

The facial stereotypies of adults diagnosed as having mental retardation and tardive dyskinesia were examined through a kinematic analysis of video-taped lip and tongue motions. A control group of healthy adult subjects without mental retardation was also examined in the production of preferred rates of lip and tongue oscillatory motions to provide a basis to assess the degree of movement variability in the stereotypies. The inter- and intraindividual variability of the movement form characteristics of the lip and tongue stereotypic motions was higher in the subjects with mental retardation. Results suggest that the low variability of discrete properties of movement kinematics may not be a defining feature of stereotypies. The concept of invariance in stereotypies may relate only to the topological kinematic properties of the movement sequence that provide the basis to infer that the same stereotypic movement sequence was reproduced from observation to observation.

Adult↗