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At least 1,243 records · Page 69Linked to original sources
PubMed1995

The menstrual cycle, science and femininity: assumptions underlying menstrual cycle research.

This paper examines the relationship between popular knowledge of menstruation and scientific research. It suggests that despite evidence to indicate that pre-menstrual cognitive, behavioural and emotional 'impairment' is relatively rare, the population notion that PMS routinely affects many women adversely is difficult to displace. It concludes that mainstream menstrual cycle research is subject to the influence of misogynist mythology upheld as staunchly by women influenced by patriarchy as by men. Reasons are suggested which lie in the differential power of claims to knowledge.

Adult↗
PubMed2005

Detecting continuity violations in infancy: a new account and new evidence from covering and tube events.

Recent research on infants' responses to occlusion and containment events indicates that, although some violations of the continuity principle are detected at an early age e.g. Aguiar, A., & Baillargeon, R. (1999). 2.5-month-old infants' reasoning about when objects should and should not be occluded. Cognitive Psychology 39, 116-157; Hespos, S. J., & Baillargeon, R. (2001). Knowledge about containment events in very young infants. Cognition 78, 207-245; Luo, Y., & Baillargeon, R. (in press). When the ordinary seems unexpected: Evidence for rule-based reasoning in young infants. Cognition; Wilcox, T., Nadel, L., & Rosser, R. (1996). Location memory in healthy preterm and full-term infants. Infant Behavior & Development 19, 309-323, others are not detected until much later e.g. Baillargeon, R., & DeVos, J. (1991). Object permanence in young infants: Further evidence. Child Development 62, 1227-1246; Hespos, S. J., & Baillargeon, R. (2001). Infants' knowledge about occlusion and containment events: A surprising discrepancy. Psychological Science 12, 140-147; Luo, Y., & Baillargeon, R. (2004). Infants' reasoning about events involving transparent occluders and containers. Manuscript in preparation; Wilcox, T. (1999). Object individuation: Infants' use of shape, size, pattern, and color. Cognition 72, 125-166. The present research focused on events involving covers or tubes, and brought to light additional examples of early and late successes in infants' ability to detect continuity violations. In Experiment 1, 2.5- to 3-month-old infants were surprised (1) when a cover was lowered over an object, slid to the right, and lifted to reveal no object; and (2) when a cover was lowered over an object, slid behind the left half of a screen, lifted above the screen, moved to the right, lowered behind the right half of the screen, slid past the screen, and finally lifted to reveal the object. In Experiments 2 and 3, 9- and 11-month-old infants were not surprised when a short cover was lowered over a tall object until it became fully hidden; only 12-month-old infants detected this violation. Finally, in Experiment 4, 9-, 12-, and 13-month-old infants were not surprised when a tall object was lowered inside a short tube until it became fully hidden; only 14-month-old infants detected this violation. A new account of infants' physical reasoning attempts to make sense of all of these results. New research directions suggested by the account are also discussed.

Cognition↗
PubMed2004

Searching for intellectual turning points: progressive knowledge domain visualization.

This article introduces a previously undescribed method progressively visualizing the evolution of a knowledge domain's cocitation network. The method first derives a sequence of cocitation networks from a series of equal-length time interval slices. These time-registered networks are merged and visualized in a panoramic view in such a way that intellectually significant articles can be identified based on their visually salient features. The method is applied to a cocitation study of the superstring field in theoretical physics. The study focuses on the search of articles that triggered two superstring revolutions. Visually salient nodes in the panoramic view are identified, and the nature of their intellectual contributions is validated by leading scientists in the field. The analysis has demonstrated that a search for intellectual turning points can be narrowed down to visually salient nodes in the visualized network. The method provides a promising way to simplify otherwise cognitively demanding tasks to a search for landmarks, pivots, and hubs.

Internet↗
PubMed1999

Loving openness as a meta-world hypothesis: expanding our vision of mind and medicine.

In 1942, Stephen C. Pepper published a seminal book, World Hypothesis, that sought to explain how people create hypotheses about the world. Pepper proposed that there were four basic world hypotheses: (1) formistic (the hypothesis that nature exists as categories); (2) mechanistic (the hypothesis that nature obeys cause-effect relationships); (3) contextual (the hypothesis that processes in nature are relative and context dependent); and (4) organismic (the hypothesis that processes in nature reflect interactive relationships in systems). Most classical and modern theories of science and medicine implicitly adopt one or more of these foundational hypotheses. In 1997, Schwartz and Russek proposed that there were four additional world hypotheses: (5) implicit process (the hypothesis that nature consists of invisible forces and information, such as energy and consciousness); (6) circular causality (the hypothesis that nature consists of circulating interactions that inherently change over time); (7) creative unfolding (the hypothesis that processes in nature reflect flexible designs or plans that have adaptive function); and (8) integrative diversity (the hypothesis that phenomena in nature reflect complex integrations of diverse processes). Theories in postmodern and integrative science implicitly adopt hypotheses 5 through 8. However, underlying the creation of the eight world hypotheses is an implicit meta-world hypothesis which we term loving openness (the hypothesis that phenomena in nature reflect levels of openness and caring). This paper briefly explains the origin and implications of the loving openness meta-world hypothesis for understanding mind-body healing in medicine, the reordering of values in integrative medicine (with a primary focus on caring with humility), and the fostering of a new vision for twenty-first century frontier science, spirituality, and medicine.

Attitude↗
PubMed2026

Neuroimaging anxious children and adolescents before and after cognitive behavioral therapy: a systematic review.

OBJECTIVE: This systematic review investigates brain changes in youths with anxiety disorders following cognitive behavioral therapy (CBT) and neural markers that predict CBT responses. METHODS: We conducted a systematic search using the electronic databases PubMed, Web of Science, and ProQuest. The inclusion deadline was set to October 27, 2025. We included fifteen peer-reviewed neuroimaging studies that examined the effects of CBT in youths under 19 years old with a primary clinical diagnosis of an anxiety disorder based on DSM-5 criteria. RESULTS: Although the existing literature is marked by substantial diversity in methods and outcomes, task-related neural response in the anterior cingulate cortex (ACC, 2/8, 25.0%), insula (1/8, 12.5%) increased from pre to post CBT and these changes were further correlated with clinical symptom improvements. Moreover, CBT outcomes were predicted by pre-treatment activity or connectivity in the ACC and amygdala (3/13, 23.0%). A smaller proportion of studies (2/13, 15.3%) found that activity or connectivity in the insula, precuneus/cuneus, postcentral gyrus, and activity or structure in the nucleus accumbens (NAcc) predicted response to CBT. The low consistency of these findings was driven by methodological variability, low reliability of the neural markers, and relatively small sample sizes. CONCLUSIONS: This review highlights promises of neural predictors and outcomes to enhance anxiety disorder treatments in children and adolescents, facilitating future personalized and effective CBT. Beyond this initial promise, the field is hindered by methodological inconsistencies and limited replications. While longitudinal and personalized approaches are important next steps, the central challenge remains: identifying neural markers that are both reliable and robust.

Adolescent↗
PubMed1995

Pharmacotherapy of cognitive impairment in Alzheimer's disease: a review.

Experimental pharmacotherapy of cognitive impairment in Alzheimer's disease has seen a recent proliferation of drug trials involving a wide variety of drugs. Many of the earlier studies focused on cholinergic agents. However, subsequent advances in basic and biological sciences have broadened the scope of therapeutic strategies beyond the neurotransmitter approaches to include neurotrophic, metabolic-enhancing, membrane-modifying, and antitoxic agents, and have also provided rationale for developing antiamyloid and anti-infective therapies. For the clinician, it has not been easy to keep abreast of these developments. In this article, I present an overview of the cognition-enhancing drugs that have been used in the past, of those currently under investigation, and of new drugs and strategies that are likely to receive attention in the next few years.

Aged↗
PubMed2000

Ethical issues in communicating science.

Most of the publicized work on scientific ethics concentrates on establishing professional norms and avoiding misconduct. The successful communication of science is the responsibility of all involved in the process. In one study, the increased incidence of autism and other social developmental disorders in males was investigated by examining individuals with Turner's syndrome (XO females). In the national newspaper this became "Genetic X-factor explains why boys will always be boys". The steps by which a study on developmental disorders, published in a highly prestigious journal, was transformed into an article in the science section which 'explained' the socially expected gender-based behavior of genetically normal children are fascinating and, unfortunately far too typical. The scientists wrote an excellent article that has just one sentence at the end that hesitantly suggests that the findings might, with further study, have some relevance to understanding normal behavior. The general interest article in the front of the journal gave a good account of the research, but suggested more strongly that there could be an in-built biological dimorphism in social cognition. This was misrepresented in the press as proof of gender differences that "undermines the trend towards sexual equality", and both illustrates cultural bias and provides fodder for feminist critiques of science. The study has been made to appear to be biased in favor of justifying the social structure of society, and yet it was the translation from the scientific study to national news that produced this transformation to biased genetic determinism. It is poor communication of the actual science, coupled with a lack of skepticism on the part of the public, that contributes to such a misapplication of science. Scientists should resist the urge to generalize their results to make them more compelling. The science community should not allow misconstructions of scientific facts to go unchallenged. Journalists, for both the scientific publication and the newspaper, should resist the inclination to embellish the finding with social significance that is not present. For their part, readers must be doubly skeptical of any finding that appears to underwrite any current social hierarchy. We are all responsible for a communication and interpretation of science that is as accurate and socially responsible as possible.

Communication↗
PubMed2003

Pain assessment in nonverbal children with severe cognitive impairments: the Individualized Numeric Rating Scale (INRS).

Children's Hospital Boston began a major pain assessment and management initiative 3 years ago: Pain assessment and management are considered one of the institution's primary standards of care. The initiative included State of the Science meetings with internationally renowned nursing pain researchers and clinicians. These meetings generated nursing staff interest in specific applications of what is known about pain; how evidence-based knowledge can be used to ask population-specific clinical questions; and how an evidence-based approach can be applied to systematically develop, implement, and assess interventions that suit a population's clinical needs. This article is an example of an evidence-based pain assessment project at Children's Hospital Boston that focused on nonverbal children with cognitive impairments. After developing a clinical question, the authors did a literature review and a benchmarking analysis of best practice. The pilot of an adapted, existing pain assessment tool is described in this article.

Child↗
PubMed1987

Philosophic analysis of a theory of clinical nursing.

Knowledge in nursing requires development of theories that address both the science and art of the professional practice discipline. "A Theory of Clinical Nursing" was analyzed to explicate the epistemologic dimensions within an historic perspective. Epistemologic dimensions defined by the philosophy of science--approaches to theory development, sources of knowledge, and methodology--were characterized from two perspectives, scientific inquiry and historicism. The major perspectives in the scientific mode, namely, mechanism, empiricism, logical positivism, and logical empiricism, were analyzed along the three dimensions of theory development, sources of knowledge, and methodology. Trends in theoretical developments in nursing were related to the scientific and historic perspectives and to the epistemologic dimensions. Juxtaposing the diversity of knowledge required for nursing science and practice, and the values systems of the practitioners, revealed the inadequacy of the scientific model. Nursing knowledge explication required several modes of inquiry to articulate the scientific basis of the discipline and the art of delivery of the practice. The historicist approach framed scientific work with the prevailing World View. The Rubin theory was located within the matrix of approaches to inquiry and perspectives in nursing science. Labeled by the theorist as both a nursing research and a nursing care model, "A Theory of Clinical Nursing" represented a transition model of nursing, undergirded by the major conceptualizations and methodologies of field, psychoanalytic, and social behaviorist traditions, but implicitly coalescing the art with the science of nursing. The theory addressed core concepts of person, situation, and nursing care, as well as major process themes of change and interaction. Nursing theories of a more narrow range, such as maternal role attainment and maternal identity, nested within the theory, while subsequent theoretical clarifications and expansions have been constructed by students of the theorist. In the hierarchy of knowledge conceptualizations, Rubin's theory represents a disciplinary matrix: ordering theories, methods, and exemplars; giving direction to the development of theories of nursing that address empirical problems of the discipline; and cohering to the metaparadigm of nursing. Philosophic analysis of theories of nursing can yield an articulated, clearly depicted framework of concepts and their relationships from which new understandings may emerge.

Cognition↗
PubMed1979

Carving nature at its joints? Observations on a revised psychiatric nomenclature.

The recent decision by the American Psychiatric Association to revise its Diagnostic and Statistical Manual of Mental Disorders provides an opportunity for psychologists and other interested professionals to examine assumptions that underlie classification systems used in mental health settings. The present article attempts to underscore the influence of classification systems in this field on our cognitive activity as clinicians, to place the medical model that underlies DSM-III in perspective within contemporary thought in the philosophy of science, and to comment on some specific changes in the new manual.

Diagnosis, Differential↗
PubMed2004

Translating research findings of chronic kidney disease management to clinical practice: Challenges and opportunities.

Chronic Kidney disease (CKD) has been identified as a public health epidemic, fueled in part by improved outcomes of both diabetic and cardiac patient populations, as well as by the increasing recognition that it is possible to identify CKD at earlier stages. The estimated 8 to 10 million Americans that have CKD, with its concomitant morbidity and mortality, have the potential to overwhelm the current system of specialty practice medicine and health care resources. How can clinicians, clinician scientists, and health care administrators translate research findings into clinical practice in an effective manner to improve the care of this burgeoning patient group? The challenge of translating research into clinical care requires identification of that which we do and do not know, communication of knowledge between those who do and do not know, and efficient collection of information for systematic evaluation. This article will describe the challenges of translating current research findings into clinical practice. There is a need to identify the complexity of CKD disease processes and issues associated with delivery of care and to describe the difficulties in the dissemination of new knowledge to physicians. Because of the propensity of CKD to affect identifiable groups of patients, we will discuss the potential challenges of these strategies given the racial, ethnic, and cultural diversity in North America. A potential solution to these challenges is a new paradigm of "process-based medicine" that integrates clinical and basic science research findings with multidisciplinary and shared care models of health care delivery. In this context, attention to advances in information technology, the cognitive processes that underlie physician learning, and the findings of outcome research may ensure true integration of clinical research and clinical practice.

Communication Barriers↗
PubMedDate not supplied

Psychosocial theories of depression for individuals with intellectual and developmental disabilities: a historicist perspective.

The mental health care system has historically marginalized individuals with intellectual and developmental disabilities (I/DD). Until the mid-1980s, many clinicians doubted that individuals with I/DD were capable of depression (Sovner & Pary, 1993). Although it is now generally accepted that individuals with I/DD do have depression, they may not be treated or may be inappropriately treated (Matson et al., 2000). A historicist perspective takes into account the effect of marginalization on science and practice. Depression has both biological and psychosocial aspects. Key groups of theories regarding the psychosocial aspects of depression include psychodynamic/psychoanalytic, behavioral, cognitive, and ecological/interpersonal theories (Clark, Beck, & Alford, 1999; Joiner, Coyne, & Blalock, 1999). The application of psychosocial theories of depression to individuals with I/DD continues to reflect their marginalization and oppression. Behavioral theories of depression are limited in their conceptions for research, identification, and treatment of depression but continue to be used widely with individuals with I/DD. Cognitive theories of depression are widely used in research and treatment of depression in the general population, but have limited usage among individuals with I/DD. Interpersonal theories of depression are used in the general population and have many benefits, but are only now being investigated for use with individuals with I/DD. In this article, theories of depression as applied to individuals with I/DD are discussed from a historicist perspective.

Child↗
PubMed2002

Prediction of graduate major from cognitive and self-report test scores obtained during the high school years.

Using information from Project TALENT's 11-yr. follow-up (Wise, et al. 1979), 8 graduate major groups were formed for males, 6 for females. Three of the female groups were supplemented by undergraduate majors to increase sample size. Descriptive canonical discriminant analyses were conducted in each sex, high school grade, and separate sets of cognitive and self-report predictors that were administered in high school. Finally, analyses of the combined predictors were conducted in both sexes for the 9th grade only. Two to four canonical discriminants were retained for interpretation on two criteria: lambda probabilities and size of eigenvalues. Discrimination among groups is more effective in males than in females and in later than in earlier grades. Self-report tests discriminate more effectively among graduate major groups than cognitive ones in the cognitively restricted range of talent. Gains in differentiating among groups from adding cognitive to self-report predictors in the 9th grade are relatively modest. The two sets of predictors define overlapping if not identical dimensions. The first two cognitive functions are important supplements to a measure of general intelligence. For both sexes, a combination of mechanical, spatial, and mathematical tests distinguish science majors from those in the humanities and social sciences who appear on a verbal function.

Adolescent↗
PubMed2000

[A challenge to conquest of neurological diseases].

For the last three decades, neurology has witnessed remarkable progress in both basic sciences and clinical researches. They include detection of abnormal genes in common degenerative and metabolic diseases, clarification of brain mechanisms of movement and cognition with neurophysiology including unit recording from basal ganglia neurons, neuroimaging and neuropsychology tests. Treatment of intractable chronic diseases has also progressed. Medical, surgical and immunosuppressive treatment for Parkinson's disease, immunological diseases, and for certain metabolic diseases are examples. Neurologists in Japan contributed in research progress in the various fields. However, services in clinical medicine have devoted mainly in neurodegenerative, immunological diseases and myopathy. Promotion of nationwide clinical service for cerebrovascular disease, epilepsy and dementia is required. Research in neurology in the next century should be promoted in various fields with different methodology and targets; genes, molecular mechanisms, cellular activity, neural networks, brain as a whole and a human subject. Particularly integrated function of he brain shall be studied thoroughly not only from biological but also from psychological and social point of view. Leaders in neurology in Japan, particularly professors of neurology have been asked to chair all the activities of education, research and clinics. Merits of this system were reflected in connection of clinical and research data, resulting in establishment of new disease showing unusual combination of symptoms and signs. In future, coordination among specialists in different fields are required for further promotion of clinical researches and training of neurologists. Qualified neurological services in ordinary clinics can be achieved with cooperation of personnels in a team where neurologists are required to play a key role aiming at assurance of best QOL for patients and families.

Brain↗
PubMedDate not supplied

The radiographer's role: part scientist, part humanist.

Radiography curricula generally do a good job of defining psychomotor and cognitive objectives, but a clear definition of the professional role of the radiographer is lacking. This article advances the thesis that the radiologic sciences must make caring a primary role of the radiographer as is the case in other health care professions.

Humans↗
PubMed1983

[The relation of general to special pathology].

As most important fundaments of the general pathology the theory of the mechanisms of pathogenesis, the close relations to the general biology and the theory of science are described more in detail. Moreover, every pathologist must deal with the conditions of general-pathological evidence concerning the theory of cognition. Finally it is extraordinarily important to show the significance of the general pathology and of the constituting it theoretical thinking for the pathologist, the physician and the student. Since medicine is more and more studied under theoretical scientific viewpoints, for every physician a scientific basis knowledge is necessary.

Germany, East↗
PubMed2003

The science of antipsychotics: mechanistic insight.

With the introduction of conventional antipsychotics in the 1950s, clinicians began to expect effective treatment of positive symptoms of schizophrenia. However, these drugs do not resolve negative and cognitive symptoms of schizophrenia and are also associated with serious side effects, including extrapyramidal side effects (EPS) and tardive dyskinesia. In 1989, clozapine was introduced and labeled the first new antipsychotic owing to its improved efficacy and side-effect profile. Clozapine proved effective in alleviating many of the positive, negative, and cognitive symptoms of schizophrenia, without causing inevitable EPS or tardive dyskinesia. Over the past decade, a number of different new antipsychotics have been developed. These drugs have an affinity for multiple dopamine-receptor subtypes as well as serotonin, norepinephrine, and glutamate receptors, allowing for better treatment outcomes. The antagonism of the 5-HT2A receptor may be responsible for improvement in negative symptoms and decrease in EPS. In addition to providing enhanced efficacy, the affinity of the new drugs for multiple receptors introduces new side effects not seen with the conventional agents, including weight gain. Each new antipsychotic has a unique receptor-binding profile that corresponds to its pharmacologic and side-effect profile. Understanding the differences in mechanisms of action of new antipsychotics will allow physicians to better choose treatment that meets the needs of each individual patient.

Antipsychotic Agents↗
PubMed2005

When things don't talk: knowledge and belief in the inter-war humanism of Charles Singer (1876-1960).

The science historian Charles Singer might seem to have shared with positivists a widely held commitment to observation as the foundation of knowledge. Yet in fact Singer's historiography was peculiarly unconcerned with instruments, models and other artefacts. Such tools might have been expected to present crucial empirical evidence for the historical arguments and ideal material for the didactics which pioneers such as Singer associated with their mission of a 'scientific humanism'. In their hands, physical things did not translate into epistemic things. This was deliberate. Yet while the configuration of science history which would distance it from material objects seems to speak of a shift from the visual to texts, the ocular technologies deployed in Singer's histories rather point to a co-existence of different kinds of visuality in that period's scholarship. As the academic and the museological aspects of science history pulled apart, the visuality of the museum came to be complemented by texts that vitally relied on images. The function of such images was to create proximity with the cognitive desires around whose traffic these histories became paper theatres of knowing. In bypassing material theatres and crafting realities that he understood to be empirically undemonstrable, Singer purposefully developed the story of understanding nature not as entailing obedience to its established results, but instead as embodying an attitude of continuing enquiry.

Historiography↗