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PubMed2005

Compressibility changes accompanying conformational transitions of apomyoglobin.

We used high-precision density and ultrasonic velocity measurements to characterize the native (N), molten globule (MG), and unfolded (U) conformations of apomyoglobin. The molten globule states that were studied in this work include the MG(pH4)(NaCl) state observed at pH 4 and 20 mM NaCl, the MG(pH4)(NaTCA) state observed at pH 4 and 20 mM sodium trichloracetate (NaTCA), the MG(pH2)(NaCl) state observed at pH 2 and 200 mM NaCl, and the MG(pH2)(NaTCA) state observed at pH 2 and 20 mM NaTCA. We used our densimetric and acoustic data to evaluate changes in adiabatic compressibility associated with the acid- or salt-induced N-to-MG, MG-to-U, MG-to-MG, and U-to-MG transitions of the protein. The N-to-MG(pH4)(NaCl) and N-to-MG(pH4)(NaTCA) transitions are accompanied by decreases in compressibility of -(3.0 +/- 0.6) x 10(-6) and -(2.0 +/- 0.6) x 10(-6) cm3 g(-1)bar(-1), respectively. The N-to-MG(pH2)(NaCl) and N-to-MG(pH2)(NaTCA) transitions are associated with compressibility changes of -(4.9 +/- 1.1) x 10(-6) and (0.7 +/- 0.9) x 10(-6) cm3 g(-1) bar(-1), respectively. We interpret these data in terms of the degree of unfolding of the various molten globule forms of apomyoglobin. In general, our compressibility data reveal significant disparities between the various equilibrium molten globule states of apomyoglobin while also quantitatively characterizing each of these states. Volumetric insights provided by our data facilitate gaining a better understanding of the folding pathways, intermediates, and kinetics of apomyoglobin folding.

Animals↗
PubMed1995

Time-dependent changes in the response of cartilage to static compression suggest interstitial pH is not the only signaling mechanism.

The goal of the present study was to reexamine the role of interstitial pH in regulating the biosynthetic rate in cartilage tissue by addressing two research questions: (a) Do small, short-term changes in interstitial pH, induced independently by two different mechanisms (namely, by controlling the pH of the medium or by mechanical compression), result in biosynthetic rates commensurate with those expected from the "natural" relationship between interstitial pH and biosynthesis? and (b) Are the effects of changes in the pH of the medium or in compression the same for short-term (14-hour) and long-term (60-hour) exposures? Biosynthetic rates were estimated from incorporation of sulfate and proline into explants of bovine epiphyseal cartilage during the final 14 hours of culture. These rates decreased with decreasing pH of the medium, with increasing compression, and with decreasing native glycosaminoglycan content; or, expressed in terms of interstitial pH, acidification induced by compression or by lowering the pH of the medium resulted in a decreased biosynthetic rate, whereas interstitial acidification effected by increasing glycosaminoglycan content enhanced it. When the time for which tissue was exposed to changes in the pH of the medium was increased from 14 to 60 hours, the relationship between the biosynthetic rate and the pH remained constant whereas the relationship between the biosynthetic rate and compression was reversed. These data suggest that the transduction mechanisms underlying the response to pH of the medium and compression differ and that some adaptation or stimulation by modest levels of compression can occur with longer exposures. Interstitial pH is not the sole determinant of biosynthesis, and it cannot really account for the long-term response of cartilage tissue to static compression.

Analysis of Variance↗
PubMed2006

Age- and sex-specific differences in the factor of risk for vertebral fracture: a population-based study using QCT.

UNLABELLED: We used QCT scans obtained in 687 men and women, 21-97 years of age, to estimate the factor of risk for vertebral fracture, Phi(vert), defined as the ratio of spinal loading to vertebral strength. With age, vertebral strength declined and Phi(vert) increased significantly more in women than men. Age- and sex-specific differences in Phi(vert) closely resembled previously reported vertebral fracture incidence. INTRODUCTION: Despite the high prevalence of vertebral fractures, little is known about the interaction between spinal loading and vertebral fragility. MATERIALS AND METHODS: We assessed the ratio of spinal loading to vertebral strength (i.e., the factor of risk, Phi(vert)) in an age- and sex-stratified population-based sample of 700 women and men 21-97 years of age. We measured volumetric BMD (vBMD, mg/cm3) and cross-sectional area (CSA, cm2) of the midvertebral bodies of L1-L3 using QCT and computed vertebral compressive strength from these data using engineering beam theory. A biomechanical model of the trunk was used to estimate compressive forces applied to the L3 vertebral body during standing, bending forward, and bending forward while lifting 10 kg. The factor of risk for fracture, Phi(vert), was computed as the ratio of spinal compressive force to vertebral strength for each activity. RESULTS: Men had a higher vertebral strength at all ages, largely because of their greater CSA. Whereas both sexes exhibited a marked decline in vertebral compressive strength with age (p < 0.001), the decline was greater in women than men (-43% versus -31%, p = 0.008). Compressive forces on L3 were greater in men than women, because of their greater body weight and height. For both sexes, forces during bending and lifting were 8-fold higher than those experienced during upright standing. For all activities, Phi(vert) increased with age, but significantly more so in women than men (p < 0.001). For bending and lifting, Phi(vert-bending) exceeded 1.0 in 30% of women and 12% of men > or =50 years of age, values that are similar to the reported frequency of vertebral fracture. CONCLUSION: These findings illustrate potential mechanisms underlying vertebral fractures and provide strong rationale for further evaluation of this QCT-based biomechanical approach for assessment of fracture risk.

Adult↗
PubMed1993

Tibialis anterior R-1 response: physiological behaviour, normative data and clinical utility in L4-L5 radicular compression.

A modified H-reflex, known as R-1 response, was recorded in healthy subjects by averaging 200 responses from the moderately contracting tibialis anterior muscle (TA) after repetitive submaximal stimulation of common peroneal nerve. Physiological changes to different modes of stimulation and recording were studied and normative data obtained at the most reliable parameters. Subsequently, the test is applied to 36 patients with clinical and myelographic evidences of L5 or L4-L5 radicular compression (with or without S1 radicular compression). Increasing the force of muscle contraction resulted in increase in amplitude up to a certain limit, with no change in latency. Increasing the current from subliminal to submaximal stimulation caused initial increase and subsequent fall in the amplitude without change in the latency. The change in the stimulus frequency from 0.5 to 3 Hz did not alter latency or amplitude but the higher frequencies sometimes did. On changing the position of the foot from plantarflexed to dorsiflexed, an increase in amplitude and reduction in duration of the response was noted. Fifty subjects were studied using stimulus intensity just enough to produce 200-400 microV M-response, stimulus duration of 1.0 msec, stimulus rate of 3 Hz and the muscle force sufficient to keep the foot in complete dorsiflexion. The tibialis anterior R-1 response (TAR-1) could be recorded reliably from both legs in all the subjects. The take-off point was sharp and in no subject was there any difficulty in measuring the latency to onset point. On repeating the test, the onset point of the response was superimposable. Latency showed linear correlation with height and age. Among the patients, 21 out of 25 cases of unilateral (84.0%) and 10 out of 11 cases of bilateral (90.9%) radicular compression had abnormal findings. Abnormalities included significant a right-left latency difference within the normal range of absolute latencies, unilateral or bilateral prolongation of latency to onset point and attenuation or absence of the response. It was concluded that the TAR-1 is an important and reliable test for the study of functional integrity of L4-L5 spinal segments in lumbo-sacral sensorimotor root lesions.

Adolescent↗
PubMed1993

The myth of 100% oxygen delivery through manual resuscitation bags.

OBJECTIVE: To determine the actual oxygen delivery of the manual resuscitation bags (MRBs) hanging at the bedsides of patients receiving mechanical ventilation. DESIGN: Descriptive study of 24 MRBs in use at the patient's bedside from six adult ICUs at a 1100-bed Mid-Atlantic medical center. METHODS: MRBs were Puritan Manual Resuscitators with reservoir. Oxygen concentration delivered was measured with a Ventronic Oxygen Analyzer Model 5575. Oxygen flow to the MRB was recorded before collecting data and then set at 15 L/min. The MRBs were compressed three times, with a 5-second interval between compressions. RESULTS: Oxygen flow before data collection varied from 6 L/min to 15 L/min. Measurements taken at the exit port before MRB compression ranged from 23% to 97%. Oxygen concentration ranged from 26% to 95%, with a mean of 59%. The oxygen values for each compression time were significantly lower than 100% (p < 0.001). The first compression values differed significantly from the second compression (p < 0.001) and the second differed from the third compression (p < 0.01). CONCLUSION: MRBs are not delivering the level of oxygen nurses have assumed. In addition, variation in oxygen delivery occurs from compression to compression.

Clinical Nursing Research↗
PubMed2005

Lossless generalized-lSB data embedding.

We present a novel lossless (reversible) data-embedding technique, which enables the exact recovery of the original host signal upon extraction of the embedded information. A generalization of the well-known least significant bit (LSB) modification is proposed as the data-embedding method, which introduces additional operating points on the capacity-distortion curve. Lossless recovery of the original is achieved by compressing portions of the signal that are susceptible to embedding distortion and transmitting these compressed descriptions as a part of the embedded payload. A prediction-based conditional entropy coder which utilizes unaltered portions of the host signal as side-information improves the compression efficiency and, thus, the lossless data-embedding capacity.

Algorithms↗
PubMed2003

Load sharing in Premier and Zephir anterior cervical plates.

STUDY DESIGN: An in vitro biomechanical study using a simulated anterior cervical discectomy and interbody fusion model to compare the load sharing properties of two semiconstrained cervical (Premier and Zephir) plates. OBJECTIVES: To determine the percent load transmission through these plates and grafts under simple axial compression. SUMMARY OF BACKGROUND DATA: No published data exist as to the load transmission through these semiconstrained plates. METHODS: Cadaveric calf spines were subjected to axial compression loading while instrumented with an interbody graft and with the graft plus one of the plates. Load transmission was computed through an analysis of the load-displacement data. RESULTS: A mean load transmission of 23% was shared by the Premier plate. The Zephir, a more constrained plate but still semiconstrained, shared a mean of 32% of the load. CONCLUSIONS: The semiconstrained plates tested allow more graft loading than some previously tested constrained plates. However, there are differences between the research methods used in these studies that provide a less than satisfactory comparison.

Animals↗
PubMed2004

Intrinsic bone tissue properties in adult rat vertebrae: modulation by dietary protein.

Bone strength depends on bone mass, geometry, microarchitecture, and intrinsic tissue quality. Whether intrinsic bone tissue properties could be influenced by changes in dietary protein is not known. To address this issue, nanoindentation tests were performed on the lateral, anterior, and posterior site of L5 vertebral bodies in adult female rats fed a normal protein containing diet and in ovariectomized (OVX) rats receiving an isocaloric low protein diet with or without isocaloric essential amino acids supplements. The tissue properties varied significantly between the different sites (anterior, posterior, lateral), suggesting possible effects of heterogeneous stress distribution on the vertebrae in vivo. Isocaloric low protein intake associated with ovariectomy led to significant decreases of indentation modulus, hardness, and dissipated energy on the posterior vertex. Axial compression tests of adjacent vertebral bodies were correlated with the indentation results. Correlations between macroscopic mechanical data obtained by axial compression of vertebral body, and intrinsic tissue properties measured by nanoindentation test suggest that postelastic behavior strongly varied with material fragility detected on the tissue level. Macroscopic stiffness however may be dominated by bone geometry changes and less by variations of intrinsic bone tissue properties. Combining parameters of tissue properties and bone mineral density was highly predictive of vertebral body ultimate strength. Besides geometry and microarchitecture, intrinsic bone tissue properties are important determinants of the mechanical competence of rat vertebrae. Changes in intrinsic tissue properties could thus contribute to the increased bone fragility found in protein undernutrition.

Animals↗
PubMed2006

The impact of temporal compression and space selection on SVM analysis of single-subject and multi-subject fMRI data.

In the present study, we compared the effects of temporal compression (averaging across multiple scans) and space selection (i.e. selection of "regions of interest" from the whole brain) on single-subject and multi-subject classification of fMRI data using the support vector machine (SVM). Our aim was to investigate various data transformations that could be applied before training the SVM to retain task discriminatory variance while suppressing irrelevant components of variance. The data were acquired during a blocked experiment design: viewing unpleasant (Class 1), neutral (Class 2) and pleasant pictures (Class 3). In the multi-subject level analysis, we used a "leave-one-subject-out" approach, i.e. in each iteration, we trained the SVM using data from all but one subject and tested its performance in predicting the class label of the this last subject's data. In the single-subject level analysis, we used a "leave-one-block-out" approach, i.e. for each subject, we selected randomly one block per condition to be the test block and trained the SVM using data from the remaining blocks. Our results showed that in a single-subject level both temporal compression and space selection improved the SVM accuracy. However, in a multi-subject level, the temporal compression improved the performance of the SVM, but the space selection had no effect on the classification accuracy.

Adult↗
PubMed2005

A web service-based Grid portal for Edgebreaker compression.

BACKGROUND: In health applications, and elsewhere, 3D data sets are increasingly accessed through the Internet. To reduce the transfer time while maintaining an unaltered 3D model, adequate compression and decompression techniques are needed. Recently, Grid technologies have been integrated with Web Services technologies to provide a framework for interoperable application-to-application interaction. OBJECTIVES: The paper describes an implementation of the Edgebreaker compression technique exploiting web services technology and presents a novel approach for using such services in a Grid Portal. The Grid portal, developed at the CACT/ISUFI of the University of Lecce, allows the processing and delivery of biomedical images (CT--computerized tomography--and MRI--magnetic resonance images) in a distributed environment, using the power and security of computational Grids. METHODS: The Edgebreaker Compression Web Service has been deployed on a Grid portal and allows compressing and decompressing 3D data sets using the Globus toolkit GSI (Globus Security Infrastructure) protocol. Moreover, the classical algorithm has been modified extending the compression to files containing more than one object. RESULTS AND CONCLUSIONS: An implementation of the Edgebreaker compression technique and related experimental results are presented. A novel approach for using the compression web service in a Grid portal allowing storing and preprocessing of huge 3D data sets, and subsequent efficient transmission of results for remote visualization is also described.

Algorithms↗
PubMed2006

Compression of fluorescence microscopy images based on the signal-to-noise estimation.

Modern microscopic techniques like high-content screening (HCS), high-throughput screening, 4D imaging, and multispectral imaging may involve collection of thousands of images per experiment. Efficient image-compression techniques are indispensable to manage these vast amounts of data. This goal is frequently achieved using lossy compression algorithms such as JPEG and JPEG2000. However, these algorithms are optimized to preserve visual quality but not necessarily the integrity of the scientific data, which are often analyzed in an automated manner. Here, we propose three observer-independent compression algorithms, designed to preserve information contained in the images. These algorithms were constructed using signal-to-noise ratio (SNR) computed from a single image as a quality measure to establish which image components may be discarded. The compression efficiency was measured as a function of image brightness and SNR. The alterations introduced by compression in biological images were estimated using brightness histograms (earth's mover distance (EMD) algorithm) and textures (Haralick parameters). Furthermore, a microscope test pattern was used to assess the effect of compression on the effective resolution of microscope images.

Algorithms↗
PubMedDate not supplied

Noise-resistant fitting for spherical harmonics.

Spherical harmonic (SH) basis functions have been widely used for representing spherical functions in modeling various illumination properties. They can compactly represent low-frequency spherical functions. However, when the unconstrained least square method is used for estimating the SH coefficients of a hemispherical function, the magnitude of these SH coefficients could be very large. Hence, the rendering result is very sensitive to quantization noise (introduced by modern texture compression like S3TC, IEEE half float data type on GPU, or other lossy compression methods) in these SH coefficients. Our experiments show that, as the precision of SH coefficients is reduced, the rendered images may exhibit annoying visual artifacts. To reduce the noise sensitivity of the SH coefficients, this paper first discusses how the magnitude of SH coefficients affects the rendering result when there is quantization noise. Then, two fast fitting methods for estimating the noise-resistant SH coefficients are proposed. They can effectively control the magnitude of the estimated SH coefficients and, hence, suppress the rendering artifacts. Both statistical and visual results confirm our theory.

Algorithms↗
PubMed2006

Intervertebral disc degeneration can predispose to anterior vertebral fractures in the thoracolumbar spine.

UNLABELLED: Mechanical experiments on cadaveric thoracolumbar spine specimens showed that intervertebral disc degeneration was associated with reduced loading of the anterior vertebral body in upright postures. Reduced load bearing corresponded to locally reduced BMD and inferior trabecular architecture as measured by histomorphometry. Flexed postures concentrated loading on the weakened anterior vertebral body, leading to compressive failure at reduced load. INTRODUCTION: Osteoporotic fractures are usually attributed to age-related hormonal changes and inactivity. However, why should the anterior vertebral body be affected so often? We hypothesized that degenerative changes in the adjacent intervertebral discs can alter load bearing by the anterior vertebral body in a manner that makes it vulnerable to fracture. MATERIALS AND METHODS: Forty-one thoracolumbar spine "motion segments" (two vertebrae and the intervertebral disc) were obtained from cadavers 62-94 years of age. Specimens were loaded to simulate upright standing and flexed postures. A pressure transducer was used to measure the distribution of compressive "stress" inside the disc, and stress data were used to calculate how compressive loading was distributed between the anterior and posterior halves of the vertebral body and the neural arch. The compressive strength of each specimen was measured in flexed posture. Regional volumetric BMD and histomorphometric parameters were measured. RESULTS: In the upright posture, compressive load bearing by the neural arch increased with disc degeneration, averaging 63 +/- 22% (SD) of applied load in specimens with severely degenerated discs. In these specimens, the anterior half of the vertebral body resisted only 10 +/- 8%. The anterior third of the vertebral body had a 20% lower trabecular volume fraction, 16% fewer trabeculae, and 28% greater intertrabecular spacing compared with the posterior third (p < 0.001). In the flexed posture, flexion transferred 53-59% of compressive load bearing to the anterior half of the vertebral body, regardless of disc degeneration. Compressive strength measured in this posture was proportional to BMD in the anterior vertebral body (r2 = 0.51, p < 0.001) and inversely proportional to neural arch load bearing in the upright posture (r2 = 0.28, p < 0.001). CONCLUSIONS: Disc degeneration transfers compressive load bearing from the anterior vertebral body to the neural arch in upright postures, reducing BMD and trabecular architecture anteriorly. This predisposes to anterior fracture when the spine is flexed.

Aged↗
PubMed2006

Medical image compression using DCT-based subband decomposition and modified SPIHT data organization.

OBJECTIVE: The work proposed a novel bit-rate-reduced approach for reducing the memory required to store a remote diagnosis and rapidly transmission it. METHOD: In the work, an 8x8 Discrete Cosine Transform (DCT) approach is adopted to perform subband decomposition. Modified set partitioning in hierarchical trees (SPIHT) is then employed to organize data and entropy coding. The translation function can store the detailed characteristics of an image. A simple transformation to obtain DCT spectrum data in a single frequency domain decomposes the original signal into various frequency domains that can further compressed by wavelet-based algorithm. In this scheme, insignificant DCT coefficients that correspond to a particular spatial location in the high-frequency subbands can be employed to reduce redundancy by applying a proposed combined function in association with the modified SPIHT. RESULTS AND CONCLUSIONS: Simulation results showed that the embedded DCT-CSPIHT image compression reduced the computational complexity to only a quarter of the wavelet-based subband decomposition, and improved the quality of the reconstructed medical image as given by both the peak signal-to-noise ratio (PSNR) and the perceptual results over JPEG2000 and the original SPIHT at the same bit rate. Additionally, since 8x8 fast DCT hardware implementation being commercially available, the proposed DCT-CSPIHT can perform well in high speed image coding and transmission.

Algorithms↗
PubMed1994

[Contribution to the study of pelvic stress during weight-bearing. Role of the pubic branch and trabecular bone].

INTRODUCTION: Several authors have reported evidence of loosening of the acetabular component in 14 per cent of cases at 10 years follow-up. To understand this phenomena, parametric studies of the acetabulum have involved finite element analysis, photo elastic models or strain gauges. The differing and sometimes contradictory results were due to the way the model was solicited. If the classic "Resultant" is accurate for the study of the forces on the hip, Pauwels described other forces on the pelvis during the gait. The effect of the application of these other forces on the acetabulum are the object of this study. MATERIALS AND METHOD: Four pelvises were loaded with different forces. Nine strain gauges were pasted around the acetabulum. The pelvis was loaded up to 140 Kg and a compressive force was applied to the pubis by 10 Kg increments up to 40 Kg. The stress data with and without the second force were recorded. A cortical window was bored on the anterior inferior iliac spine. Through this patch, the trabecular bone of the acetabular roof was cut up to disturb its mechanical properties. The load was once again applied to the pelvis and the stress data recorded. RESULTS: The compressive force applied to the symphyseal surface decreases the deformation of the posterior acetabular rim and increases deformation in the proximity of the ischio-iliac and iliopubic junctions. The disruption of trabecular bone generates an increase in deformation mainly perpendicularly to the acetabular rim. DISCUSSION: The decrease of the stress on the posterior acetabular rim is interpreted as a reduction of the solicitations on a fragile zone and its increase on the iliopubic and ischio iliac junctions expresses the application of the acetabular horn on the femoral head permitting better settling of the hip during the gait. The constatation of a stress increase around the acetabulum after disruption of the traecbular bone is interesting. The bone behavior with different acetabular cup models on different pelvis may be studied by strain gauges pasted on the cortical bone. The variable quality of the trabecular bone may introduce an error factor in the measurement. CONCLUSION: The deformation of the acetabulum during gait has to be studied following the different forces described by Pauwels. The compressive force on the pubic symphysis during one leg stance permits a decrease of the stress on the acetabular rim and an increase in the setting of the femoral head. Different qualities of trabecular bone change the deformation of the cortical bone for an equivalent load. This incites us, in comparative studies, to be careful in the deduction of the acetabular roof stresses from the recorded cortical bone deformations.

Aged↗