Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Origination patterns”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,225 records · Page 68Linked to original sources
PubMed1986

Humoral hypercalcemia of malignancy in nude mouse model of a canine adenocarcinoma derived from apocrine glands of the anal sac. Biochemical, histomorphometric, and ultrastructural studies.

A serially transplantable tumor line, designated CAC-8, has been developed in nude mice from a spontaneously occurring adenocarcinoma of the anal sac from a hypercalcemic dog. Nude mice with transplanted CAC-8 developed hypercalcemia (mean 16.3 +/- 0.6 mg/dl) and moderate hypophosphatemia without bone metastasis. Urinary excretion of calcium and hydroxyproline were increased 6- and 2.3-fold, respectively. Urinary excretion of cAMP was moderately increased but phosphorus excretion was not significantly altered. Serum 1,25-dihydroxycholecalciferol was increased significantly in tumor-bearing nude mice in proportion to the magnitude of tumor-induced hypercalcemia. Histomorphometric evaluation of lumbar vertebrae from nude mice with CAC-8 revealed decreased total and cortical bone volume, a 3.3-fold increase in bone resorption rate and a 2.5-fold increase in bone formation rate at the tissue level. The transplanted CAC-8 has maintained the histologic pattern of the original carcinoma up to the present sixth passage. Ultrastructural evaluation of transplanted tumor cells revealed 150-250-nm secretory-like granules. The granules did not stain by using an ultrastructural cytochemical (uranaffin) stain specific for neuroendocrine secretory granules. Ultrastructurally, the parathyroid glands of nude mice with CAC-8 appeared inactive with large intracytoplasmic whorl of agranular membranes. These data suggest the transplanted carcinoma secreted a humoral factor which resulted in hypercalcemia. The tumor line (CAC-8) propagated in nude mice represents an animal model of humoral hypercalcemia of malignancy that shares many features with the syndrome described in human patients. Unique features of this transplanted carcinoma associated with hypercalcemia include increased serum dihydroxycholecalciferol, increased rate of bone formation as well as bone resorption, an absence of bone metastases, and evidence of parathyroid gland suppression.

Adenocarcinoma↗
PubMed1986

The development of hepatocellular cancer in humans.

The biological characteristics of hepatocellular cancer vary appreciably in different parts of the world, but especially between regions with very high and low incidences of the tumour. Hepatocellular cancer is multifactorial in origin, and the pattern of its aetiological associations differs between populations at high and low risk. In Africans and Chinese, who have the highest incidences of hepatocellular cancer, the hepatitis B virus is the most important causal association. The viral carrier state is acquired during early childhood, and carries a relative risk for the development of the tumour of over 200. Integration of hepatitis B virus DNA probably acts as a genotoxic initiator in the multistep process of hepatocarcinogenesis, although the precise mechanisms involved have not been determined. Aflatoxin ingestion may also have an aetiological role in high incidence regions, probably as a genotoxic or epigenetic promoter to hepatitis B virus-initiated carcinogenesis. In low risk populations cirrhosis is the most important causal association of hepatocellular cancer. The cirrhosis is often the result of alcohol abuse, but the tumour may complicate all aetiological forms of this disease. Whether neoplasia is an inevitable consequence of the hyperplasia of cirrhosis, or the increased hepatocyte turnover rate acts as a promoter is not known. Hepatitis B virus infection plays a lesser part, and aflatoxin no part at all.

Adult↗
PubMed1977

[Morphologic study of the arterial vasa vasorum of the pulmonary veins in dogs].

The authors studied 54 hearts of dog, to try and find a pattern of the origin, traject and distribution of the vasa vasorum of the great vessels in the heart of the dog. They used the injection-corrosion-fluorescence method imagined by one of them, verifying the good penetrability of the substance they injected and a fine visualization under Wood light. They observed that the arterial vasa vasorum of the pulmonary veins come from the atrial branches of the circumflex artery, from an atrial antero-right branch of the artery of sinusatrial node, branches from the right-coronary artery and from the bronchial arteries. The systematize the arterial blood supply of the different sides of the pulmonary veins, though it is not a rigid classification as the atrial arterial branches, supplying the vasa vasorum, show a great variability of size and there are several anastomosis between them.

Animals↗
PubMed1987

Identification of platelet antigens by monoclonal antibodies using crossed immunoelectrophoresis with immunoblotting of the monoclonal antibody.

A method is described for the identification of antigens by monoclonal antibodies. This is applicable whenever precipitating antibodies to the same antigens from a different species are available. The method is based upon: Separation and immunoprecipitation of cellular proteins with a polyspecific antiserum in crossed immunoelectrophoresis in the presence of the non-denaturing detergent Triton X-100 and the monoclonal antibody. Coprecipitation of the monoclonal antibody with its antigen. Subsequent passive transfer of the monoclonal antibody in the antibody-antigen complex onto a nitrocellulose membrane. Visualization of the blotted antibody using an enzyme-linked secondary antibody and a chromogenic substrate. Identification of the corresponding antigen by comparisons to the immunoprecipitate pattern of the original immunoplate. To test this method we have analyzed the detection of the antigens recognized by six previously described monoclonal antibodies against platelet membrane proteins and von Willebrand factor. Specific immunoblots were obtained in each case using small amounts of monoclonal antibodies. Thus, the technique provides an alternative when epitopes are denatured by SDS, and avoids the use of radioactively labelled monoclonal antibodies.

Antibodies, Monoclonal↗
PubMed1988

[Human cervical cancer transplantable to athymic mice].

Pregnancy in nude mice proved to be a favourable period for a successful human cervical tumor transplantation. This approach made it possible to obtain human cervical tumors, serially transplanted to nude mice. After several passages the tumor acquired the ability to be transplanted to nonpregnant female mice. The tumor retained a histological pattern of an original human tumor.

Animals↗
PubMed1988

[Reasons for repeat operations in patients with tumors of the ovaries].

The paper deals with the analysis of reasons for repeat surgery in 242 patients who had undergone sparing operations on the inner genitals for tumors of various origin. In 121, sparing surgery had been performed for benign tumor of the ovary whereas in 70--for underdiagnosed malignancy. At the time of the first operation, 55 patients were more than 45 years of age; 33 of them subsequently died of advanced ovarian cancer. Out of 187 cases who had been operated on at younger age, 37.9% subsequently underwent surgery for malignant tumor of the second ovary. The origin and histological pattern of ovarian tumor should be considered when choosing the extent of surgery. Cases of sparing surgery for ovarian tumors should be followed-up.

Adult↗
PubMed1987

The lumbosacral plexus of the Japanese serows, Capricornis crispus.

The lumbosacral plexus of the Japanese serow was grossly investigated on 30 fresh specimens. 28 of 30 showed 6 lumbar vertebrae and 2 of the remaining had 5. The communicating pattern among segmental origins from L3 to S5 revealed a variability of the plexus in both types of 5 and 6 lumbar vertebrae. The ratio of prefixed, median fixed and postfixed plexuses in 6 lumbar vertebral type was nearly 2:6:1. The serow's plexus was basically similar to that of domestic ruminants.

Animals↗
PubMed1967

Clinical conference on leukemia. Chromosome studies in leukemia.

This review discusses the significance of chromosomal abnormalities found in leukemia with the bias of belief that these have a primary role or are the mechanism of action of leukemogenic agents. The Philadelphia chromosome (Ph(1)) is present in marrow cells examined without culture at any stage of most patients with chronic granulocytic leukemia (CGL). the presence of this chromosome is of diagnostic and prognostic value.Varied chromosomal abnormalities have been found in acute leukemia. Each abnormality, which may be unique, is absent in remission, found again at relapse and is seldom changed by therapy. Abnormalities may be of number of chromosomes (aneuploid) or structural rearrangements resulting in "marker" chromosomes, Ranges of abnormal numbers of chromosomes, when present, usually have related patterns which suggest origin of several cell types from one initial cell. Cells from patients with increased risk of leukemia owing to genetic factors have a high incidence of chromosome breakage and structural rearrangements suggesting a mechanism for production of clones of abnormal, possibly leukemic, cells.

Adult↗
PubMed1984

[Struma ovarii and strumal carcinoid].

Seven ovarian tumours (3 mature teratomas, 2 strumas with malignancy 2 strumal carcinoids) have been examined histologically, hystochemically and electron-microscopically. It is shown that the cell composition of the strumal teratoma tissue is very similar to that of the ectopic thyroid. The follicular cells may proliferate either into the benign tumour (apudoma) or typical thyroid carcinoma. Parafollicular cells may give rise to C-cell hyperplasia with the amyloid deposits in the stroma. The so-called strumal carcinoid of the ovary represents probably the C-cell tumour. Its "strumal" component may be considered as preexisting follicles invaded by tumour apudocytes or as the site of tumour origin displaying the pattern of a non-medullary thyroid apudoma.

APUD Cells↗
PubMedDate not supplied

[The dominant and interhemispheric relations].

The role of the dominant in the interhemispheric asymmetry and interhemispheric relationships in animals is discussed. Examples are given of lateral specialization of their brain. The interhemispheric asymmetry are described: bilaterality of origin, the mozaic pattern, a certain stability. An asymmetry model created by lateralized light source is analysed. The result was used to study interhemispheric relationships. The role of the dominant in the organization of the callosal common path is discussed. A conclusion was drawn that the dominant is a major mechanism of the functional interhemispheric asymmetry and interhemispheric relationships.

Animals↗
PubMed1983

Central myelin in the shark Scyllium stellare (Elasmobranchii, Selachii).

The central myelin of the phylogenetically ancient shark Scyllium stellare (Elasmobranchii, Selachii) was examined at the electron microscope. The known different chemical compositions of the myelin in higher and lower vertebrates is not associated in the Scyllium with a lack of any basic structural myelin elements, but is probably linked to variations in the myelin compactness and periodicity. Several unusual myelin structures and irregular patterns of unknown origin have been observed. The relationship between myelin-forming cells and the most external layers of myelinated structures suggest the possibility that the cytoplasmic glial wrapping is not the only mechanism responsible for central myelination in this vertebrate.

Animals↗
PubMed1983

[Metatypical basaloma. A case report].

Report of a female patient with a so-called metatypical carcinoma of big size causing destruction of the facial skull and penetration into the cerebral frontal lobe. After classification of the metatypical carcinoma into the group of basalioma tumors similar computertomographic patterns of different origin are pointed out.

Aged↗
PubMed1983

[Human freedom between self realization and self destruction].

Men consider only those motives valuable, which originate from inborn patterns of behaviour, and that means in the first place most of the different activities in the course of living together. In primitive communities, when holding together and wrestling with a combined effort against natural adversities or rival tribes, each individual acquires a homogeneous basis of habits in doing and thinking which become irrefutable matters of course.--In case of economical surplus consolidation of bigger social units gets under way.--That leads step by step--starting always from pioneering élites--in the course of many generations to increasing awareness in the conduct of life and at the same time to dwindling of the emotionally fixed matters of course. In the final stage of evolution, therefore, everyone should consequently acquire for himself a framework of habits and attitudes, representing a compromise between selfish and altruistic tendencies and granting his thoughts and actions steadiness, assurance, and self-confidence.--If, however, owing to affluence, adverse living conditions do not force joint exertions and concord, individualistic expansion, competition, and rivalry arise and undermine the human relations. As a result increasingly self-realization is claimed to the debit of the fellow-men. But in view of the fact that the individual as a gregarious being cannot exist without trustworthy social ties and esteem, a rising number of men comes into a conflict between individualistic desire for expansion and yearning for the security of a community. Exposed to such a situation a lot of people are unable to adjust to a harmonious living together.

Aptitude↗
PubMedDate not supplied

Heterogeneity and selection of neoplastic neurogenic rat cells in vivo and in vitro.

Analysis of chromosome numbers and flow cytometric measurements of relative DNA content have been performed on four neoplastic neurogenic rat cell lines obtained from fetal BD IX-rat brain cells exposed to N-ethyl-N-nitrosourea (EtNU) in vivo, which sequentially underwent neoplastic transformation in cell culture. In vitro, the cell lines showed varying degrees of ploidy (ranging from near-diploid to near-hexaploid values) and chromosome aberrations. When grown in vivo as solid tumours in BD IX-rats and in thymus deficient nude mice, or in intraperitoneal diffusion chambers in rats, the near diploid cell lines were stable. In the lines with higher ploidies the proportion of cells with near-diploid values increased. Upon retransfer to cell culture, the cell lines gradually changed to the original in vitro pattern. However, in some cases an elevated near-diploid fraction persisted during culture after retransfer. Despite the selection of malignant cells with different ploidy in vivo and in vitro, their ultrastructural morphology remained unchanged. Thus, in this system, near-diploid cells are favoured under conditions of in vivo growth.

Animals↗
PubMed1981

[Femoral neck fractures in children. About 14 cases (author's transl)].

The authors study 14 femoral neck fractures in children after a four and half years follow up. They point out the scarcity of these fractures in children. They describe their therapeutic methods and results. They corroborate the bad prognosis of this injury (femoral neck necrosis or further growth trouble) and emphasise the importance of a long term follow up to appreciate precisely the sequellar growth trouble. They discuss the responsibility of the femoral neck's vascularisation pattern in the origin of the sequella. They ask two questions : -- Is it useful to treat these fractures in emergency? -- Is the surgical dogma still valid?

Adolescent↗
PubMed1980

Some fundamental aspects of the biomechanics of overground versus treadmill locomotion.

The literature shows a wide difference of opinion about the mechanical equality of, or difference between treadmill and overground locomotion. This difference in opinion is often related to the coordinate system which implicitly or explicitly is used. With help of a few theoretical examples of energy calculations this paper shows that the description of treadmill locomotion with respect to a fixed coordinate system can lead to faulty conclusions. It is concluded that as long as the beltspeed is constant a coordinate system should be used which moves with the belt. In such a system no mechanical difference exists in comparison with overground locomotion with respect to a fixed coordinate system. All differences found in locomotion patterns must therefore originate from other than mechanical causes.

Biomechanical Phenomena↗
PubMed1993

Two novel monoclonal antibodies reactive with different components of the rat thymic epithelium.

Two novel monoclonal antibodies (mAbs) (PT10B7 and PT13D11) have been raised against molecules of rat thymic epithelial cells (TEC). Streptavidin-biotin immunoperoxidase staining and double immunofluorescence using these mAbs and anti-cytokeratin (CK) antibodies showed that PT10B7 and PT13D11 mAbs bound to different components of rat TEC. PT10B7 mAb reacted with cortical and a subset of medullary TEC, whereas PT13D11 mAb labeled subcapsular/perivascular and most medullary TEC, including TE-R 2.5 TEC line of medullary origin. Their staining patterns were different from those seen using mAbs to CK10, CK18 and CK19 polypeptides and other anti-rat TEC mAbs produced so far. The differences in immunoreactivity of these two mAbs on rat thymus during ontogeny and on other epithelial cells of adult rats were also seen. Namely, PT13D11 stained ectoderm-derived epithelia, whereas PT10B7 stained some cells of simple epithelia. Cumulatively, these results reveal a fine phenotypic heterogeneity within rat thymic epithelium.

Animals↗
PubMed1995

Allogeneic bone marrow transplantation for fucosidosis.

Bone marrow transplantation was performed on an 8-month-old boy who was diagnosed as having fucosidosis following the diagnosis of the disease in his older brother. Although he was asymptomatic and his development was normal, abnomalities were found on an MRI scan prior to transplant. In the absence of a suitable related donor, an unrelated volunteer donor was used. Conditioning for the transplant consisted of busulphan and cyclophosphamide. Graft-versus-host disease prophylaxis consisted of in vitro T cell-depletion of the bone marrow and in vivo administration of cyclosporin. The post-transplant period was complicated by moderately severe graft-versus-host disease. Engraftment was documented by the presence of donor levels of alpha-fucosidase, donor blood group and tissue type (difference in the DQ antigen), and chromosomal polymorphism pattern of donor origin. Eighteen months after transplant, there is evidence of mild neurodevelopmental delay. By contrast, his elder sibling showed far greater developmental delay at the same age. The patient's MRI scan shows improvement. We believe this to be the first case of human fucosidosis treated by bone marrow transplantation.

Bone Marrow Transplantation↗