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At least 1,225 records · Page 68Linked to original sources
PubMed1987

Unexpectedly normal cilia and spermatozoa in an infertile man with Kartagener's syndrome.

We investigated a 28-year-old, infertile male patient with the characteristic clinical signs of Kartagener's syndrome (i.e. bronchiectasis, recurrent sinusitis, situs inversus). The patient had tried unsuccessfully for 3 years to become a father, and no cause of infertility was detected in his wife. The functional capacities tested in vitro of nasal and tracheal ciliated cells, spermatozoa and neutrophils were found to be normal. The tracheo-bronchial clearance was not impaired. The ultrastructure of ciliary and flagellar axonemes was normal. This case of Kartagener's syndrome without axonemal abnormalities raises the questions of the factors responsible, on the one hand, for the patient's organ asymmetry and respiratory tract diseases and, on the other hand, for the couple's infertility.

Adult↗
PubMed1987

Immotile cilia syndrome in an aged dog.

An 11-year-old Dalmatian was examined and treated for bilateral nasal discharge and cough of 6 months' duration. Response to medical treatment and surgical intervention was unsatisfactory. Histologic examination of lung tissue revealed chronic severe catarrhal bronchitis and bronchiolitis with bronchiectasis. Histologic findings and barium sulfate bronchography indicated abnormal mucociliary clearance in the respiratory tract. Electron microscopy revealed abnormalities or deletions of outer and/or inner dynein arms in 26% of the ciliary profiles from the affected dog. Similar abnormalities were not found in 500 ciliary profiles from age- and gender-matched control dogs.

Animals↗
PubMed1985

Activation of the nasal cilia. Preliminary study in healthy subjects.

The effect of the drug HR-6 containing adenosine triphosphate in three concentrations and of a placebo on nasal mucociliary function was studied in sixteen healthy subjects. Nasal mucociliary function was measured on both sides of the nose with a radioisotopic method before and after the drug administration. The nasal mucociliary transport rate was increased by the active drug, on the average, by 2.0-3.2 mm/min in all three concentrations and by 0.2 mm/min in the placebo group, when one side of the nose was taken into account. When the average of the mucociliary function rate on both sides of the nose was calculated, the active drugs were found to increase the transport rate from 6.0 to 8.9 mm/min. The results of this preliminary study indicate the need for further studies in patients with impaired mucociliary function.

Adenosine Triphosphate↗