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At least 1,207 records · Page 67Linked to original sources
PubMed1987

Effect of reserpine on the differentiation of the external granular layer of the cerebellum in the chick embryo.

In this work we analyse the effect produced by reserpine on the development of thickness and cell number in the external granular layer in the cerebellum of chick embryo. A striking 48-hour histogenetic delay is observed in the treated embryos relative to controls, as show by greater thickness and cell density of this layer in the former, as well as by retarded appearance of a typical radial morphological organization of the external granular layer.

Animals↗
PubMedDate not supplied

Reserpine and cerebral vasospasm.

Cerebral vasospasm was produced in the dog basilar artery by topically applied five-day-old clotted autologous blood, but not by freshly drawn blood. The spasm was reversed by methysergide, an antiserotonin agent. However, vasospasm was not produced by five-day-old clotted autologous blood from dogs pretreated with reserpine. This suggests platelet serotonin or a similar, unidentified substance as the vasospastic element in dog blood responsible for experimental vasospasm from topically applied whole blood. Other experimental data support these findings.

Animals↗
PubMed2000

The new drugs (chlorpromazine & reserpine): administrative aspects. 1956.

The article on the new drugs reprinted below appeared in the February 1956 issue of Mental Hospitals. It is based on a discussion held during the Seventh Mental Hospital Institute in October 1955 in Washington, D.C. Chlorpromazine and reserpine had been available in the United States less than two years when the institute participants met to discuss how their hospitals were coping with the demands of the new treatments. In a commentary and analysis beginning on page 333, Robert Cancro, M.D., considers the broader impact of the introduction of neuroleptics and examines the concerns of the 1956 institute participants in the context of today.

Antipsychotic Agents↗
PubMed1984

Reserpinization: effects on parotid gland function.

Chronic reserpinization of mice and rabbits affected parotid gland function; cholinergic and beta-adrenergic-stimulated amylase release were significantly reduced, and cyclic-AMP and cyclic-GMP levels were significantly elevated above control-stimulated levels. Amylase released by dibutyryl-c-AMP was also reduced, suggesting a defect in stimulus-secretion coupling subsequent to c-AMP formation.

Amylases↗
PubMed1975

The chronically reserpinized rat as a possible model for cystic fibrosis. I. Submaxillary gland morphology and ultrastructure.

Rats treated for 7 days with reserpine develop structural changes in the submaxillary gland that resemble those that have been reported in cystic fibrosis. The salivary exocrinopathy is characterized by increased amounts of PAS-reactive mucoprotein in the acinar cells and by obstruction and dilatation of ducts by precipitated material with the same staining characteristics as those found in the acinar elements.

Animals↗
PubMedDate not supplied

Comparative effects of dextroamphetamine and reserpine on halothane and cyclopropane anesthetic requirements.

Cyclopropane minimum alveolar concentration (MAC) values in dogs following intravenous administration of 0.5, 1 or 2 mg/kg of dextroamphetamine were 27.8, 28.4, and 28.4 volumes percent, respectively. Those values did not differ significantly from each other but were 44 percent greater than average control (no dextroamphetamine(MAC values. Halothane MAC values following the same dextroamphetamine doses were 1.51, 1.71, and 1.64 volumes percent. These values were 75 percent greater than average controls, and this increase was significantly more than the 44 percent noted with cyclopropane. In contrast, 2 mg/kg of reserpine decreased halothane MAC 20 percent vut decreased cyclopropane MAC 40 percent- the difference between the two anesthetics again being statistically significant. These results suggest that alteration of anesthetic potency by centrally active adrenergic drugs depends on the sympathetic activity induced by the anesthetic. Conversely, this suggests that anesthetics may influence their own potency by altering central nervous system adrenergic activity.

Animals↗
PubMed1976

[Effects of methamphetamine and a reserpine-like drug on norepinephrine and dopamine metabolism in the rat brain].

Simple and sensitive methods for the separation and determination of catecholamines and their metabolites by thinlayer microcrystalline cellulose chromatography have been developed and applied to the analysis of norepinephrine (NE) and dopamine (DA) metabolism in the brain of Wistar rats given 12C-NE or 14C-DA intraventricularly. 14C-DA in the whole brain declined more rapidly than did 14C-NE. The percentage of unchanged 14C-NE in total radioactivity in the brain of rats administered 14C-NI was high, while on the other hand, the percentage of unchanged 14C-DA in cases of 14C-DA was low. In the metabolism of 14C-DA, the deaminated and O-methylated deaminated metabolites showed transient and delayed temporary rises, respectively. Drugs which affect the metabolism of catecholamines were also examined. Methamphetamine reduced NE, deaminated and O-methylated deaminated metabolites, and markedly elevated normetanephrine in the brain of rats given 14C-NE. Regarding the metabolism of DA, methamphetamine increased 3-methoxytyramine and homovanillic acid and reduced deaminated metabolites, but had no effect on DA and NE. On the other hand, a reserpine-like drug (Ro4-1284) reduced NE and increased deaminated and O-methylated deaminated metabolites in the metabolism of NE, and reduced to a great extent DA and NE and increased homovanillic acid in the metabolism of DA. From these results, it is concluded that the effect of methamphetamine was more evident in NE metabolism than DA, while the effect of Ro4-1284 was more evident in DA metabolism than NE.

2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-↗
PubMed1976

Recurrence of estrous cycles in the light-induced persistent estrous rats by reserpine.

Effect of continuous illumination (LL) on ovarian functions was compared at various ages between the rats exposed to LL from 70 days of age (LL-70) and exposed to LL from the day of birth (LL-0). LL-0 rats retained corpora lutea in their ovaries in higher incidence than LL-70 rats. Effect of reserpine on the restoration of cyclicity was studied in LL-0 and LL-70 rats shortly after they became persistent-estrous. LL-0 rats restored cyclicity in higher incidence than in LL-70 rats.

Animals↗
PubMedDate not supplied

Variations in melanin and riboflavin content of amphibian liver under the influence of reserpine and amphetamine.

By means of paper chromatography, Lactobacillus casei test and the staining method with the Feulgen reaction, the effects of reserpine and amphetamine on riboflavin and melanin were studied in the liver of Triturus cristatus. It was demonstrated that the concentrations of both melanin and riboflavin can be altered by the influence of these drugs. From the results obtained it is suggested that riboflavin shows a correlation with the density of melanin.

Amphetamine↗
PubMed1979

The effect of reserpine, oestradiol and in-vitro perfusion on oviduct calcium levels in the mouse during egg transport.

Mouse oviduct calcium content, determined by atomic absorbance after ashing of the tissue, showed a significant fall on Day 2 of pregnancy followed by a significant rise on Day 3. This pattern was altered by administration of reserpine and oestradiol in doses which were shown to alter the rate of egg transport. In-vitro perfusion of the oviduct, capable of maintaining muscular activity and back and forth movement of eggs for 24 h, was associated with lack of forward progressive motion of eggs and by a more rapid increase in tissue calcium levels during incubation than occurred in vivo.

Animals↗
PubMed1989

Reserpine withdrawal psychosis.

A case of reserpine withdrawal psychosis is reported. This uncommon condition is described as a true withdrawal psychosis and may be due to dopamine receptor supersensitivity.

Aged↗
PubMed1987

Effects of saliva from chronically reserpinized rat on Na and K transport in perfused main excretory duct of submandibular gland of normal rat.

Reserpine (RES) (0.5 mg/kg body wt, ip) was administered to rats for 7 days. On Day 8 saliva was evoked from these animals by intraperitoneal injection of pilocarpine nitrate (10 mg/kg body wt) and saliva from submandibular and parotid glands was collected separately. These collected salivas were used to perfuse through the main ducts of the submandibular glands of normal rats. After a control period of perfusion of the main duct with bicarbonate saline solution, parotid saliva from RES rats was perfused through the duct followed by regular perfusion. There was inhibition of Na absorption (22%) and K secretion (23%). Moreover, when submandibular saliva from treated rat was perfused through the main duct prior to regular perfusion, there was a decrease in Na absorption (31%) and K secretion (28%). In contrast, perfusion of the main duct with either parotid or submandibular saliva from normal rats caused no significant changes in Na and K transport. The present experiments confirm previous studies that there is some Na-inhibitory factor(s) present in saliva of the chronically RES-treated rat.

Animals↗
PubMed1989

Effects of carbamylcholine and isoproterenol on electrolyte fluxes in perfused main duct of submandibular gland of reserpinized rat.

Administration of reserpine (RES) at a dosage of 0.5 mg/kg body wt, ip daily for 7 days was found to lower the dose of carbamylcholine and isoproterenol that alters sodium and potassium transport by cells of the main duct of rat submandibular gland. In the perfused main excretory duct of the submandibular gland of the RES rat, administration of carbamylcholine at a dosage of 1 microgram/kg body wt, inhibited net efflux of sodium (17%) and administration of isoproterenol at a dosage of 2 micrograms/kg body wt increased net efflux of sodium (20%); these drugs, at the same dosages, did not induce significant change in electrolyte flux of normal rat. At a dosage of 5 micrograms/kg body wt, carbamylcholine decreased net influx of potassium (15%) in the RES rat but was without effect on normal rat. Isoproterenol at the dosage of 5 micrograms/kg body wt significantly inhibited net influx of potassium in both the RES rat and normal rat. The data suggested that the duct cells developed supersensitivity to sympathomimetic and parasympathomimetic stimulation after chronic RES treatment.

Animals↗
PubMedDate not supplied

Effects of stimulation of raphe nuclei on ponto-geniculo-occipital syndrome evoked by reserpine in cats.

Stimulation of the dorsal raphe nucleus in the cat caused inhibition of ponto-geniculo-occipital waves induced by reserpine. Electrical stimuli with frequency of 10/sec. caused stronger effect than low-frequency impulses. The results indicate the PGO generating mechanisms (related probably with noradrenergic neurons of the nucleus locus coeruleus is suppressed by raphe nuclei.

Animals↗
PubMed1975

Blockade by reserpine of methylphenidate-induced release of brain dopamine.

The cerebroventricular systems of cats were perfused by introducing artificial cerebrospinal fluid into a lateral ventricle and collecting the perfusate at the aqueduct. 3-H-tyrosine was continuously added to the perfusing cerebrospinal fluid and the perfusate was analyzed for 3-H-catecholamines. Intraventricular or intravenous administration of methylphenidate increased the efflux of 3-H-dopamine. In cats pretreated with reserpine, this response to methylphenidate was reduced while the efflux of 3-H-dopamine caused by delta-amphetamine was slightly increased. These results provide direct biochemical evidence in support of the hypothesis that the central stimulant action of amphetamine and methylphenidate result from their abilities to preferentially release dopamine from "newly synthesized" and "stored" pools, respectively.

Animals↗
PubMed1975

Quantitative electroencephalographic studies of the effects of ethanol in rabbits= I. Interaction between ethanol and reserpine.

At a dose of 1 g/kg i.v. ethanol induced in the cortical EEG of rabbits a synchronization which lasted 2-3 hours. Thereafter a pronounced hyper-stimulation occurred which persisted up to 4 hours. Pre-treatment of the animals with reserpine reduced markedly the initial synchronization and abolished the delayed stimulant effect. These findings are discussed in terms of possible interaction between acetaldehyde and biogenic amines.

Animals↗
PubMed1975

[Morphine interaction with reserpine and amphetamine on prolonged administration to rats].

The authors carried out studies on 300 white rats of the Wistar strain and examined the influence of reserpien and amphetamine on creating physical dependence to morphine in rats after sixty days of combined application. Resepine, used continuosty with morphine, hindered the development of tolerance to the analgetic and toxic effect of morphine. However on the background of a three-day administration in rats with reserpine the morphine revealed considerably less toxicity. The amphetamine did not stop the development of the morphine dependence. The amphetamine, administered tere singly for a period of sixty days, created dependence in the rats. The results are discussed in view of the participation of cerebral catecholamines and serotonine in the creotion of morphine dependence.

Amphetamine↗