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Evaluation of transducer performance for buttock-cushion interface pressure measurements.

To assess the performance of transducers used clinically to measure pressure at the skin-cushion interface of seated patients, transducers were placed between slabs of gel and/or foam materials compressed between platens. The recorded pressures consistently exceeded the nominal pressures calculated using the surface area of the slabs. This overestimation, observed in both miniature diaphragm transducers and air cell transducers, appeared to result from preferential loading of the transducer due to insufficient structural compliance in the environs. On the other hand, air cell transducers placed at a skin-foam interface beneath the thighs of human subjects gave readings which agreed closely with subcutaneous tissue pressure measurements obtained from a wick catheter inserted at the same location. These results suggest that, although pressure measurements are prone to error due to load sharing, results obtained clinically from subjects on soft cushions are reasonably accurate because of the high compliance of human soft tissue and the foam. Under low loads these distribute the pressure equitably and avoid concentrations of load on the transducer.

Buttocks↗

Therapeutic arterial embolisation in children.

Arterial embolisation was performed in five paediatric patients. Indications were hypersplenism in two, gastrointestinal bleeding in two and treatment of an aneurysmal bone cyst in one. Embolisation provided definitive treatment in each case with no complications.

Bone Cysts↗

Experimental partial splenectomy.

Partial splenectomy was performed on 25 dogs, removing the lower third of the spleen by a transverse incision. Stronger bleeding was ligated while parenchymatous haemorrhage was covered with Gelaspon plus Topostasin or Surgicel. The substances were sutured to the spleen with Dexon suture. Both substances proved advantageous, but the application of Gelaspon induces less tissue reaction and results in thinner neocapsule.

Animals↗

Microembolization techniques of vascular occlusion: radiologic, pathologic, and clinical correlation.

Vascular occlusion is described using microemboli of a predetermined size for the treatment of neoplastic conditions with a "capillary barrier." Particulated microemboli of either 40--60 micron Gelfoam powder or 200--1,000 micron polyvinyl alcohol foam (PVA) are best. Fluid embolic agents such as silicone fluid are used in lesions without a capillary barrier. The radiographic, pathologic, and clinical results in three patients are described in detail. Microembolization is useful in the treatment of neoplastic conditions for it produces tumor necrosis in addition to hemostasis.

Adult↗

The healing of autologous spongiosa and heterologous materials in the periodontal bone pocket. An animal experimental study.

In animal experiments with fully-grown beagle dogs we followed the healing of autologous spongiosa, collagen and binding gelatine by the use of polychrome sequential labelling. We found that when autologous spongiosa is transplanted into the periodontal intrabony pocket, the new material is fully remodelled after 6 weeks. When collagen is implanted, there is also a large amount of bone formed during this time. There was very little new bone formation after 6 weeks when binding gelatine was implanted.

Acridines↗

Selective arterial embolization in renal tumors.

Selective arterial embolization with Gelfoam was performed in 45 cases of hypernephroma. In 33 cases this technique has been utilized as preoperative procedure and almost always (97%) nephrectomy was facilitated: 97% of the cases had slight or moderate operative bleeding; in 82% of the cases separation of the tumor-containing kidney from adjacent tissues was easy. Embolization has been employed in 12 inoperable patients and was effective mainly in management of bleeding. Angiographic controls after embolization (from 13 to 162 days) were performed 8 times and it was assessed that the efficacy of the procedure on primary tumor growth is limited in time by renal artery revascularization. The embolized patients never presented severe complications, except several episodes of transitory renal failure.

Adenocarcinoma↗

A comparison of three-dimensional growth characteristics of cultured primitive marrow stroma derived from genetically anemic and normal mice.

This study examines the ultrastructure of mouse defective marrow stroma when cultured as a three-dimensional organization of cells. Gelfoam sponges impregnated with agar medium allowed the three-dimensional organization of newly formed stromal cells derived from the crevices of marrow-depleted bones of Steel mutant mice (Sl/Sld) with defective stroma and also from mice with normal stroma (Sl +/+, W/Wv, and W +/+. Ultrastructural comparisons of 5- to 14-day cultures revealed that the mutant defective stromal cells developed normally, viz. i) proliferated and formed a three-dimensional organization of stroma, ii) stimulated residual hemopoietic precursors to form myeloid cells, and iii) formed a variety of stromal cell types characterized by variable quantities of Golgi bodies and ER, glycogen, filaments, and round cytoplasmic granules. The Steel-Dickie strain, however, included bacilliform electron-dense granules in both normal and mutant stroma. The only ultrastructural deficiency in Sl/Sld stroma was the absence of a category of "activated" cells that occurred within normal cell populations.

Anemia↗