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At least 1,243 records · Page 69Linked to original sources
PubMed1998

Efficacy of a mixed glycoprotein vaccine against pseudorabies in pregnant sows.

A pseudorabies virus (PRV) glycoprotein-mixed vaccine was prepared by heparin-affinity chromatography from PRV-infected PK-15 cell lysates. In our previous study, the trial vaccine was induced protection with suppression of virus shedding in one-month-old pigs and generation of cytotoxic T lymphocyte (CTL) response in mice. In this study, the effect of the trial vaccine on suppression of both virus shedding and reproductive failure in pregnant sows was examined. Three sows were vaccinated twice until one week before mating. Each of them was infected intranasally with 10(6) TCID50 of PRV on day 28, 54, or 85 after mating, respectively. Three other sows were also mated and challenged at the same time as the respective control. The vaccinated sows produced virus-neutralizing antibodies. Sows with high level of VN antibody lowered the level and period of virus shedding after challenge. The maximum level of shed-virus titers in vaccinated sows were 10(1.25) to 10(3) times lower than controls. Vaccinated sows shed virus for 1 or 5 days, while controls shed for 8, 9, or 12 days. No abortion or stillbirth was observed in vaccinated sows during pregnancy. On the other hand, control sow challenged at a late stage of pregnancy showed abortion and stillbirth. The results obtained here indicate that our trial vaccine is effective to prevent reproductive failure by pseudorabies virus.

Abortion, Veterinary↗
PubMedDate not supplied

Prostacyclin and hormone levels in patients with symptoms of miscarriage and infection.

During pregnancy, acsending infection into the uterus, is followed by local increase of cyclooxygenase-2 (COX-2) activity, and consequently elevated prostaglandin production. Subclinical infections of fetal amniotic membranes are well known to cause preterm delivery. Spreading of infection from vagina and cervix into uterine cavity, can be tragic for the fetus. The aim of this study was to reveal wether lower genital tract infections are associated with symptoms of threatened miscarriage. Our investigation included 140 patients with symptoms of threatened miscarriage and 70 patients with uncomplicated pregnancies. Infections were detected by vaginal or cervical smears as well as tests for Chlamydial infection. Levels of prostacyclin, main prostaglandin product during pregnancy, were evaluated via its stable metabololite, 6-keto-PGF1-alpha. Both prostaglandin levels and hormones were determined by ELISA method. We found that serum values of prostacyclin were elevated, while levels of estradiol, progesterone and prolactin were significantly lower in patients with lower genital tract infections. Increased prostacyclin levels in pregnancies complicated by lower genital tract infections are caused by stimulation of COX/2 enzyme, due to elevated production of various cytokines which are possibly a compensatory mechanism resolving problems caused by bacterial endotoxines.

6-Ketoprostaglandin F1 alpha↗
PubMed2000

Safety and efficacy of Brucella abortus strain RB51 vaccine in captive pregnant elk.

Brucella abortus strain RB51 is a laboratory-derived rough mutant of virulent B. abortus strain 2308 used as a vaccine because it induces antibodies that do not react on standard brucellosis serologic tests. Strain RB51 vaccine was evaluated in pregnant captive elk (Cervus elaphus) to determine (1) if it induced abortion and (2) if it protected against abortion following subsequent challenge. The time period of this study (February-June, 1998) was similar to field conditions where elk are vaccinated and possibly exposed to B. abortus. Fourteen elk were randomly and equally divided into vaccinated and control groups. The vaccinated group was vaccinated intramuscularly with 1.03 x 10(10) colony-forming units (CFU) of strain RB51 and seroconverted postvaccination. Antibodies to strain RB51 were detected by a modification of an existing dot-blot assay. Both groups were challenged 40 days postvaccination with 9.8 x 10(6) CFU of B. abortus strain 2308 administered intraconjunctivally. The first abortion occurred 38 days postchallenge. Abortion occurred in all control elk and in five of seven vaccinated elk 5 to 12 wk postchallenge (P = 0.23). Mixed strain RB51 and 2308 infections were present in fetuses and vaginas from the vaccinated group whereas only strain 2308 was cultured from control group fetuses and vaginal swabs. Further evaluation of strain RB51 will be necessary to determine if it will be safe and efficacious in free-ranging pregnant elk.

Abortion, Veterinary↗
PubMed1992

[Diagnostic and prognostic value of specific immune response to Cytomegaloviruses in pregnant women with a history of habitual abortion].

The authors analyze the usefulness of specific serologic tests for anti-CMV antibodies of the IgG and IgM classes for the prediction of the course of pregnancy and choice of immunocorrective therapy of women suffering from habitual abortions. Detection of specific IgM antibodies to cytomegalovirus with the use of Abbott diagnostic system was found highly informative, for it permitted a differential diagnosis of the cause of habitual abortions and monitoring of the treatment efficacy. Enzyme immunoassay of TBH in blood serum samples of pregnant women helped monitor the course of pregnancy.

Abortion, Habitual↗
PubMedDate not supplied

Positive support.

Explore the source record for details and available documents.

Abortion, Spontaneous↗
PubMed1992

Sepsis in pregnancy.

Sepsis remains an uncommon, but potentially devastating problem in the previously healthy pregnant patient. Although septic sequelae, including organ failure and shock, are unusual, they are likely to lead to morbidity and mortality as high, or higher, than in the general population. At the present time, hemodynamic support, surgery, and antimicrobial therapy aimed at reducing polymicrobial aerobic and anaerobic infection remain the gold standard of therapy. New antimediator and anti-inflammatory therapies offer promise of improved survival in the general and obstetric population with severe sepsis.

Abortion, Septic↗
PubMed1992

IgM and IgG antibodies specific to rubella in child bearing women.

Three hundred fifty five pregnant women were tested for IgM and IgG type of antibodies by Enzyme Immuno Assay (EIA). Sero-positivity for IgM and IgG antibodies were 13% and 29% respectively. Of 212 pregnant women with abortion, 39 (18%) and 80 (38%) were sero-positive and of 143 pregnant women with normal reproductive performance, 7 (5%) and 23 (16%) were positive for IgM and IgG respectively. Premarital screening and vaccination of Sero-negative girls is recommended to reduce morbidity and mortality related to rubella virus.

Abortion, Spontaneous↗
PubMed2004

[Chlamydia trachomatis infection in women seeking termination of pregnancy 1985-2000].

BACKGROUND: The purpose of this study was to analyse trends for Chlamydia trachomatis infection in a population of women seeking termination of pregnancy, and to assess whether socio-demographic characteristics are predictive of such infections. MATERIAL AND METHODS: Since 1983 women seeking abortion in the university hospital in Trondheim have been systematically tested for Chlamydia trachomatis. Data on 11,376 abortions (1985-2000) were included in the study and results were analysed with logistic regression. RESULTS: Age-adjusted prevalence of Chlamydia trachomatis decreased from 9.0% to 5.0% in 1999-2000. The prevalence was highest among the youngest women. Single and cohabiting women had a higher prevalence of chlamydial infections than married women. INTERPRETATION: Women terminating their pregnancy are an excellent population for sentinel surveillance of Chlamydia trachomatis infection because of their young age, high proportion of singles, and relative inconsistent use of contraception. Even though the prevalence of Chlamydia trachomatis has decreased over the 16-year study period, it is still high for women seeking abortion, especially in the youngest age groups.

Abortion Applicants↗
PubMed2004

[Seroprevalence of toxoplasmosis among women having spontaneous abortion and pregnant women following in a center of health up-town in Dakar].

A prospective survey carried on 70 women having a spontaneous abortion and 70 pregnant women was achieved in the center of health Roi Baudouin of Guediawaye (Senegal) between November 2001 to April 2002 to study the toxoplasmosis in the two groups. Anti-toxoplasmosis antibodies were searched for on all women by a technical solid-phase enzyme immunoassay. The solid-phase is a combs. The seroprevalence of the toxoplasmosis is 37.1% among women having aborted and 40% for pregnant women. The difference is not statistically significant (p = 0.729). The seroconversion is 22.8% among women having aborted and 10% for pregnant women. The difference is statistically significant (p = 0.041). The research of factors favoring the infestation, related to through food habits, pleads in favor of a contamination during childhood, essentially soil and/or eating undone meat. With regard the high percentage of not immunized women (62.9% for women having aborted and 60% for pregnant women), it is necessary to take prophylactic measures to prevent congenital toxoplasmosis.

Abortion, Spontaneous↗
PubMedDate not supplied

The PCR assessed prevalence of Chlamydia trachomatis in aborted tissues.

BACKGROUND: Infections caused by Chlamydia trachomatis (ChT) are the most prevalent sexually transmitted bacterial infections worldwide. ChT is a cause of cervicitis, endometritis, salpingitis, tubal infertility and ectopic pregnancy. Perinatal infections with ChT have been associated with premature rupture of membranes, stillbirth, preterm delivery, and in newborns with conjunctivitis and pneumonia. There are controversial data referring to the association between colonisation by ChT and the risk of spontaneous abortion. Only few studies investigated the prevalence of ChT antigens in aborted tissues. AIM: To determine the prevalence of ChT in patients with spontaneous pregnancy loss using Polymerase Chain Reaction (PCR). MATERIALS AND METHOD: We completed prospective analysis of 50 patients after spontaneous abortions. The prevalence of ChT infections was assessed by PCR performed in samples taken during curettage following miscarriage. RESULTS: ChT was present in 16 (32%) of samples. Other pathogens of the lower genital tract were found in cultures from 11 patients. CONCLUSIONS: The prevalence of ChT infections in early abortions in this study was found to be surprisingly high. It implies the importance of screening of women planning pregnancy and pregnant women for this disease.

Aborted Fetus↗
PubMed2005

[Prevalence and association of porcine circovirus type 2 (PCV2), porcine parvovirus (PPV) and porcine reproductive and respiratory syndrome virus (PRRSV) in aborted fetuses, mummified fetuses, stillborn and nonviable neonatal piglets].

Porcine circovirus type 2 (PCV2) seems to cause reproductive failure in sows not only in experimental studies. A retrospective study was made with a total of 252 aborted fetuses, mummified fetuses, stillborn and nonviable neonatal piglets to determine the presence of PCV2, porcine parvovirus (PPV) and porcine respiratory and reproductive syndrome virus (PRRSV) by PCR. PCV2 was found in all stages of gestation in 27.1 percent of samples examined. A statistically significant association could be shown between the detection of PCV2 and PRRSV. However, no significant association was seen between the detection of PCV2 and PPV and between PPV and PRRSV.

Abortion, Veterinary↗
PubMed2004

Seroprevalence of rubella in pregnant women in Kashmir.

The present study was conducted to determine the seroprevalence of rubella in pregnant women in Kashmir. One thousand nine hundred and eighteen pregnant women in age group of 20-35 were divided into two groups. Group I (n=892) consisted of women with previous history of repeated abortion (507), single abortion (220), intrauterine death (149), stillbirth (14) and premature delivery (2). Group II (n=1028) pregnant women with previous normal delivery. A total of 1918 pregnant women were screened for rubella IgM antibodies out of which 16.74% were positive. In women with bad obstetric history (Group I) 26.12% were positive as compared to 8.96% in women with no significant obstetric history (Group II). The IgM antibody positivity was higher in women with previous history of intrauterine death (IUD) 58.38% followed by stillbirth 57.14%, premature delivery 50%, abortion 21.8% and recurrent abortion 17.55%. The high prevalence of disease in this region demands urgent needs for prevention. Moreover antenatal cases should be screened as early diagnosis and time intervention will help in proper management of these cases.

Abortion, Habitual↗
PubMed2001

[Prevalence of Toxoplasma gondii and analysis of specific immunoglobulins concentration in serum of women during the reproductive period in a sample of Włocławek population].

The aim of the study, from 1996 to 1999, was to investigate the serological course of prevalence Toxoplasma gondii in 985 women of procreation period. In non - pregnant women the incidence of Toxoplasma gondii specific IgG was significantly higher (59.0 +/- 1.9%) than in pregnant women (43.4 +/- 2.8%). Specific IgM was less frequent (from 1.47 +/- 1.02% to 1.76 +/- 0.66%).

Abortion, Spontaneous↗