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Familial polyposis coli.
Familial polyposis coli is a syndrome of autosomal dominant inheritance that ultimately causes colonic cancer if untreated. Diagnosis at the presymptomatic stage is imperative. Patients with the disease, as well as family members at risk, need intense support, education, surveillance and follow-up. Benign and malignant extracolonic manifestations, such as osteomas, desmoid tumors, medulloblastomas and glioblastomas, may appear even before the polyposis is clinically evident. When symptoms of the polyps are present, two-thirds of the patients already have colonic cancer.
[On the evolutive potential of recto-colic polyps (anatomo-clinical study)].
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Rationale of surgical management of recto-colonic polyps.
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Colotomy or resection for colonic polyps.
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[Rectocolic polyps and polyposis. Anatomopathologic study].
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[Rectocolic polyps and piolyposis].
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Metastasis and development of malignancy in benign colonic polyps.
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[Apropos of the so-called "degeneration" of pedicular polyps of the recto-sigmoid].
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[Colorectal polyps: nomenclature and therapy].
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[Colorectal polyps and their endoscopic therapy].
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[The preponderant role of the radiologist in the prevention of recto-colonic carcinoma by the detection of polyps (author's transl)].
The adenomatous polyp is considered to be the precursor of recto-colonic carcinoma. The detection of polyps would appear to be ensured with maximum effectiveness by double contrast barium enema and the authors recommend the routine use of this technique for this purpose. The aim of the radiologist should no longer be merely that of the diagnosis of carcinoma of the colon and rectum, but also its prevention by enabling colonoscopic excision of glandular polyps.
Generalized dermal perifollicular fibromas with polyps of the colon.
The cases of 2 siblings with a rare, generalized genodermatosis have been reported, the most conspicuous feature being multiple perifollicular fibromas. In this type of dermal hamartomas, an apparent autosomal dominant trait was noted as well as the association with a small number of colon polyps in one of the patients. The author assumes a distinct dermo-intestinal syndrome not reported hitherto, which can be differentiated from Gardner's syndrome.
Gardner's syndrome - a case report.
Gardner's syndrome is the association of multiple colonic polyps (familial adenomatous polyposis coli - FAP) with sebaceous cysts and jaw osteomas. The significance of this dominantly inherited condition to the dentist is that the colonic polyps usually undergo malignant change by the fourth decade and the extra-intestinal lesions may be apparent before those in the bowel. As such, early detection of multiple jaw osteomas and/or multiple sebaceous cysts (particularly on the scalp) may lead to appropriate further investigation and treatment which might be life saving. Diagnosis of this condition also has implications for other family members.