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PubMedDate not supplied

Organ culture of the 16th gestation day mouse labyrinth. A model suggestion for pre- and post-partum development.

The 16th day mouse embryo inner ear was explanted and cultured "in vitro" for 6 days, which corresponds to 1 day post-partum development "in vivo". A normal development occurred both when the inner ear anlage was divided into a vestibular and a cochlear portion and when it was cultured as a whole. The present model system may provide a helpful tool in the study of both normal development and inner ear pathology.

Animals↗
PubMedDate not supplied

Analysis of trace elements in the human labyrinth by using proton microprobe.

The concentration of zinc in the spiral tract is age-dependent. The accumulation of zinc starts at the bone surface towards the fundus of the internal auditory meatus and continues throughout the whole thickness of the separating wall to reach in advanced age the bone surface towards the basal coil of the cochlea. The concentration of calcium decreases with age. These findings prove our previous histological and densitometric as well as macroscopical investigations of this region.

Adolescent↗
PubMed1988

Experimental mumps virus-induced labyrinthitis. Immunohistochemical and ultrastructural studies.

Guinea pigs were inoculated with mumps virus (Torii strain) by the intralabyrinthine or intravascular route and their cochleas were examined by immunofluorescence and electron microscopy. In these animals, viral antigen was detected in the cochleas, most often in the stria vascularis. However, viral infection was produced only in those with intralabyrinthine inoculation. The cochlear lesion commonly observed in this study was severe degeneration of the organ of Corti, which was usually found in the basal turn. Morphological evidence of viral infection, as depicted by intracellular strands of nucleocapsids and budding of the virus at the endolymphatic surface, was prominent in both the stria vascularis and Reissner's membrane. The cochlear location of mumps infection correlated closely with that of the viral antigen formerly reported in newborn hamsters.

Animals↗
PubMed1990

Cytoskeletal network of intermediate filament proteins in the adult human vestibular labyrinth.

The cytoskeleton of adult human vestibular hair cells lacks intermediate filament (IF) proteins, whereas in fetal material immunoreactivity for cytokeratin (cks; a subclass of IFs) occurs in both types of hair cells. The shift in the cytoskeletal composition can be hypothesized to their onset of physiological function. Since the IFs are extremely rigid intracellular structures, they provide considerable mechanical stability. The entire cytoplasm of all supporting cells in the epithelial lining of all five vestibular organs is filled with cks. In this way most vestibular hair cells become compartmentalized, each with a rigid shell surrounding it. The distinct delineation of IF proteins in adult tissues, in contrast to fetal inner ear organs in which often a rather general cytoplasmic expression occurs, probably reflects their anatomical basis for their function.

Ear, Inner↗
PubMed1999

Of bugs and drugs. A guide through the labyrinth of antimicrobial therapy for respiratory tract infections.

Choosing appropriate antimicrobial therapy is no longer a simple process. Even for the common problems of respiratory tract disease in children and adults, selection is complicated by both increasing microbial resistance and the daunting number of extended-spectrum antibiotics now on the market. In this article, Drs Singh and Arrieta look at the problem from all aspects and give their specific recommendations.

Acute Disease↗
PubMed1991

Capital PPS: trekking through the labyrinth.

The Health Care Financing Administration's (HCFA's) new method of paying for Medicare inpatient capital costs will pay a hospital under either a fully prospective system or a hold harmless method. The new system includes a payment floor on total capital, a revised outlier payment system, and an exceptions process by which some hospitals can receive additional capital payments. HCFA plans to phase in the new system over a 10-year period.

Capital Expenditures↗
PubMedDate not supplied

Through the labyrinth.

Explore the source record for details and available documents.

Adaptation, Psychological↗