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Charnley total hip arthroplasty with use of improved techniques of cementing. The results after a minimum of fifteen years of follow-up.

Three hundred and fifty-seven consecutive Charnley total hip arthroplasties were performed in 320 patients with use of a so-called second-generation technique of cementing between July 1976 and June 1978. This technique includes use of a distal femoral intramedullary cement plug, hand-mixing of the cement, and use of a cement gun to deliver the cement into the femoral canal in a retrograde fashion. At the time of the latest follow-up evaluation, a minimum of fifteen years after the arthroplasty, 130 patients (142 hips) were still alive, 189 patients (214 hips) had died, and one patient (one hip) had been lost to follow-up. A radiograph was made for 116 (82 per cent) of the 142 hips in the 130 surviving patients. Of the 356 hips that had not been lost to follow-up, thirty-three (9 per cent) had had a revision and two (1 per cent), a Girdlestone resection arthroplasty during the follow-up period. Nineteen hips (5 per cent) were revised because of aseptic loosening of the femoral or acetabular component, or both (two hips); seven (2 per cent), because of loosening with infection; and seven (2 per cent), because of dislocation. The two resection arthroplasties were performed because of loosening with infection; both were done in patients who died before the time of the latest follow-up evaluation. Of the 142 hips in the 130 patients who were alive at a minimum of fifteen years, twenty-two (15 per cent) had been revised: fifteen (11 per cent), because of aseptic loosening; three (2 per cent), because of loosening with infection; and four (3 per cent), because of dislocation. Revision of the femoral component because of aseptic loosening (excluding components that were revised because of dislocation or infection) was performed in four (1 per cent) of the entire series of 356 hips and in three (2 per cent) of the 142 hips in the 130 patients who survived for at least fifteen years. Two of the 356 hips and two of the 142 hips had aseptic loosening of the acetabular as well as the femoral component at the time of the revision. Loosening of the femoral component, defined as aseptic loosening leading to revision or as definite or probable radiographic loosening, occurred in ten (3 per cent) of the 356 hips and in six (5 per cent) of the 116 hips for which radiographs were made at a minimum of fifteen years. The acetabular component was revised because of aseptic loosening in seventeen (5 per cent) of the entire series of 356 hips and in fourteen (10 per cent) of the 142 hips in the 130 patients who survived for at least fifteen years. The acetabular component loosened without infection in forty-one (12 per cent) of the 356 hips and in twenty-six (22 per cent) of the 116 hips for which radiographs were made at a minimum of fifteen years. In two of these patients, the femoral component was also revised. Thus, of the entire series of 356 hips, two had a revision of the femoral component alone because of aseptic loosening; fifteen, a revision of the acetabular component alone; and two, a revision of both components. Of the 142 hips in the 130 patients who survived for at least fifteen years, one was revised for loosening of the femoral component alone; twelve, for loosening of the acetabular component alone; and two, for loosening of both components. These findings demonstrate long-term durability of fixation of the femoral component but less reliable fixation of the acetabular component, even when the surgeon is experienced and improved techniques of cementing are used.

Activities of Daily Living↗

Prospective serial technetium diphosphonate and indium-111 white blood cell labeled imaging in primary uncemented total hip arthroplasty.

Although technetium diphosphonate (TcMP) and Indium-111 white blood cell labeled (Ind-WBC) imaging are reported useful in identifying aseptic and septic loosening in cemented hip arthroplasty, their usefulness has not been identified in uncemented porous coated hip arthroplasty. We attempted to define the natural history of TcMP and Ind-WBC imaging in primary P.C.A. uncemented total hip arthroplasty. Twenty-five hips in 21 patients were scanned immediately postoperatively, at 3 months, 6 months, 12 months, 18 months, and 24 months after surgery with both TcMP and Ind-WBC tracers. Clinical and radiographic follow-up were also obtained at each interval. Intensity and distribution of tracer activity were recorded as well as the time when stabilization occurred around the acetabulum, femoral porous surface areas, and femoral stem tip. Acetabular cup and femoral porous surface areas stabilized in the first year on both TcMP and Ind-WBC imaging. Focal femoral hip activity continued at 24 months in 72% of TcMP and 24% of Ind-WBC images. TcMP and Ind-WBC images used to assess uncemented total hip arthroplasty should not be over interpreted. Although persistent intense activity after one year around the acetabulum and porous surface femoral areas should be considered abnormal for both TcMP and Ind-WBC scans, femoral tip activity is present in the majority of patients, with or without thigh pain, at 24 months on TcMP scans. Tip activity can also persist at 24 months on Ind-WBC images and should be interpreted in conjunction with TcMP images.

Acetabulum↗

Early inpatient rehabilitation after elective hip and knee arthroplasty.

CONTEXT: Inpatient rehabilitation after elective hip and knee arthroplasty is often necessary for patients who cannot function at home soon after surgery, but how soon after surgery inpatient rehabilitation can be initiated has not been studied. OBJECTIVE: To test the hypothesis that high-risk patients undergoing elective hip and knee arthroplasty would incur less total cost and experience more rapid functional improvement if inpatient rehabilitation began on postoperative day 3 rather than day 7, without adverse consequences to the patients. DESIGN: Randomized controlled trial conducted from 1994 to 1996. SETTING: Tertiary care center. PARTICIPANTS: A total of 86 patients undergoing elective hip or knee arthroplasty and who met the following criteria for being high risk: 70 years of age or older and living alone, 70 years of age or older with 2 or more comorbid conditions, or any age with 3 or more comorbid conditions. Of the 86 patients, 71 completed the study. INTERVENTIONS: Random assignment to begin inpatient rehabilitation on postoperative day 3 vs postoperative day 7. MAIN OUTCOME MEASURES: Total length of stay and cost from orthopedic and rehabilitation hospital admissions, functional performance in hospitals using a subset of the functional independence measure, and 4-month follow-up assessment using the RAND 36-item health survey I and the functional status index. RESULTS: Patients who completed the study and began inpatient rehabilitation on postoperative day 3 exhibited shorter mean (+/-SD) total length of stay (11.7+/-2.3 days vs 14.5+/-1.9, P<.001), lower mean (+/-SD) total cost ($25891+/-$3648 vs $27762+/-$3626, P<.03), more rapid attainment of short-term functional milestones between days 6 and 10 (36.2+/-14.4 m ambulated vs 21.4+/-13.3 m, P<.001; 4.8+/-0.8 mean transfer functional independence measure score vs 4.3+/-0.7, P<.01), and equivalent functional outcome at 4-month follow-up. CONCLUSION: These data showed that high-risk individuals were able to tolerate early intensive rehabilitation, and this intervention yielded faster attainment of short-term functional milestones in fewer days using less total cost.

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The pathology of total joint arthroplasty. I. Mechanisms of implant fixation.

The clinical results of total joint arthroplasty are usually excellent, but surgeons, radiologists, and pathologists are often called upon to evaluate, in one way or another, the stability of the implants. These evaluations are aided by an understanding of the basic pathophysiology of total joint arthroplasty. The first part of this two-part review, will summarize the mechanisms whereby total joint implants achieve fixation. The second part will describe and illustrate the most important mechanisms of implant loosening. The "gold standard" for hip and knee arthroplasty is to use polymethylmethacrylate bone cement to anchor the implant to bone, but the optimal surface texture of cemented implants is controversial. Some surgeons advocate a rough implant texture to facilitate bonding between implant and cement; other surgeons prefer a smooth, polished implant to minimize abrasion of cement. Implant loosening can be initiated by particles of cement generated at either the implant/cement, or cement/bone interface. Uncemented implants with porous metal surfaces achieve a variable amount of bone ingrowth, but some designs have excellent clinical results. Maximal bone ingrowth usually occurs along surfaces that are relatively close to cortical bone. Implants with bioactive coatings, such as hydroxyapatite achieve rapid bone apposition. The amount of bone that persists on uncemented implants long-term is determined by many variables, inlcuding the quality of the coating, the overall implant design, and factors that influence local bone remodeling.

Animals↗

Outcome following deep wound contamination in cemented arthroplasty.

Infection remains a devastating complication of joint replacement surgery causing a significant burden to both patient and surgeon. However, despite exhaustive prophylactic measures, intraoperative contamination still occurs during cemented arthroplasty with current infection rates of 1-2%. A study was undertaken to determine the incidence of perioperative contamination in cemented arthroplasty patients, to identify contaminating organisms, to identify contaminated regions within the operative wound, to identify factors associated with increased contamination, and finally to assess the medium-term clinical outcome in patients with confirmed intraoperative wound contamination. Eighty consecutive patients undergoing hip and knee cemented arthroplasty were prospectively enrolled over a 6-month period. All scrubbed personnel wore total body exhaust isolation suits and procedures were carried out in ultra-clean air theatres. Of 441 samples, contamination was identified at 21 sites (4.8%) representing a cohort of 18 patients (22.5%). Longer duration of surgery predisposed to higher contamination rates while lower contamination rates were significantly related to fewer gowned personnel within the ultra-clean system, and fewer total personnel in theatre during the procedure. None of the patients developed clinical evidence of deep prosthetic infection at follow-up. We noted a high incidence of intraoperative contamination despite standard prophylaxis. However, this was not reflected by a similar rate of postoperative infection. This may be due to a small bacterial inoculum in each case or may be due to the therapeutic effect of perioperative intravenous antibiotic prophylaxis.

Anti-Bacterial Agents↗

Functional outcome of fracture neck of femur treated with total hip replacement versus bipolar arthroplasty in a South Asian population.

INTRODUCTION: Endoprosthetic replacement is a popular method of treatment for fracture neck of femur in the elderly. Unipolar, bipolar and total hip endoprosthesis are all used. The aim of this paper is to compare the functional results of bipolar arthroplasty with that of total hip arthroplasty in a South Asian population. MATERIALS AND METHODS: Sixty-one patients who underwent prosthetic replacement for fracture neck of femur between May 1997 and Dec 2002 were followed-up prospectively. Twenty-nine patients were treated with total hip replacement and thirty-two were treated with bipolar arthroplasty. At the time of the last follow-up, twenty-four patients had expired and seventeen could not be traced. The results in the remaining twenty are presented. RESULTS: The period of follow up ranged from 24 months to 90 months, with a mean of 58.5 months. The mean Harris Hip Score for the bipolar group was 86.93, and for the total hip group was 83.82. More than a third of our patient population died within 5 years of endoprosthetic replacement. CONCLUSION: The functional outcome is equally good whether bipolar or total hip replacement is used, in the elderly, in a South Asian population. More than a third of our patient population expired within 5 years of prosthetic replacement; therefore it may be wise to choose the less expensive treatment modality in resource poor countries.

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Is suction drainage necessary after total joint arthroplasty? A prospective study.

A prospective evaluation of 98 patients who had undergone a total hip or knee arthroplasty was conducted to assess the effect of postoperative suction drainage. Sixty-six patients undergoing elective total hip arthroplasty and 32 patients undergoing total knee replacement were randomly allocated to undergo either suction drainage or no drainage of the wound. Statistical analysis of the results showed no difference in wound healing, severity of wound haematoma, postoperative blood transfusion requirement, range of motion and duration of the hospitalization between the two groups. We conclude that the use of closed suction drainage provides no apparent advantage after uncomplicated total hip or knee arthroplasty.

Adult↗

Reduction of blood loss using tranexamic acid in total knee and hip arthroplasties.

There have been several attempts to reduce postoperative blood loss in patients undergoing total arthroplasty. Benoni et al. reported the usefulness of tranexamic acid in total knee arthroplasty (TKA). We investigated its effect in TKA and total hip arthroplasty (THA). Blood loss was significantly reduced in patients given tranexamic acid in both the TKA and THA groups, and no severe complications, such as venous or pulmonary thrombosis, were noted in any of the patients who received the agent. Administration of tranexamic acid seems to be useful for reducing postoperative blood loss in TKA and THA.

Antifibrinolytic Agents↗

Targeted postoperative care improves discharge outcome after hip or knee arthroplasty.

OBJECTIVE: To determine whether targeted postoperative care, based on preoperative risk assessment, can increase the number of patients who are discharged home directly from acute care after elective hip or knee arthroplasty. DESIGN: Quasiexperimental with historical control. SETTING: A public university teaching hospital. PARTICIPANTS: One hundred patients who had an elective hip or knee arthroplasty. INTERVENTIONS: Between January and July 2001, 50 patients had their risk of discharge to extended inpatient rehabilitation assessed preoperatively with a newly developed Risk Assessment and Prediction Tool (RAPT). Postoperative management was targeted on the basis of the identified level of risk. Results were compared with those of a similar group of 50 patients treated between January and July 2000. MAIN OUTCOME MEASURES: Discharge destination, length of stay (LOS), and readmission rates. RESULTS: The percentage of patients discharged directly home increased significantly, from 34% during 2000 to 64% in 2001 (P=.002), with no increase in readmission rates in the 12 months postdischarge. In addition, the mean acute hospital LOS decreased by 1.1 days to 7.5 days in 2001 (P=.02). CONCLUSIONS: Use of the RAPT and targeted postoperative care resulted in more patients being discharged directly home after hip or knee arthroplasty while hospital LOS further decreased.

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Determinants of the subjective functional outcome of total joint arthroplasty.

The aim of the study is three-fold: (i) to analyze association between early subjective functional outcome of total joint arthroplasty (TJA) and patient-related risk factors; (ii) to evaluate the six-month subjective functional outcome of TJA as compared with subjective functional status of non-operated outpatients; (iii) to evaluate TJA self-perceived amelioration rates compared to the status of an age-matched sample from a general medical practice. A prospective consecutive study was performed upon 100 elderly inpatients with recent primary total hip arthroplasty (THA) or total knee arthroplasty (TKA) for osteoarthritis. Interviews on preoperative status and short-term outcome were performed at admission and six months after surgical intervention with Western Ontario and MacMasters Universities Osteoarthritis Index (WOMAC). One hundred aged-matched consecutive outpatients were screened for osteoarthritis and interviewed with the same questionnaire in a single session. Differences between baseline and follow-up scores were evident and statistically significant for both TJA groups, although THA patients showed more improvement. The comparison between TJA patients at baseline and age-matched osteoarthritis outpatients highlighted less impairment among outpatients. The situation reversed six months after the intervention. Objective functional outcome of post-operative rehabilitation has not revealed predictive value for the six-month outcome of TJA in terms of self-perceived functional status. Logistic regression analysis indicated that preoperative status was the only significant predictor of higher WOMAC scores six months after TJA. The survey confirms the early benefit of THA or TKA for osteoarthritis, but a less favorable subjective functional outcome is expected at six months when preoperative subjective functional status is severely compromised.

Activities of Daily Living↗

Self-perceived distress and self-perceived functional recovery after recent total hip and knee arthroplasty.

The research was aimed at verifying whether psychological distress and depression are associated to reduced functional improvement following arthroplasty. Thirty-six patients with total knee arthroplasty (TKA) and 36 patients total hip arthroplasty (THA) were enrolled at the beginning of their rehabilitation. The mean age in TKA patients was 71.3+/-7.8 years (S.D.). The mean age in THA patients was 67.9+/-8.4 years. The Western Ontario and MacMasters Universities Osteoarthritis Index (WOMAC) and the Hospital Anxiety and Depression (HAD) were applied. Forty-four percent of THA and 58% of TKA showed over-threshold HAD scores at admission. The proportion was even higher considering HAD-Depression sub-scale, where 55% of THA and 61% of TKA patients had over-threshold scores. Lack of depression prompted better functional outcome in TKA. The effect of depression on TKA functional improvement was still significant after adjusting for age and sex. No association was found for THA patients. In order to maximize rehabilitation benefit it is then suggested that patients with recent TKA intervention are screened for distress and depression at admission and that psychological symptoms are treated if over-threshold.

Activities of Daily Living↗

Postoperative management after total hip and knee arthroplasty.

Despite major advances in the field of total joint arthroplasty, a standardized postoperative management protocol currently does not exist following total hip arthroplasty (THA) and total knee arthroplasty (TKA). A survey was mailed to the active members of the American Association of Hip and Knee Surgeons to investigate issues such as postoperative rehabilitation and activity restriction. The information derived from this survey provides the total joint surgeon with a compilation and consensus of responses that can serve as the foundation for a standardized postoperative protocol for THA and TKA surgery.

Activities of Daily Living↗

Ileus following total hip or knee arthroplasty is associated with increased risk of deep venous thrombosis and pulmonary embolism.

Venous thromboembolic disease (VTD), deep venous thrombosis and pulmonary embolism, causes morbidity and mortality following total hip and total knee arthroplasties, while ileus complicates up to 4.0%. The clinical courses of 2,949 patients undergoing 3,364 consecutive primary and revision total hip and total knee arthroplasties, radical debridements, and reimplantations at one institution over a 2-year period were reviewed to examine the relationship between ileus and VTD. VTD prophylaxis consisted of aspirin and intermittent plantar pulse boots for all patients except those at high risk, who received parenteral chemical prophylaxis and boots. Ileus occurred in 62 patients (2.1%) and symptomatic DVT in 51 (1.7%). With ileus, the incidence of DVT was 8.1%: odds ratio 5.5 (P =.0036). Symptomatic pulmonary embolism occurred in 7 patients (0.24%); with ileus the incidence was 3.2%: odds ratio 19.6 (P =.0082). A significant increase was observed in rates of VTD with ileus. We recommend using parenteral chemical and mechanical prophylaxis in patients with ileus following total hip and total knee arthroplasties.

Arthroplasty, Replacement, Hip↗

Intramedullary total femoral replacement for salvage of the compromised femur associated with hip and knee arthroplasty.

Severely compromised femora because of prosthetic loosening, osteolysis, or periprosthetic fracture around total hip and knee arthroplasties are increasing. Two approaches that create an intramedullary total femoral (IMTF) replacement are reported. Twenty-three IMTF replacements in 22 patients were performed at 2 institutions. Seven revision total knee arthroplasties with a stemmed component were linked to a well-fixed hip stem with a custom intramedullary sleeve. Sixteen IMTF replacements involved revision of both hip and knee arthroplasties which were connected via an intercalary segment with morse taper junctions. Follow-up averaged 36 months. Complications included 2 dislocations, 2 deep infections, and 2 knee revisions for tibial loosening. Advantages over conventional total femoral replacement or ORIF include less dissection, maintenance of soft tissue attachments, and immediate component stability to allow for early mobilization.

Aged↗

Obesity and perioperative morbidity in total hip and total knee arthroplasty patients.

The incidence of obesity in 1071 total hip arthroplasty (THA) patients and 1813 total knee arthroplasty (TKA) patients and its effect on perioperative morbidity were evaluated prospectively. Fifty-two percent of TKA and 36% of THA patients were obese (body mass index >or=30). The obese patients were significantly younger, with a higher proportion of obese TKA patients being women. Higher rates of diabetes and hypertension were found in obese patients. Higher postoperative infection rates were observed in patients with body mass index 35 or higher. The odds ratio was 6.7 times higher risk for infection in obese TKA patients and 4.2 times higher for obese THA patients. The increased risk of infection in obese patients undergoing total joint arthroplasty must be realized by both the patient and surgeon.

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Preoperative or postoperative self-efficacy: which is a better predictor of outcome after total hip or knee arthroplasty?

OBJECTIVE: Self-efficacy is considered an important determinant of outcome after total hip or knee arthroplasty. Aim of this study is to evaluate the contributions of preoperative and short-term postoperative self-efficacy in predicting long-term outcome. METHODS: Self-efficacy was determined in 103 total hip and knee arthroplasty patients preoperatively and 6 weeks postoperatively with the Self-Efficacy for Rehabilitation Outcome Scale (SER). The 6-month outcome was assessed with a disease-specific and a generic self-report questionnaire and an objective measure of function (walking speed). Multiple linear regression analyses were used to examine the value of preoperative and short-term postoperative self-efficacy in predicting 6-month outcomes. RESULTS: Preoperative self-efficacy was only a significant predictor of long-term postoperative walking speed, with higher self-efficacy resulting in faster walking speed at the long-term measurement (R(2)=0.47). Short-term postoperative self-efficacy was a significant predictor of the long-term postoperative generic outcome measure (physical functioning: R(2)=0.30; mental health: R(2)=0.53) and of walking speed (R(2)=0.66), with higher self-efficacy resulting in a better long-term outcome. CONCLUSION: Short-term postoperative self-efficacy seems a better predictor of long-term outcome after total hip or knee arthroplasty than preoperative self-efficacy. PRACTICE IMPLICATIONS: Interventions should focus on enhancing short-term postoperative rather than preoperative self-efficacy.

Activities of Daily Living↗

Duration of anesthesia and venous thromboembolism after hip and knee arthroplasty.

OBJECTIVE: To determine whether longer duration of anesthesia predisposes patients undergoing orthopedic surgery to venous thromboembolism (VTE). PATIENTS AND METHODS: We conducted a secondary analysis of a retrospective case-control study that examined risk factors for postoperative VTE in postmenopausal women. We matched women aged 50 years and older with radiographically confirmed postoperative VTE (cases) by age, surgeon, year of surgery, and surgical joint (knee vs hip) with women without postoperative VTE (controls). Duration of anesthesia, operative variables, demographic data, comorbid illnesses, and laboratory data were determined by medical record review. RESULTS: Eighty-eight cases were matched with 181 controls. Duration of anesthesia of 3.5 hours or longer (corresponding to the upper tertile of patients) was strongly associated with postoperative VTE compared with a shorter duration of anesthesia (odds ratio, 3.58; 95% confidence Interval, 2.11-6.16; P < .001). This relationship was maintained after controlling for multiple covariates with propensity score methods, Including type of arthroplasty, route of anesthesia, type of antithrombotic prophylaxis, and surgical approach. In multivariate analysis, the Important predictors of VTE included anesthesia duration of 3.5 hours or longer, type of antithrombotic prophylaxis, revision (vs primary) arthroplasty, and allogeneic blood transfusion. CONCLUSION: We found a marked association between the duration of anesthesia and postoperative VTE in patients undergoing Joint arthroplasty. Although it is possible that unmeasured intraoperative variables account for this relationship, we suggest that duration of anesthesia may be an important risk factor for postoperative VTE after orthopedic surgery.

Anesthesia↗

The effect of intraoperative intravenous fixed-dose heparin during total joint arthroplasty on the incidence of fatal pulmonary emboli.

All patients who underwent primary total knee arthroplasty (TKA), revision TKA, primary total hip arthroplasty (THA), and revision THA between January 1, 1990, and December 31, 1996, were retrospectively reviewed to determine the incidence of fatal pulmonary emboli. All TKA patients received 1,000 U of intravenous heparin sodium before the tourniquet was inflated and an additional 500 U of intravenous heparin sodium before the inflation of the second tourniquet during bilateral TKA. All THA patients received 1,000 U of intravenous heparin sodium at the time of the skin incision and 500 U of intravenous heparin sodium before preparation of the femoral canal. The overall incidence of fatal pulmonary emboli was extremely low (TKA, 0.096%; THA, 0.16%). With this regimen of intravenous intraoperative heparin, postoperative aspirin, thromboembolic disease hose, and early ambulation, there is no risk of postoperative bleeding, it is inexpensive, and there is no concern on how long to keep the patients on this regimen postoperatively. We recommend this regimen for the prevention of fatal pulmonary emboli after total joint arthroplasty.

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