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At least 1,207 records · Page 67Linked to original sources
PubMed1988

Pharmacologic management of inflammatory joint disease.

Successful management of the arthritides demands a thorough understanding of the disease processes and the modes of action of those medications used to combat pain and joint destruction. Nonsteroidal antiinflammatory drugs are useful in controlling the symptoms of a broad range of arthritic diseases, while the utility of the various disease-modifying agents lies in their ability to change the course of disease activity. A review of these pharmaceutical agents and their clinical usefulness is presented.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed2005

Inflammatory joint disease and severe ischemia of the extremities revealing thromboangiitis obliterans in a female.

Thromboangiitis obliterans (or Buerger disease) is a rare vascular disease that selectively affects young males who are inveterate smokers. We report a case in a young female smoker who presented with recurrent episodes of polyarthralgia and distal extremity ischemia. The initial diagnosis was connective tissue disease, and the correct diagnosis was established only 7 years after symptom onset. Joint manifestations are common in thromboangiitis obliterans and usually antedate the diagnosis, which should be considered in patients with superficial venous thrombosis, upper limb ischemia, or Raynaud's phenomenon. This is true even in females, as shown by the case described here.

Adult↗
PubMed1982

Late-onset peripheral joint disease in ankylosing spondylitis.

We reviewed the records of 150 patients with definite ankylosing spondylitis who had significant peripheral arthritis and were seronegative and found 7 patients who had the onset of peripheral arthritis after their spinal disease became inactive. This late-onset peripheral arthritis may lead to significant joint deformity, and aggressive therapy may be warranted.

Aged↗
PubMedDate not supplied

Why does chronic inflammatory joint disease persist?

Inflammation is a beneficial host response to tissue damage. Most episodes of inflammation resolve spontaneously and do not persist. However, in rheumatoid arthritis (RA), as in a number of other chronic inflammatory diseases, the inflammatory response persists and a stable inflammatory infiltrate accumulates in the joint. What drives this persistence and the relative contribution of infiltrating leucocytes and stromal cells such as fibroblasts to the stability of the inflammatory process are the subject of this article. Fibroblasts play an important role in defining the disordered synovial microenvironment in RA. Through their production of a variety of cytokines and constitutive chemokines they directly alter the behaviour of infiltrating leucocytes, leading to their inappropriate survival and retention. These findings suggest that stromal cells such as fibroblasts play an important role in the switch from acute resolving to chronic persistent arthritis by allowing lymphocytes to accumulate in the wrong place at the wrong time.

Arthritis↗
PubMed2000

[Radiosynoviorthesis in inflammatory joint diseases].

The use of beta-(beta) emitting radionuclides for radiosynoviorthesis (RSO) has been a well established therapy for inflammed joints for more than 40 years. Radionuclides are often applied to patients with rheumatoid arthritis as local therapy. The choice of the radionuclide is empirical. The evaluation of the therapeutic success is mainly based on the improvement of the joint motion. MRI and other radiological examinations have not been proved to be reliable for diagnosis of the therapeutic success. The aims of this manuscript are to familiarize physicians with the different radionuclides, to explain the therapeutic success which can be expected due to dosimetric data, and to present the three phase bone scintigraphy as a valuable instrument for the evaluation of the therapeutic success.

Arthritis, Rheumatoid↗