Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “ACETYLSALICYLIC ACID”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,243 records · Page 69Linked to original sources
PubMed1992

Absorption of acetylsalicylic acid from the rat nasal cavity.

The fate of salicylate in the plasma of rats was followed after nasal, intravenous, and oral administration of 2.0-mg doses of aspirin. Aspirin was well absorbed following nasal administration of a neutralized, nonirritating solution containing triethanolamine. The rate of absorption was slower than that of other nasally administered drugs, such as propranolol or progesterone. The bioavailability of aspirin following nasal administration was 100%, whereas the oral bioavailability was only 58.8% at the dose studied.

Absorption↗
PubMed1980

The influence of acetylsalicylic acid, phenylbutazone, indomethacin, and flufenamic acid on the kinetics of leucocytes during acute inflammation.

Five groups of ten male Wistar rats each were used for the purpose of this experiment. All subjects suffered from sterile acute inflammation in the peritoneal cavity. A sterile beef heart infusion broth reinforced with proteose-peptone was injected to cause the inflammation. The following substances mixed with tragacanth gum were given orally at in 12 h intervals: --Acetalsalicylic acid 150 mg/kg body weight to the first group; --Phenylbutazone 100 mg/kg body weight to the second group; --Indomethacin 15 mg/kg body weight to the third group; --Flufenamic acid 100 mg/kg body weight to the fourth group. Finally the fifth group received only tragacanth gum. The rats were sacrificed after 48 hours and leucocytes were collected from the peritoneal cavity by washing with 5 ml 0.9% NaCl solution. The total leucocyte number and the percent of each type were estimated for each group individually. A statistically significant decrease in the number of leucocytes migrated to the peritoneal cavity due to the inflammation was observed in rats that received one of the drugs (group I to IV) when compared to rats that received only the excipient (group V). Likewise, significant differences were noted in the composition of each type.

Analgesics↗
PubMed1978

[Clinical and in-vitro studies of the therapeutical range of acetylsalicylic-acid to prevent deep vein thrombosis (author's transl)].

In three consecutive studies, acetylsalicyliclysine using the dosages 0.9 g/48 h, 1.8 g/24 h and 3.6 g/24 h, was examined in order to see its effect in preventing deep vein thrombosis (DVT) after elective hip joint surgery. DVT was diagnosed by the 125-i-fibrinogen-test. No reduction of postoperative DVT was found under any of the administered AS-lysine dosages. The collagen-induced platelet aggregation was significantly decreased in all three groups. However, under the low AS-lysine dosages, aggregation was less inhibited with the incidence of DVT than without DVT. In the group with the 3.6 g-dosage, aggregation was maximally inhibited, without any significant difference related to the occurrence of DVT. The results reveal no therapeutic range of AS-lysine to prevent postoperative venous thrombosis.

Aged↗