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At least 1,207 records · Page 67Linked to original sources
PubMed1986

Renal function in spinal cord injury: a preliminary report.

To investigate the effect of current bladder management techniques on renal function in spinal cord injury (SCI), we followed 99 patients by frequent examinations, excretory urograms, and iothalamate short renal clearances. Fifty-eight percent of the subjects emptied their bladders by catheter-free methods (bladder retrained), 32% by intermittent self-catheterization, and 10% by indwelling urethral catheters. All remained clinically well, but more and earlier excretory urogram abnormalities occurred in the intermittent self-catheterization group. Twenty-one percent of the intermittent self-catheterization group but only 5% of the bladder retrained group had excretory urogram abnormalities. Declines of more than 10% in short renal clearance values were noted in 30% of intermittent self-catheterization patients and in 15% of bladder retrained patients. Our preliminary data support the need for close surveillance and follow-up after SCI rehabilitation, even in patients appearing clinically well. These data also suggest that renal function can be preserved with current bladder management methods, with bladder retraining having a slight edge over intermittent self-catheterization.

Acute Disease↗
PubMed1985

[Experiences with the nonionic contrast medium iopamidol in cerebral angiography].

The rate of cerebral angiographies is bound to diminish in the present era of new imaging methods of low invasiveness. However, this examination method will continue to be an often decisive method to effect diagnostic visualisation of the cerebral vessels, so that the introduction of contrast media with low toxicity and good tolerance represents a great step forward, the more so since the risk of general anaesthesia can be often avoided. This fact, together with the substantial improvement in catheter technique, raises the method--provided it is conducted in special well-equipped departments--to a level of high diagnostic value, complications having become extremely rare if not completely eliminated.

Adolescent↗
PubMed1985

Experience with iopamidol in myeloradiculography.

Myeloradiculography with Iopamiro 300 produced by Bracco was carried out in 110 patients. In 97.2% the diagnostic evidence produced was excellent. It was difficult to make an exact diagnosis in 2.7% of cases, in whom there was a strong dilution as the contrast material moved from the lumbar into the cervical area of the spine. The side effects were slight and occurred only in a small proportion of patients. No neurotoxic complications or psychological changes were observed.

Adolescent↗
PubMed1977

Adverse effects of water-soluble contrast media in myelography, cisternography and ventriculography. A review with special reference to metrizamide.

The adverse effects following lumbar myelography and ventriculography with meglumine iothalamate (Conray Meglumin), meglumine iocarmate (Dimer-X, Bis-Conray) and metrizamide (Amipaque), and after thoracic and cervical myelography and cisternography with metrizamide are reviewed. In addition to the published material information given to Nyegaard & Co. from several hospitals participating in clinical trials with metrizamide is also reported. The frequency of minor adverse effects (headache, nausea, vomiting) seems to be about the same with all the three water-soluble contrast media. Convulsions, either localized to the lower part of the body or generalized, may be a problem with meglumine iothalamate and meglumine iocarmate, while the epileptogenic effect is markedly lower with metrizamide. With a technique directed towards preventing contrast medium of high concentration from passing intracranially, the frequency of serious adverse effects may be kept at a very low level. Late adverse effects (adhesive arachnoiditis) occurring after all other water-soluble contrast media are a very minor problem after metrizamide. Serious complications have not been recorded following ventriculography and cisternography with metrizamide. Metrizamide is considered to be the water-soluble contrast medium best suited for use in the subarachnoid space and cerebral ventricles.

Cerebral Ventriculography↗
PubMedDate not supplied

[Cardiac complications of intravenous digital angiography. Comparison of ionic and nonionic contrast media].

The review of 1405 digital intravenous subtraction angiographies carried out in the period may 1982-february 1985 showed in about 2% of the cases cardiac symptoms, which arose during or after the examination. In the great majority of the cases the symptomatology was characterized by angina pectoris. In order to better understand these data and analysing the results of the literature, a trial has been performed in 100 patients who underwent DSA. They have been divided into two groups in which two different contrast media, ionic (sodium meglumine diatrizoate) and non ionic (iopamidol) have been randomly injected. A detailed cardiologic anamnesis has been collected and EKG has been performed before and after each injection with pre-established gaps. The results showed that the incidence of cardiac symptoms and EKG variations is lesser with the non ionic contrast medium: therefore this agent is to be preferred at least in patients at risk from cardiologic point of view.

Acute Disease↗
PubMed1985

[Complications following myelography with positive contrast media (Pantopaque, Amipaque). Pathomorphologic findings in 2 fatal cases].

It is reported on three patients which suffered from severe side effects after cervical myelography using Amipaque (cases 1 and 3) and Pantopaque (case 2). In 2 cases death occurred after 13 days (case 2) respectively 17 days (case 3). Worsening of the clinical symptoms appeared in all cases within four days after myelography. In the first 2 cases inflammatory alterations prevailed whereas in the third case complications probably based on mechanical irritations of nerval and vascular structures. In the 2 lethal cases autopsy offered a prostatic cancer with vertebral and intraspinal metastases respectively syringobulbia and cervical syringomyelia beside an ependymoma of the cervical spinal cord as incurrable complaints. The various side effects and complications after myelography using positive contrast media as well as their causes are discussed.

Aged↗
PubMed1985

[Acute cardiac side effects of iodecol, a new nonionic dimer roentgen contrast medium, in intracoronary injection].

The effects of intracoronary injections of Iodecol, a nonionic-dimeric contrast medium (iodine content 350 mg/ml, osmolality 0.34 osmol/kg, viscosity 13.8 mPa X s) on haemodynamics, coronary blood flow, ECG, and cationic content as well as osmolality of coronary sinus blood have been evaluated and compared to those of Iopamidol and Amidotrizoate. Experiments were carried out in 9 closed-chest dogs using heart catheterisation techniques. After Iodecol and Iopamidol only positive inotropism was seen while Amidotrizoate initially had cardiodepressive effects. Iodecol caused less increase of peak velocity of pressure rise and systolic blood pressure than Iopamidol. All contrast media led to an increase in coronary blood flow of the same extent. ECG changes were most marked following Amidotrizoate and only slight after Iodecol. Decrease of cationic content and increase of osmolality in coronary sinus blood were seen after each compound. Changes were only small after Iodecol and always greater after Amidotrizoate. Moreover, an overproportional decrease of coronary sinus calcium content was seen after Amidotrizoate due to calcium binding. Thus, based on these animal experiments, a further slight reduction of acute cardiac side effects during coronary arteriography could be expected from the use of nonionic dimeric compounds, compared to ionic and currently used nonionic contrast media.

Animals↗
PubMed1985

Assessment of compensatory renal function and [125I]iothalamate clearance in sheep.

Compensatory renal function and sodium [125I]iothalamate clearance were studied in 4 adult Merino ewes. Renal clearances of inulin (CIN), iothalamate (CIOT), and p-aminohippurate (CPAH) were used to measure renal function before and 7 and 170 days after 50% and 75% reductions in renal mass. Renal mass reduction to 50% of normal was achieved by ligation of the right renal artery, and to 25% of normal by ligating the right renal artery and branches of the left renal artery. Renal function (CIN and CPAH) after 50% renal mass reduction was 78% of normal on postligation day (PLD) 7 and 64% of normal on PLD 170. This decrease in renal function between PLD 7 and 170 was significant (P less than 0.05). Renal function (CIN and CPAH) after 75% renal mass reduction was 55% of normal on PLD 7 and 48% on PLD 170; however, this decrease in renal function between PLD 7 and 170 was not significant. Results indicated that, shortly after 50% renal mass reduction by renal arterial ligation, renal function in ewes was greater than that previously reported after unilateral nephrectomy and that a further decrease in renal function developed within 6 months after ligation. The mean CIOT in healthy ewes was 2.46 ml/min/kg of body weight. In healthy ewes and in ewes after renal mass reduction, regression of the simultaneous CIOT and CIN was CIOT = 0.276 + 1.05 CIN. The CIOT was higher than the corresponding CIN, and remained significantly (P less than 0.01) and consistently higher. Therefore, iothalamate can be used to estimate glomerular filtration rate in sheep, although a correction factor is required.

Animals↗
PubMedDate not supplied

Pharmacokinetics of high-dose azlocillin sodium in patients with cystic fibrosis.

The pharmacokinetics of high-dose azlocillin sodium was studied in 18 patients with cystic fibrosis. Nine male and nine female patients with a mean age of 14.7 years (range 3 to 29 years) participated in the study. They received azlocillin 450 mg/kg/day (as the sodium salt) in six divided doses. During a steady-state dosing interval, a dose of azlocillin was coadministered with a 10-mg/kg dose of iothalamate sodium as a 30-minute infusion. Serum concentrations of azlocillin and iothalamate were determined by high-pressure liquid chromatography assay. The data were analyzed using model-independent methods. The mean elimination rate constant for azlocillin was 0.64 +/- 0.22 hr-1 and the mean serum half-life was 1.22 +/- 0.39 hr. Total clearance of azlocillin, calculated by noncompartmental analysis, was 77.2 +/- 26.4 mL/min/sq m. Glomerular filtration rate, as estimated by measuring iothalamate clearance, was 79.6 +/- 21.9 mL/min/sq m. The total clearance of azlocillin correlated with iothalamate clearance. Patients with cystic fibrosis appear to eliminate azlocillin more rapidly than healthy individuals. This rapid elimination warrants the use of high doses to maintain high serum concentrations.

Adolescent↗