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At least 1,225 records · Page 68Linked to original sources
PubMed1990

[Computer study of pathologic factors influencing survival in colorectal carcinoma--a multivariant stepwise discriminant analysis].

Five quantitative pathologic parameters and three clinicopathologic parameters in 80 colorectal carcinoma patients with different prognosis were studied with a multivariant stepwise discriminant analysis on computer. The results showed that DNA index (DI), nucleocytoplasmic ratio (NCR), histologic grade and Dukes' stage were significant factors influencing the survival. With these factors, a 4-variable Fisher's discriminant function was established, which could correctly identify 81.25% and 83.75% of the predicted cases (Jacknife Procedure and Reclassification) Sensitivity of the two methods was 87.80%. The results indicate that the multivariant stepwise discriminant analysis on quantitative pathologic parameters combined with clinicopathologic parameters is of value in predicting prognosis of colorectal carcinoma patients.

Adenocarcinoma↗
PubMed1990

The phenotypic heterogeneity of mouse thymic stromal cells.

Sixteen monoclonal antibodies (mAb) were produced against mouse thymic stromal elements. These mAb fell into two groups of reactivity: (i) thymic epithelial markers (screened and presented according to the guidelines proposed in the 1989 Rolduc Thymic Epithelial Workshop); and (ii) non-epithelial thymic markers. Specificities of these mAb included extensive subpopulations of both epithelial and non-epithelial thymic stromal cells, as well as isolated stromal cells, demonstrating some of the complex microspecificities in existence within the thymic microenvironment. Furthermore, six of these mAb demonstrated shared antigenicity between thymocytes and thymic stromal cells, revealing greater similarities than previously recognized between these two components. Three mAb detected antigens illustrating three consecutive layers of the blood-thymus barrier: the vascular endothelium; connective tissue of the capsule and perivascular spaces; and the connective tissue associated with the basal laminae lining these regions. This study illustrates unequivocably that there are indeed complex and varied microenvironments existing within the thymus, and emphasizes the need for reclassification of these cells.

Animals↗
PubMed1990

[Studies on the crystallization tendency of calcium oxalate in urine--a study of experimental and computer-assisted determination of the risk of urinary calculi formation].

In this study a method o the semiquantitative determination of the crystallization tendency for calcium oxalate in urine is described. It is based on the addition of a well-defined amount of ammonium oxalate (31.3 nmol) to a urine sample (30 ml). The so caused clouding of the urine is measured by a photometer 20 min later. The method guarantees an acceptable reproducibility and is simple to be performed in each clinical laboratory. The results of mathematical correlation and discriminant analysis show that the calcium concentration influences the crystallization of calcium oxalate as most of all urinary constituents. Furthermore, evidence of a high specificity of the method is given by a reclassification rate of about 80% in the discriminant analytical computation.

Adolescent↗
PubMed1990

[Anxiety disorders in children: do any risk factors exist?].

Anxiety disorders in children are currently undergoing reclassification. On the basis of a review of the literature, the authors have attempted to point out the main evidence suggesting that a number of risk factors are associated with childhood anxiety disorders. Age and sex seem to influence the risk of anxiety disorder. The child's personality is of central importance: studies of the concept of "temperament" carried out in recent years have underscored that inhibition and introversion in early childhood are associated with an increased risk for anxiety disorders in later childhood. A low socioeconomic setting also seems to be a risk factor whose incidence varies across types of anxiety disorder. Familial risk factors have a very strong effect: children of parents with current or past anxiety disorders with or without mood disorders are at increased risk for anxiety disorders; this risk varies according to the type of disorder in the parents (for instance, the respective roles of panic attacks and avoidance behaviors remain unclear). Lastly, comorbidity is also an important factor: most children with anxiety disorders also have one or several other anomalies, usually anxiety or mood disorders.

Adolescent↗
PubMed1979

Antigenic variation among strains of the New Jersey serotype of vesicular stomatitis virus.

Four strains of vesicular stomatitis virus--New Jersey (Hazelhurst, Guatemala, Panama, and Concan) were compared by cross-neutralization and complement-fixation tests. They were indistinguishable by complement-fixation test; however, by plaque-reduction neutralization method, slight antigenic differences were observed between the Hazelhurst and the three other strains. It is concluded that these antigenic differences are insufficient to warrant reclassification of vesicular stomatitis virus--New Jersey into two distinct subtypes, as has been recently proposed.

Animals↗
PubMed1989

Progressive capillary nonperfusion in temporal branch retinal vein obstruction.

We studied 31 eyes with nonischemic temporal branch retinal vein obstruction (TBRVO) of six months' duration or less. Each eye had an initial and at least one follow-up fluorescein angiogram according to the clinical course. Five eyes had sufficient additional capillary nonperfusion by angiography to warrant reclassification into the ischemic category. This conversion to an ischemic TBRVO pattern was documented as early as one month and as late as 14 months (average 5.2 months) after initial evaluation. Males dominated the progressive group (P less than 0.005); age, sex, initial visual acuity, and associated medical and ocular conditions were not significantly different between progressive and nonprogressive eyes (P greater than 0.05). A nonischemic TBRVO may convert to an ischemic pattern, placing these eyes at increased risk for the subsequent development of neovascular complications.

Aged↗
PubMed1989

[Normal and borderline ambulatory arterial pressures. A new method for establishing reference values].

Ambulatory arterial pressures, both systolic (SAP) and diastolic (DAP), together with heart rate were measured every 15 minutes during 24 hours, using a Spacelabs 5200 apparatus, in 168 male subjects of mean age 21 +/- 1 years. According to the WHO criteria, 72 subjects had normal arterial pressure (clinical DAP less than or equal to 90 mmHg, clinical SAP less than or equal to 140 mmHg), and 86 subjects had untreated borderline arterial hypertension (abnormal clinical pressures, with clinical DAP less than or equal to 95 mmHg and clinical SAP less than or equal to 160 mmHg). On the basis of the WHO criteria, a sizeable part of pressure profiles in the normal and hypertensive groups overlapped. The Mc Queen method, derived from cluster analysis, considerably reduces this overlap. The method defines and objective criterion which enables the subjects to be reclassified in cases where clinical and ambulatory pressures "contradict each other". Such reclassification applied in about 20% of our subjects. This leads to a new definition of reference groups based on both clinical pressure and ambulatory pressure profile. The WHO criteria remain the basis for this classification. The Mc Queen method may be used to define normal and borderline arterial pressure profiles in male and female subjects of different age-groups.

Adult↗
PubMed1989

[The effect of a cardiac rehabilitation program on return to work].

Return to work (RW) of patients (pts) after AMI or CABG was compared between a center with (I) and one without (II) Cardiac Rehabilitation (CR) (outpatient; accelerated over 2-3 months; with ECG-monitored dynamic exercises 3 x 1 h/week; multidisciplinary). Over a 6 (I) and 4 (II) year period, 554 (I) and 555 (II) pts were examined; only pts who were active prior to the event, i.e. 61% in I and 21% in II, were considered for this study. Of the active subgroup, 79% returned to work in I compared to only 62% in II. Major differences were found depending on profession, i.e. selfemployers (I) 89% -- (II) 75% professionals (I) 82% -- (II) 71% and blue collars (I) 67% -- (II) 52%. From correlations between time to return to work (TRW) and professional reclassification (PR) with the type of cardiovascular disease (CVD), occupation (O) and age (A) the following conclusions could be made: --TRW vs O: blue collars returned later; there was also a high % in this group who did not return: 36% (I) and 48% (II). --TRW vs A: in I the majority returned to work within 6 months, regardless of A. In II a higher % of younger pts (-50 y) returned within 6 months. In case of no return, the higher the age of the pts, the lower the % of RW. --TRW vs CVD: in I return to work was later after CABG than after AMI.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

Taxonomic clarification of Cladosporium trichoides Emmons and its subsequent synonyms.

Cladosporium trichoides Emmons has been treated by some mycologists as a synonym of Cladosporium bantianum (Sacc.) Borelli and has been transferred to the genus Xylohypha (Fr.) Mason. In the present study, a herbarium specimen of C. bantianum (Torula bantiana Sacc.) Borelli, prepared by Saccardo, was compared with a herbarium specimen and a living type culture of C. triochoides by light and scanning electron microscopy (SEM) and was found to be dissimilar. Herbarium specimens and living cultures of Xylohypha nigrescens, the type species of the genus Xylohypha, were also compared with those of C. trichoides and other pathogenic Cladosporium species. Fundamental differences were found between X. nigrescens and Cladosporium species, in colony morphology, manner of sporulation and conidial morphology. All Cladosporium isolates produced olive-black colonies regardless of environmental conditions, bore brown pigment on the walls of the vegetative hyphae as well as on the walls of the fruiting structures and produced branched chains of conidia either from well differentiated or poorly differentiated conidiophores, or directly from the hyphae. By SEM, conidia showed strong to moderately protruded hila, and the basal contour of the conidia was always truncated. On germination, hyphal tubes were produced randomly from the surface of the conidia. In contrast, X. nigrescens produced white colonies with or without brown centres, depending on the culture medium, bore pigment on the conidial walls and on conidiogenous cells but not on the vegetative hyphae and produced infrequently branched conidial chains, usually from intercalary conidiogenous cells which were globose to hat-shaped. Conidial hila were nonprotruding but, instead, were deeply concave and pore-like. The basal contour of the conidia was round and germ tubes were produced only from the pore-like hila. These results indicate that C. triochoides Emmons is different from C. bantianum (Sacc.) Borelli and that the reclassification of C. trichoides into the genus Xylohypha was not warranted.

Animals↗
PubMed1989

[Prognosis in patients in intensive care from the aspect of renal function].

The authors evaluated in 82 patients 228 findings of renal functions. Twenty-nine patients with a total number of 113 findings died. In those who died frequently the values of renal functional parameters were beyond the reference limits, indicating various failures (high serum creatinine, high serum urea, elevated fractional osmolal and water excretion, reduced creatinine clearance). In those who died tubular osmotic diuresis was more frequent, while overflow osmotic diuresis was found mostly in the surviving patients. By means of linear discrimination analysis vectors of parameters were assessed suitable for evaluation of the relationship of renal functions and the prognosis and functional shapes of so-called renal prognostic indicators. In the calculation of renal prognostic parameters the following ones prove useful: serum creatinine (SKrea), creatinine clearance (CKrea), serum osmolality (SOsm), osmolality of urine (UOsm), sodium cation in serum (SNa), fractional excretion of water (FeH2o), of potassium (FeK), osmolal (FeOsm), urinary excretion per 24 hours of creatinine (DuKrea), sodium (DuNa) and potassium (DuK). The best prognostic effectiveness was obtained from the calculation of the renal prognostic indicator (RPU) according to the following equation: RPU = SOsm.0.0178--CKrea.0.944 + FeK.0.854 + + DuKrea.0.0665--DuNa.0.0022 + DuK.0.0047--4.931. The RPU value rises with the deteriorating prognosis of the patients; in those who died it reaches more frequently positive values, in surviving patients the values are negative. By reclassification, using this prognostic index, 82% of the patients with a favourable prognosis and 68% with a poor prognosis (those who died) were correctly classified, i. e. a total of 74% patients.

Critical Care↗
PubMed1989

[Hodgkin's disease--a histologic problem].

Since the Rye classification of Hodgkin's disease, many lesions which resemble Hodgkin's disease microscopically have been described. The histological features of Hodgkin's disease, including the BNLI subclassification of nodular sclerosis, and the lesions which resemble Hodgkin's disease microscopically such as reactive lymph node hyperplasias, some non-Hodgkin's B- and T-cell lymphomas are reviewed. Recent reclassifications of lymphomas originally diagnosed as Hodgkin's disease have indicated that the disease was overdiagnosed, before the description of these lesions and before the development of monoclonal antibodies.

Hodgkin Disease↗
PubMed1989

[Classification and evaluation of oncologic prognosis and risk factors].

The decision findings for a risk-dependent therapeutic strategy in oncology needs an individual prognostic estimation of the risk of recurrence. That target event permits the simultaneous classification of the case in an determined therapeutic modality. In according to Bayes' formula it is possible to estimate the risk of recurrence using one or several factors. It requires beforehand the research of every factor for his influence on the target variable by calculation of sensitivity and specificity in a reclassification matrix of an independent test group. Several factors increase the expense of procedures in such a manner that it is only possible to realize the calculations by a discriminance analysis or a multiple correlation analysis using a comfortable computer program. However this procedure is required because the oncologic prognosis models always represent multivariate nonlinear connections.

Bayes Theorem↗
PubMed1989

AIDS cases with no identified risk: artifact or reality? The Connecticut example.

Connecticut's 66 AIDS cases initially reported with no identified risks (NIRS) were reviewed and intensively investigated. Investigation resulted in reclassification of 45 cases (68.2%) to categories of known risk; one case (1.5%) was misdiagnosed as AIDS. Twenty cases (30.3%) remain NIRS because no risk could be established at this time. Evidence that NIRS represent reporting artifact, rather than unknown or new modes of transmission, was found. (1) NIRS are cases for which information on sexual behavior is highly sensitive or difficult to obtain. After investigation, 72% of reclassified Connecticut NIRS were determined to have risks related to sexual transmission. (2) The percentage of NIRS fluctuates according to reporting source and method of investigation. Within Connecticut, major reporting sources vary from a high of 15% to a low of 0% NIRS among their cases. The most effective method for establishing risks was to obtain information from reporting sources.

Acquired Immunodeficiency Syndrome↗
PubMed1989

Malignant lymphoma of the gastrointestinal tract and mesentery. A clinico-pathologic study of the significance of histologic classification. NHL Study Group of the Comprehensive Cancer Center West.

A series of 92 malignant lymphomas of the gastrointestinal tract and mesentery obtained from a population-based registry was studied to assess whether the newly defined concept of mucosa-associated lymphoma has clinical relevance. The cases were grouped according to localization; gastric, intestinal, and mesenteric lymphoma. All cases were reviewed histologically, graded according to the Working Formulation, and reclassified according to the Kiel classification, which was modified to include the categories low- and high-grade mucosa-associated lymphoma. Clinical data, as well as staging and follow-up data, were related to both the original diagnosis and the diagnosis after reclassification. The results showed that the distribution of the types of lymphoma is related to site: centroblastic lymphoma was predominant in the stomach, lymphoblastic in the bowel, and follicular centroblastic-centrocytic in the mesentery. Gastrointestinal lymphoma was disseminated in approximately 50% of the patients at presentation. Survival analysis revealed that classification according to the original Kiel classification and grading according to the Working Formulation provided important prognostic information, whereas introduction of mucosa-associated lymphoma as an entity did not. It was concluded that modification of current classifications to include a separate category for mucosa-associated lymphoma is not useful.

Gastrointestinal Neoplasms↗
PubMed1989

[Grading of brain tumors using computer-assisted analysis of CT images and anamnestic data].

For the classification of various brain tumours data from 139 patients with histologically proven diagnosis were used. With linear discriminant analysis and hierarchic classification of clinical and anamnestic data and features obtained by Walsh-transformation of image data presently 7 classes of tumours are differentiated with an estimated classification rate of 85% and reclassification rate of 92%.

Brain Neoplasms↗
PubMed1979

[Myelosarcoma as the 1st manifestation of myelosis].

Myelosarcoma of the nodes, middle ear, rib, and spinal epidural space was observed in five cases as preceding the diagnosis of myelosis. In two cases involving epidural localization malignant lymphoma was misdiagnosed and reclassification only at the time of postmortem. Myelosarcoma is best distinguished from other types of tumour by means of the histochemical proof of naphthol-AS-D-chloracetatesterase.

Adult↗
PubMed1988

An enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to Pasteurella pneumotropica in murine colonies.

An ELISA for the detection of class specific IgG antibodies to Pasteurella pneumotropica was developed for the serological diagnosis of infections in mouse colonies. Heat inactivated whole cell preparations of an isolate of P. pneumotropica biotype Heyl (strain P 166) served as antigen for the ELISA procedure and for immune serum production in germ-free Han:NMRI mice. Cross reactions with the autochthonous flora of Han:NMRI SPF-mice were not observed, but were evident when a P. pneumotropica antiserum was tested against other antigens of the Pasteurella-Actinobacillus group. According to the reclassification of this bacterial group proposed by Mutters et al. (1), strains of the following species were tested: P. anatis, P. canis, P. dagmatis, P. langaa, Pl multocida sub. multocida, P. pneumotropica biotype Jawetz, P. stomatis, Actinobacillus equuli and A. lignieresii. Clear cross reactions could be shown with P. pneumotropica biotype Jawetz and A. equuli and to a lesser extent with P. anatis. Antibody formation profiles after nasal infection of Han:NMRI mice exhibited a primary rise of IgG-type antibody titer between 17 to 21 days post infection. Investigations of different mouse colonies free and infected with P. pneumotropica revealed good correlations between serological and bacteriological findings.

Animals↗
PubMed1985

Revision of the case definition of acquired immunodeficiency syndrome for national reporting--United States. Centers for Disease Control, Department of Health and Human Services.

Since the first case definition of the acquired immunodeficiency syndrome was published in 1982, minor revisions have been made in the list of diseases used as indicators of underlying cellular immunodeficiency, and, more recently, the human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) has been identified as the cause of the syndrome. To reflect these changes, the Conference of State and Territorial Epidemiologists suggested resolutions to the case definition of the syndrome that the Centers for Disease Control will immediately adopt. These revisions will result in the reclassification of less than 1% of cases previously reported.

Acquired Immunodeficiency Syndrome↗