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[The dependence of the temperature response to pyrogens on the ambient temperature and the initial body temperature].

The dependence of the temperature response to injection of Freund's complete adjuvant (FCA) containing killed and dried Mycobacterium butyricum on ambient temperature within 8-10, 14-16, 20-22, 26-28 degrees C ranges and initial body temperature was studied in experiments on rats, guinea pigs, and rabbits. The duration of the hyperthermic response was maximal at an ambient temperature 14-16 degrees C, and its dynamics can be divided in 2 phases, initial febrile and subsequent subfebrile. An increase in rectal temperature after application of the agent was the higher the lower was its initial value and vice versa. The hyperthermic response to FCA did not occur at 8-10 degrees C.

Analysis of Variance↗
PubMed1998

[Morphofunctional mechanisms of responses of sympathetic ganglia to the high external temperature and pyrogen exposure].

Reactive changes of structural and functional organization of pre- and paravertebral sympathetic ganglia were studied in experimental fever and under the effect of high temperatures using electron microscopy and histochemical methods. Changes in histochemical and ultramicroscopic characteristics of neuroglial complex, synaptic apparatus and of histohematic barrier were demonstrated. Correlation between those changes and the dose and duration of the challenge was established.

Animals↗