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1,213 records · Page 68Linked to original sources
PubMed1980

[Experiences in sleep induction with sinophenin in children (a contribution to the differential diagnosis of cerebral seizure disorders)].

In view of the necessity of the search for time-economically justifiable bioelectrical investigation procedures yielding the required information in practice and meeting the demands for a supplementation of the electro-encephalographic diagnosis, an attempt was made to assess the importance of the Sinophenin sleep provocation method under consideration of frequent neuropsychiatric problems in children. The correlation between age-bound specificity of the kind of fits, the sleeping-waking rhythm and its different pharmacological modifiability were established as an expression of a functional approach.

Adolescent↗
PubMedDate not supplied

[The effect of neuroleptics on blood proteins during development of toxic cerebral edema-brain swelling].

Simulation of toxic brain edema-swelling allowed one to analyze the dynamics of blood protein alteration in presence of various neuroleptics. Alterations in blood protein fractions correlated with dynamics of nervous tissue impairments. All the drugs studied exhibited similar antiswelling action involving the gamma-globulin sub-system activation. At the same time, the neuroleptics with activating and depriving effects demonstrated an oppositely directed influence on blood albumins.

Animals↗
PubMed1976

Acute hypertension immediately after coronary artery surgery.

Hypertension immediately after coronary surgery is a problem in about one third of the patients so treated. This report discusses the possible causes of postoperative hypertension and describes several means of controlling the complication.

Acute Disease↗
PubMed1994

[The effect of combolen on the erythrocyte distribution in the dog].

The effect of Combolen (3.9 mg/kg bw s.c.) on the distribution of erythrocytes in dogs was investigated. After application of Combolen, the hematocrit of the animals decreased exponentially within 1 h by 21%. The reversal of the reduction began from 2 h after the time of application, amounting to 4% within the first day and finishing by the fourth day. After injection of 51Cr-labelled erythrocytes, radioactivity in the circulation of Combolen-treated dogs decreased exponentially within 2 h by at least 30%. It was concluded that the dog's spleen, under physiological conditions, contains about 10% of the animal's blood. The time-courses of the decrease of hematocrit and radioactivity in the circulation were found to be very similar. In accordance with this observation, a high correlation (r = 0.97) between the level of radioactivity after injection of radio-labelled erythrocytes and the corresponding hematocrit values after application of Combolen was found. After application of erythrocytes, labelled with 99mTc, an extensive distribution from the circulation into the spleen was observed by scintigraphy. This process can be understood by using a closed-compartment model. An equation, based on this model, describes the observed time course of the hematocrit values, as well as the number of 51Cr-labelled erythrocytes, in Combolen-treated dog. Presumably, the observed effect of Combolen is the result of the relaxation of the smooth muscle cells in the trabeculae of the spleen, caused by central-nervous depression of sympathetic tone. Combolen seems to be a suitable tool in pre-clinical testing of a novel blood preserve with dog as a test animal. Its potent ability to eliminate erythrocytes from circulation is distinguishable from the sequestration of damaged red cells. Furthermore, its ability to prevent the spleen from uncontrolled hematocrit modulating actions in addition to its sedative effects is considered to be an invaluable advantage.

Animals↗