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PubMed1981

[Effect of a factor (factors) secreted by human amnion cells on the proliferative activity of normal and transformed fibroblasts].

The effect of FL-medium obtained upon cultivation of the human amniotic cells (FL) on the proliferative activity of intact (from spleen of C3H mice) and transformed (L-cells) fibroblasts was studied. The effect depended on the intensity of cell division: in case of high mitotic activity of fibroblasts in the control cultures FL-medium inhibited their proliferation and in case of low activity stimulated their division. It is suggested that the human amniotic cells secrete a factor (s) regulating the mitotic activity of cells in the culture medium.

Amnion↗
PubMed1995

Comparative studies of Ca N-acetylhomotaurinate and Ca N-acetyltaurinate. I. Effects on the ionic transfer through the isolated human amnion.

The effects of two taurine and homotaurine derivatives (Ca N-acetyltaurinate: ATACa and Ca N-acetylhomotaurinate: AOTACa) were studied on the ionic transfer through a membranous model: the human isolated amniotic membrane. The ionic transfer was evaluated by measurements of the various components (cellular and paracellular) of the total conductance across the membrane. AOTACa influenced all the components of the total ionic conductance without flux ratio modifications and the general action scheme was a biphasic effect: decrease conductance with low concentrations and increase conductance with high concentrations. This effect might be important in the case of lower or higher supplementation. ATACa only interfered with some conductance components and this action was predominantly monophasic (decreased or increased conductance). This study indicates differential actions between two closely related molecules on a membranous model.

Acamprosate↗