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Premature valve closure in patients with a mitral Starr-Edwards prosthesis and aortic incompetence.

A mitral Starr-Edwards ball valve has, in three patients with concomitant aortic incompetence, permitted recognition of intermittent premature valve closure by auscultation and this has been documented by phonocardiograms. In two instances the observations were confirmed during cardiac catheterization. The features of premature Starr valve closure are described and the mechanism is discussed.

Aortic Valve↗

Appearance of atrial sound after reversion of atrial fibrillation.

To determine the incidence and time of onset of the atrial sound after reversion of atrial fibrillation in patients with myocardial disease, 12 patients with arteriosclerotic heart disease and 4 patients with primary myocardial disease were followed with serial auscultation as well as daily simultaneous apical phonocardiogram, apex cardiogram, and lead II electrocardiogram. Their average age was 52.3 years. Each patient had been in atrial fibrillation for 6 months to 2 years' duration; 13 were reverted to sinus rhythm with DC capacitor discharge and 3 with quinidine sulphate. All 16 patients developed an atrial sound when in sinus rhythm, but only 2 on the day of reversion; the other 14 patients developed an atrial sound on the first to the sixth day after reversion (average third day). The atrial sound persisted in each patient. This study indicates that the atrial sound as a manifestation of diminished ventricular compliance may be absent in patients with myocardial disease immediately after reversion of atrial fibrillation and may later appear as left atrial function improves.

Adult↗

Transmission of audible praecordial gallop sounds to right supraclavicular fossa.

To evaluate the significance of audible gallop sounds in the right supraclavicular fossa we performed simultaneous external heart sound recordings at 50 and 100 Hz at the left ventricular apex, left sternal border, and right supraclavicular fossa in 50 patients with audible gallop sounds at the left ventricular apex. In each patient heart sounds were recorded with a simultaneous jugular phlebogram, apex cardiogram, and carotid pulse tracing. In 44 patients an apical fourth heart sound coincident with the 'a' wave of the apex cardiogram was recorded, and in 32 (73%) the fourth heart sound was audible and recordable in the right supraclavicular fossa. A left ventricular third heart sound, coincident with the rapid filling wave of the apex tracing, was present in 25 patients but was recorded in the right supraclavicular fossa in only 7 (28%). Intracardiac phonocardiography (high-fidelity catheter) was performed in six patients with left ventricular gallop sounds and in each instance arterial transmission of the third or fourth heart sound, or both, was present. Five additional patients had a prominent jugular venous 'a' wave, but only two had a soft parasternal fourth heart sound. Intracardiac phonocardiography in these five patients failed to reveal transmission of right ventricular gallop sounds to the superior vena cava. We conclude that since left ventricular gallop sounds commonly are transmitted to the right supraclavicular fossa auscultation in this area is often helphful in their detection. In addition, a prominent jugular venous 'a' wave sometimes produces recordable presystolic vibrations that are occasionally audible as well.

Clavicle↗

Non-ejection systolic clicks and mitral systolic murmurs in black schoolchildren of Soweto, Johannesburg.

A survey was conducted on 12 050 Black schoolchildren, aged 2 to 18 years, in the South Western Townships of Johannesburg (Soweto), and the prevalence of non-ejection systolic clicks and late systolic murmurs was determined. One or both of these auscultatory findings were detected in 168 children, yielding a prevalence rate of 13-99 per 1000 in the school population. A female preponderance of 1-9:1 was present and there was a strong linear increase in prevalence with age, with a peak rate of 29-41 per 1000 in 17-year-old children. A non-ejection click was the only abnormal auscultatory finding in 123 children (73%) and a mitral systolic murmur in 8 (5%), whereas in 37 (22%) both these findings were present. Of the latter 37 children, the murmur was late systolic in 32; in 5 it was early systolic. Auscultation in different postures was important in the detection of both non-ejection clicks and mitral systolic murmurs. Experience in the detection of these auscultatory findings influenced the frequency with which they were heard. Electrocardiographic abnormalities compatible with those previously described in the billowing mitral leaflet syndrome were present in 11 of 158 children. The aetiology of these auscultatory findings in this community remains unknown. In the same survey, a high prevalence rate of rheumatic heart disease was recorded and the epidemiology of the non-ejection clicks and these mitral systolic murmurs showed similarties to that of rheumatic heart disease. Though the specific billowing mitral leaflet syndrome almost certainly accounts for some of these auscultatory findings, a significant proportion may have early rheumatic heart disease. Further elucidation of this problem is necessary.

Adolescent↗

Variable diastolic rumbling murmur caused by floating left atrial thrombus.

A 53 year old man with a history of rheumatic mitral stenosis was admitted to hospital because of recurrent fainting spells. Auscultation showed a variable diastolic rumbling murmur. Simultaneous echo- and phonocardiograms demonstrated a floating left atrial thrombus; when this passed into the left ventricular inflow tract and obstructed the mitral valve orifice the diastolic murmur disappeared.

Diastole↗

Auscultatory characteristics of normally functioning Lillehei-Kaster, Björk-Shiley, and St Jude heart valve prostheses.

Auscultatory and echocardiographic and phonocardiographic studies were performed on 26 patients who had a total of 11 Lillehei-Kaster, 16 Björk-Shiley, and 18 St Jude heart valve prostheses functioning normally in the aortic or mitral positions or both. With all types and positions of prostheses a distinct closing sound was always detected. It was frequently heard in two parts which, according to echocardiographic and phonocardiographic studies, resulted from the onset and completion of the valve closure. An opening sound could be heard from all Björk-Shiley and St Jude valves but from only four of the 11 Lillehei-Kaster valves. The opening sounds due to mitral prostheses consisted of two to three closely spaced clicks detected as a faint early diastolic crackle on auscultation. Echocardiography with phonocardiography indicated that they were related to the onset and termination of the disc opening excursion. In the aortic position the valves always produced early to mid-systolic murmurs, and a soft early diastolic murmur was also heard in seven of 23 patients. A mid-diastolic rumble was heard in 12 of 22 patients with mitral prostheses. Normally functioning tilting disc valve prostheses produce characteristic auscultatory findings, and familiarity with these findings will be useful in clinical evaluation of patients with these prostheses.

Adult↗

Early diastolic clicks after the Fontan procedure for double inlet left ventricle: anatomical and physiological correlates.

M mode echocardiograms and simultaneous phonocardiograms were recorded in four patients with early diastolic clicks on auscultation. All had double inlet left ventricle and had undergone the Fontan procedure with closure of the right atrioventricular valve orifice by an artificial patch. The phonocardiogram confirmed a high frequency sound occurring 60-90 ms after aortic valve closure and coinciding with the time of maximal excursion of the atrioventricular valve patch towards the ventricular mass. One patient had coexisting congenital complete heart block. The M mode echocardiogram showed "reversed" motion of the patch towards the right atrium during atrial contraction. Doppler flow studies showed that coincident with this motion there was forward flow in the pulmonary artery with augmentation when atrial contraction coincided with ventricular systole. The early diastolic click in these patients was explained by abrupt cessation of the motion of the atrioventricular valve patch towards the ventricular mass in early diastole. In one patient atrial contraction led to a reversal of this motion and was associated with forward flow in the pulmonary artery.

Adolescent↗

Breath sounds in the clinical assessment of airflow obstruction.

In a group of 34 inpatients showing varying degrees of airflow obstruction we studied the relationship between breath sound intensity (BSI) and abnormalities of lung function. The BSI was evaluated by chest auscultation to provide a score, in a manner similar to that described by Pardee et al. (1976), and was found to correlate closely with indices of airflow obstruction of their logarithms such as specific conductance (r = 0.759), maximal expiratory flow at 50% of vital capacity (r = 0.790), forced expiratory volume in one second (r = 0.768), and forced expiratory volume to vital capacity ratio (r = 0.860). Correlations with lung volumes, although statistically significant, were weaker. Multiple correlation studies showed that BSI score correlated independently with indices of both airflow obstruction and lung distension. In our experience, BSI score can be useful not only in the detection but also the quantification of airflow obstruction, although its predictive power is impaired in subjects with associated restrictive disorders. It can also fail to detect mild, pure airflow obstruction.

Adult↗

Pierre Adolphe Piorry (1794-1879): pioneer of percussion and pleximetry.

Piorry was born in Poitiers on 31 December 1794. As a medical student he served in the Napoleonic war in Spain. His teachers in medicine included Corvisart, Bayle, Broussais, and Magendie; he qualified in 1816 with an MD thesis: "On the danger of reading medical text books by the laity"! Laënnec's invention of the stethoscope (1816) and De l' Auscultation Médiate (1819) inspired Piorry to make an analogous contribution to the technique of percussion (which had been originally described by Auenbrugger in his Inventum Novum in 1761 and translated from the Latin into French by Corvisart in 1808). This led to Piorry's invention in 1826 of the pleximeter (le plessimétre) to help outline the internal organs (l'organographisme), which he described inDe la Percussion Médiate (1828). Piorry became renowned as a professor of medicine in many of the great Parisian hospitals (Charité, Pitié, and Hôtel Dieux). In 1832 he was appointed to L'Hospice de la Salpétrière, where he held a famous course of clinical lectures. He wrote prolificly on many aspects of medicine and published more than twenty books. He was, in addition, a poet of some distinction, and wrote a remarkable long poem Dieu, L'Ame et la Nature (1853). Piorry held his neologisms-for example, toxin, toxaemia, septicaemia, etc.-are still in use. This, together with the mixed reception that his advocacy of pleximetry received from his medical contemporaries, made him a controversial figure. He died on 29 May 1879.

Auscultation↗

R T H Laënnec 1781--1826 his life and work: a bicentenary appreciation.

René Théophile Hyacinthe Laënnec was born on 17 February 1781 in Quimper and spent much of his youth in Nantes, where his uncle Guillaume was Dean of the Faculty of Medicine. He was considerably influenced by his uncle and went to study medicine in Paris where he qualified in 1804. Among his teachers were Corvisart and Bayle who stimulated his interest in the clinical diagnosis of diseases of the chest and especially tuberculosis, from which Laënnec himself suffered. His clinical experience and morbid anatomical dissections at the Necker Hospital culminated in his invention of the stethoscope (1816) and the writing of his masterpiece De l'Auscultation Médiate (1819) which may be regarded as the pioneer treatise from which modern chest medicine has evolved. Despite his great success in Paris, laënnec always retained a great love for his native Brittany. When his health finally broke down, he returned to his home Kerlouarnec, near Quimper, and died there on 13 August 1826, aged 45 years. On the occasion of the bicentenary of his birth we pay homage to the memory of this great French physician.

Auscultation↗

Joseph Skoda 1805-81: a centenary tribute to a pioneer of thoracic medicine.

Joseph Skoda was born on 5 December 1805 in Pilsen, Bohemia, and studied medicine in Vienna, where he became professor of medicine in 1846. His clinical researches into cardiopulmonary disease at the Allgemeine Krankenhaus were complementary to the pathological anatomical studies carried out there by Karl von Rokitansky. Skoda had been stimulated by the pioneer work on percussin and auscultation of the Paris school of medicine, but his own researches simplified the classification of physical signs taught by the French masters, Laënnec and Piorry. Skoda's findings were collected in his magnum opus, Abhandlung über Perkussion und Auskultation (1839), in which he described his famous eponymous physical sign, "Skodaic resonance." Skoda was sceptical of the medical treatment then available and was labelled a "therapeutic nihilist." Together with Rokitansky, he helped to make Vienna, for a time, the focal point of medical teaching in Europe. He died on 13 June 1881.

Anniversaries and Special Events↗

Spectral and waveform characteristics of fine and coarse crackles.

Two acoustically different types of lung crackles, fine and coarse, occur in different pathophysiological conditions. To differentiate these crackles from objective characteristics of frequency information, crackles were recorded from 16 patients with pulmonary fibrosis judged clinically to have "fine" crackles and from 10 with chronic bronchitis who had mainly "coarse" crackles. Time expanded waveforms (1/4 cycle duration, initial deflection width, two cycle duration, and 9/4 cycle duration; duration of the first 1/4, 2/4, 8/4, and 9/4 cycles of crackle waveforms) were examined and fast Fourier transform analysis (peak and maximum frequencies) was performed. All waveform measurements for fine crackles were significantly smaller than those for coarse crackles. Peak and maximum frequencies for fine crackles were significantly higher than those for coarse crackles. Although there was some overlap in these values for individual crackles between the two groups when average values of these measurements were calculated for each patient, there was no overlap between fine and coarse crackles and the two groups could be clearly separated. Log peak frequency and log maximum frequency correlated better with 9/4 cycle duration (r = 0.85, 0.84) and two cycle duration (r = 0.87, 0.86) than with 1/4 cycle duration (r = 0.66, 0.77) or initial deflection width (r = 0.67, 0.79). Early and late segments of crackles have different characteristics, probably related to the origin of the sound and the resonance of the lung respectively. These results suggest that spectral and waveform characteristics may help to improve the accuracy of pulmonary auscultation and increase knowledge of how crackles are generated.

Adult↗

Murmurs associated with mitral annular calcification and aortic sclerosis.

BACKGROUND: Auscultation of patients with mitral annular calcification on echocardiography revealed a particular constellation of findings. OBJECTIVE: To test the hypothesis that a particular auscultatory constellation provides a high degree of certainty in diagnosing the combination of mitral annular calcification and aortic sclerosis so often found in the elderly. METHODS: Two groups of patients were studied to evaluate the particular auscultatory constellation under consideration which consisted of: (1) a harsh ejection systolic murmur heard from the 2nd right interspace to the cardiac apex and usually loudest between the 3rd left interspace and the apex; (2) the murmur radiates from the apex towards the left axilla and radiates poorly or not at all from the 2nd right interspace to the neck, and (3) the 2nd heart sound at the cardiac base is normal in intensity, and no ejection clicks are present. Group 1 consisted of patients with mitral annular calcification on echocardiographic examination, and group 2 consisted of patients in whom the particular constellation of auscultatory findings was present and who were then referred for echocardiographic assessment. RESULTS: The particular auscultatory constellation under investigation allowed the diagnosis of the presence of the combination of mitral annular calcification and aortic sclerosis with substantial accuracy. CONCLUSION: The findings in this exploratory study suggest that the pathologic combination of mitral annular calcification and aortic sclerosis can be diagnosed with a reasonably high degree of certainty in elderly patients, if the particular auscultatory configuration is identified.

Aged↗

Limb girdle muscular dystrophy: a non-invasive cardiac evaluation.

The heart was evaluated noninvasively in 20 strictly selected patients with limb girdle muscular dystrophy (LGMD) without cardiopulmonary symptoms. In 80% of the patients (16/20) abnormalities were detected of: cardiac auscultation in 45% (9/20); creatine kinase isoenzyme levels in 40% (8/20); electrocardiogram (ECG) in 50% (10/20); ambulatory 24-hour ECG in 24% (4/17), and echocardiogram in 25% (5/20). Chest radiographs showed normal cardiac shadows and lung fields. In this cross-sectional study there was no correlation between the presence of cardiac abnormalities and patient age, disease duration or degree of weakness. There was no relation between the findings detected by the different techniques. Whether the cardiac abnormalities are related to dystrophic affection of the heart requires pathological study. It is also unclear if these 'benign' abnormalities are indicators of future, potentially dangerous, cardiac disease in LGMD, and whether close follow-up is necessary or beneficial.

Adult↗

Rales in silicosis. A correlative study with physiological and radiological abnormalities.

Pulmonary auscultation, pulmonary function tests and radiological examination were done in 127 hospitalized patients with silicosis. Fine crackle (FC) was heard in 21.3% of patients, coarse crackle (CC) in 28.5%, rhonchi or wheeze (RorW) in 25.2% and friction rub (FR) in 5.5%. In complicated silicosis the incidence of rales was paradoxically lower than in simple silicosis (54.6 vs. 83.3%, respectively, p less than 0.05). In simple silicosis, patients with CC and/or RorW had lower %VC and FEV1/FVC%, but in complicated silicosis, the relation between the presence of rales and pulmonary functional status was not so apparent. These results suggest that in relatively advanced silicosis, all kinds of rales are heard, and in simple silicosis, rales are useful indicators of physiological impairment, but in complicated silicosis, they do not seem to be so useful.

Aged↗

Mitral valve prolapse in patients with prior rheumatic fever.

It is known that rheumatic heart disease frequently results in isolated mitral regurgitation without concomitant mitral stenosis, especially in countries with a high prevalence of rheumatic fever. However, more recent surgical pathologic data also have demonstrated a high incidence of mitral valve prolapse in cases of rheumatic heart disease, which suggests that rheumatic fever may be a cause of mitral valve prolapse. To determine whether this association of mitral valve prolapse and rheumatic heart disease is present in a stable clinic population, we studied 30 patients who had an apical systolic murmur and a well-documented history of rheumatic fever with dynamic auscultation, two-dimensional echocardiography, and pulsed Doppler examinations. Twenty of the 30 patients (67%) had findings on physical examination consistent with isolated mitral regurgitation and 25 patients (84%) had mitral regurgitation by Doppler examination. Echocardiography demonstrated mitral valve prolapse in 24 patients (80%), whereas only one of the total study group had echocardiographic findings consistent with mitral stenosis. We conclude that (1) the presence of an isolated systolic murmur in patients with a history of rheumatic fever frequently represents pure mitral regurgitation secondary to mitral valve prolapse and (2) postinflammatory changes in valvular tissue resulting from rheumatic fever may be the etiology of mitral valve prolapse in these patients.

Adult↗

Prevalence and predictors of audible physiological third heart sound in a population sample aged 36 to 37 years.

BACKGROUND: A physiological third heart sound (S3) is common in youth but allegedly very rare after the age of 40 years. The mechanism of its disappearance is not known. The aim of this work was to study the prevalence and predictors of physiological S3 in a population-based sample of persons approaching 40 years of age. METHODS AND RESULTS: A random sample of 120 persons born in 1954 was invited; 93 (42 men) entered the study. Their physical activity, alcohol and tobacco consumption, and salt intake were quantified by diary follow-up. The presence of an S3 was determined by auscultation and confirmed by phonocardiography. Left ventricular (LV) size, mass, and systolic function were assessed by M-mode echocardiography and LV filling by Doppler velocimetry of transmitral flow. An audible S3 was detected in 22 subjects, 1 of whom had heart disease. The prevalence of physiological S3 was 23.1%. Subjects with physiological S3 had a lower body mass index (22.3 +/- 2.8 versus 24.6 +/- 4.1 kg/m2 [mean +/- SD], P = .005), lower heart rate (63 +/- 7 versus 68 +/- 10 beats per minute, P = .015), higher peak early diastolic transmitral velocity (67 +/- 10 versus 58 +/- 8 cm/s, P = .002), and higher acceleration of early diastolic velocity (717 +/- 148 versus 622 +/- 122 cm/s2, P = .012) than those without S3. No differences were noted in the lifestyle characteristics, blood pressure, or LV mass and systolic function. Body mass index and peak early diastolic transmitral velocity were independent predictors of physiological S3 in logistic regression analysis. CONCLUSIONS: Nearly one fourth of persons approaching their forties still have an audible physiological S3. The presence of S3 is predicted by leanness and a high early diastolic LV inflow velocity; the disappearance of S3 is unlikely to be secondary to increasing blood pressure and relative LV hypertrophy, as is widely presented, but reflects a more primary age-related alteration of LV early diastolic function.

Adult↗