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Results for “Program Development”

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At least 1,225 records · Page 68Linked to original sources
PubMed2000

Diagnosis of neonatal pig diarrhea.

To be effective, swine practitioners should develop a unit health program. Development should involve unit managers, owners, and employees involved in day-to-day operations. Emphasis on training personnel and management to reduce disease and collection of accurate records is necessary. Routine diagnostics are needed to solve disease problems. Communication with laboratory personnel to ascertain what samples are needed for diagnosis of particular problems cannot be overemphasized. General diagnosis of disease problems outlined by Vinson can be similarly followed within the specifics of diarrheal problems within units. 1. Observe symptoms exhibited by pigs, i.e., huddling, fecal material around perineum, extreme thirst, etc. 2. Evaluate the degree of morbidity and potential production losses. 3. Analyze possible specific causes of symptoms, i.e., environmental cleanliness, affected litter distribution, age of affected neonates, and other populations affected. 4. Examine live animals, i.e., obtain serum samples from a random population, take rectal temperatures of affected neonates, and evaluate fecal pH. 5. Necropsy dead or dying pigs [that] appear to represent the problem. 6. Submit live pigs or appropriate tissues from necropsied pigs to a diagnostic laboratory. 7. Re-evaluate environmental conditions that may be contributing to the problem (remember, unit employees are a part of the pigs' environment). 8. Evaluate management procedures contributing to the disease problem, i.e., lack of adherence to all-in all-out, rapid turn-around decreasing cleaning time etc. Following this format and communicating with diagnosticians should provide for positive results for the producers both entities serve.

Animals↗
PubMed1995

Quality control in a peritoneal dialysis program.

A reliable and effective quality-control program in the peritoneal dialysis (PD) unit requires a team effort. Historically, the nursing staff has been responsible for PD program development, and in some programs the physicians are frankly uninvolved. An enthusiastic, knowledgeable, and committed physician is necessary. In the early days of continuous ambulatory peritoneal dialysis in the United States, lack of physician understanding and commitment tarnished the image of this promising, evolving therapy. After recognizing this problem, Baxter embarked on an intensive effort to upgrade the expertise of the physicians. Concurrently, PD programs were identified with successful outcomes and "best demonstrated practice" techniques were promulgated. The key to quality control is the involvement of all members of the team, including physicians, nurses, dietitians, social workers, technicians, administrators, and patients. A commitment is needed for continuing education, continuing reevaluation of policies and procedures, and the empowerment of all team members to achieve the programmatic goals.

Education, Medical, Continuing↗
PubMed2003

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.

CD4+CD25+ regulatory T cells are essential for the active suppression of autoimmunity. Here we report that the forkhead transcription factor Foxp3 is specifically expressed in CD4+CD25+ regulatory T cells and is required for their development. The lethal autoimmune syndrome observed in Foxp3-mutant scurfy mice and Foxp3-null mice results from a CD4+CD25+ regulatory T cell deficiency and not from a cell-intrinsic defect of CD4+CD25- T cells. CD4+CD25+ regulatory T cells rescue disease development and preferentially expand when transferred into neonatal Foxp3-deficient mice. Furthermore, ectopic expression of Foxp3 confers suppressor function on peripheral CD4+CD25- T cells. Thus, Foxp3 is a critical regulator of CD4+CD25+ regulatory T cell development and function.

Animals↗
PubMed2003

Developing intervention programs for children with stuttering and concomitant impairments.

School-aged children who stutter often present concomitant impairments in articulation and language that can complicate treatment. In this article, a framework is offered for designing intervention programs for such children. It is stressed that clinicians must first identify clinical priorities by determining the severity of the impairments, their impact on daily activities, others' reactions to the impairments, and the likelihood of unassisted recovery. Several potential treatment models are presented, as are general treatment principles and specific treatment strategies for three profiles of children who stutter. Suggestions are also provided for including parents and teachers in the intervention plan.

Articulation Disorders↗
PubMed2005

Developing a programmed restriction endonuclease for highly specific DNA cleavage.

Specific cleavage of large DNA molecules at few sites, necessary for the analysis of genomic DNA or for targeting individual genes in complex genomes, requires endonucleases of extremely high specificity. Restriction endonucleases (REase) that recognize DNA sequences of 4-8 bp are not sufficiently specific for this purpose. In principle, the specificity of REases can be extended by fusion to sequence recognition modules, e.g. specific DNA-binding domains or triple-helix forming oligonucleotides (TFO). We have chosen to extend the specificity of REases using TFOs, given the combinatorial flexibility this fusion offers in addressing a short, yet precisely recognized restriction site next to a defined triple-helix forming site (TFS). We demonstrate here that the single chain variant of PvuII (scPvuII) covalently coupled via the bifunctional cross-linker N-(gamma-maleimidobutryloxy) succinimide ester to a TFO (5'-NH2-[CH2](6 or 12)-MPMPMPMPMPPPPPPT-3', with M being 5-methyl-2'-deoxycytidine and P being 5-[1-propynyl]-2'-deoxyuridine), cleaves DNA specifically at the recognition site of PvuII (CAGCTG) if located in a distance of approximately one helical turn to a TFS (underlined) complementary to the TFO ('addressed' site: 5'-TTTTTTTCTCTCTCTCN(approximately 10)CAGCTG-3'), leaving 'unaddressed' PvuII sites intact. The preference for cleavage of an 'addressed' compared to an 'unaddressed' site is >1000-fold, if the cleavage reaction is initiated by addition of Mg2+ ions after preincubation of scPvuII-TFO and substrate in the absence of Mg2+ ions to allow triple-helix formation before DNA cleavage. Single base pair substitutions in the TFS prevent addressed DNA cleavage by scPvuII-TFO.

Cross-Linking Reagents↗
PubMedDate not supplied

Using principles of community-based participatory research to enhance health data skills among local public health community partners.

In a prior statewide health disparities assessment, local community public health and social service professionals indicated a need for technical capacity growth in order to understand and effectively utilize health data. Using a community-based participatory research approach in addressing this need, health data training was provided to 26 individuals with the primary goals being to provide capacity to identify health disparities that result in higher morbidity and mortality, and to provide the skills needed to access, interpret, and utilize health data. Satisfaction surveys showed that an overwhelming majority of participants were extremely pleased with the training. Follow-up telephone interviews (100% response rate) conducted 2 months after the training indicated positive results, with participants discussing how they felt empowered to find, interpret, and use data as a result of the training. Results of a 6-month follow-up questionnaire (54% response rate) further supported the program's desired outcome to expand participants' knowledge and use of health data. This pilot project illustrated how utilizing a community-level partnership approach to program development not only enhances the utilization of such programs but also helps sustain participants' knowledge and skills.

Community Participation↗