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PubMed1994

Racial disparities in reported prenatal care advice from health care providers.

OBJECTIVES: The relationship between certain maternal behaviors and adverse pregnancy outcomes has been well documented. One method to alter these behaviors is through the advice of women's health care providers. Advice from providers may be particularly important in minority populations, who have higher rates of infant mortality and prematurity. This study examines racial disparities according to women's self-report of advice received from health care providers during pregnancy in four areas: tobacco use, alcohol consumption, drug use, and breast-feeding. METHODS: Health care providers' advice to 8310 White non-Hispanic and Black women was obtained from the National Maternal and Infant Health Survey. RESULTS: After controlling for sociodemographic, utilization, and medical factors, Black women were more likely to report not receiving advice from their prenatal care providers about smoking cessation and alcohol use. The difference between Blacks and Whites also approached significance for breast-feeding. No overall difference was noted in advice regarding cessation of drug use, although there was a significant interaction between race and marital status. CONCLUSIONS: These data suggest that Black women may be at greater risk for not receiving information that could reduce their chances of having an adverse pregnancy outcome.

Adolescent↗
PubMedDate not supplied

A behavioral and neuroanatomical investigation of the lethality caused by gestational day 11-13 retinoic acid exposure.

In a companion article, we report that there is a sensitive period for all-trans retinoic acid (RA) lethality on gestational days (GD) 11-13. When dams were given 10 mg/kg RA daily for 3 consecutive days on GD 11-13, a number of pups were found dead in the home cage on the day of birth, and the remainder inevitably died due to an apparent inability to nurse. Here we report a set of experiments further investigating these effects. Dams were exposed PO to 10 mg/kg RA or oil vehicle on GD 11-13. Fetuses were removed by Cesarean section on the afternoon of GD 21, culled, and fostered to non-treated dams that had given normal vaginal delivery a day earlier. Maternal behavior was observed for the first 6 h after fostering. The next morning all surviving pups were given a brief behavioral evaluation, including the ability to attach to the nipple of anesthetized foster dams. At the time of C-section, culls were killed and brains were quickly removed and placed in fixative. A series of paraffin-embedded, cresyl-violet-stained serial sections of a representative brain stem from each litter was prepared. RA exposure did not increase fetal mortality. Treated litters were as large as controls, and virtually all treated fetuses were alive in utero. However, unlike controls, some treated fetuses appeared to have difficulty in initiating spontaneous breathing when delivered by C-section, and considerable physical stimulation was required before normal breathing began. As in the previous report, RA-exposed pups did not have milk in their stomachs after 18 h on the foster dam; further, they did not attach to the maternal nipple, and they had greater difficulty than controls in maintaining an upright posture. Examination of serial sections of the medulla indicated that the hypoglossal nucleus appeared grossly normal in the RA-exposed pups. In contrast, the inferior olive and the area postrema were affected by RA exposure. Both nuclei were normally located, but exhibited reduced cell density and/or intensity of staining. In the inferior olive the dorsal and principal nuclei were primarily affected, to the degree that about one quarter of treated brains had no identifiable principal nucleus. We conclude that RA exposure on GD 11-13 causes abnormal development of cell-dense regions of the medial medulla, and these abnormalities may account for the difficulty these animals experience in beginning spontaneous breathing and in nursing. These breathing and nursing problems in turn almost certainly account for the high mortality seen during natural birth and for the subsequent failure to thrive, respectively.

Animals↗
PubMed1977

Group housing of pregnant mice reduces copulatory receptivity of female progeny.

To assess the effect of perinatal environment on adult reproductive behavior, masculine and feminine sexual behaviors of offspring from group-housed C57BL/6J parental females were compared to behaviors of offspring from control parental females housed in male/female pairs. Female offspring born to and raised by previously group housed parental females were less sexually receptive following ovariectomy and hormone replacement than offspring of control parental females. Male offspring born to and raised by previously group-housed parental females exhibited shorter latencies to ejaculation and shorter anogenital distances than offspring of control parental females. Fostering and cross-fostering, procedures to control for the effects of group-housing on maternal behavior, both increased the frequency of abnormal scrotal sacs. Group housing during pregnancy alters the adult reproductive behavior of the offspring. The reduction of receptivity in female offspring could play a role in cyclical changes in population density of confined groups.

Animals↗
PubMed2005

APeg3, a novel paternally expressed gene 3 antisense RNA transcript specifically expressed in vasopressinergic magnocellular neurons in the rat supraoptic nucleus.

Vasopressin (VP) and oxytocin (OT) play critical roles in the regulation of salt and water balance, lactation, and various behaviors and are expressed at very high levels in specific magnocellular neurons (MCNs) in the hypothalamo-neurohypophysial system (HNS). In addition to the cell-specific expression of the VP and OT genes in these cells, there are other transcripts that are preferentially expressed in the VP or OT MCNs. One such gene, paternally expressed gene 3 (Peg3), is an imprinted gene expressed exclusively from the paternal allele that encodes a Kruppel-type zinc finger-containing protein involved in maternal behavior and is abundantly expressed in the VP-MCNs. We report here the robust expression in the VP-MCNs of an RNA, which we designate APeg3 that is transcribed in the antisense direction to the 3' untranslated region of the Peg3 gene. The APeg3 mRNA is about 1 kb in size, and the full-length sequence of APeg3, as determined by 5' and 3' RACE, contains an open reading frame that predicts a protein of 93 amino acids and is predominantly expressed in VP-MCNs. Both Peg3 and APeg3 gene expression in the VP-MCNs increase during systemic hyperosmolality in vivo, demonstrating that both of these genes are osmoregulated.

3' Untranslated Regions↗
PubMed1982

Cognitive correlates of infant attention and maternal stimulation over the first year of life.

This study investigated the predictability of cognitive differences at 12 months from infant and maternal behaviors at 4 months. Babies who showed more habituation and faster habituation at 4 months scored higher on the Bayley Scales and had larger speaking vocabularies at 12 months. Success with select 4-month Bayley Scale items also predicted 12-month Bayley scores but did not predict speaking vocabulary. Additionally, 4-month-olds who vocalized more or who more frequently manipulated objects spoke more words at 12 months and als tended to score higher on the Bayley Scales at 12 months. Frequent maternal stimulation at 4 months, specifically, by encouraging babies' attention to objects, correlated with the size of speaking vocabulary at 12 months; a cross-lagged panel correlation suggested that maternal stimulation positively influenced infants' cognitive development. Regression analyses examined the power of combinations of infant and maternal predictors. Overall, the results show that some individual differences in cognition may be predictable across the first year of life.

Attention↗
PubMed2000

Organization and parent-of-origin-specific methylation of imprinted Peg3 gene on mouse proximal chromosome 7.

Peg3 is the first imprinted gene to be identified on mouse proximal chromosome 7; the human PEG3 homologue is on chromosome 19q13.4. Peg3 encodes a C(2)H(2)-type zinc finger protein that is expressed only from the paternal allele in embryos and adult brain. The gene has been shown to regulate maternal behavior and offspring growth and has been implicated in the TNF-NFkappaB signal pathway. Here we show that Peg3 consists of nine exons spanning 26 kb. The 5' region of the gene contains a region rich in repeated sequences and a CpG island. Analysis of expressed sequence tags revealed a transcript present upstream of the island and on the strand opposite to Peg3. These structural features and DNA sequences are conserved in mouse and human. The 5' region of Peg3 is preferentially methylated on the inactive maternal allele, as shown by comparing embryos with paternal (PatDp. prox7) and maternal (MatDp.prox7) duplication of proximal chromosome 7. Recently, a new maternally expressed Zim1 gene located downstream of Peg3 was identified, which suggested that another imprinted cluster is present on proximal chromosome 7.

Animals↗
PubMed1975

Evidence for a sensitive period in the human mother.

In certain animal species immediate separation of a mother from here young for a brief period after deliver (the sensitive period) may result in aberrant maternal behaviour. In the human, disorders of mothering, including child abuse, increase disproportionately in situations associated with early neonatal separation of mother and infant, such as prematurity. Mothers in the United States who were offered early contact with their premature infants showed differences in attachment behaviour when compared with mothers whose first contact with their infants was three weeks after delivery. Mothers who had one hour of close physical contact with their nude full-term infants within the first two hours after delivery and who had 15 extra hours of contact in the frist three days behaved significantly differently during a physical examination of the infant at one month and one year, and in their speech to their infants at two years, from a control group of mothers who had only routine contact. In a similar study in Guatemala, mothers who had 45 minutes of early extra contact showed significantly more attachment behaviour at the time of the first breast-feeding (12 hours). These and other studies in the human suggest that shortly after birth there is a sensitive period which appears to have long-lasting effects on maternal attachment and which may ultimately affect the development of the child.

Auditory Perception↗
PubMed1990

Rats exposed prenatally to alcohol exhibit impairment in spatial navigation test.

Prenatal exposure to ethanol causes learning disabilities and low I.Q. scores. The objective of the present studies was to investigate whether exposure of rats to ethanol in utero, would induce a deficit in spatial memory in adult life. Pregnant rats were fed with an ethanol diet from day 1 of pregnancy till parturition. Control rats were either pair-fed with an isocaloric sucrose diet or were fed with lab-chow ad libitum. On the first day of birth, offspring exposed to ethanol in utero were placed with a control mother fed with lab-chow, while offspring of the lab-chow fed dams were placed with ethanol-treated dams. At 40, 60 and 90 days postnatally, behavioral testing was performed using the Morris swim maze, a test of spatial memory. Results indicated that the offspring exposed to ethanol in utero presented deficits in spatial memory processes. Ethanol did not completely block the learning of the swim maze task but the alcohol-exposed offspring exhibited longer latencies to perform the task, swam longer distances prior to locating and climbing onto the platform, and when the platform was removed, searched for it in all 4 quadrants of the pool. Restricted caloric intake during gestation and maternal behavior in early postnatal life also induced deficits in the performance on the swim maze task. However, these deficits were mild and short-lasting being absent at 60 and 90 days of age. In contrast, the deficits induced by ethanol were more severe and longer-lasting, being present in adult life.

Animals↗
PubMed1983

Length of day-care attendance and attachment behavior in eighteen-month-old infants.

Differences in the attachment behavior of 18-month-old full-time, part-time, and non-day-care infants from intact middle-class homes were compared. Mothers of the day-care infants had made arrangements to return to work before their infants' birth, and all the infants had been placed in day-care homes before 9 months of age. The study involved 2 sessions: a home observation and the strange-situation procedure in a laboratory setting. The home-observation and rating scale scores of maternal behaviors directed at the child yielded few group differences. More full-time day-care children (but not part-time children) were found to display avoidance of the mother during the final reunion episode of the strange-situation procedure than did non-day-care children. The length of the daily separation appears to be an important determinant of day-care effects on infant-mother attachment.

Anger↗
PubMed1995

Influence of the presence of chicks on the ability to resume incubation behavior in domestic hens (Gallus domesticus).

In this study, hormonal and behavioral changes associated with nest deprivation in the absence or in the presence of chicks (replaced every day or not) were investigated in incubating hens. Prolactin levels decreased, whereas LH and E2 levels increased following nest deprivation. Surprisingly, the presence of chicks had no effect on prolactin changes. However, the presence of chicks significantly limited increases in plasma LH and estradiol. Furthermore, this inhibitory effect was greater when day-old chicks were replaced every day. On the other hand, the presence of chicks induced the emergence of specific maternal behavior, while, surprisingly, one-third of the nest-deprived hens without chicks continued to incubate. After a 3-day deprivation period, readiness to renest was maintained for a percentage of hens. Thus more than 2/3 of hens deprived of the nest for 3 days in the presence of chicks returned to their nests during the first day of being allowed to do so, versus less than 1/3 of hens without chicks among those that previously disrupted incubation behavior. Plasma prolactin concentrations of these renesting hens increased rapidly and reached again levels characteristic of incubating hens. We conclude that, under our experimental conditions, presence of chicks maintains readiness to incubate without maintaining high levels of plasma prolactin.

Animals↗
PubMed1991

Patterns of inhibition to the unfamiliar in children of normal and affectively ill mothers.

Patterns of 2-3 1/2-year-old children's inhibition and their well and depressed mothers' behaviors in nonsocial and social unfamiliar situations were examined in 88 dyads. Type of unfamiliarity was associated with 2 forms of children's inhibition. 4 more specific patterns were identified: in the nonsocial situation, Inhibition to New Environment with Proximity to Mother; in the social situation, Retreat to Mother, Passivity/Withdrawal from a Stranger, and Wary/Timid Response. The unipolar depressed mothers, particularly those who were recently symptomatic and had a history of the most serious illness, had children who were most inhibited. Serious affective impairment was also associated with the least maternal facilitation of the children's approach to the unfamiliar. Boys were more inhibited to a new environment and girls were more inhibited to a new person. Relations between child inhibition and maternal behaviors suggested that for toddlers and their mothers, encounters with the unfamiliar are interactive events.

Bipolar Disorder↗
PubMed2005

Implementation of mandatory Medicaid managed care in Missouri: impacts for pregnant women.

OBJECTIVES: To assess the impact of mandatory Medicaid managed care in Missouri on prenatal care, maternal behavior, and low birth weight among pregnant women enrolled in Medicaid. STUDY DESIGN: Pre-post design using a comparison group with birth certificate and Medicaid enrollment data in 1995 and 2000. METHODS: Pregnant women delivering in 38 counties that implemented managed care in Medicaid were compared preimplementation and postimplementation with pregnant women delivering under Medicaid in 78 counties that remained fee-for-service (FFS) for separate samples of white (37,561) and black (13,640) non-Hispanic women. We calculated difference-in-difference estimates using linear probability regression models that controlled for maternal characteristics and time-invariant county differences. Analyses were stratified based on Medicaid enrollment before and after conception, managed care region, and marital status. RESULTS: Both managed care and FFS counties showed large improvements in prenatal care measures over time for both white and black women. Managed care was associated with a smaller percentage point increase relative to FFS counties in adequate care among whites of 1.9 and among blacks of 8.5, and a larger decrease in smoking of 4.8 and in Women, Infants, and Children Program enrollment of 2.3 among white women. No pattern across managed care regions was found with respect to timing of implementation. Smaller effects were evident among black and single women. CONCLUSIONS: Although women experienced significant improvements statewide in prenatal care under Medicaid, improvements were smaller for managed care counties. Managed care may have a positive impact on smoking cessation, but other policy changes may be needed to improve birth outcomes.

Adolescent↗