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[Comparative epidemiologic analysis of multiple sclerosis in areas of Central and Southern Europe].

Epidemiological data concerning multiple sclerosis (MS) and collected by roughly the same methods in the regions of Rostock (GDR) and Schumadija-Pomoravlje (Yugoslavia) are presented. In both regions the females were earlier and more frequently attacked than the males; possible genetic, etiopathogenetic and other factors are discussed. The age at which the disease becomes manifest is about the same in both regions and was 30.9 and 30.8 years respectively. A prevalence of 60.4 and an incidence of 2.9 per 100 000 inhabitants were calculated for the Rostock region. The corresponding data for the Yugoslavian region were 20.3 (prevalence) and 0.89 (incidence). The disease is more common among the urban than among the rural population in Yugoslavia; the comparison of mortality due to MS revealed no appreciable differences.

Adult↗

[The dental status of schoolchildren from abroad in Canton Zurich 1992 to 1994].

Between 1992 and 1994 DMF-experience was determined in several hundred schoolchildren from the City of Zurich and 16 small communities distributed over the whole Canton. Immigrants were distinguished from permanently resident children with respect to their length of residence. Children who had arrived after the age of 5 or 6 (kindergarten-age) showed higher caries prevalence; e.g., at the age of 12, 2.00 (16 communities) and 3.14 (City of Zurich) as compared to 1.13 and 1.24 DMFT. Children in special classes for learning German, who had arrived from former Yugoslavia the year before, had 3.64 DMFT at the age of 12. All the children, whether Swiss nationals or non-citizens, who were integrated into the school dental service of the City, had satisfactory treatment levels. In contrast, recent immigrants from former Yugoslavia had about half of their diseased teeth unfilled and often badly destroyed. Therefore, fortnightly tooth-brushings were introduced as a first measure to lower caries activity.

Adolescent↗

[Personal experience in the treatment of tuberculosis in patients in war areas].

In the four-year period (1991-1995), 96 tuberculosis patients from the war areas of former Yugoslavia were treated in the Clinic for Lung Diseases of Military Medical Academy, that makes 31% of total number of sick and treated for tuberculosis-309 (100%). In group I (patients from war areas) there were 45 cases of cavernous pulmonary tuberculosis (47%), 28 bilateral (29%), 16 pleurisy (16.7%) and 6 cases of extensive pulmonary tuberculosis (5.1%). Among 213 patients (100%) from group II (patients from FR Yugoslavia), 81 patients had cavernous pulmonary tuberculosis (38%), 49 patients had bilateral (23%), 33 patients had pleurisy (15.5%) and 6 patients had extensive pulmonary tuberculosis (2.8%). In group I the diagnosis was bacteriologically and/or histopathologically proved in 94.8% cases: by finding of acid-resistant bacilli in sputum and other biological materials in 69 patients (72%), by positive Löwenstein's cultures in 73 patients (76%) and by histopathological result of tuberculosis inflammation in 34 patients (35.4%). In group II tuberculosis was bacteriologically and/or histopathologically proved in 134 patients (63%) by acid-resistant bacilli in sputum and other biological materials, in 141 patient (66%) by positive Löwenstein's culture and in 71 patient by positive histopathological results. Pulmonary tuberculosis in war areas is characterized by greater frequency of severe clinical forms (cavernous, bilateral and extensive) and by high direct bacillarity.

Adult↗

Posttraumatic growth after war: a study with former refugees and displaced people in Sarajevo.

Research carried out with survivors of a variety of different traumata indicates that a large proportion of them perceive positive changes in themselves after the trauma. This study investigated whether posttraumatic growth also could be found among people who had been exposed to particularly severe traumata over a period of several years (1991 to 1995) during the war in the area of the former Yugoslavia. Included in the study were two representative samples of adult former refugees and displaced people who lived anywhere in former Yugoslavia before the war and were currently living in Sarajevo, Bosnia and Herzegovina, three and a half years after the war. The main instrument was a new Bosnian translation of the Posttraumatic Growth Inventory. Results indicated some differences in the factor structure as compared with the original instrument. The overall means for the scale were considerably lower than reported in most studies on other kinds of trauma. Younger people reported considerably more growth than older people.

Adaptation, Psychological↗

The acetylcholinesterase reactivator HI-6 (1-[[[4-(aminocarbonyl)pyridinio]methoxyl]methyl]- 2-[(hydroxyimino)methyl]-pyridinium dichloride): a comparative study of HI-6 samples from various sources.

A comparison of the chemical purity, toxicology and potency of HI-6 (1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2- [(hydroxyimino)methyl]-pyridinium dichloride) obtained from various sources (Canada, Israel, Yugoslavia, The Netherlands, United Kingdom) was performed. There were no significant differences between HI-6 obtained from Israel, Yugoslavia, The Netherlands and Canada regarding their potency, when combined with atropine, as an antidote of organophosphate poisoning. HI-6 obtained from the United Kingdom was significantly more toxic and less potent than any of the other HI-6 samples. In addition, the results of this study showed that there was no significant difference between HI-6 prepared as a laboratory batch and HI-6 prepared commercially with regards to chemical purity, toxicology or potency.

Animals↗

[Vaccination status and sociodemographic variables in Viennese public school students].

A representative sample of 585 children, attending 2nd grade elementary school in Vienna, was examined. Vaccination certificates were collected, the parents' attitudes towards recommended vaccinations and data on sociodemographic variables were obtained by questionnaire. Compared to 95.9% of the less educated only 90.4% of the higher educated parents are interested that their children receive all vaccinations recommended (p < 0.01). When the dominant country equals "Austria", parents are more reluctant (p < 0.05) to have their children vaccinated (80.4%), compared to others (former Yugoslavia 92%, Turkey 90.9%, other countries 93.1%). A complete immunization against Diphtheria, Tetanus and Poliomyelitis (DT/OPV) was observed in 65.3% of the children. DT/OPV and additionally Mumps and Measles (MM) in 54% and DT/OPV + MM and Pertussis in 43.8% respectively. The immunization coverage is significantly higher (p < 0.01) in children with the dominant country = Austria (DT/OPV 70.7%, DT/OPV + MM 61.8%, DT/OPV + MM + Pertus sis 51.1%) compared to children from former Yugoslavia (DT/OPV 56.3%, DT/OPV + MM 34.5%, DT/OPV + MM + Pertussis 24.1%), Turkey (DT/OPV 54.5%, DT/OPV + MM 40.9%, DT/OPV + MM + Pertussis 33.3%), and "other countries" (DT/OPV 41.4%, DT/OPV + MM 34.5%, DT/OPV + MM + Pertussis 24.1%).

Austria↗

A comparative study of Diaporthe/Phomopsis fungi on soybean from two different regions of the world.

A comparative study was conducted with soybean material presenting symptoms of the Diaporthe/Phomopsis complex that was collected in two distant geographical regions of the world: Beltsville, MA, USA, and Vojvodina, Yugoslavia. Contrasting with earlier findings, great variability in the disease symptoms was observed, and one or more Phomopsis species could be isolated from lesions presenting similar characteristics. Among the thirty-three isolates obtained from the lesions the following species were identified: D. phaseolorum var. caulivora, P. phaseoli (teleomorph D. phaseolorum var. sojae, rare), P. longicolla (found for the first time on the soybean fields of Yugoslavia), Phomopsis sp., and one culture showing intermediate characters of D. phaseolorum var. caulivora and D. phaseolorum var. sojae. Much diversity was also found in the cultural characters of the the isolates from both localities, presumably indicating evolutionary and adaptation processes.

Journal Article↗

The inverse relation of average population blood pressure and stroke mortality rates in the seven countries study: a paradox.

This study attempts to explain the unexpected finding of an inverse population (ecological) relationship between mean systolic blood pressure levels and stroke death rates in 25 years follow-up of the Seven Countries Study, a cross-cultural study of cardiovascular disease. Sixteen cohorts of all men aged 40-59 in seven countries (one cohort in the USA, two in Finland, one in the Netherlands, three in Italy, two in Croatia (former Yugoslavia), three in Serbia (former Yugoslavia), two in Greece, two in Japan) were surveyed from 1958 to 1964. Risk factors and personal characteristics were measured and follow-up for vital status and cause of death was then carried out over 25 years. Analyses were based on comparisons of mean levels of risk factors and death rates within and among the 16 cohorts. Mean entry population levels of systolic blood pressure among the cohorts were strongly and inversely related with their 25-year stroke death rates (R -0.55; CI -0.81 and -0.06; p = 0.0276). Within cohorts in contrast, the individual relation of blood pressure and stroke was strongly positive and significant in 14 of the 16 cohorts. Mean population levels of serum cholesterol were inversely and strongly related to stroke death rates (R -0.79; CI -0.92 and -0.46; p = 0.0003), while the partial correlation coefficient of systolic blood pressure, computed in models including serum cholesterol, became small and not significant (-0.05; CI -0.55 and +0.48; p = 0.8537). Age at death for stroke (average 68.9 +/- 7.1 years) was significantly higher than age at dath from myocardial infarction and sudden death (average 65.8 +/- 7.8 years) suggesting a competition effect between the conditions. Multivariate models including population average systolic blood pressure and serum cholesterol provided no added explanation for the lack of direct and significant relationship of population blood pressure with stroke death rates. They were based on these variables: age at stroke death, age at myocardial infarction death or and sudden death, death rates from myocardial infarction and sudden death, the interaction term of systolic blood pressure with serum cholesterol and the multivariate coefficients for systolic blood pressure from Cox models run in individuals. Similar findings were obtained using diastolic instead of systolic blood pressure and excluding the Japanese cohorts. The paradox of the inverse ecologic relation of population blood pressure and stroke mortality and a direct relation for individual is only partly explained by the cofounding effect of population mean serum cholesterol levels. An effect of low cholesterol levels on excess stroke mortality cannot be excluded. A major limitation of the study was our inability to segregate thrombotic from heamorrhagic strokes.

Adult↗

Differences in body fat and central adiposity between Swedes and European immigrants: the Malmö Diet and Cancer Study.

OBJECTIVE: Comparative data on ecological differences in body fatness and fat distribution within Europe are sparse. Migration studies may provide information on the impact of environmental factors on body size in different populations. The objective was to investigate differences in adiposity between European immigrants and native Swedes, specifically to examine gender differences and the effect of time since immigration, and to compare two selected immigrant groups with their native countrymen. RESEARCH METHODS AND PROCEDURES: A cross-sectional analysis of 27,808 adults aged 45 to 73 years participating in the Malmö Diet and Cancer prospective cohort study in Sweden was performed. Percentage body fat (impedance analysis) and waist-hip ratio (WHR) were compared between Swedish-born and foreign-born participants. RESULTS: Obesity was 40% more prevalent in non-Swedish Europeans compared with Swedes. Controlling for age, height, smoking, physical activity, and occupation, it was found that women born in the former Yugoslavia, southern Europe, Hungary, and Finland had a significantly higher percentage of body fat, and those from Hungary, Poland, and Germany had more centralized adiposity compared with Swedish women. Men born in the former Yugoslavia, Hungary, and Denmark had a significantly higher mean percentage of body fat compared with Swedish-born men, whereas Yugoslavian, Finnish, and German men differed significantly in mean WHR. Length of residence in Sweden was inversely associated with central adiposity in immigrants. A comparison between German and Danish immigrants, their respective native populations, and Swedes indicated an intermediate positioning of German immigrants with regard to body mass index and WHR. DISCUSSION: Differences in general and central adiposity by country of origin appear to remain after migration. Central adiposity seems to be more influenced than fatness per se by time of residency in Sweden.

Adipose Tissue↗

Forensic investigations in Kosovo: experiences of the European Union Forensic Expert Team.

The international community has intervened ethnic hostilities in Kosovo, the Federal Republic of Yugoslavia. A team of Finnish forensic experts worked in December 1998 and January 1999 in Kosovo under the mandate of the European Union. The team investigated human remains from three locations of alleged ethnic violence. Concerning the events in Klecka, Volujak and Racak, the International Criminal Tribunal for the former Yugoslavia received documents of great gravity. The standard methods of forensic pathology were complemented with radiological, forensic odontological, physical anthropological and molecular genetic investigations.

Journal Article↗

[Prevalence of caries, fissure sealants and filling materials among German children and children of migrants].

The aim of this study was to collect information on dental health and dental care of German children and children of migrants for planning oral health promotion in the Rems-Murr-district. To meet this aim all first and fourth degree children in primary and special schools were examined. The dmft- and DMFT-Index, the number of fissure sealants, the filling material used and the children's nationality were recorded. The dmft of 6- and 7-year-olds was 1.50 among Germans, 4.61 among German migrants from Russia, 4.02 among Turks, 4.05 among children from former Yugoslavia, 2.35 among Italians, 1.95 among Greeks and 3.76 among children of other nationalities. At the age of 9 to 10 years Germans had an average of 0.31, German migrants from Russia 0.77, Turks 1.19, children from former Yugoslavia 1.32, Italians 0.64, Greeks 0.69 and children of other nationalities 0.57 DMF-teeth. In both age groups the proportion of caries-free children was highest among Germans and lowest among Turks. Also, more migrants than Germans were referred to a dentist for caries treatment. Compared to the Germans fewer migrants had at least one tooth sealed. The proportion of amalgam fillings to the total number of fillings was higher among 9- and 10-year-olds of Turkish, Italian or Yugoslavian origin than among other nationalities. The results of this study show that further development of oral health promotion programmes for children and parents with Turkish and Russian cultural background has the top-most priority.

Child↗

Cytoplasmically inherited reproductive incompatibility in Tribolium flour beetles: the rate of spread and effect on population size.

This paper reports on the effects of a cytoplasmically inherited reproductive incompatibility in different genetic strains of the flour beetle, Tribolium confusum. We measured the rate of spread and the effect of host population size using different initial frequencies of infection with a cytoplasmic factor that mediates reproductive incompatibility. There were two experiments, in one the infected and uninfected lines were from the same genetic strain, b-Yugoslavia. In the other, the infected line was from the "high cannibalism" bIV strain and the uninfected line from the "low cannibalism" bI strain. We estimate that the fitness ratio of infected to uninfected in b-Yugoslavia is 0.63 and the observed rate of spread for this strain corresponds to a model of cytoplasmic inheritance that takes into account the productivity differences between the infected and cured lines. In the bI-bIV experiment, because the uninfected and infected lines are from different genetic strains, we cannot partition the effects of the cytoplasmic factor from other factors. The rate of spread in the bI-bIV experiment is faster in males and slower in females than predicted from a model of cytoplasmic inheritance. In both experiments, productivity varies with initial infection frequency; however, the relationship is not explained by a simple model that predicts lower population size at intermediate infection frequencies.

Animals↗

Changes in population cholesterol levels and coronary heart disease deaths in seven countries.

BACKGROUND: Are trends in coronary heart disease deaths based on risk factor changes? OBJECTIVE: To study the relationship between trends in coronary deaths and changes in blood cholesterol in the Seven Countries Study. MATERIAL AND METHODS: Sixteen cohorts of men aged 40-59 years from seven countries (U.S.A., Finland, the Netherlands, Italy, Croatia (former Yugoslavia), Serbia (former Yugoslavia), Greece, Japan) were units for the analyses of serum cholesterol measured at entry and after 5 and 10 years, and for mortality over 25 years. RESULTS: In the populations, the ecological relationship of mean serum cholesterol at entry to late coronary heart disease death rates during the 10- to 25-year follow-up was weak, with an R-square of 0.31. Cholesterol measurements made at year 10, and an indicator of cholesterol change during the first 10 years, increased the association (R-square, 0.49). A negative and significant interaction was shown between baseline population cholesterol levels and their 10-year change. As an indicator of acceleration in mortality, cholesterol change over 10 years was also positively correlated (partial R-square 0.44) with the ratio of 25-year to 5-year deaths. CONCLUSIONS: In the Seven Countries Study, late coronary heart disease death rates are largely "explained' by changes in blood cholesterol levels during the early phases of the study, mainly due to increases in lower cholesterol levels among some cohorts.

Adult↗

The incidence and outcome of penetrating and blunt trauma in central Bosnia: the Nova Bila Hospital for War Wounded.

OBJECTIVES: Since February 1992, the civil war in the former Yugoslavia has left over 140,000 people dead. This study describes the injuries and outcome of patients treated at a provisional war hospital in Bosnia and compares mortality rates with war hospitals from prior armed conflicts. DESIGN: This is a retrospective review of 1,703 trauma patients treated between March 1993 and October 1993 at the Nova Bila War Hospital. RESULTS: In Bosnia, the overall mortality was 10.3% (5.0% dead on arrival and 5.3% inhospital deaths). Head injuries, seen in 19.2% of patients, had a mortality of 23.8%. The odds of sustaining a gunshot wound were 2.8 times greater in Bosnia than in Vietnam (p < 0.05). The odds of sustaining a head injury were 1.1 to 1.6 times greater in Bosnia than in Lebanon and Afghanistan (p < 0.05). The overall mortality odds in Bosnia were 3.1 times greater than in Vietnam (p < 0.001), but were equal to those in Lebanon and Afghanistan. CONCLUSIONS: Despite limited personnel and supplies, the inhospital mortality rate was comparable with those found in other war hospitals. The Nova Bila Hospital represents a unique response to the great medical need brought about by the continued fighting in the former Yugoslavia.

Adolescent↗

Overview: epilepsy surgery in developing countries.

Epilepsy surgery (ES) is addressed in relation to economic classifications of national resources and welfare in developing countries. A decade ago, ten developing countries conducted ES; now 26 such countries have reported results of ES. A number of international authorities define indicators of national economic welfare. Adopting the economic classification of the International Monetary Fund. we find that ES is nonexistent in 98% of African countries, 76% of Asian countries, 58% of European countries, 82% of Middle East countries, and in 86% of countries of the Western Hemisphere. The 1980-1990 global ES survey conducted by the International League Against Epilepsy identified ten developing countries reporting ES (DCRES): Brazil, China, Czechoslovakia, Hungary, Mexico, Poland, Taiwan, the U.S.S.R., Yugoslavia, and Viet Nam. The present survey based on the proceedings of the 19th-23rd International Epilepsy Congresses and Medline reports from 1991 to November 1999 revealed at least 26 (18.3%) DCRES of 142 developing countries: Argentina, Brazil, Chile, China, Colombia, Czech Republic, Egypt, Estonia, Hungary, India, Iran, Israel, Korea, Lithuania, Mexico, P.R.China, the U.S.S.R., Singapore, Slovenia, South Africa, South Korea, Taiwan, Turkey, Ukraine, Uruguay, and former Yugoslavia. National vital statistics expose the hardships of developing countries. The population ratio of developed countries to developing countries is approximately 1:5. The reverse per capita Gross Domestic Product ratio is 20:1. Great disparities exist in vital statistics, all to the disadvantage of the DCRES. The World Health Organization defines health-related sectors geographically, then divides developing countries into several subgroups. Disability caused by length of disease and years lived with disability can be quantified monetarily for epilepsy, and the total health expenditures of developed and developing countries can be compared. The DCRES are short of technology, and their ES teams must choose from an excess of surgical candidates, investigating with computed tomography, magnetic resonance imaging, noninvasive video-electroencephalography, and neuropsychology. The surgical outcomes achieved are similar to those in the developed world, but at a fractional cost. To internationalize ES, outcome, cost, and savings from care, evolution of assessment methodology is needed. Also needed is general support from the developed world.

Adolescent↗

Food patterns and health problems: health in southern Europe.

The health status description refers to 7 countries of southern Europe, i.e. Portugal, Spain, France, Italy, Malta, Yugoslavia and Greece, and is mainly derived from official mortality data. In general the health status of southern European countries, as related to the adult population, seems satisfactory and improving along the last 10-15 years in spite of the adverse trends of some diseases. As compared to central, northern and eastern European countries, the southern ones enjoy relatively low mortality and morbidity rates from coronary heart disease and cardiovascular diseases in general, from lung cancer, from large bowel cancer and all-causes mortality, whereas they suffer from strokes and liver cirrhosis at relatively high rates. An exception is made by Yugoslavia where trends in death rates from cardiovascular diseases and all-causes mortality are definitely increasing like it has happened in eastern Europe during the last 20 years. Data from official mortality records are supported by information on incidence, mortality and risk factor distribution derived from population studies like the Seven Countries Study, the Erica and the Monica Project.

Cardiovascular Diseases↗

Migrants' admissions to hospital: a retrospective study in Como from 1994 to 1998.

BACKGROUND: International migrants represent only 4.5% of the world's population, but they may become a challenge for host countries. The aim of the study was to assess the impact of this population on health parameters in Como county, on the northern border of Italy. METHODS: A retrospective analysis of migrants' admissions at Sant'Anna Hospital in 1998 was done, and compared to data from 1994. RESULTS: Of 47,378 total admissions at our hospital, 268 involved migrants (0.5%), mostly from the former Yugoslavia, with a slight preponderance of females; 22 out of 268 migrants were admitted in the Infectious Diseases Department (8.2%), mainly from Africa. Most admissions were classified as Drug Related Group (DRG), but an increasing number of miscellaneous DRGs are reported, including obstetric ones. CONCLUSIONS: The emergence of a female population among migrant admissions, and the relevance of delivery DRGs in 1998, may suggest that, after a first immigration wave of rather healthy men in search of good job opportunities during the first years of the 90s, we are now observing a second wave of migrants: their families. The increasing number of patients from the former Yugoslavia reported in 1998, could suggest that a third wave is expected in the near future: these will be irregular migrants and refugees.

Communicable Diseases↗

Observations on brucellosis due to Brucella melitensis.

A special study was made of the problem of brucellosis due to Brucella melitensis in visits to Mexico City in 1948, to the FAO/WHO Brucellosis Centres at Montpellier (France), Florence (Italy), and Rijeka (Yugoslavia) in 1951, and to Spain in 1952. Br. melitensis infection in human beings causes more severe illness than Br. abortus infection. It develops primarily in rural communities living in close contact with goats and sheep; cattle and swine may also harbour the infection.In diagnosis, the agglutination test has proved the most satisfactory procedure; testing would be more uniformly reliable if a single antigen were used. Lack of funds and technical assistance have in many instances limited the bacteriological studies upon which a more definitive diagnosis of brucellosis depends.Antibiotics, Brucella vaccines, and colloidal preparations of gold and silver-used separately and in combination-have proved of varying therapeutic value, although response to antibiotics is less favourable than in cases of Br. abortus infection.While the drastic measures-involving the slaughter of about 10,000 sheep-taken in Slovenia, Yugoslavia, in the late 1940's, against an outbreak of brucellosis, is an inspiring example of how the disease can be eradicated, the removal of all diseased animals is rarely feasible economically. It is hoped that future research will reveal a practicable alternative in the immunization of sheep and goats against the disease.

Animals↗