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Using clinical evidence to manage pharmacy benefits: experiences of six states.

Medicaid agencies report that pharmacy costs are a major driver of overall program spending growth. Many states believe that clinical evidence can be used to curtail pharmacy costs while ensuring beneficiary access to needed prescription drugs. In 2004, researchers from the National Academy for State Health Policy and Georgetown University conducted site visits to examine how state Medicaid agencies in California, Florida, Kansas, Michigan, Missouri, and Washington manage their pharmacy benefits. This brief focuses on states' use of clinical evidence and preferred drug lists. It summarizes the states' experiences in four areas of pharmacy benefit management: the role of pharmaceutical and therapeutics committees in developing preferred drug lists; use of prior approval processes to enforce preferred drug lists; the role played by the Drug Effectiveness Review Project in helping states manage drug utilization; and the management of behavioral health pharmaceuticals.

Antidepressive Agents↗

The P&T Society.

Explore the source record for details and available documents.

Aged↗

[Orphan drugs].

Diseases lacking in satisfactory therapies, named orphans (over 60% of the known), raise the problem of the availability of new drugs to be discovered and evaluated on toxicological and clinical bases. The estimated cost for the full development of a drug makes it not profitable (and therefore orphan drug) in the case of rare diseases and the typical diseases of developing countries. The USA with the Orphan Drug Act have faced the former, whereas WHO with the "Tropical Diseases Research" programme has faced the latter. Uncommon formulations and dosages of known substances and products no longer marketed as non-profitable are considered orphans drugs as well.

Centers for Disease Control and Prevention, U.S.↗

A method classifying biologics for formulary decision making.

Pharmacy and Therapeutics Committees have been trying to determine the correct way to incorporate biologic agents into their formularies. As with any new drug, the first step is to determine the appropriate category or classification in which they will be evaluated. The biologics present some challenges to classification in significant ways. Even though two or more biologics may have a common indication, their differences in mechanism of action, method of delivery, dosing schedule, and other factors may be important considerations in choice of a useful classification. A method is suggested and illustrated, utilizing the group of biologic agents commonly used to treat psoriasis (including, for illustrative purposes, alefacept, efalizumab, etanercept, and infliximab).

Biological Products↗

[Dilemmas of the pharmacist, 7th edition of Hungarian National Formulary in practice].

Most important event of year 2004 of the history of Hungarian pharmacy was the release of the 7th edition of the National Formulary. The general part of the new formulary expanded, remarks on the preparations are more detailed and dispensing technologies are more elaborated. Knowledge base on pharmaceutical substances and incompatibility is inserted as novelty. Following the principles of modern pharmacy practice the new National Formulary excludes pills, though it is still accepted as an alternative dosage form. Usage of tablets, hard gelatine capsules and medication stick as a new dosage forms are introduced. The aim of my study was to prepare and examine some new compositions of the new edition of the National Formulary to help the pharmacist's work. Results confirmed the novel solutions of the new National Formulary.

Formularies as Topic↗

The economic burden associated with prior authorizations in an allergist office.

Costs for managed care organizations to process prior authorizations (PAs) for nonformulary medications have been estimated to be dollars 20-25 per request. Costs for physicians to process these requests have not been studied extensively. A data collection tool was developed and used by physicians and nurses to document time spent on processing PAs. Data were collected over 8 weeks and 117 requests were processed. Nurses averaged 5.6 +/- 6.5 calls per day per nurse and spent an average of 17 minutes per call. Physicians averaged 1.9 +/- 1.2 calls per day averaging 5.8 +/- 5.0 minutes per call. During the study period nurses spent >40 hours on 231 calls and physicians spent >8 hours on 154 calls. Based on the hourly rate of the nurses and physicians, the total cost in this specialty practice was dollars 17.77 per PA. Of the 117 PA requests, 98.7% were approved the first time they were processed. There are substantial costs with processing PAs for nonformulary drugs on the physician office side of managed care as well as on the insurance side of the process. Specialty physicians should have a different process for obtaining notformulary medications because almost 100% of their requests are granted.

Allergy and Immunology↗

Assessing Medicare prescription drug plans in four states: balancing cost and access.

Success of the Medicare prescription drug benefit depends on private organizations offering beneficiaries appropriate access to medications while controlling costs. There is limited guidance, however, as to what constitutes best practice in benefit and formulary design. This issue brief examines Medicare stand-alone prescription drug plans in the four most populous Medicare states-California, Florida, New York, and Texas. While there are similar offerings in all four states, there is wide variation in the amount of drugs covered, how drugs are accessed by beneficiaries, and prior authorization requirements. Plans with lower premiums are more likely to have additional formulary tiers and no coverage in the "doughnut hole"-the gap faced by many beneficiaries between $2,250 and $5,100 in costs. Given the many choices facing beneficiaries, the Centers for Medicare and Medicaid Services should monitor experiences to determine whether plans are meeting the needs of Medicare beneficiaries, particularly the frail and disabled.

Aged↗

Cost efficiency and formulary considerations for statin therapy.

Extensive epidemiologic evidence and reports issued by the National Cholesterol Education Program have repeatedly identified low-density lipoprotein cholesterol (LDL-C) as the primary target in reducing the primary and secondary risk of coronary events. With recent evidence supporting a more aggressive approach using higher potency statins, and a lower threshold for initiating drug therapy for high-risk patients, providers and administrators in managed care are charged with finding the most effective and cost-effective means of attaining these goals. Changes in the market, such as newer high-potency statins and statin combinations available at lower cost and expiration of patents on widely accepted brand drugs, have provided practitioners with the ability to reduce LDL-C at lower costs than ever. The cost-efficiency analysis presented here finds that, for low-to-moderate reduction (<40%), generic lovastatin and simvastatin provide the lowest cost per 1% LDL-C reduction. Similarly, for reduction greater than 40%, branded rosuvastatin and ezetimibe/simvastatin have the lowest cost per 1% reduction.

Cholesterol, LDL↗

[Wuwei Handai yijian (Wuwei Medical Bamboo Slips of the Han Dynasty) as evidential material for exploring the origin of Shang han Za bing Lun (Treatise on cold pathogenic and miscellaneous disease)].

Since there are only very few Chinese medical literature in the Han and preceding dynasties extant, it is very difficult to investigate the origins of both the herbs and formulas in the book Shanghan Zabing Lun (Treatise on Cold Pathogenic and Miscellaneous Disease) and the status of that of the contemporary period. The Chinese medical bamboo slips of the Han dynasty unearthed from the tombs in Wuwei, Gansu Province in 1972, had been speculated by archeologists to be a medical literature written in the early period of the Eastern Han Dynasty, or, 150 years earlier than the time Zhang Zhongjing's book written at the end of the Eastern Han dynasty, Thus, it can provide evidence for the study on the source of herbs and formulas in Shanghan Zabing Lun.

China↗

[Clinical features of Wei Yuheng].

Wei Yuheng held that the endogenous miscellaneous diseases are mostly caused by liver diseases, highly stressed the treating method of nourishing yin to generate liver. He claimed that liver deficiency is mostly caused by congenital factors, sexual strain or improper treatment. He criticized that the improper treatment by elder generations mainly was caused by their ignorance of tonifying the liver based on the saying of "no tonifying treatment for the liver". Wei Yuheng's medical theories and clinical experiences are scattered in his book Xu Mingyi Lei'an (Supplement to Classified Case Records of Celebrated Physicians). Wang Mengying collected part of his thoughts and experiences and wrote the book Liuzhou Yihua (Liuzhou Medical Talks). Although Wang Mengying's book could deduce part of the thoughts of Wei Yuheng, it didn't disclose his theories completely. It is known to all that the compound recipe Yiguan Jian is a representative formula of Wei Yuheng to tonify liver yin. Actually, it can be concluded from the analysis of Xu Mingyi Lei'an that he used Fructus Lycii (Gouqi) as a main herb to tonify liver yin in the method of nourishing yin to generate liver. Based on the idea that there are accept, restriction, generation and transformation relationship among the lung, kidney and liver yin, so he also always used Radix Glehniae (Beishashen), Radix Ophiopogonis (Maidong), Radix Rehmanniae Recens (Shengdihuang), and Radix Rehmanniae Preparata (Shudihuang) in his compound recipes. If the yin blood is insufficient, Semen Ziziphi Spinosae (Suanzaoren) should be added. In order to prepare a out way for phlegm-heat caused dy liver yin deficiency, a lubricative, Semen Trichosanthis (Gualouren) was always used and raw Semen Coicis Recens (Shengyiyiren) too. Sichuan Rhizoma Coptidis (Chuanhuanglian) can be used to clear fire-heat, and Fructus Meliae Toosendan (Chuanlianzi) for pain caused by fire-heat.

China↗