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PubMedDate not supplied

Immunology and immunogenetics in metabolic diseases.

The first part of the work reviews some general data regarding the HLA system and emphasizes the principal implications of this system in diabetes mellitus and other metabolic diseases. Part two discusses pathoimmunological mechanisms in metabolic pathology (on the one hand those linked to autoimmunity, on the other those linked to immunologic deficiency of enzymatic origin). Finally, some immunologic aspects in the treatment of metabolic diseases are outlined.

Antibody Formation↗
PubMed1985

Immunogenetic studies of recurrent spontaneous abortions in humans.

31 clinically defined couples suffering between 3 and 17 consecutive idiopathic spontaneous abortions have been studied. The female partners demonstrated a lower frequency than expected of serum lymphocytotoxic antibodies. Sharing of HLA-A, B or DR antigens was not significantly increased overall within these couples compared with controls, although two couples did show marked HLA sharing (greater than or equal to 4 antigens shared at HLA-A, B and DR loci). There was increased apparent HLA-A and HLA-B locus homozygosity in these women compared with controls (p less than 0.02 and p less than 0.005, respectively), with no significant apparent homozygosity either at HLA-DR or in the males. An increased prevalence of HLA-A, B and DR antigen phenotypes characteristic of various extended haplotypes was also observed in these couples.

Abortion, Habitual↗
PubMed1977

Immunogenetic studies on the rhesus monkey (Macaca mulatta): XI use of blood groups in problems of parentage.

A battery of 21 alloimmune blood typing reagents was developed and used for resolving cases of disputed parentage in the rhesus monkey (Macaca mulatta). Using these reagents, the breeding records of a large colony of rhesus monkeys were monitored. Among 1263 complete families typed, 46 (3.6%) disputed parentage cases were discovered by excluding an assigned parent. Of these disputed parentage cases, 76% were resolved and the most probable parents assigned. In addition, the paternity of 63% of the infants born into a man-made troop which included several unrelated adult males was determined. The probability of excluding an incorrectly assigned (randomly chosen) male as a father was calculated as 73% when all 21 reagents are employed.

Alleles↗