Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “TOXOPLASMOSIS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,207 records · Page 67Linked to original sources
PubMed1989

Serologic diagnosis of toxoplasmosis in cats fed Toxoplasma gondii tissue cysts.

Serum samples derived from 7 cats 3 to 950 days after cats were fed tissue cysts of Toxoplasma gondii were evaluated using Sabin-Feldman dye, modified agglutination, indirect hemagglutination, and latex agglutination tests. The modified agglutination test, using whole formalin-preserved tachyzoites, was more sensitive for diagnosis of toxoplasmosis than were other tests. Titers from the modified agglutination test that used formalin-preserved tachyzoites were higher than those from the modified agglutination test that used acetone-preserved tachyzoites. Although cats had no clinical signs of toxoplasmosis, T gondii antibody titers remained high (greater than 1:1,000) for up to 29 months.

Agglutination Tests↗
PubMed1989

[The effect of a subretinal injection of Toxoplasma gondii on the serum antibody titer in a rabbit model of ocular toxoplasmosis].

A single subretinal injection of RH toxoplasma initiated an experimental toxoplasmosis of the eyes in big chinchilla rabbits. This animal model was used to study the development of the serum IgG level against toxoplasma. As a rule, the specific antibody level rose between the 9th and the 20th day following injection. At that time, the peak of inflammation had already been exceeded. An influence of cyclophosphamide0 or complete Freund's adjuvant on the humoral immune response of the animals to toxoplasma could not be detected. An attempt is made to interpret the findings deviating from the toxoplasmosis of the human eye.

Animals↗
PubMed1989

[Complex treatment of toxoplasmosis in women with a history of severe obstetric problems].

A total of 43 females with chronic required toxoplasmosis and habitual abortion were exposed to comprehensive investigation and etiological treatment with regard to toxoplasmosis. In the majority of cases combined involvement of various organs and systems was revealed. Treatment of 14 pregnant women in presence of threatened abortion positively affected not only the course and outcomes of advancing pregnancies but the development of future pregnancies as well.

Abortion, Habitual↗
PubMed1989

Haemorrhage in cerebral toxoplasmosis. A report on a patient with the acquired immunodeficiency syndrome.

A patient with the acquired immunodeficiency syndrome (AIDS) presented to hospital with a haemorrhagic cerebral lesion. The lesion was biopsied and electron microscopy confirmed a diagnosis of toxoplasmosis. Although known in congenital cases, haemorrhagic infarction is unknown in adults suffering from cerebral toxoplasmosis. Severe vasculitis with subsequent thrombosis and extensive fibrinoid necrosis of the vessel wall or direct parasitism of endothelial cells with subsequent destruction and seepage of blood appear to be the possible mechanisms in a situation where the T-cell immune mechanism and tissue cell response are compromised. Other intracerebral haemorrhagic lesions in AIDS were reviewed.

Acquired Immunodeficiency Syndrome↗
PubMed1989

[Clinico-immunological characteristics of patients with ocular toxoplasmosis].

The results of clinical observations on 34 patients with toxoplasmosis affecting mainly eyes over the period of 2-6 years are presented. The presence of antibodies to Toxoplasma, the content of IgA, IgM and IgG, as well as a number of characteristics of the T and B immunity systems in these patients were determined in their dynamics. For control, similar characteristics were determined in 28 practically healthy persons. During the period of observation the patients showed multiple fluctuations in the level of titers of serological reactions with toxoplasmic antigens and changes in the severity of the clinical picture. In contrast to healthy persons, toxoplasmosis patients were found to have statistically significant changes in a number of characteristics of the T immunity system. The content of B lymphocytes remained within normal limits. Complex treatment with the use of immunostimulating agents proved to be effective only in some of the patients.

Adjuvants, Immunologic↗
PubMed1989

[Congenital toxoplasmosis with delayed immune response].

In typical cases the diagnosis "toxoplasmosis connata" is based on clinical symptoms and positive serological findings. When the infection of the fetus occurred a short time before birth the neonate seems still normal and the disease develops in the postnatal period. In such cases the specific antibody production may be delayed. We present a case report with well documented first infection of the mother between the 15th and 30th gestational week but with no specific treatment. The baby was born without clinical signs of a toxoplasmosis infection and developed the disease 2-3 weeks later; the serological test (complement fixation test, KBR) was negative at the 24th postnatal day. Specific antimicrobial therapy could be started after serological conversion between the 4th and 5th postnatal week. Problems of diagnostics and delayed therapy are discussed.

Animals↗
PubMed1989

Laser treatment of toxoplasmosis.

Medical treatment of toxoplasmosis may not be effective always, or toxicities may preclude further use of medications. In this situation, laser photocoagulation may be considered. Three cases of toxoplasmosis were treated with krypton/argon laser photocoagulation. One case required retreatment. All remained quiescent after treatment.

Adult↗
PubMed1988

Congenital acquired immunodeficiency syndrome and congenital toxoplasmosis: pathologic support for a chronology of events.

We report a case of congenital acquired immunodeficiency syndrome (AIDS) with congenital opportunistic toxoplasmosis. The thymic histopathology was that seen in childhood AIDS cases and not that seen in primary congenital toxoplasmosis. The toxoplasma infection was selectively localized to the brain and the serum titers were paradoxically low as reported in most adult cases of AIDS with secondary infection by the parasite. These findings strongly suggest that the infection by the human immunodeficiency virus (HIV) preceded the toxoplasma infection in the fetus.

AIDS Serodiagnosis↗
PubMedDate not supplied

[Determination of specific IgM using column chromatography in immunologic diagnosis of toxoplasmosis].

The usefulness of detecting specific IgM antibodies in the immunodiagnosis of toxoplasmosis is fraught with false positive and false negative results. For instance false positivity can be obtained when rheumatoid factor is present in the serum while false negativity can occur because competing levels of IgG antibodies. We report the results obtained by the use of a simplified chromatographic method, commercially available in kits, for the separation of IgM from IgG in the immunodiagnosis of toxoplasmosis. The 1564 sera tested by indirect immunofluorescent technique (IFA) showed that 119 (7.6%) were positive if the whole serum was tested and only 7 (0.4%) after the chromatographic separation. This suggests that the use of this method can notably reduce the number of false results in sera with high IFA titer of IgM to toxoplasma.

Antibodies, Protozoan↗
PubMed1988

Lesions in transplacentally induced toxoplasmosis in goats.

Fifteen pregnant does were inoculated orally with 10 to 1,000 oocysts of the GT-1 strain of Toxoplasma gondii. Two does were euthanatized on postinoculation days (PID) 10 and 14, and the remaining 13 does aborted or delivered kids transplacentally infected with T gondii on PID 9 to 65. Tissues of all 34 fetuses or kids from the inoculated does were examined for gross and microscopic lesions. Placental necrosis and encephalomyelitis were the most prominent lesions. Toxoplasma gondii invaded the fetal placenta between PID 9 and 11 and invaded fetal tissues 2 to 3 days later. Necrosis attributed to toxoplasmosis, confined to cotyledons, was found in all placentas examined on PID 18. Encephalomyelitis was found in most fetuses or kids between PID 30 and 65. Lesions in fetal tissues were sparse. Because T gondii is rarely found in lesions, histologic examination of the fetal tissues is not likely to help in diagnosing every case of transplacentally induced toxoplasmosis in goats.

Abortion, Veterinary↗
PubMed1988

Impact of primary prevention on the incidence of toxoplasmosis during pregnancy.

Until now, it was assumed that primary prevention of congenital toxoplasmosis was possible by means of specific hygienic measures. A prospective survey of pregnant women was made at a hospital in Brussels over the period 1979-1986 to assess the impact of such a prevention program. In the first study period (1979-1982), when no prophylactic measures were taught, 2986 consecutive women demonstrated a seroconversion rate of 1.43% among the nonimmunized subjects; 1.07% of the seropositive patients had high antibody levels in their first serum sample. In the second study period (1983-1986), all 3563 patients were instructed to adopt prophylactic measures. The seroconversion rate in seronegative patients and the percentage of patients with high initial antibody level were 0.95 and 1.26%, respectively. Although the percentage of seroconversion was reduced by 34% in the second study period, this difference did not attain significance. These results indicate that the impact of a primary prevention program aimed at reducing congenital toxoplasmosis is limited.

Animals↗
PubMed1986

[Toxoplasmosis after bone marrow transplantation].

An opportunistic infection with Toxoplasma gondii is a rare complication in the immunocompromised host following bone marrow transplantation. In addition to the variability in the clinical picture, difficulty in interpretation of the antibody titers is one of the main obstacles limiting early diagnosis of manifest toxoplasmosis. This report deals with 3 patients out of 86 bone marrow transplant recipients who had manifest toxoplasmosis mainly affecting the central nervous system and cardiac muscle. The clinical picture was that of acute disseminated encephalitis and myocarditis, while the nature of the disease was only disclosed at autopsy.

Adult↗
PubMed1987

Toxoplasmosis of the central nervous system.

Toxoplasmosis is usually an asymptomatic infection, but symptomatic cases are becoming more common with the rise in AIDS cases and the increased number of patients receiving immunosuppressive therapy. Toxoplasmosis of the central nervous system occurs most often in immunocompromised hosts. Brain biopsy may be necessary for diagnosis. Pyrimethamine and sulfadiazine are active against T. gondii, but they do not affect the encysted organisms.

Adult↗
PubMedDate not supplied

[Serological study of toxoplasmosis and echinococcosis in cattle breeders and abattoir personnel in Benin].

In Benin, a serological study of toxoplasmosis and hydatid disease has been effected among bovine stock-breeders and the staff of the slaughter-houses in comparison with a sample of blood donors. Our results reveal the highest rate of toxoplasmosis infection (87%) among the staff of the slaughter-houses, whereas the bovine stock-breeders are the most exposed population to hydatid disease with a 9% prevalence. There is no mention of similar works in Benin in medical literature.

Abattoirs↗
PubMedDate not supplied

[Chorioretinitis caused by toxoplasmosis: study of 65 cases].

Sixty five patients with an ophthalmoscopic diagnosis of chorioretinitis who, underwent complement fixation tests and intradermoreaction using Toxoplasma antigens were studied. 95,4% of them disclosed antibody titers with the former and 58,5% reactors were found with the latter. Sixty five individuals with neither backgrounds nor clinical symptoms of toxoplasmosis were used as control, and 27,7% of reactors in both tests were likewise found. The differences among results are highly statistically significant; this points out toxoplasmosis as an important cause of chorioretinitis in our patients. Complement fixation tests were more sensitive than intradermoreactions as well as specific as the latter. Results were correlated to age, sex and animal contacts.

Adolescent↗
PubMed1985

[Toxoplasmosis in the African tropical zone. Preliminary studies].

Toxoplasmosis in Tropical African area was not subject to many publications but the results indicate that toxoplasmosis may influence the health of the populations. We present prevalence studies carried out in the Central African Republic, Mali, Niger, Burkina-Faso, Togo to find toxoplasma-antibodies by Agglutination of Latex. For adults the lower percentage was found in the North Central African Republic villages (40%) and the higher in Mali (nearly 70%). These high percentages justify a larger epidemiological study in Tropical Africa.

Adolescent↗
PubMed1985

[Toxoplasmosis in Japan. Comparative study of different regions].

Specificities of Japan by geography, culture, and low incidence for Toxoplasmosis were examined in this epidemiological study. 1 731 human sera were examined by several immunological tests but these results are related with Agglutination-Latex test. The sera came from North (Hokkaido), Middle (Tokyo area) and South (Okinawa). The ratio for the whole Japan towards Toxoplasmosis is 24.7% but the increase of antibodies with age is late: rate of positivity 4.6% up to 17 years old and nearly 30% after 30 years old. Cats, business, climate do not seem to influence the human infection. It is consumption of meat and particularly raw meat which influence the results: 40.8% positive results among eaters of raw meat and 22% among those not eating meat or eating it well cooked.

Adolescent↗