Effects of L-dopa on self-stimulation and brain biogenic amines in rats.
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For rats that bar pressed for intracranial electrical stimulation in a 2-lever matching paradigm with concurrent variable interval schedules of reward, the authors found that the time allocation ratio is based on a multiplicative combination of the ratio of subjective reward magnitudes and the ratio of the rates of reward. Multiplicative combining was observed in a range covering approximately 2 orders of magnitude in the ratio of the rates of reward from about 1:10 to 10:1) and an order of magnitude change in the size of rewards. After determining the relation between the pulse frequency of stimulation and subjective reward magnitude, the authors were able to predict from knowledge of the subjective magnitudes of the rewards and the obtained relative rates of reward the subject's time allocation ratio over a range in which it varied by more than 3 orders of magnitude.
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Long term exposure of adult male Sprague Dawley rats to rewarding brain stimulation produced alterations in open field behavior in comparison to nonstimulated controls. Initial activity was increased while movement latency was decreased for the experimental animals. Grooming and defecation were essentially unchanged by stimulation. These findings suggest a selective and tonic influence of brain stimulation upon exploration.
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