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PubMed2005

The serum glycoprotein fetuin-A promotes Lewis lung carcinoma tumorigenesis via adhesive-dependent and adhesive-independent mechanisms.

Fetuin-A is a serum glycoprotein in the cystatin family associated with the regulation of soft tissue calcification. We tested the role of systemic fetuin in tumor cell growth and metastasis by injecting Lewis lung carcinoma (LLC) cells into fetuin-A null and their wild-type (WT) littermate control C57BL/6 mice via the tail vein, s.c., and intrasplenic routes. In the experimental metastasis assay, the lungs of the WT mice were filled with metastatic nodules, whereas the lungs of the fetuin-A null mutant mice were virtually free of colonies at the end of 2 weeks. Lung colonization responded to the levels of serum fetuin-A in a dose-dependent manner, as observed by the formation of half as many colonies in mice heterozygous for the fetuin-A locus compared with homozygous WT mice and restoration of lung colonization by the administration of purified fetuin-A to fetuin-A-null mice. Serum fetuin-A also influenced the growth of LLC cells injected s.c.: fetuin-A-null mice developed small s.c. tumors only after a substantial delay. Similarly, intrasplenic injection of LLC cells resulted in rapid colonization of the liver with metastasis to the lungs within 2 weeks in the WT but not fetuin-A null mice. To examine the mechanism by which fetuin-A influences LLC colonization and growth, we showed that LLC tumor cells adhere to fetuin-A in a Ca(2+)-dependent fashion, resulting in growth of the tumor cells. These studies support the role of fetuin-A as a major growth promoter in serum that can influence tumor establishment and growth.

Animals↗
PubMed1989

[Adhesion of dental resin to tooth structure--syntheses and adhesion to tooth structure of various aliphatic methacrylates with a carboxylic group].

Twelve aliphatic methacrylates with a carboxylic group [succinate (2 MES, 5 MPeS and 10 MDS), methylsuccinate (2 MEMS, 5 MPeMS and 10 MDMS), maleate (2 MEM, 5 MPeM and 10 MDM) and citraconate (2 MEC, 5 MPeC and 10 MDC)] were synthesized by the addition of four dicarboxylic acid anhydrides to each of three different alkylene chain length hydroxy methacrylates to investigate the relationship between the methacrylate structure and its bonding to tooth. The bond strength of methacrylates to polished tooth surface decreased with increasing alkylene chain lengths under dry conditions, but water immersion reduced this change. The bond strength of succinate and maleate to polished tooth surface was higher than that of methylsuccinate and citraconate under dry conditions. All methacrylates showed high bond strength to etched enamel, with maleate showing the highest bond strength. On the other hand, the bond strength of 2 MEM and 5 MPeM to etched dentin was markedly high, and about 5 microns thick resin reinforced dentin at the interface between etched dentin and resin (2 MEM or 5 MPeM) was observed by SEM and EPMA analysis.

Adhesiveness↗