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At least 1,225 records · Page 68Linked to original sources
PubMed1983

[Bilateral congenital lower lip fistulas].

Congenital lower labial fistulas are extremely rare. This deformity of the vermilion border of the lower lip constantly appears symmetrically to the midline in a frontal direction with blind ending ducts and oval openings. The different pathogenetic causes are reviewed in accordance with the different gradual malformations described in the literature. In contrast to the upper cleft lip and/or cleft palate, congenital bilateral fistulas of the lower lip form a new, distinct syndrome explained by an arrested development leading to cross sulci resulting from a pathological cleaving process. In most cases a striking inheritance pattern with an autosomal dominant trait is associated with this disease. A family suffering from bilateral congenital lower lip fistulas and their leukocyte antigens are presented. All members of this family affected with this anomaly expressed an A3 Bw60 antigen suggesting a close correlation with the HLA-system of the major histocompatibility complex on the leukocytes.

Child↗
PubMed1981

The prevalence of congenital heart disease among the population of a metropolitan cleft lip and palate clinic.

The entire infant population of the Tufts-New England Medical Center Cleft Palate Clinic was reviewed, and the prevalence rates of congenital cardiac anomalies were calculated. The overall prevalence rate of congenital heart disease among the facial cleft clinic population was 6.7%, with a prevalence rate of 9.1% among patients with submucous cleft palate, 7.7% with congenital palato-pharyngeal incompetence, 0% with cleft lip only, 5.3% with unilateral cleft lip and palate, 12.5% with bilateral cleft lip and palate, 4.3% with cleft palate only, 13.6% with Pierre-Robin anomaly, 7.1% with cleft lip and palate and a syndrome diagnosis, 16.7% with cleft palate and a syndrome diagnosis.

Child↗
PubMed1982

Late results following different methods of cleft lip repair.

This is a review of the cleft lip repair of 232 patients. Three groups were compared, one repaired according to the Hagedorn-Le Mesurier-Steffensen technique, another by the Tennison method and a third using the Pfeifer wave-line procedure. Muscular union was best following Pfeifer's wave-line procedure. Both the Hagedorn-Le Mesurier-Steffensen and the Tennison lips were often too long, while the Pfeifer lips were more often too short. Reconstruction of Cupid's bow was somewhat more harmonious following Tennison's method. There was a trend towards fewer disturbing scars with the Pfeifer's procedure. We feel that these findings support our 1970 decision to operate all cleft lips according to the wave-line procedure.

Child↗
PubMed1981

Thyroxin-induced differential mortality of mouse embryos with cleft lip.

Administration of thyroxin in midgestation has been reported to prevent spontaneous cleft lip in term fetuses of genetically predisposed mice. Attempts to repeat this finding have given ambiguous results. The experiment was therefore repeated using CL/Fr and A/HeJ mice, and various thyroxin dosages. The embryos were examined on days 13 and 14, earlier in gestation than in previous studies. The usual complement of cleft-lip embryos, 21% in CL/Fr and 10% in A/HeJ, was present, but they were often dead. At all dosages of thyroxin that caused embryonic mortality, differential mortality of cleft-lip embryos at term after thyroxin treatment is thus due to their increased mortality, not to prevention of the lip defect.

Animals↗
PubMed1995

A long-term appraisal of the unilateral complete cleft lip repair: one surgeon's experience.

The authors reviewed 85 patients with unilateral complete cleft lip repaired with a low triangular flap technique. Clefts were classified into four categories, depending on the degree of deformity. The clinical results, as evidenced in standardized slides, were assessed by a professional panel using a weighted formula adapted from that devised by Williams. The Farkas-Lindsay anthropometric technique was also used to measure all dimensions of the lip and nose, with the results calculated as a ratio of the cleft to normal side. The findings demonstrated that the method of classification was consistent and reliable. As expected, the panel gave the postoperative results of the Simonart's and mild-degree clefts the highest ratings, with the severe clefts having the lowest. The consultant surgeons awarded the highest marks and the clinical fellows, the lowest. The residual nasal deformity continues to be the challenge rather than the lip defect, as evidenced by an average of 1.7 revisionary procedures on the nose compared with 0.7 on the lip. A combination of subjective and objective methods of evaluation has been incorporated into a critical clinical review of these patients.

Adolescent↗
PubMed1995

EMG studies of lip and cheek activity in sucking habits.

Pronounced lip and mentalis (perioral) muscle activity was developed during thumb and dummy sucking. Cheek (Buccinator) activity was less evident, showing light to moderate activity. Lip and cheek activity was more noticeable during dummy sucking than thumb sucking. Sucking water through a straw and swallowing produced similar functional patterns to thumb sucking: strong lip and mentalis activity but comparatively low buccinator activity. Activity at rest in perioral muscles was pronounced among thumb and dummy suckers, while buccinator activity was negligible. Lip and cheek activity was substantially less, both at rest and during sucking, in a control group of children who were not thumb suckers.

Adolescent↗
PubMed1993

Dermatoglyphics in cleft lip and cleft palate anomalies.

Dermatoglyphic characteristics of sixty nine cases of cleft lip with or without cleft palate and twenty eight isolated cleft palate cases were evaluated for digital patterns, interdigital patterns, palmar simian crease and sydney line, and model types of C- and D-line terminations. Increased frequency of ulnar and radial loops than the arches and whorls was observed in cleft lip with or without cleft palate patients compared to controls. Interdigital patterns were less frequent in cleft lip and cleft palate patients. Simian crease and Sydney line were more common in patients than in controls. Model types of C- and D-line terminations showed variations in patients and controls. Wider 'atd' angle (more than 30 degrees) and dermatoglyphic asymmetry were noted in the patient groups. The findings suggest the dichotomy or heterogeneity of cleft lip and cleft palate anomalies. The role and utility of dermatoglyphics in genetical etiology of congenital defects were emphasized.

Adolescent↗
PubMedDate not supplied

Facial growth and development in unilateral complete cleft lip and palate from palate surgery up to adulthood.

Mixed longitudinal and cross-sectional roentgen-cephalometric data were used for studies of the growth and development of the face in unilateral complete cleft lip and palate from the time of primary palatoplasty up to adulthood. The results were compared with the data obtained in controls at the age of 5 years and in adults. The vertical growth of the upper and lower face exceeded its sagittal growth. The lower face showed a higher growth rate in both directions than did the upper face. The depth of the maxilla showed the lowest growth rate. The height of the upper lip increased very little as well. The most important deviation in facial development consisted of the deficient growth of maxillary depth and the prolongation of the lower face. Both these deviations develop predominantly after palate surgery and the former resulted in a gradual retrusion of the maxilla, a flattening of the face, and impairment of sagittal jaw relations. The reduction of upper face height, the posterior position of the maxilla, and the shortening of the mandible (both of the body and ramus) represented, on the contrary, early changes. The a persisting posterior rotation of the mandible, changes in the shape of the mandible, and vertical disproportion of the face increased with age, the steep slope of the mandibular body remaining at the level ascertained in early childhood. An improvement in the occlusion of incisors was obtained prior to the age of 12 years, but it regressed during the period of puberty. The prominence of the upper lip gradually decreased and the lip was short.

Adolescent↗
PubMed1993

Median facial dysplasia in unilateral and bilateral cleft lip and palate: a subgroup of median cerebrofacial malformations.

The median facial dysplasia group of patients is a unique, distinct, definable group characterized by mid-line facial deficiencies in the presence of a unilateral or bilateral cleft lip with or without cleft palate and without clinically detectable anomalies of the brain. This group of patients comprised 2 percent of new cleft lip and palate patients. The midline facial deficiencies in median facial dysplasia are characterized by a poorly defined Cupid's bow, absence of the labial frenulum and anterior nasal spine, deficient columella, and poorly developed septal cartilage and premaxilla. One of the central incisors may be absent or rudimentary. There are no definable gross abnormalities of the brain. The results of intelligence tests of median facial dysplasia patients have a normal distribution and are not significantly different from those of a noncleft normal population. Unoperated and operated median facial dysplasia patients all have typical midfacial growth disturbances below the norm for their ages. The classification of median facial dysplasia patients as well as other median cerebrofacial anomalies, the embryologic basis of these deformities, and the clinical results of their treatment are helpful in understanding some of the problems related to the treatment of the cleft lip and palate patient. Median facial dysplasia patients demonstrate an inherent potential for poor midfacial growth. Deficiencies of soft tissue such as a lack of the Cupid's bow make it difficult to reconstruct the lip and nose satisfactorily.

Abnormalities, Multiple↗
PubMed1996

Lip cancer: a review.

Dental examinations should routinely include examination of the lips by visual inspection and palpation. The primary risk factor for lip cancer is actinic damage. Squamous cell carcinoma of the lip accounts for about nine per cent of all oral cancers, but there has been a downward trend in the number of cases reported from 1973 to 1984. This trend may be due to the increased use of sunscreens. The clinical presentation and management of lip cancer are discussed.

Carcinoma, Squamous Cell↗
PubMed1977

Treatment of lip keratoses (actinic cheilitis) with topical fluorouracil.

Topical (5-fluorouracil [5-FU]) as a 5% solution was used to treat isolated actinic keratoses of the lips as well as diffuse actinic damage of the lower lip. Although producing considerable temporary discomform final results proved excellent, with recurrences in only two of 12 patients treated. Preliminary biopsy of suspicious infiltrated areas is mandatory, as is careful follow-up to ensure complete healing. Topical fluorouracil is an alternative to surgical excision of the vermillion border of the lip in those patients with severe diffuse actinic damage of the lips.

Administration, Topical↗
PubMedDate not supplied

Cleft lip and palate associated with malformation of the central nervous system: a prospective neurosonographic study.

A prospective neurosonographic study was undertaken on 190 patients with non-syndrome cleft lip and/or palate. Among them, six cases (3.2%) demonstrated malformations of the central nervous system. Included were four cases of midline cleft lip and palate showing holoprosencephaly; one case of bilateral cleft lip and midline cleft palate showing dysplasia of the septum pallicidum and one case of bilateral cleft lip and palate showing dysgenesis of corpus callosum. The patients with midline clefts were not obligatory associated with malformation of the brain, but their incidence was higher (four of nine case or 44.4%). The neurosonogram provides a portable, low cost, non-invasive and efficient technique in the diagnosis of gross anomaly of the neonatal brain, and can thus serve as a screening test in those patients with clefts.

Abnormalities, Multiple↗
PubMedDate not supplied

[Reconstructive surgery of the upper lip with esthetic-functional recovery].

Two cases are reported of reconstructive surgery of the upper lip in patients who had squamous cell carcinoma, using the Bürrow technique. This technique is more used in lower lips because it does not involve esthetic unity. We have opted for it in the upper lip also, using a variation in the lip commissure incision, getting a significant functional and esthetic result.

Adult↗
PubMed1996

Regional epidemiological features of lip, oral cavity, and oropharyngeal cancer.

Lip, oral cavity, and oropharyngeal cancer are among the most common forms of the disease in the world. These types of cancer display significant geographic, ethnic, and socioeconomic variations. We examined the cases of cancer of the lip, oral cavity, and oropharynx diagnosed in the Department of Otolaryngology at the University of Uludağ School of Medicine during the last 5 years, July 1990 to June 1995, and recorded the epidemiological features of these tumors. The Department of Otolaryngology treated a total of 26,225 in- and outpatients during the 5-year period. 320 of these patients (1.2%) were seen for head and neck cancer. 42 of the 320 patients (13.1%) were diagnosed with cancer of the lip, oral cavity, and oropharrynx. After the larynx, this was the second most frequent location of malignant head and neck tumors. We discovered the following epidemiological and pathological features: (1) The incident rate was highest in patients between 41 and 60 years of age. (2) 70% of the patients were male, and 76% of them had a history of tobacco/alcohol use. (3) Occupation had no apparent relevance (four of the patients were farmers). (4) Approximately one third of the patients had undergone medical therapy prior to diagnosis. (5) One third of the patients had initially seen a dentist for treatment, and approximately half had poor dental and oral hygiene. (6) The most frequent symptom was ulceration. (7) Histopathological examination revealed squamous cell carcinoma in 88% of the cases. (8) The cancer was localized to the lip in 31% of cases, oral cavity, 50%, and oropharynx, 19%. (9) Almost half of the cancer cases were diagnosed in advanced stage (stages III and IV).

Adult↗
PubMed1996

Variability in upper lip posture to overjet changes in 12-year-old Nigerian children.

One thousand and sixteen 12-year-old Nigerian primary school children were examined for upper lip posture at different overjet values. Upper lip positions were assessed using the Jackson's criteria. The most common lip position was Jackson class 3 with 72 per cent. Positions 0 and 1 were not common features. Normal overjet value of 2-4 mm was found in 82 per cent of the sample population. The findings from this investigation also showed very little significant relationship between variation of overjet at different upper lip positions.

Analysis of Variance↗
PubMed2005

Systematic review of a marine nutriceutical supplement in clinical trials for arthritis: the effectiveness of the New Zealand green-lipped mussel Perna canaliculus.

BACKGROUND: Nutritional supplements, such as Seatone, which contain freeze-dried tissue from the New Zealand green-lipped mussel Perna canaliculus, are sold in many countries to relieve arthritic symptoms and to aid in the regeneration of arthritic and injured joints. METHODS: Searches for all published controlled trials on the clinical effectiveness of green-lipped mussel, as a nutritional supplement with potential health benefits for arthritis, were carried out from four independent databases. No language restrictions were imposed, and the review was undertaken from extracted data and was assessed critically according to predefined criteria by the authors. RESULTS: Reports of clinical studies, using freeze-dried mussel powder, show mixed outcome measures and are not conclusive, with only two of five randomized controlled trials attesting benefits for rheumatoid and osteoarthritis patients. Similarly, animal studies have likewise yielded mixed findings. In both these cases possibly due to the lack of stabilization of the omega-3 polyunsaturated fatty acids, now known to be the basis of anti-inflammatory activity. CONCLUSION: There is little consistent and compelling evidence, to date, in the therapeutic use of freeze-dried green-lipped mussel powder products for rheumatoid or osteoarthritis treatment, particularly in comparison to other cheaper alternative nutriceutical supplements of proven efficacy. However, further investigations are necessary to determine whether green-lipped mussel supplements, such as Seatone, are therapeutic options in the management of arthritis.

Animals↗
PubMed1988

Actinic prurigo of the lower lip. Review of the literature and report of five cases.

Actinic prurigo (AP) is a chronic, familial, photodermatitis that primarily affects American Indians. It is more prevalent in young females and may be evident clinically as a pruritic lower lip cheilitis that typically does not respond to conventional therapy. Other clinical features associated with AP include conjunctivitis, alopecia of the eyebrows, and formation of pterygia. The histologic features of AP have been described as nonspecific. We are presenting five cases of AP in which the major clinical manifestation was a pruritic, unsightly lower lip cheilitis. All of our patients were American Indians. Three patients were from the same family. The youngest patient was 10 years old and the oldest was 69 years old. All five cases were characterized histologically by numerous germinal centers within the lamina propria and a dense perivascular plasma cell infiltrate. In four of the five cases, there was a moderate to dense infiltrate of eosinophils. All five patients had been generally unresponsive to conventional therapy. With the exception of the youngest patient, all had had the disease for at least several years. One patient, now deceased, had the lower lip lesion surgically removed for cosmetic reasons. To our knowledge, this is the first report in the dental literature that describes the clinical and histologic features of AP of lower lip.

Adult↗
PubMed1991

Cloning of several lignin peroxidase (LIP)-encoding genes: sequence analysis of the LIP6 gene from the white-rot basidiomycete, Phanerochaete chrysosporium.

A Phanerochaete chrysosporium BKMF1767 genomic library, constructed in the BamHI site of vector YRp12, was screened with the lignin peroxidase(LIP)-encoding cDNAs, CLG4 and CLG5, that have been shown to encode LIP2 (previously H2) and LIP6 (previously H10), respectively. Six distinct LIP genomic clones, designated pGLG1, pGLG2, pGLG3, pGLG4, pGLG5, and pGLG6, were isolated in this study. Probe CLG4 hybridized only to pGLG1. Probe CLG5 gave intense hybridization to pGLG2 and weaker hybridization to clones pGLG3 through pGLG6, but showed little or no hybridization to pGLG1. These results, in agreement with previous biochemical results, indicate the existence of LIP gene subfamilies. The limits and transcriptional orientation of the LIP gene in each clone were determined. The sequence data showed that pGLG2 contains the LIP6 gene, which encodes a protein identical in amino acid (aa) composition to that encoded by CLG5. It contains a leader sequence of 27 aa and a mature protein of 344 aa (Mr 36,607). Archetypal TATA-box-like and CAAT-box-like sequences in the 5'-noncoding region are located 51 and 97 nt upstream from the cDNA start point, respectively. S1 nuclease analysis of the 5' region of LIP6 revealed two transcription start points 8 nt apart downstream from the TATA box. Comparison of the sequence of LIP6 with its corresponding cDNA CLG5 showed that the gene contains nine small introns which range in size from 50 to 62 bp. These introns contained consensus splice junction sequences similar to those reported in other fungal and yeast introns.

Amino Acid Sequence↗