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[Morphology and histogenesis of so-called fibrous mesothelioma (submesothelial fibroma)].

Clinico-morphological characteristics of a tumor (6 observations) designated in the literature as fibrous mesothelioma are presented. This benign slowly growing tumor appears as an incapsulated dense nodule connected with the visceral layer of the pleura by a thin fibrous "pedicle". Microscopical structure of the tumor consists of outgrowths of monomorphic spindle-shaped cells, hyalinosis foci and abundance of blood vessels in some of its areas. Tumor cells ultrastructurally correspond to fibroblast indicating the connective tissue genesis of the so-called fibrous mesothelioma. This tumor should be distinguished from the group of mesotheliomas and be better called submesothelial fibroma.

Adult↗

Central cementoossifying fibroma of the maxillary sinus: a review of six cases.

We present the radiographic findings of six patients with central cementoossifying fibromas of the maxilla. CT typically demonstrated large, spherical tumors in the maxillary alveolar ridge, filling and expanding the maxillary sinus and extending to involve the ipsilateral hard palate. The central tumors ranged from having soft-tissue density with scattered foci of high density to being heavily calcified.

Adult↗

[Diagnosis and treatment of chondromyxoid fibroma of bones].

Under observation were 23 patients, aged from 9 to 57 years, with chondromyxoid fibroma of bones. All patients were treated surgically. In 5 cases the involved bone was resected, in 6--edge resection with homoplasty and in 7--segmental resection with automoplasty were employed, in 4--amputation, in 1--exarticulation in the coxa. 20 patients are being kept under observation for 1-7 years without any recurrence and metastases, one patients is still being treated. Two patients died as a result of lung metastases.

Adolescent↗

[Central odontogenic fibroma].

Odontogenic fibroma is an infrequent benign tumor, originating in the mesenchyma and including an inactive odontogenic epithelial component. The central form, of which one case is reported here, is expressed by a relatively well-delineated radiolucent area, whose interest and difficulty lie in the differential diagnosis. On the basis of a review of the literature, details are given on the clinical, clinicopathologic, diagnostic and therapeutic data.

Adolescent↗

Pulmonary sclerosing hemangioma in a woman with multiple uterine fibromas, cysts to thyroid and kidney.

Pulmonary sclerosing hemangioma (PSH) is a relatively rare, homogeneous solitary tumor. Its complex histology may suggest a number of malignancies. We report one case diagnosed in a 62-years-old woman with a tendency to benign tumors (uterine fibromas) and cystes (thyroide, kidney). Bronchoscopy was normal. Pulmonary scintiscan was not done. Chest X-ray showed a 2 x 2 cm solitary, dense, homogeneous, delimited nodule of the LLL. The intraoperatory diagnosis of adenocarcinoma led to lobectomy. The final diagnosis of PSH was done on fixed and stained samples. She is in good condition after 13 months of follow-up.

Adenocarcinoma↗

[Chondromyxoid fibroma of the thoracic spine: a case report and review of the literature].

A case of chondromyxoid fibroma (CMF) arising from the 5th right costovertebral junction and spreading into spinal canal causing spinal cord compression is presented. A myelotomography revealed a complete block at T5 level. The patient underwent a decompressive laminectomy with removal of an epidural tumor. This specimen was sent for pathological examination and interpreted as a CMF. The patient had a neurological improvement, post operative MRI revealed a spinal cord free of compression, and we decided on the follow up of the case. Two years later there was recurrence of the tumor. A posterolateral access by costotransversectomy was made and the lesion was resected. The patient had a neurological improvement which persists on the follow up (two years, at present). Clinical, radiologic and histologic findings, surgical management and recurrence are discussed. The pertinent literature is reviewed.

Adult↗

[Fibroma in pregnancy].

In this paper, the authors discuss 51 cases of uterine fibromatosis complicating pregnancy. From resulting data, and from an evaluation of the literature data, there emerges the present tendency to effect a conservative therapy of fibromas complicating a pregnancy.

Adult↗

[Should desmoid fibromas be operated?].

The 30-year experience of P.A. Herzen Moscou Cancer Research Institute in the treatment of soft tissue desmoid fibromas (DF) is summarized. A comparative study of effectiveness of surgical, combined, radiation and medicamentous methods was carried out. Frequency of recurrences after surgical treatment made up 94%, after combined treatment with preoperative radiation it decreased 3-fold (27.5%), in cases of postoperative radiation it made up 53%, and after radiation therapy--15.7%. However radiation therapy may have limitations due to necessity for irradiation of large tumour masses and usage of high-dose ionized irradiation which results in development of postradiation tissue damages. Further research brought about an original chemohormonal therapy (tamoxiphen, vinblastin, methotrexate), which provides stable recovery in 81.3% of patients. Principal positions for management of DF are formulated.

Antineoplastic Combined Chemotherapy Protocols↗