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[A case of omphalith in a patient with seborrheic keratosis of the umbilicus].
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Testosterone and anabolic steroids and acne fulminans.
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[Hygienic aspects of wash water reclamation systems].
The quality of reclaimed wash water and the composition of used wash water can be best determined by pH, oxygen chemical index, electric conductivity and chlorides that show individual variations but are sex-independent. Wash water contained mostly staphylococci and small amounts of sarcines, diplococci and micrococci. The use of washing and disinfecting agents may significantly modify the microbial characteristics of wash water, reducing noticeably its microbial content and increasing the content of organic substances and chlorides due to chemicals they include and due to more effective removal of sebaceous secretion. It is indicated that chemical components of washing and disinfecting agents that produce organic contaminants should be given special attention when developing a wash water reclamation system.
Tinea versicolor of the face in black children in a temperate region.
Tinea versicolor is a common superficial fungal infection that typically affects young adults in warm, humid climates. We describe two young black children in the temperate northeastern Ohio area with tinea versicolor limited to the face. The occurrence of tinea versicolor on the face is unusual, as is its appearance before puberty. The mycologic and pathophysiologic characteristics of tinea versicolor infection are discussed, and several hypothesis are offered to explain the presence of tinea versicolor in these patients.
[Porphyrin content of secretions from the facial skin sebaceous glands of healthy persons and rosacea patients].
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Acne vulgaris. The past. The present and the future.
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Acne: the ashes of a burnt out controversy.
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Acne vulgaris in childhood. Pathogenesis and management.
Acne vulgaris is a common skin disorder. Although it is most prevalent in the second decade of life, its beginnings are heralded by increased activity of the sebaceous glands and faulty follicular keratinization, which are already evident in mid to late childhood. The subsequent and increasing proliferation of the follicular anaerobic diphtheroid microflora contribute further as an important pathogenic factor in the generation of inflammatory lesions. Treatments of acne, therefore, are aimed at reducing the follicular anaerobic bacteria, counteracting the follicular hyperkeratosis, and inhibiting the activity of sebaceous glands.
Neglected aspects in the management of acne.
Acne is the result of excessive grease on the skin. The successful treatment of acne depends essentially on the degreasing of the skin to an extent which produces peeling, which is the observable index of adequate treatment. The use of antibiotics is supplementary to degreasing and peeling. Degreasing is best achieved by thrice daily washing with Neutrogena acne cleansing soap, followed by the application of a benzoyl peroxide preparation of a suitable strength. If necessary, further degreasing can be achieved by cleansing with isopropyl alcohol after washing with the Neutrogena soap.
A major advance in the treatment of severe acne.
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[Measurement of sebaceous excretion in man].
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[Hormonal aspects of acne].
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The effect of 13-cis-retinoic acid on sebaceous glands.
The drug, 13-cis-retinoic acid, which has been demonstrated to have a marked effect on nodulocystic acne, probably has several mechanisms of action. This article summarizes the effects on the sebaceous glands, and the accompanying changes in cutaneous lipids that result from 13-cis-retinoic acid therapy. These changes in lipid composition support the concept that linoleate may be of importance in the pathogenesis of acne.
Isotretinoin revisited.
Isotretinoin (13-cis-retinoic acid) remains the drug of choice for treatment of severe, recalcitrant nodulocystic acne that is unresponsive to conventional therapy, including oral antibiotics. The drug has been shown to produce dramatic clearing of lesions and prolonged remissions. The length of remission may be dependent on both the dosage used and the duration of therapy. Since fetal malformations have been observed in infants born of mothers taking isotretinoin during pregnancy, it is mandatory to prevent women who are pregnant or may become pregnant during treatment from taking isotretinoin. Because the half-life of isotretinoin is ten to twenty hours, and because it is eliminated from the body rapidly enough, women may become pregnant one month after discontinuation of therapy without an increased risk of birth defects. Common side effects of the drug include mucocutaneous reactions, serum lipid alterations, eye irritation, and myalgias. Less commonly observed are hyperostoses and exuberant granulation tissue, and rarely, pseudotumor cerebri. Recommendations for substantially reducing or eliminating these effects are made.
Perception of dominance status through conspecific scent in the desert gerbil Meriones hurrianae.
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[Immunologic study of the nasal mucus and secretion in chronic otitis media with closed tympanum].
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