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PubMedDate not supplied

A study of squamous cell carcinoma of the lip at West Virginia University Hospitals from 1980-2000.

The goal of this study was to review the patterns of relapse and outcome for patients with squamous cell carcinoma of the lip treated at West Virginia University Hospitals, and to assess the tumor factors that may influence the prognosis of patients. A total of 52 patients were identified in a retrospective review of all lip cancer patients referred to West Virginia University Hospitals between 1980 and 2000. Relevant data was extracted from the medical records of each patient, as well as information from the Cancer Registry. Most patients were men (86%) with T1N0 cancers (52%) of the lower lip. Less than 10% had nodal disease at diagnosis. Following treatment, 31% of patients relapsed, 7 at the primary site and 9 at regional lymph nodes. The relapse rate was 15% for T1 lesions, whereas it increased to 44% for T2 lesions. The overall crude 5-year survival rate was 69%. These findings highlight an increased relapse rate and mortality for a subgroup of patients diagnosed with a more aggressive form of lip cancer. Treatment and follow up of these patients should accordingly be more aggressive.

Adult↗
PubMed2004

Tooth and lip responses to three commonly prescribed premolar extraction sequences: a review of recent research findings.

AIM: To review and discuss the dental and lateral profile soft tissue effects of orthodontic treatment involving three different premolar extraction patterns (4/4, 4/5, 5/5). METHOD: The results of three previously reported studies were compared and discussed. RESULTS: Wide ranges of individual variation were found for the amounts of forward molar movement and incisor retraction, and for changes in the depths of upper and lower lip curves within all three premolar extraction pattern groups. The amount of pretreatment crowding and the residual space following initial alignment were the two factors most likely to influence changes in tooth positions during treatment. Treatment changes in the curvature of the lips were influenced by the pretreatment thickness of the lips at the vermilion level. CONCLUSION: Factors other than simply the choice of premolar extraction pattern influence positional changes in the molars, incisors and lips during orthodontic treatment.

Bicuspid↗
PubMed2005

[The occurrence of the cleft lip and/or palate in cleft-twins].

UNLABELLED: Twin pregnancies are associated with an increased risk of congenital malformation, illness and higher incidence of newborns during labour. They are noticed to have been more frequent in Poland in recent years. Based on the hospital records we reviewed the most common facial anomaly in twins--the cleft lip and palate. The frequency of this malformation occurrence in Poland is 1:502 in newborns. The etiopathogenesis of this malformation, in 17-20%, results from genetic factors. Researches on the occurrence of cleft lip and palate in twins strongly confirm the heredity of the malformation. THE AIM OF THE STUDY: The analysis of the occurrence frequency of the cleft lip and/or palate in cleft-twins was the main objective in our study. MATERIAL AND METHODS: In the study of 21 sets of cleft-twins, 6 of them were monozygotic and 15 were dizygotic. It was assessed on the basis of data that was received from parents, same-sex twins and physical likeness. Twin-siblings who had cleft anomalies, always had cleft lip and palate or an isolated cleft palate. RESULTS: The outcome showed that twins were not a subject to increased or decreased risk of cleft anomalies. Moreover, clefts did not increase the risk of twin-siblings labour. The hypothesis that a monozygotic twin pregnancy is a factor of increased risk of cleft anomaly was not confirmed. Presented data can be used in genetic counseling. In all likelihood, in the nearest future there will be chances for working out the cleft prophylaxis. CONCLUSION: Twin pregnancy does not changes risk of cleft anomaly and its occurrence does not increase of twin-siblings labor.

Catchment Area, Health↗
PubMed2006

[Treatment of cleft lip and palate: past, present and future].

Comparing the survey results of 224 Centers of Cleft Lip and Palate in the United States with the current status in China, and reviewing the experience and lessons systemically, we could get a conclusion that the repair of cleft lip and palate depends on the experience and excellent skills of the surgeons, and its important role in combined and sequential treatment (team approach) of cleft lip and palate should not be ignored. The team approach program requires multidisciplinary cooperation and good compliance of the patients. In order to improve the treatment outcomes of cleft lip and palate, it is necessary for us to study the advanced program and methods and combined the situation of our country.

China↗
PubMed2006

[Individual repair technique of microform cleft lip: state of art].

OBJECTIVE: To explore an technique to repair the microform cleft lip (MCL). METHODS: The individual method was used to repair the MCL, a contrastive research was carried to analyzed the result. RESULTS: It was found that the form of the cupid's bow was good, and the configure of the upper lip was reconstructed. The deficit of the orbicularis muscle was overcame and the function was satisfying by this procedure. Symmetry was recovered. CONCLUSIONS: Individual technique is an available method to repair the microform cleft lip. Furthermore, this technique is also promising to repair the other kinds of cleft lip.

Cleft Lip↗
PubMed2006

The place of the histopathologic exam for establishing the profile of the squamous cell carcinoma of the lower lip with a high degree of malignity.

UNLABELLED: The squamous cell carcinoma of the lip has a metastasizing potential by lymphatic or/and sanguine ways. OBJECTIVE: Knowing the profile of the squamous cell carcinoma of the lip with a high degree of metastasizing. PATIENTS AND METHOD: We have analyzed on a group of 322 patients the influence of the degree of the histological differentiation of the tumor and the influence of the seriousness of the invasion over the metastasized potential. The bioptic fragments have been processed according to the usual histological technique paraffin embedding, and the sections have been colored with Hematoxylin-Eosin. Some of the cases have been immunomarked, to confirm the diagnosis, with antibody anti-cytokeratins, anti-vimentin, anti-protein S100 and anti-alpha actin. RESULTS: 12.24% of the patients with tumors with Broders II degree, 28.5% of those with Broders III degree and 52.94% of those patients with Broders IV degree presented metastasis, that show that the incidence of the regional ganglionary metastasis is higher in the case of the tumors with a low histological differentiation (test chi(2), p<0.001). 1.88% of the patients with an invasive squamous cell carcinoma under 6 mm and 38.60% of those with tumors of over 6 mm presented metastasis, that show that the risk of metastasizing is higher when the profoundness of the invasion is over 6 mm (test chi(2), p<0.001). In two cases we faced the changing of the malignity degree, meaning that it got worse passing from the Broders III degree (primary tumor) to Broders IV degree (relapse of the tumor). CONCLUSIONS: The histological differential degree of the tumor and the profoundness of the invasion are two important parameters when shaping the profile of the squamous cell carcinoma of the lip with a high degree of metastasis. The degree of malignity of the tumor may worsen during the evolution of the lip cancer, raising the risk of metastasizing as well.

Adult↗
PubMedDate not supplied

[Association of congenital upper and lower double lip].

The frequency of the congenital double lip is scarcely mentioned in the literature. There is no previous report on the bilabial congenital double lip. This association consists of a mucosae fold at the free edge of the lip, which is projected at smiling and opening of the mouth. Histologically, the mucous salivary glands are either hypertrophic or normal with little connective tissue and covered by a cornified epithelium. There is no muscle tissue found. We present the report of two cases of bilabial congenital double lip treated surgically by the elliptical resection of the mucosae folds.

Adult↗
PubMed1989

[Case of bimaxillary protrusion and lip evaluation on cephalogram].

One of the goals of orthodontic treatment is to obtain the best balance and harmony of facial lines, especially it is important to retract the lip in bimaxillary case. A 12-year and 4-month-old boy was first seen with the chief complaint of excessive lips protrusion. We treated him by the edgewise method for 34 months, and evaluated the change of facial profile. Excessive lip protrusion was eliminated, and arch leveled. Overjet and overbite were reduced. Mandibular growth increased the prominence of the chin, and reduce the protrusion of the lower lip.

Humans↗
PubMed1989

[Hearing disorders in patients with cleft lip and palate].

Hearing threshold in cleft lip/or palate was assessed in 316 ears by pure tone audiometry. Normal hearing threshold was found in almost a half (164/51,9%) of the ears examined. Hearing defects were most frequently observed in cases of complete unilateral cleft palate (48/60%), whereas they were least frequently recorded in cases of cleft lip (15/19,2%). Complete bilateral cleft lip and palate was associated with conduction deafness in 29 (42,9%) ears examined, thus occupying the last but one place according to the frequency of association between deafness and cleft defects. A hearing conduction gap or more than 40 dB was most frequently present in complete cleft lip and palate (7/5,6%), followed by cleft palate (4/5%). Submucous cleft palate was observed to be less frequently accompanied by conduction deafness (9/56,2%) as compared to complete cleft palate, despite a common feature of bone and muscle support discontinuity. Cleft lip was least frequently accompanied by conduction deafness, but it was still present to a relatively high percentage when compared to the cleft-free population.

Adolescent↗
PubMed1989

Radiosensitivity of mouse lip mucosa: influence of anesthesia, carbogen, and a new high O2 carrying perfluorochemical emulsion.

The effect of a new perfluorochemical emulsion based on F-66E (54%, w/v) which carries, in combination with carbogen, twice as much oxygen as Fluosol-DA 20% was tested on the radiation response of the lip mucosa of unanesthetized mice. Mice were pretreated with 0.015 ml/g of the F-66E emulsion in the presence of carbogen for 1 h prior to and during irradiation. There was a significant increase in the mortality rate following the highest radiation dose in mice given F-66E emulsion plus carbogen. The reactions of lip mucosa of mice given F-66E emulsion and/or carbogen were not significantly different from that of the control group using three end points (average score, mean peak, incidence of mucosal desquamation), but the peak mucosal reaction was delayed. The radiosensitivity of the mouse lip mucosa to Ethrane, an anesthetic gas inhaled with carbogen, was also tested. The reaction of lip mucosa in the anesthetized mice was significantly greater than that of the control group. There was also a significant increase in the mortality rate following the two highest radiation doses.

Anesthesia, Inhalation↗
PubMedDate not supplied

[Results of treatment of cancer of the lip].

A study was carried out in Sancti Spiritus Province in the 1984-1986 period about the results of the treatment of lip cancer. Male patients were the most affected by lip cancer (CIE 8-140) in our series. The place of the tumor was predominantly the lower lip (p less than or equal to 0.001). Surgical treatment was used in 96.8% of the cases and the cuneiform (wedge-shaped) exeresis was the most commonly used method in the early stages of the disease (T1 y T2). Castañón keloplasty was the reconstructive procedure used in 18.7% of the patients. Local sepsis was present in 31.2% of the patients undergoing surgery, occurring most frequently in upper lip tumors.

Female↗
PubMed1978

An unusual case of median cleft lip with orbital hypotelorism--a missing link in the classification.

De Myer (1963) classified median-facial anomalies into two groups: 1. Median cleft lip with orbital hypotelorism 2. Median cleft lip with orbital hypertelorism. The first group is characterised by median-cleft lip, absence of premaxilla, nasal skeleton, and crista galli. In addition, there is a holoprosencephaly which may involve the whole forebrain or a smaller part of the brain. In this group, the children die within the first year or during childhood and always suffer from mental retardation. In this report, we present a 12-year-old child with an unusual form of median cleft lip with hypotelorism without brain deformity.

Child↗
PubMed1988

Nonsurgical correction of cleft lip nasal deformity in the early neonate.

Auricular cartilage is soft and plastic, and congenital auricular deformities are easily corrected nonsurgically in the early neonatal period. Alar cartilage is the same kind of elastic cartilage as auricular cartilage. Therefore, alar cartilage is also malleable in the early neonate. When cleft lip repair is performed around the age of three months, it is difficult to obtain good nasal shape without surgical correction. In the early neonate, there is a fair possibility for success in the nonsurgical correction of cleft lip nasal deformity. We performed cleft lip repair accompanied with nonsurgical correction of nasal deformity in 48 neonates aged two to seven days. A special retainer was placed in the affected nostril during the postoperative period for three months. In 10 cases, preoperative nonsurgical correction with a special retainer began in the early neonatal period and the lip repair was done at about three months of age. Following observation of 40 infants for 12 months or longer, their nasal shapes and symmetry were considered superior to those conventionally operated on at about three months of age without nonsurgical correction of their nasal deformity during the early neonatal period. Except for one case of nasal infection, there were no other complications.

Bandages↗
PubMed1988

Perceptions of appearance and speech by adolescent patients with cleft lip and palate and by their parents.

This study surveyed 102 patients with cleft lip, cleft palate, or cleft lip and cleft palate (ages 13 to 19) and their parents to assess satisfaction with appearance, speech ability, and intelligibility. The data were based upon standardized interviews conducted at a cleft palate treatment center, using simple questions with high face validity. Surgical experience was high among this sample, as reflected by the finding that the majority of patients (55.7%) had had three or more operations on the face or mouth. Patient ratings of facial appearance showed that most patients were very pleased (59.3%) or moderately pleased (13.2%); others were somewhat (18.7%) or very (8.8%) disappointed. Many parents indicated that their children expressed occasional (22.0%) or frequent (27.5%) concerns about appearance. Nearly all patients (91.9%) felt that their operations had accomplished what they expected, though some of the cleft lip patients (35.7%) and their parents (43.9%) were less than very pleased with the appearance of the lip. When asked how pleased they were with the way they presently talked, most patients (69.1%) were very pleased, though some disappointment was expressed. Although often pleased with their current speech status, many patients rated themselves as only moderately understandable (19.1%) or as not understandable (8.5%). No significant gender effects were found in satisfaction, appearance, or speech ratings. There were no significant differences found between parent and child ratings. The findings indicate that at a center delivering team-based cleft palate care, both adolescent patients and their parents have considerable concerns about appearance and speech results.

Adolescent↗
PubMed1987

[A new concept of normal and pathologic development of the primary palate. 2. The formal genesis of the open and covered cleft lip and jaw].

In part 1 of this work we have shown that in each mammalian embryo the nasal fin represents a masked physiological cleft lip and jaw. In this double-layered "Epithelmauer" the process of epithelium separation along the differentiation-line may undergo various fates: 1. It can completely fail to take place (resulting in total cleft lip and jaw) or can be interrupted (resulting in incomplete cleft). 2. The persisting oral epithelium of the nasal fin may be loosened and moved away with a little temporal retardation. Thereby the potential osteoblasts and myoblasts cannot meet and join at right time and they retract away from the midline epithelial seam. The minimal and subcutaneous cleft lip and the submucous clefts of the jaw and the mesenchymal bridges may result. 3. Only in very rare cases the cleft lip and jaw develop in another way, namely if the underdeveloped facial processes do not meet.

Animals↗
PubMed1986

Craniofacial morphology in unilateral cleft lip and palate prior to palatoplasty.

Roentgencephalometric studies were carried out in 30 boys with unilateral cleft lip and palate approximately five years of age, none of whom had had a palatoplasty. A comparison with 27 normal individuals matched in age showed that most basic deviations of the craniofacial configuration recorded in adults developed at an early age, often prior to palatoplasty, i.e., reduced height of the upper face, maxillary dentoalveolar retroinclination, displacement of the upper jaw backwards, widening of some components of the maxillary complex, and a shortening of the mandibular body and ramus associated with changes in the mandibular shape. Only the length of the upper jaw was not reduced. The shortening of this dimension occurred postoperatively at a more mature age. The described basic deviations exerted untoward effects on further facial parameters (proportions, retrusion of the jaws, limitation of anterior growth rotation, maxillomandibular and other interrelations, and malocclusion). The height of the upper lip showed a similar shortening as in adults, but lip thickness was not reduced. There was good prominence of the upper lip.

Cephalometry↗
PubMed1986

Cervical vertebral anomalies in cleft lip and palate.

A survey was made of the upper cervical vertebrae in children with cleft lip and palate in order to determine the prevalence of cervical vertebral anomalies. The cleft sample consisted of 105 patients attending for orthodontic treatment. It was subdivided into cleft lip (CL), cleft palate (CP), unilateral cleft lip and palate (UCLP) and bilateral cleft lip and palate (BCLP) subgroups. A control was comprised of 120 orthodontic patients. The cervical vertebral anomalies were classified into two types, posterior arch deficiency (PAD) and fusion anomalies (FUS). The results confirmed that the cervical vertebral anomalies occurred significantly more often in the cleft sample (13%) than in the controls (0.8%), p less than 0.001. The total prevalence of cervical vertebral anomalies was similar in the four cleft sub-samples, but the occurrence of each of the two types of cervical vertebral anomalies showed a more differentiated pattern. Posterior arch deficiency occurred significantly more often in cleft palate (CP), (16%) than in controls p less than 0.001, but fusions did not occur more frequently in any cleft groups than in controls.

Axis, Cervical Vertebra↗
PubMed1978

[The value of radiotherapy in the treatment of lip neoplasms].

About 80% of carcinomatous lesions of the lip are smaller than 2 cm in diameter, have little tendency to infiltrate, grow in the lower lip, are histologically well differentiated and do not have, or develop later, regional metastases. Of these carcinomas 95% are cured by the various methods of radiotherapy. The criteria for a more serious prognosis, such as expansive growth, deeper infiltration, location on the upper lip and/or the commissures, undifferentiated grading and regional lymphatic metastases, are found only in a minority of patients with carcinoma of the lip. However, even for tumors of the T3 category rates of cure of over 90% are reported, as confirmed by our own results with supervoltage irradiation with fast electrons of the betatron during the years 1961-1970. The techniques and indications of interstitial Curietherapy with iridium-192 wires are described. The treatment of primary lymphnode metastases, which should be confirmed histologically or cytologically before therapy, is described in detail. Neck dissection is superior to irradiation therapy. General elective neck dissection, as normally performed for carcinoma of the oral cavity, is not justified because of the low rate of metastases and the results of elective therapy. A case report demonstrates the poor prognosis in patients with regional fixed metastases.

Hair Removal↗