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[Effect of acetylsalicylic and mefenamic acids on cytoarchitectonic of skin in rats with acute local cryogenic trauma].

The effect of acetylsalicylic (250 mg/kg) and mephenamic (50 mg/kg) acids on the process of skin cytoarchitectonics restoration was studied in rats with acute local cryogenic traumas induced by acting with a stream of ethyl chloride upon epilated back skin area (1.5 cm2). The animals were killed under narcosis on the 12th day of post-treatment observation. Both acetylsalicylic and mephenamic acids were administered per os twice per day over various periods after cryogenic damage. The effect depended on the treatment duration. The normal skin cytoarchitectonics was restored by acetylsalicylic acid in half, and by mephenamic acid, in one-third of cases (for a "combined" administration scheme).

Administration, Oral↗

PubMed2003

Environmental-temperature injury in a Canadian metropolis.

This study performed a preliminary investigation of the incidence and determinants of environmental-temperature injury among residents of Montreal Island, Quebec, Canada. Incidence rates, mortality rates and determinants of environmental-temperature injury were estimated for Montreal Island's 1,802,309 urban and suburban residents. Sources of information included coroner's reports, death certificates, hospital discharge summaries, and hospital chart reviews. The estimated incidence rate for environmental-temperature injury requiring hospitalization on Montreal Island was 3.1 per 100,000 person-years. The estimated mortality rate for all environmental-temperature injuries on Montreal Island was 0.3 per 100,000 person-years. The majority of hospitalizations and deaths were due to cold injury. Male gender, alcohol intoxication, psychiatric illness, older age, and homelessness were suggestive of important risk factors in cold injury. All deaths due to heat injury occurred in elderly females. Montreal Island's ambulance transport service, with its unique database, was identified as a novel surveillance design for environmental-temperature injury. Knowing more about the incidence and determinants of environmental-temperature injury may suggest priorities for interventions to decrease morbidity and mortality.

Aged↗

PubMed1951