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Long-term followup after exstrophy closure: late improvement and good quality of life.

Now that we have observed the growth and development of 17 of our anatomically reconstructed exstrophy patients through 20 or more years of followup, we are convinced that reconstruction should be the preferred primary treatment. Most of these patients are healthy, attractive, well educated adults and have achieved emotional maturity and stability, despite their many problems. Anatomical reconstruction also has considerable advantages over other current treatments for exstrophy that were not apparent initially.

Bladder Exstrophy↗

Further experience with staged ureterocolocolostomy urinary diversion.

Disenchantment with the long-term results with ureterosigmoidostomy and ileal loop urinary diversion led to increased use of the nonrefluxing colon conduit. In 1978, we reported our initial experience with 3 adult patients in whom such a diversion was initially performed followed by conversion with an end-to-side colocolostomy achieving a staged nonrefluxing ureterocolocolostomy. We believed that a staged procedure would allow decompression of the upper urinary tract away from the fecal stream, that one could confirm the adequacy of the nonrefluxing tunnels prior to exposure to the fecal stream, and that this might have a lower instance of electrolyte problems and pyelonephritis. Further follow-up on these original 3 patients as well as our experiences with two others, as reported here has somewhat tempered our initial enthusiasm.

Adult↗

Spontaneous bladder rupture after colocystoplasty. Case report.

An 18-year-old girl had bladder extrophy managed by sigmoid cystoplasty with clean intermittent catheterization. Spontaneous bladder rupture occurred 12 months after reconstructive surgery. The diagnosis was made by ultrasound with abdominal tapping and cystography under fluoroscopy. Management included intravenous antibiotics, laparotomy and closure of the perforation. The diagnosis was delayed and postoperative intraperitoneal abscess formation occurred.

Adolescent↗

Ureterocystoplasty: the 'bladder' augmentation of choice.

OBJECTIVE: To reduce the complications of enterocystoplasty by augmenting the bladder with a megaureter. PATIENTS AND METHODS: Ureterocystoplasty was performed in eight children aged 20 months-15 years. Three had impaired renal function and three were in established chronic polyuric renal failure. RESULTS: The seven older children were dry by day with clean intermittent catheterization and the youngest, at the age of 3 1/2 years, had a dry interval of 2 h after catheterization. The three children with polyuric renal failure required nocturnal catheterization or were wet at night. The post-operative urodynamics showed a significant improvement in all cases with abolition of detrusor instability in seven patients and a reduction in end filling pressure. Bladder volume increased from a mean of 100 ml (range 45-215) to 311 ml (range 150-450) (P = 0.01). There was no deterioration in renal function. CONCLUSION: The early results of ureterocystoplasty compare favourably with those of enterocystoplasty without the risks of long-term metabolic and neoplastic complications.

Adolescent↗

[Complications from reconstructive surgery in childhood].

When urogenital malformations were corrected standard operations have made their way which achieve good results in the hand of specialists. The most favourable form of the supravesical discharge of urine in children are different and, when judged, undergo a temporary change. Combinations of malformations, bad tendency of healing in inferior tissue, intervention in recidivations and complicated courses force to modified operation methods according to the situation. The courses of 4 problematical cases are described.

Adolescent↗

The management of urinary incontinence in the exstrophy complex, posterior urethral valves, and infrasphincteric ureters.

Urinary incontinence is a debilitating problem that requires careful evaluation. Causes of incontinence in children are numerous, and once the mechanism of incontinence has been identified, management can be planned carefully. The management and outcome in children born with the exstrophy-epispadias complex, posterior urethral valves, and children who have an infrasphincteric ureteric orifice are discussed in this article.

Bladder Exstrophy↗

Induction of cloacal exstrophy in the chick embryo using the CO2 laser.

We have developed a model for cloacal exstrophy in the chick embryo using the Cavitron AO 300 CO2 laser. Embryos between 68 and 76 hours of development have been injured caudal to the omphalomesenteric vessels in the region of the tail bud in ovo. This has resulted in the induction of cloacal exstrophy in 5 of 59 chicks that survived ten days after injury. Evidence from this model suggests that cloacal exstrophy is caused by early disruption of the cloacal membrane or that group of cells responsible for its subsequent development.

Animals↗