Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “SALICYLIC ACID”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,207 records · Page 67Linked to original sources
PubMed1980

Renal clearance of salicylic acid and salicyluric acid in the rat and in the isolated perfused rat kidney.

The renal clearance of salicylate (SA) and salicyluric acid (SU) was studied after i.v. bolus injection of 5 mg/kg of SA to ureter cannulated rats and after administration of 1 to 20 mg of SA or 2.5 to 10 mg of SU to the isolated perfused rat kidney. Previous studies in this laboratory have shown that SA and SU are metabolically interconverted in the isolated perfused rat kidney. The renal clearance of SU was greater than the glomerular filtration rate after either SA or SU administration. SA renal clearance was much less than the glomerular filtration rate when SA was administered but was greater than the glomerular filtration rate when it was formed from SU. The data support the hypothesis that administered SA is cleared differently than SA formed from SU in the isolated perfused rat kidney, presumably due to rate-limiting diffusion of SA into the cell.

Animals↗
PubMed1997

Quantitation of acetaminophen and salicylic acid in plasma using capillary electrophoresis without sample pretreatment. Improvement of precision.

Capillary electrophoresis has become one of the most attractive techniques in the analysis of biological samples. Pharmaceuticals in human plasma can easily be determined on uncoated fused-silica capillaries without any sample pretreatment. Intra- and inter-day precision values of about 1-2% R.S.D. (n = 20) and 2-3% R.S.D. (n > 80) respectively are obtained using a sodium dodecyl sulfate-containing borate buffer, pH 10 and acetonitrile as a between-run rinsing reagent. This method is highly robust, no breakdowns of the current or capillary blockings were observed for several weeks. The general applicability is demonstrated for several model drugs. The effectiveness of other rinsing procedures including enzyme-containing solutions, different organic solvents and hydrofluoric acid is discussed.

Acetaminophen↗
PubMed1995

Copper(II) interactions with nonsteroidal antiinflammatory agents. I. Salicylic acid and acetylsalicylic acid.

Recently a growing body of evidence has accumulated on the beneficial effects of copper compounds toward various models of inflammation, and copper complexes of nonsteroidal antiinflammatory drugs (NSAIDs) have been shown to be more effective in this respect than the parent agents. However, the origin of this activity remains unclear: The ability of NSAIDs to influence copper metabolism is still questionable, and apart from the claimed SOD-like activity of copper salts in vivo, relatively little is known about how copper-NSAID interactions may help regulate the inflammatory process. Before the potential role of copper-NSAID complexes versus inflammation can be elucidated, speciation studies are necessary (i) to analyze the overall influence of these drugs on copper metabolism and (ii) to discriminate the individual complexes likely to represent the active form of the drug in vivo. In this paper, copper(II) complex equilibria with salicylic and acetylsalicylic acids--and benzoic acid used as a reference--as well as the mixed-ligand complex equilibria generated by these binary systems and L-histidine [main low-molar-mass ligand of copper(II) in blood plasma] have been investigated under physiological conditions (37 degrees C; 0.15-M NaCl). Confirming previous observations by others, resulting simulated plasma copper distributions virtually rule out any quantitative influence of salicylate on copper tissue diffusion at therapeutic levels. Even though, as is presently shown, both salicylate and acetylsalicylate may favor the gastrointestinal absorption of copper, it seems unlikely that salicylate can exert its antinflammatory activity predominantly through copper complexation. The assertion that copper-NSAID complexes represent the active forms of NSAIDs therefore seems to be of limited significance for salicylate.

Anti-Inflammatory Agents, Non-Steroidal↗